| UniProt ID | FANCA_HUMAN | |
|---|---|---|
| UniProt AC | O15360 | |
| Protein Name | Fanconi anemia group A protein | |
| Gene Name | FANCA | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1455 | |
| Subcellular Localization | Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic. | |
| Protein Description | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.. | |
| Protein Sequence | MSDSWVPNSASGQDPGGRRRAWAELLAGRVKREKYNPERAQKLKESAVRLLRSHQDLNALLLEVEGPLCKKLSLSKVIDCDSSEAYANHSSSFIGSALQDQASRLGVPVGILSAGMVASSVGQICTAPAETSHPVLLTVEQRKKLSSLLEFAQYLLAHSMFSRLSFCQELWKIQSSLLLEAVWHLHVQGIVSLQELLESHPDMHAVGSWLFRNLCCLCEQMEASCQHADVARAMLSDFVQMFVLRGFQKNSDLRRTVEPEKMPQVTVDVLQRMLIFALDALAAGVQEESSTHKIVRCWFGVFSGHTLGSVISTDPLKRFFSHTLTQILTHSPVLKASDAVQMQREWSFARTHPLLTSLYRRLFVMLSAEELVGHLQEVLETQEVHWQRVLSFVSALVVCFPEAQQLLEDWVARLMAQAFESCQLDSMVTAFLVVRQAALEGPSAFLSYADWFKASFGSTRGYHGCSKKALVFLFTFLSELVPFESPRYLQVHILHPPLVPGKYRSLLTDYISLAKTRLADLKVSIENMGLYEDLSSAGDITEPHSQALQDVEKAIMVFEHTGNIPVTVMEASIFRRPYYVSHFLPALLTPRVLPKVPDSRVAFIESLKRADKIPPSLYSTYCQACSAAEEKPEDAALGVRAEPNSAEEPLGQLTAALGELRASMTDPSQRDVISAQVAVISERLRAVLGHNEDDSSVEISKIQLSINTPRLEPREHMAVDLLLTSFCQNLMAASSVAPPERQGPWAALFVRTMCGRVLPAVLTRLCQLLRHQGPSLSAPHVLGLAALAVHLGESRSALPEVDVGPPAPGAGLPVPALFDSLLTCRTRDSLFFCLKFCTAAISYSLCKFSSQSRDTLCSCLSPGLIKKFQFLMFRLFSEARQPLSEEDVASLSWRPLHLPSADWQRAALSLWTHRTFREVLKEEDVHLTYQDWLHLELEIQPEADALSDTERQDFHQWAIHEHFLPESSASGGCDGDLQAACTILVNALMDFHQSSRSYDHSENSDLVFGGRTGNEDIISRLQEMVADLELQQDLIVPLGHTPSQEHFLFEIFRRRLQALTSGWSVAASLQRQRELLMYKRILLRLPSSVLCGSSFQAEQPITARCEQFFHLVNSEMRNFCSHGGALTQDITAHFFRGLLNACLRSRDPSLMVDFILAKCQTKCPLILTSALVWWPSLEPVLLCRWRRHCQSPLPRELQKLQEGRQFASDFLSPEAASPAPNPDWLSAAALHFAIQQVREENIRKQLKKLDCEREELLVFLFFFSLMGLLSSHLTSNSTTDLPKAFHVCAAILECLEKRKISWLALFQLTESDLRLGRLLLRVAPDQHTRLLPFAFYSLLSYFHEDAAIREEAFLHVAVDMYLKLVQLFVAGDTSTVSPPAGRSLELKGQGNPVELITKARLFLLQLIPRCPKKSFSHVAELLADRGDCDPEVSAALQSRQQAAPDADLSQEPHLF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSDSWVPNS ------CCCCCCCCC | 52.21 | 26852163 | |
| 4 | Phosphorylation | ----MSDSWVPNSAS ----CCCCCCCCCCC | 38.98 | 26852163 | |
| 34 | Ubiquitination | AGRVKREKYNPERAQ HHHHHHHHCCHHHHH | 55.12 | - | |
| 35 | Phosphorylation | GRVKREKYNPERAQK HHHHHHHCCHHHHHH | 31.06 | 25072903 | |
| 42 | Ubiquitination | YNPERAQKLKESAVR CCHHHHHHHHHHHHH | 61.62 | 22817900 | |
| 44 | Ubiquitination | PERAQKLKESAVRLL HHHHHHHHHHHHHHH | 57.57 | 21906983 | |
| 44 | Ubiquitination | PERAQKLKESAVRLL HHHHHHHHHHHHHHH | 57.57 | 21906983 | |
| 44 (in isoform 1) | Ubiquitination | - | 57.57 | 21890473 | |
| 44 (in isoform 2) | Ubiquitination | - | 57.57 | 21906983 | |
| 70 | Ubiquitination | EVEGPLCKKLSLSKV HCCCCHHHCCCCCCE | 65.51 | 29967540 | |
| 71 | Ubiquitination | VEGPLCKKLSLSKVI CCCCHHHCCCCCCEE | 42.16 | 22817900 | |
| 73 | Phosphorylation | GPLCKKLSLSKVIDC CCHHHCCCCCCEECC | 39.20 | 24719451 | |
| 76 | Ubiquitination | CKKLSLSKVIDCDSS HHCCCCCCEECCCCC | 48.80 | 21963094 | |
| 126 | Ubiquitination | SSVGQICTAPAETSH CCHHCCCCCCCCCCC | 36.99 | 27667366 | |
| 161 | Ubiquitination | YLLAHSMFSRLSFCQ HHHHHHHHHHHHHHH | 4.27 | 21963094 | |
| 165 | Phosphorylation | HSMFSRLSFCQELWK HHHHHHHHHHHHHHH | 23.90 | - | |
| 174 | Ubiquitination | CQELWKIQSSLLLEA HHHHHHHHHHHHHHH | 24.20 | 21963094 | |
| 181 | Ubiquitination | QSSLLLEAVWHLHVQ HHHHHHHHHHHHHHH | 15.07 | 22817900 | |
| 236 | Phosphorylation | DVARAMLSDFVQMFV HHHHHHHHHHHHHHH | 18.87 | 27461979 | |
| 249 | Ubiquitination | FVLRGFQKNSDLRRT HHHHCHHCCCCHHCC | 57.04 | 21906983 | |
| 249 | Ubiquitination | FVLRGFQKNSDLRRT HHHHCHHCCCCHHCC | 57.04 | 21906983 | |
| 249 (in isoform 1) | Ubiquitination | - | 57.04 | 21890473 | |
| 249 (in isoform 2) | Ubiquitination | - | 57.04 | 21906983 | |
| 261 | Ubiquitination | RRTVEPEKMPQVTVD HCCCCHHHCCCCHHH | 67.60 | 21906983 | |
| 261 | Ubiquitination | RRTVEPEKMPQVTVD HCCCCHHHCCCCHHH | 67.60 | 22817900 | |
| 261 (in isoform 1) | Ubiquitination | - | 67.60 | 21890473 | |
| 261 (in isoform 2) | Ubiquitination | - | 67.60 | 21906983 | |
| 267 | Ubiquitination | EKMPQVTVDVLQRML HHCCCCHHHHHHHHH | 5.14 | 21963094 | |
| 271 | Ubiquitination | QVTVDVLQRMLIFAL CCHHHHHHHHHHHHH | 28.69 | 21963094 | |
| 293 | Ubiquitination | QEESSTHKIVRCWFG CCCCCCCHHHHHHHH | 42.88 | - | |
| 303 | Phosphorylation | RCWFGVFSGHTLGSV HHHHHHCCCCCHHHC | 27.53 | - | |
| 309 | Phosphorylation | FSGHTLGSVISTDPL CCCCCHHHCCCCCHH | 21.27 | - | |
| 323 | Phosphorylation | LKRFFSHTLTQILTH HHHHHHHHHHHHHHC | 30.24 | - | |
| 329 | Phosphorylation | HTLTQILTHSPVLKA HHHHHHHHCCCCCCH | 23.18 | - | |
| 335 | Ubiquitination | LTHSPVLKASDAVQM HHCCCCCCHHHHHHH | 46.18 | - | |
| 335 | Ubiquitination | LTHSPVLKASDAVQM HHCCCCCCHHHHHHH | 46.18 | 21906983 | |
| 335 (in isoform 1) | Ubiquitination | - | 46.18 | 21890473 | |
| 337 | Phosphorylation | HSPVLKASDAVQMQR CCCCCCHHHHHHHHH | 25.23 | - | |
| 347 | Phosphorylation | VQMQREWSFARTHPL HHHHHHHHHHHHHHH | 12.32 | - | |
| 351 | Phosphorylation | REWSFARTHPLLTSL HHHHHHHHHHHHHHH | 25.15 | - | |
| 357 | Phosphorylation | RTHPLLTSLYRRLFV HHHHHHHHHHHHHHH | 24.31 | - | |
| 360 | Ubiquitination | PLLTSLYRRLFVMLS HHHHHHHHHHHHHHC | 33.83 | 21963094 | |
| 381 | Phosphorylation | HLQEVLETQEVHWQR HHHHHHHHCHHHHHH | 26.35 | 26074081 | |
| 391 | Phosphorylation | VHWQRVLSFVSALVV HHHHHHHHHHHHHHH | 22.27 | 26074081 | |
| 394 | Phosphorylation | QRVLSFVSALVVCFP HHHHHHHHHHHHHCH | 17.55 | 26074081 | |
| 421 | Phosphorylation | LMAQAFESCQLDSMV HHHHHHHHCCCHHHH | 10.74 | - | |
| 458 | Phosphorylation | WFKASFGSTRGYHGC HHHHHHCCCCCCCCC | 16.96 | - | |
| 467 | Ubiquitination | RGYHGCSKKALVFLF CCCCCCCHHHHHHHH | 46.25 | 27667366 | |
| 488 | Phosphorylation | VPFESPRYLQVHILH CCCCCCCEEEEEEEC | 12.60 | - | |
| 502 | Ubiquitination | HPPLVPGKYRSLLTD CCCCCCCCHHHHHHH | 31.27 | - | |
| 502 | Ubiquitination | HPPLVPGKYRSLLTD CCCCCCCCHHHHHHH | 31.27 | 21963094 | |
| 515 | Ubiquitination | TDYISLAKTRLADLK HHHHHHHHHHHHCCC | 39.20 | 21890473 | |
| 515 | Ubiquitination | TDYISLAKTRLADLK HHHHHHHHHHHHCCC | 39.20 | - | |
| 515 | Ubiquitination | TDYISLAKTRLADLK HHHHHHHHHHHHCCC | 39.20 | 21963094 | |
| 515 (in isoform 1) | Ubiquitination | - | 39.20 | 21890473 | |
| 522 | Ubiquitination | KTRLADLKVSIENMG HHHHHCCCCCHHHCC | 34.19 | - | |
| 522 | Ubiquitination | KTRLADLKVSIENMG HHHHHCCCCCHHHCC | 34.19 | 21906983 | |
| 522 (in isoform 1) | Ubiquitination | - | 34.19 | 21890473 | |
| 531 | Phosphorylation | SIENMGLYEDLSSAG CHHHCCCCCCHHHCC | 11.15 | 27642862 | |
| 535 | Phosphorylation | MGLYEDLSSAGDITE CCCCCCHHHCCCCCC | 30.39 | 29978859 | |
| 578 | Phosphorylation | ASIFRRPYYVSHFLP EHHHCCCHHHHHHHH | 18.06 | 25072903 | |
| 579 | Phosphorylation | SIFRRPYYVSHFLPA HHHCCCHHHHHHHHH | 9.73 | 25072903 | |
| 581 | Phosphorylation | FRRPYYVSHFLPALL HCCCHHHHHHHHHHC | 7.75 | 25072903 | |
| 589 | Phosphorylation | HFLPALLTPRVLPKV HHHHHHCCCCCCCCC | 15.20 | 25072903 | |
| 599 | Phosphorylation | VLPKVPDSRVAFIES CCCCCCCHHHHHHHH | 23.68 | 25072903 | |
| 608 | Ubiquitination | VAFIESLKRADKIPP HHHHHHHHHHCCCCH | 55.61 | - | |
| 608 | Ubiquitination | VAFIESLKRADKIPP HHHHHHHHHHCCCCH | 55.61 | 21906983 | |
| 608 (in isoform 1) | Ubiquitination | - | 55.61 | 21890473 | |
| 612 | Ubiquitination | ESLKRADKIPPSLYS HHHHHHCCCCHHHHH | 57.01 | - | |
| 612 | Ubiquitination | ESLKRADKIPPSLYS HHHHHHCCCCHHHHH | 57.01 | 21963094 | |
| 631 | Ubiquitination | ACSAAEEKPEDAALG HHHHCHHCCCCCCCC | 45.25 | 29967540 | |
| 683 | Dimethylation | QVAVISERLRAVLGH HHHHHHHHHHHHHCC | 23.76 | - | |
| 695 | Phosphorylation | LGHNEDDSSVEISKI HCCCCCCCCEEEEEE | 48.91 | 28555341 | |
| 696 | Phosphorylation | GHNEDDSSVEISKIQ CCCCCCCCEEEEEEE | 30.66 | 28555341 | |
| 701 | Ubiquitination | DSSVEISKIQLSINT CCCEEEEEEEEEECC | 39.88 | 21906983 | |
| 701 (in isoform 1) | Ubiquitination | - | 39.88 | 21890473 | |
| 849 | Phosphorylation | SYSLCKFSSQSRDTL HHHHHHCCCCCCCHH | 16.98 | 17924679 | |
| 850 | Phosphorylation | YSLCKFSSQSRDTLC HHHHHCCCCCCCHHH | 34.99 | 17924679 | |
| 858 | Phosphorylation | QSRDTLCSCLSPGLI CCCCHHHHHCCHHHH | 22.62 | 17924679 | |
| 858 | Ubiquitination | QSRDTLCSCLSPGLI CCCCHHHHHCCHHHH | 22.62 | 21890473 | |
| 867 | Ubiquitination | LSPGLIKKFQFLMFR CCHHHHHHHHHHHHH | 37.09 | - | |
| 867 | Ubiquitination | LSPGLIKKFQFLMFR CCHHHHHHHHHHHHH | 37.09 | - | |
| 892 | Phosphorylation | EEDVASLSWRPLHLP HHHHHHCCCCCCCCC | 20.67 | 24719451 | |
| 921 | Sumoylation | RTFREVLKEEDVHLT HHHHHHHCCCCCEEE | 65.32 | - | |
| 921 | Sumoylation | RTFREVLKEEDVHLT HHHHHHHCCCCCEEE | 65.32 | - | |
| 1079 | Ubiquitination | QRELLMYKRILLRLP HHHHHHHHHHHHHCC | 20.99 | - | |
| 1149 | Phosphorylation | CLRSRDPSLMVDFIL HHHCCCHHHHHHHHH | 33.13 | 22817900 | |
| 1156 | Ubiquitination | SLMVDFILAKCQTKC HHHHHHHHHHCCCCC | 3.63 | 21890473 | |
| 1162 | Ubiquitination | ILAKCQTKCPLILTS HHHHCCCCCCCHHEE | 14.15 | - | |
| 1191 | Phosphorylation | RWRRHCQSPLPRELQ HHHHHCCCCCCHHHH | 33.52 | 24719451 | |
| 1199 | Ubiquitination | PLPRELQKLQEGRQF CCCHHHHHHHHHHCH | 65.84 | 21890473 | |
| 1199 | Ubiquitination | PLPRELQKLQEGRQF CCCHHHHHHHHHHCH | 65.84 | 22817900 | |
| 1199 (in isoform 1) | Ubiquitination | - | 65.84 | 21890473 | |
| 1208 | Phosphorylation | QEGRQFASDFLSPEA HHHHCHHHHHCCHHH | 30.13 | - | |
| 1217 | Phosphorylation | FLSPEAASPAPNPDW HCCHHHCCCCCCCHH | 28.74 | 25332170 | |
| 1301 | Phosphorylation | CLEKRKISWLALFQL HHHHCCCCHHHHHHC | 21.05 | - | |
| 1309 | Phosphorylation | WLALFQLTESDLRLG HHHHHHCCHHHHHHH | 23.74 | - | |
| 1344 | Ubiquitination | SLLSYFHEDAAIREE HHHHHHCCCHHHCHH | 39.17 | 22817900 | |
| 1355 | Ubiquitination | IREEAFLHVAVDMYL HCHHHHHHHHHHHHH | 10.07 | 22817900 | |
| 1373 | Phosphorylation | QLFVAGDTSTVSPPA HHHHCCCCCCCCCCC | 25.94 | 28122231 | |
| 1374 | Phosphorylation | LFVAGDTSTVSPPAG HHHCCCCCCCCCCCC | 31.39 | 28122231 | |
| 1375 | Phosphorylation | FVAGDTSTVSPPAGR HHCCCCCCCCCCCCC | 27.39 | 28122231 | |
| 1377 | Phosphorylation | AGDTSTVSPPAGRSL CCCCCCCCCCCCCCE | 25.84 | 28122231 | |
| 1387 | Ubiquitination | AGRSLELKGQGNPVE CCCCEEECCCCCHHH | 39.55 | 21906983 | |
| 1387 (in isoform 1) | Ubiquitination | - | 39.55 | 21890473 | |
| 1398 | Ubiquitination | NPVELITKARLFLLQ CHHHHHHHHHHHHHH | 25.23 | 22817900 | |
| 1398 (in isoform 1) | Ubiquitination | - | 25.23 | 21890473 | |
| 1399 | Ubiquitination | PVELITKARLFLLQL HHHHHHHHHHHHHHH | 12.54 | 29967540 | |
| 1413 | Ubiquitination | LIPRCPKKSFSHVAE HHCCCCCCCHHHHHH | 41.71 | 29967540 | |
| 1414 | Ubiquitination | IPRCPKKSFSHVAEL HCCCCCCCHHHHHHH | 37.80 | 29967540 | |
| 1449 | Phosphorylation | AAPDADLSQEPHLF- HCCCCCCCCCCCCC- | 32.80 | 17525332 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 165 | S | Phosphorylation | Kinase | AURKA | O14965 | GPS |
| 347 | S | Phosphorylation | Kinase | PRKAA1 | Q13131 | GPS |
| 351 | T | Phosphorylation | Kinase | NEK2 | P51955 | PSP |
| 1149 | S | Phosphorylation | Kinase | AKT1 | P31749 | PSP |
| 1149 | S | Phosphorylation | Kinase | AKT-FAMILY | - | GPS |
| 1149 | S | Phosphorylation | Kinase | PKB_GROUP | - | PhosphoELM |
| 1449 | S | Phosphorylation | Kinase | ATR | Q13535 | PSP |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FANCA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FANCA_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 227650 | Fanconi anemia (FA) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1449, AND MASSSPECTROMETRY. | |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1449, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-849; SER-850 ANDSER-858, AND MASS SPECTROMETRY. | |
