AZIN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AZIN1_HUMAN
• UniProt AC: O14977
• Protein Name: Antizyme inhibitor 1
• Gene Name: AZIN1
• Organism: Homo sapiens (Human).
• Sequence Length: 448
• Subcellular Localization: Nucleus .
• Protein Description: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. [PubMed: 17900240]
• Protein Sequence: MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGITSDSMMKNFFFVPSCIQLSQEDSFSAEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKGFIDDAN ------CCCCCCCCC	63.63	-
47	Ubiquitination	FFVGDLGKIVKKHSQ EEECCHHHHHHHHHH	52.18	21906983
50	Ubiquitination	GDLGKIVKKHSQWQN CCHHHHHHHHHHHHH	48.52	-
51	Ubiquitination	DLGKIVKKHSQWQNV CHHHHHHHHHHHHHH	37.28	-
63	Ubiquitination	QNVVAQIKPFYTVKC HHHEECCCCEEEEEC	19.59	-
115	Ubiquitination	IIYISPCKQVSQIKY EEEEECCCHHHHHHH	58.06	-
121	Ubiquitination	CKQVSQIKYAAKVGV CCHHHHHHHHHHCCC	22.62	-
125	Ubiquitination	SQIKYAAKVGVNILT HHHHHHHHCCCEEEE	31.20	-
140	Ubiquitination	CDNEIELKKIARNHP CCCHHHHHHHHHHCC	29.37	-
141	Ubiquitination	DNEIELKKIARNHPN CCHHHHHHHHHHCCC	54.98	-
150	Ubiquitination	ARNHPNAKVLLHIAT HHHCCCCEEEEEEEE	39.80	-
169	Ubiquitination	GGEEGNMKFGTTLKN CCCCCCEECCHHHHH	44.64	-
175	Ubiquitination	MKFGTTLKNCRHLLE EECCHHHHHHHHHHH	52.49	21906983
203	Ubiquitination	FHVSSACKESQVYVH EEECHHHCCCCEEEE	61.18	-
291	Ubiquitination	AVNIIAKKVVENDKF HHHHHHHHHHHCCCC	42.35	-
297	Ubiquitination	KKVVENDKFPSGVEK HHHHHCCCCCCCCCC	71.41	-
327	Ubiquitination	VYGSFASKLSEDLNT CCHHHHHHHHHHHCC	53.23	-
334	Phosphorylation	KLSEDLNTIPEVHKK HHHHHHCCCHHHHHH	45.25	29759185
340	Ubiquitination	NTIPEVHKKYKEDEP CCCHHHHHHHCCCCC	64.07	21906983
341	Ubiquitination	TIPEVHKKYKEDEPL CCHHHHHHHCCCCCC	46.83	-
422	Phosphorylation	MQDAGITSDSMMKNF HHHCCCCCCHHHHHE	26.26	21601212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AZIN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AZIN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AZIN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KHDR1_HUMAN	KHDRBS1	physical	21988832
OAZ3_HUMAN	OAZ3	physical	25416956
KINH_HUMAN	KIF5B	physical	26186194
KIF5C_HUMAN	KIF5C	physical	26186194
KLC1_HUMAN	KLC1	physical	26186194
KLC2_HUMAN	KLC2	physical	26186194
KLC4_HUMAN	KLC4	physical	26186194
TYDP2_HUMAN	TDP2	physical	26186194
MSRB3_HUMAN	MSRB3	physical	26186194
OAZ1_HUMAN	OAZ1	physical	26186194
OAZ2_HUMAN	OAZ2	physical	26186194
OAZ1_HUMAN	OAZ1	physical	28514442
KLC4_HUMAN	KLC4	physical	28514442
OAZ2_HUMAN	OAZ2	physical	28514442
KLC2_HUMAN	KLC2	physical	28514442
KLC1_HUMAN	KLC1	physical	28514442
TYDP2_HUMAN	TDP2	physical	28514442
KINH_HUMAN	KIF5B	physical	28514442
KIF5C_HUMAN	KIF5C	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.