OAZ2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OAZ2_HUMAN
• UniProt AC: O95190
• Protein Name: Ornithine decarboxylase antizyme 2
• Gene Name: OAZ2
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Nucleus.
• Protein Description: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity. [PubMed: 17900240 Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity]
• Protein Sequence: MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
91	Phosphorylation	EVTEVKVSSWDAVLS EEEEEEECHHHHHHC	21.72	26471730
92	Phosphorylation	VTEVKVSSWDAVLSS EEEEEECHHHHHHCC	31.78	26471730
98	Phosphorylation	SSWDAVLSSQSLFVE CHHHHHHCCCEEEEE	21.52	26471730
99	Phosphorylation	SWDAVLSSQSLFVEI HHHHHHCCCEEEEEC	21.45	26471730
101	Phosphorylation	DAVLSSQSLFVEIPD HHHHCCCEEEEECCC	26.23	26471730
134	Phosphorylation	EEKMKVNYVFICFRK HHHHCCCEEEEEECC	10.34	18083107
186	Phosphorylation	YPLDQNLSDED---- EECCCCCCCCC----	46.64	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OAZ2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OAZ2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OAZ2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AZIN1_HUMAN	AZIN1	physical	17353931

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• DB00129: L-Ornithine