OAZ1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OAZ1_HUMAN
• UniProt AC: P54368
• Protein Name: Ornithine decarboxylase antizyme 1
• Gene Name: OAZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Protein Description: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. [PubMed: 17900240]
• Protein Sequence: MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	EKEGDKPSATIHASR CCCCCCCCCEEEEEC	43.73	22210691
27	Phosphorylation	EGDKPSATIHASRTM CCCCCCCEEEEECCC	20.03	24719451
31	Phosphorylation	PSATIHASRTMPLLS CCCEEEEECCCCEEE	17.70	24719451
38	Phosphorylation	SRTMPLLSLHSRGGS ECCCCEEEEECCCCC	31.55	22210691
45	Phosphorylation	SLHSRGGSSSESSRV EEECCCCCCCCCCCE	33.25	28348404
46	Phosphorylation	LHSRGGSSSESSRVS EECCCCCCCCCCCEE	41.20	28348404
47	Phosphorylation	HSRGGSSSESSRVSL ECCCCCCCCCCCEEE	43.10	22210691
49	Phosphorylation	RGGSSSESSRVSLHC CCCCCCCCCCEEEEE	25.95	28348404
50	Phosphorylation	GGSSSESSRVSLHCC CCCCCCCCCEEEEEC	32.42	28348404
53	Phosphorylation	SSESSRVSLHCCSNP CCCCCCEEEEECCCC	15.99	28348404
152	Phosphorylation	GGALPEGSKDSFAVL CCCCCCCCCCHHHHH	31.46	-
222	Phosphorylation	AYTFERESSGEEEE- EEEEECCCCCCCCC-	50.27	27134283
223	Phosphorylation	YTFERESSGEEEE-- EEEECCCCCCCCC--	45.53	27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OAZ1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OAZ1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OAZ1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PSB4_HUMAN	PSMB4	physical	11571290
PIAS4_HUMAN	PIAS4	physical	21988832
P73_HUMAN	TP73	physical	20185758
AZIN1_HUMAN	AZIN1	physical	18062773
DCOR_HUMAN	ODC1	physical	18062773
GLGB_HUMAN	GBE1	physical	26496610
DCOR_HUMAN	ODC1	physical	26496610
RENT1_HUMAN	UPF1	physical	26496610
RAB7A_HUMAN	RAB7A	physical	26496610
TAF1B_HUMAN	TAF1B	physical	26496610
SRA1_HUMAN	SRA1	physical	26496610
CEPT1_HUMAN	CEPT1	physical	26496610
CAMP2_HUMAN	CAMSAP2	physical	26496610
AZIN1_HUMAN	AZIN1	physical	26496610
PLXA3_HUMAN	PLXNA3	physical	26496610
BRE1A_HUMAN	RNF20	physical	26496610
LENG8_HUMAN	LENG8	physical	26496610
PGM2L_HUMAN	PGM2L1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.