PLXA3_HUMAN - dbPTM
PLXA3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLXA3_HUMAN
UniProt AC P51805
Protein Name Plexin-A3
Gene Name PLXNA3
Organism Homo sapiens (Human).
Sequence Length 1871
Subcellular Localization Cell membrane
Single-pass type I membrane protein.
Protein Description Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm..
Protein Sequence MPSVCLLLLLFLAVGGALGNRPFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKCVQVRVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPKTNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGDNLGLLSREVGLRVAGVRCNSIPAEYISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTRLTISGSSLDAGSRVTVTVRDSECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLIYTYTQDPTVTRLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHISAERALTLPAMMGLAAGGGLLLLAITAVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRTASSPDSLRSRAPMITPDQETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSDS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59N-linked_GlycosylationRVFKLAPNLTELRAH
HHHHCCCCCCEEHEE		54.72UniProtKB CARBOHYD
68PhosphorylationTELRAHVTGPVEDNA
CEEHEEECCCCCCCC		26.3824425749
283PhosphorylationVEFPIGCSWRGVEYR
EEECCCCCCCCCHHH		18.00-
289PhosphorylationCSWRGVEYRLVQSAH
CCCCCCHHHHCCCCH		13.57-
451PhosphorylationGFQDAHLYETVPVVD
CCCCCEEEEECEEEC		10.3322210691
453PhosphorylationQDAHLYETVPVVDGS
CCCEEEEECEEECCC		19.2922210691
469PhosphorylationILRDLLFSPDHRHIY
HHHHHHCCCCCCEEE		29.4122210691
479PhosphorylationHRHIYLLSEKQVSQL
CCEEEEECHHHHHCC		39.9024719451
520UbiquitinationLRHRCCREGACLGAS
HHHCCCCCCCCCCCC		36.9127667366
548N-linked_GlycosylationQVRVRPNNVSVTSPG
EEEECCCCEEECCCC		30.08UniProtKB CARBOHYD
606PhosphorylationLQELRALTRGHGATR
HHHHHHHHCCCCCCH		33.35-
614PhosphorylationRGHGATRTVRLQLLS
CCCCCCHHHHHHHHC		12.96-
621PhosphorylationTVRLQLLSKETGVRF
HHHHHHHCCCCCCCC		36.7224719451
625UbiquitinationQLLSKETGVRFAGAD
HHHCCCCCCCCCCCC		15.0827667366
637N-linked_GlycosylationGADFVFYNCSVLQSC
CCCEEEECCHHHHHH		10.50UniProtKB CARBOHYD
707UbiquitinationQPLTLRAKNLPQPQS
CCCCCEECCCCCCCC		53.2127667366
738N-linked_GlycosylationRVPAVRFNSSSVQCQ
EECEEEECCCCEEEE		30.34UniProtKB CARBOHYD
746N-linked_GlycosylationSSSVQCQNASYSYEG
CCCEEEECCEEEECC		38.18UniProtKB CARBOHYD
905PhosphorylationMEESLVPSPPPGPVE
EHHHCCCCCCCCCEE		42.4322468782
958PhosphorylationTRLTISGSSLDAGSR
CEEEEECCCCCCCCC		22.42-
964PhosphorylationGSSLDAGSRVTVTVR
CCCCCCCCCEEEEEC		25.87-
1009N-linked_GlycosylationTLAIDRANISSPGLI
EEEEECCCCCCCCEE		35.25UniProtKB CARBOHYD
1036N-linked_GlycosylationEPTWSIINGSTAITV
EEEEEEECCCEEEEE		36.37UniProtKB CARBOHYD
1073N-linked_GlycosylationTNTCQVINDTAMLCK
CCCCEEECCHHHHHC		41.55UniProtKB CARBOHYD
1115N-linked_GlycosylationVQTARSLNRSSFTYY
HHHHHHCCCCCCEEC		42.93UniProtKB CARBOHYD
1122PhosphorylationNRSSFTYYPDPSFEP
CCCCCEECCCCCCCC		9.71-
1162N-linked_GlycosylationAAGSSRLNYTVLIGG
CCCCCCCCEEEEECC		29.35UniProtKB CARBOHYD
1236PhosphorylationGLLLLAITAVLVAYK
HHHHHHHHHHHHHHH		12.71-
1322PhosphorylationPVLKELDTPPNVEKA
CHHHHCCCCCCHHHH		53.95-
1328UbiquitinationDTPPNVEKALRLFGQ
CCCCCHHHHHHHHHH		48.7332142685
1397PhosphorylationLIEKNLESKNHPKLL
HHHHHHHCCCCHHHH		41.7620886841
1402UbiquitinationLESKNHPKLLLRRTE
HHCCCCHHHHHHCCH		44.19-
1461PhosphorylationAITGEARYSLSEDKL
EECCCEECCCCHHHH		22.4728102081
1462PhosphorylationITGEARYSLSEDKLI
ECCCEECCCCHHHHH		21.6228102081
1467UbiquitinationRYSLSEDKLIRQQID
ECCCCHHHHHHHHCC		41.59-
1475PhosphorylationLIRQQIDYKTLTLHC
HHHHHCCCCEEEEEE		13.91-
1476UbiquitinationIRQQIDYKTLTLHCV
HHHHCCCCEEEEEEE		33.0529967540
1509UbiquitinationSITQAKDKLLDTVYK
CHHHHHHHHHHHHHC		50.6829967540
1513PhosphorylationAKDKLLDTVYKGIPY
HHHHHHHHHHCCCCH		26.2121712546
1515PhosphorylationDKLLDTVYKGIPYSQ
HHHHHHHHCCCCHHH		12.9421712546
1549PhosphorylationILQDEDVTTKIECDW
EECCCCCCCEEEECH		34.3925332170
1550PhosphorylationLQDEDVTTKIECDWK
ECCCCCCCEEEECHH		29.8525332170
1557AcetylationTKIECDWKRLNSLAH
CEEEECHHHHHCCCE		33.4819413330
1568PhosphorylationSLAHYQVTDGSLVAL
CCCEEEECCCCEEEE		21.0819413330
1571PhosphorylationHYQVTDGSLVALVPK
EEEECCCCEEEEEEC		23.6019413330
1581PhosphorylationALVPKQVSAYNMANS
EEEECCCCCCCCCCC		23.65-
1583PhosphorylationVPKQVSAYNMANSFT
EECCCCCCCCCCCCC		9.66-
1594PhosphorylationNSFTFTRSLSRYESL
CCCCCCHHHHHHHHH		27.8624117733
1596PhosphorylationFTFTRSLSRYESLLR
CCCCHHHHHHHHHHH		33.7826699800
1598PhosphorylationFTRSLSRYESLLRTA
CCHHHHHHHHHHHHC		13.3924117733
1600PhosphorylationRSLSRYESLLRTASS
HHHHHHHHHHHHCCC		24.6226699800
1604PhosphorylationRYESLLRTASSPDSL
HHHHHHHHCCCCHHH		30.7529396449
1606PhosphorylationESLLRTASSPDSLRS
HHHHHHCCCCHHHHH		41.6228176443
1607PhosphorylationSLLRTASSPDSLRSR
HHHHHCCCCHHHHHC		30.2025159151
1610PhosphorylationRTASSPDSLRSRAPM
HHCCCCHHHHHCCCC		29.1225159151
1613PhosphorylationSSPDSLRSRAPMITP
CCCHHHHHCCCCCCC		37.7823090842
1647PhosphorylationHREGDRGSKMVSEIY
CCCCCHHHHHHHHHH		20.6224719451
1654PhosphorylationSKMVSEIYLTRLLAT
HHHHHHHHHHHHHHC		9.66-
1662UbiquitinationLTRLLATKGTLQKFV
HHHHHHCHHHHHHHH		44.27-
1675PhosphorylationFVDDLFETVFSTAHR
HHHHHHHHHHHHCCC		21.3726074081
1678PhosphorylationDLFETVFSTAHRGSA
HHHHHHHHHCCCCCH		21.9826074081
1679PhosphorylationLFETVFSTAHRGSAL
HHHHHHHHCCCCCHH		18.2826074081
1684PhosphorylationFSTAHRGSALPLAIK
HHHCCCCCHHHHHHH		26.9626074081
1692PhosphorylationALPLAIKYMFDFLDE
HHHHHHHHHHHHHHH		9.2626074081
1744PhosphorylationDIHKNSITDACLSVV
EECCCCHHHHHHHHH		19.8429116813
1768UbiquitinationTSEHRLGKDSPSNKL
CCCCCCCCCCCCCCE		60.67-
1772PhosphorylationRLGKDSPSNKLLYAK
CCCCCCCCCCEEEEC		51.0228857561
1774UbiquitinationGKDSPSNKLLYAKDI
CCCCCCCCEEEECCC		44.18-
1779UbiquitinationSNKLLYAKDIPNYKS
CCCEEEECCCCCHHH		42.51-
1815MethylationAYLVEQSRLHASDFS
HHHHHHHHCCCCCHH		30.13115385833
1822PhosphorylationRLHASDFSVLSALNE
HCCCCCHHHHHHHHH		27.43-
1825PhosphorylationASDFSVLSALNELYF
CCCHHHHHHHHHHHH		28.67-
1831PhosphorylationLSALNELYFYVTKYR
HHHHHHHHHHHHHHH		6.15-
1869PhosphorylationQIISLVSSDS-----
HHHHHHHCCC-----		34.10-
1871PhosphorylationISLVSSDS-------
HHHHHCCC-------		44.03-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PLXA3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLXA3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLXA3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of PLXA3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLXA3_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1607 AND SER-1610, ANDMASS SPECTROMETRY.

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