DCOR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DCOR_HUMAN
• UniProt AC: P11926
• Protein Name: Ornithine decarboxylase
• Gene Name: ODC1
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Protein Description: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis..
• Protein Sequence: MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFPPEVEEQDASTLPVSCAWESGMKRHRAACASASINV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Ubiquitination	AKDILDQKINEVSSS HHHHHHHHHHCCCCC	47.36	21906983
37	Ubiquitination	EVSSSDDKDAFYVAD CCCCCCCCCCEEECC	56.82	-
50	Ubiquitination	ADLGDILKKHLRWLK CCHHHHHHHHHHHHH	38.18	21906983
51	Ubiquitination	DLGDILKKHLRWLKA CHHHHHHHHHHHHHH	44.41	-
57	Ubiquitination	KKHLRWLKALPRVTP HHHHHHHHHCCCCCC	40.70	-
66	Phosphorylation	LPRVTPFYAVKCNDS CCCCCCEEEEECCCC	16.22	30631047
69	Other	VTPFYAVKCNDSKAI CCCEEEEECCCCHHH	21.10	17407445
69	Ubiquitination	VTPFYAVKCNDSKAI CCCEEEEECCCCHHH	21.10	-
69	N6-(pyridoxal phosphate)lysine	VTPFYAVKCNDSKAI CCCEEEEECCCCHHH	21.10	-
73	Phosphorylation	YAVKCNDSKAIVKTL EEEECCCCHHHHHHH	15.25	30631047
74	Ubiquitination	AVKCNDSKAIVKTLA EEECCCCHHHHHHHH	45.02	-
78	Ubiquitination	NDSKAIVKTLAATGT CCCHHHHHHHHHCCC	31.54	-
115	Ubiquitination	IIYANPCKQVSQIKY EEEEECCCCHHHHHH	55.80	-
122	Phosphorylation	KQVSQIKYAANNGVQ CCHHHHHHHHHCCCE	16.75	28165663
132	Phosphorylation	NNGVQMMTFDSEVEL HCCCEEEEECCHHHH	20.96	28165663
135	Phosphorylation	VQMMTFDSEVELMKV CEEEEECCHHHHHHH	39.07	28165663
141	Ubiquitination	DSEVELMKVARAHPK CCHHHHHHHHHHCCC	45.42	-
150	Ubiquitination	ARAHPKAKLVLRIAT HHHCCCCEEEEEEEC	45.30	-
161	Ubiquitination	RIATDDSKAVCRLSV EEECCCCCCCHHHHH	52.40	-
247	Ubiquitination	GSEDVKLKFEEITGV CCHHCEEEHEEHHCC	45.04	21906983
261	Ubiquitination	VINPALDKYFPSDSG CCCHHHHHHCCCCCC	50.03	2190698
303	Phosphorylation	VLKEQTGSDDEDESS HHEECCCCCCCCCCC	45.32	-
345	Ubiquitination	PLLQKRPKPDEKYYS HHHHCCCCCCCCCCC	69.96	-
360	S-nitrosocysteine	SSIWGPTCDGLDRIV CCCCCCCCCCHHHHH	4.38	-
360	S-nitrosylation	SSIWGPTCDGLDRIV CCCCCCCCCCHHHHH	4.38	11461922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
303	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DCOR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DCOR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DCOR_HUMAN	ODC1	physical	10623504
SSRA_HUMAN	SSR1	physical	21988832
KAT5_HUMAN	KAT5	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
OAZ3_HUMAN	OAZ3	physical	25416956
OAZ1_HUMAN	OAZ1	physical	12359729
OAZ2_HUMAN	OAZ2	physical	12359729
RSCA1_HUMAN	RSC1A1	physical	27555600

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• DB00127: Spermine