RSCA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSCA1_HUMAN
• UniProt AC: Q92681
• Protein Name: Regulatory solute carrier protein family 1 member 1
• Gene Name: RSC1A1
• Organism: Homo sapiens (Human).
• Sequence Length: 617
• Subcellular Localization: Cell membrane . Nucleus . Golgi apparatus, trans-Golgi network . Localizes at the inner side of the plasma membrane.
• Protein Description: Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network..
• Protein Sequence: MSSLPTSDGFNHPARSSGQSPDVGNPMSLARSVSASVCPIKPSDSDRIEPKAVKALKASAEFQLNSEKKEHLSLQDLSDHASSADHAPTDQSPAMPMQNSSEEITVAGNLEKSAERSTQGLKFHLHTRQEASLSVTSTRMHEPQMFLGEKDWHPENQNLSQVSDPQQHEEPGNEQYEVAQQKASHDQEYLCNIGDLELPEERQQNQHKIVDLEATMKGNGLPQNVDPPSAKKSIPSSECSGCSNSETFMEIDTAQQSLVTLLNSTGRQNANVKNIGALDLTLDNPLMEVETSKCNPSSEILNDSISTQDLQPPETNVEIPGTNKEYGHYSSPSLCGSCQPSVESAEESCPSITAALKELHELLVVSSKPASENTSEEVICQSETIAEGQTSIKDLSERWTQNEHLTQNEQCPQVSFHQAISVSVETEKLTGTSSDTGREAVENVNFRSLGDGLSTDKEGVPKSRESINKNRSVTVTSAKTSNQLHCTLGVEISPKLLAGEEDALNQTSEQTKSLSSNFILVKDLGQGIQNSVTDRPETRENVCPDASRPLLEYEPPTSHPSSSPAILPPLIFPATDIDRILRAGFTLQEALGALHRVGGNADLALLVLLAKNIVVPT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
34	Phosphorylation	MSLARSVSASVCPIK HHHHHHCCEEECCCC	18.97	-
43	Phosphorylation	SVCPIKPSDSDRIEP EECCCCCCCCCCCCH	44.75	21082442
66	Phosphorylation	SAEFQLNSEKKEHLS HHEEECCHHHCCCCC	60.43	21082442
132	Phosphorylation	LHTRQEASLSVTSTR EEECCCEEEEEEECC	22.03	-
260	Phosphorylation	TAQQSLVTLLNSTGR HHHHHHHHHHHCCCC	30.71	-
366	Phosphorylation	LHELLVVSSKPASEN HHHHHHCCCCCCCCC	25.76	22817900
368	Ubiquitination	ELLVVSSKPASENTS HHHHCCCCCCCCCCC	36.78	29967540
472	Phosphorylation	ESINKNRSVTVTSAK HHHCCCCCEEEEECC	31.37	29978859
474	Phosphorylation	INKNRSVTVTSAKTS HCCCCCEEEEECCCC	21.22	29978859
476	Phosphorylation	KNRSVTVTSAKTSNQ CCCCEEEEECCCCCC	17.38	29978859
477	Phosphorylation	NRSVTVTSAKTSNQL CCCEEEEECCCCCCE	24.35	29978859
480	Phosphorylation	VTVTSAKTSNQLHCT EEEEECCCCCCEEEE	32.40	29978859
481	Phosphorylation	TVTSAKTSNQLHCTL EEEECCCCCCEEEEE	23.13	29978859
487	Phosphorylation	TSNQLHCTLGVEISP CCCCEEEEEEEEECH	18.79	29978859
493	Phosphorylation	CTLGVEISPKLLAGE EEEEEEECHHHHCCC	11.50	29978859
495	Ubiquitination	LGVEISPKLLAGEED EEEEECHHHHCCCHH	49.71	29967540
512	Ubiquitination	NQTSEQTKSLSSNFI HCCHHHHHHHCCCEE	49.44	21906983
522	Ubiquitination	SSNFILVKDLGQGIQ CCCEEEEEECCCCHH	43.73	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
366	S	Phosphorylation	Kinase	PRKCA	P17252	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSCA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSCA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SODM_HUMAN	SOD2	physical	27555600
ANXA2_HUMAN	ANXA2	physical	27555600
CH60_HUMAN	HSPD1	physical	27555600
DCOR_HUMAN	ODC1	physical	27555600
OSTP_HUMAN	SPP1	physical	27555600
RACK1_HUMAN	GNB2L1	physical	27555600
UROM_HUMAN	UMOD	physical	27555600

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.