dbPTM

OSTP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	OSTP_HUMAN
UniProt AC	P10451
Protein Name	Osteopontin
Gene Name	SPP1
Organism	Homo sapiens (Human).
Sequence Length	314
Subcellular Localization	Secreted.
Protein Description	Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.; Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity..
Protein Sequence	MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	IPVKQADSGSSEEKQ CCCHHCCCCCHHHHH	43.52	20068231
26	Phosphorylation	VKQADSGSSEEKQLY CHHCCCCCHHHHHHH	38.23	28192239
27	Phosphorylation	KQADSGSSEEKQLYN HHCCCCCHHHHHHHH	53.99	28192239
33	Phosphorylation	SSEEKQLYNKYPDAV CHHHHHHHHHCCCHH	13.71	25072903
36	Phosphorylation	EKQLYNKYPDAVATW HHHHHHHCCCHHHHH	11.60	25072903
42	O-linked_Glycosylation	KYPDAVATWLNPDPS HCCCHHHHHCCCCHH	24.72	OGP
42	Phosphorylation	KYPDAVATWLNPDPS HCCCHHHHHCCCCHH	24.72	25072903
49	O-linked_Glycosylation	TWLNPDPSQKQNLLA HHCCCCHHHHCCCCC	58.34	76780001
49	Phosphorylation	TWLNPDPSQKQNLLA HHCCCCHHHHCCCCC	58.34	29759185
59 (in isoform 5)	O-linked_Glycosylation	-	41.05	OGP
59 (in isoform 5)	Phosphorylation	-	41.05	28355574
62	Phosphorylation	LAPQNAVSSEETNDF CCCCCCCCCHHHCCH	29.62	29255136
62 (in isoform 5)	O-linked_Glycosylation	-	29.62	OGP
62 (in isoform 5)	Phosphorylation	-	29.62	28355574
63	Phosphorylation	APQNAVSSEETNDFK CCCCCCCCHHHCCHH	32.62	29255136
66	Phosphorylation	NAVSSEETNDFKQET CCCCCHHHCCHHHHC	35.72	29255136
73	O-linked_Glycosylation	TNDFKQETLPSKSNE HCCHHHHCCCCCCCC	41.28	OGP
73	Phosphorylation	TNDFKQETLPSKSNE HCCHHHHCCCCCCCC	41.28	22199227
75	Phosphorylation	DFKQETLPSKSNESH CHHHHCCCCCCCCCC	47.32	27251275
76	O-linked_Glycosylation	FKQETLPSKSNESHD HHHHCCCCCCCCCCC	52.40	OGP
76	Phosphorylation	FKQETLPSKSNESHD HHHHCCCCCCCCCCC	52.40	22199227
78	Phosphorylation	QETLPSKSNESHDHM HHCCCCCCCCCCCCC	50.60	15869464
79	N-linked_Glycosylation	ETLPSKSNESHDHMD HCCCCCCCCCCCCCC	59.53	15869464
81	Phosphorylation	LPSKSNESHDHMDDM CCCCCCCCCCCCCCC	38.17	15869464
89	Phosphorylation	HDHMDDMDDEDDDDH CCCCCCCCCCCCCCC	64.24	27251275
99	Phosphorylation	DDDDHVDSQDSIDSN CCCCCCCCCHHCCCC	34.49	15869464
102	Phosphorylation	DHVDSQDSIDSNDSD CCCCCCHHCCCCCCC	22.21	15869464
105	Phosphorylation	DSQDSIDSNDSDDVD CCCHHCCCCCCCCCC	40.65	15869464
106	N-linked_Glycosylation	SQDSIDSNDSDDVDD CCHHCCCCCCCCCCC	49.40	15869464
108	Phosphorylation	DSIDSNDSDDVDDTD HHCCCCCCCCCCCCC	39.70	15869464
117	Phosphorylation	DVDDTDDSHQSDESH CCCCCCCCCCCCCCC	26.66	15869464
120	Phosphorylation	DTDDSHQSDESHHSD CCCCCCCCCCCCCCC	37.61	15869464
123	Phosphorylation	DSHQSDESHHSDESD CCCCCCCCCCCCCCC	31.33	15869464
126	Phosphorylation	QSDESHHSDESDELV CCCCCCCCCCCCCHH	37.34	15869464
129	Phosphorylation	ESHHSDESDELVTDF CCCCCCCCCCHHCCC	41.18	15869464
134	O-linked_Glycosylation	DESDELVTDFPTDLP CCCCCHHCCCCCCCC	44.54	15869464
134	Phosphorylation	DESDELVTDFPTDLP CCCCCHHCCCCCCCC	44.54	15869464
138	O-linked_Glycosylation	ELVTDFPTDLPATEV CHHCCCCCCCCCCCC	50.60	15869464
138	Phosphorylation	ELVTDFPTDLPATEV CHHCCCCCCCCCCCC	50.60	15869464
143	O-linked_Glycosylation	FPTDLPATEVFTPVV CCCCCCCCCCCCCCC	30.64	15869464
143	Phosphorylation	FPTDLPATEVFTPVV CCCCCCCCCCCCCCC	30.64	15869464
147	O-linked_Glycosylation	LPATEVFTPVVPTVD CCCCCCCCCCCCCCC	21.98	15869464
147	Phosphorylation	LPATEVFTPVVPTVD CCCCCCCCCCCCCCC	21.98	15869464
152	O-linked_Glycosylation	VFTPVVPTVDTYDGR CCCCCCCCCCCCCCC	21.28	15869464
152	Phosphorylation	VFTPVVPTVDTYDGR CCCCCCCCCCCCCCC	21.28	15869464
162	O-linked_Glycosylation	TYDGRGDSVVYGLRS CCCCCCCCEEEECCC	19.12	OGP
162	Dephosphorylation	TYDGRGDSVVYGLRS CCCCCCCCEEEECCC	19.12	8195113
162	Phosphorylation	TYDGRGDSVVYGLRS CCCCCCCCEEEECCC	19.12	28857561
165	Phosphorylation	GRGDSVVYGLRSKSK CCCCCEEEECCCCCC	14.32	-
181	Phosphorylation	FRRPDIQYPDATDED CCCCCCCCCCCCCCH	11.92	27251275
185	Phosphorylation	DIQYPDATDEDITSH CCCCCCCCCCHHHHH	47.50	15869464
190	Phosphorylation	DATDEDITSHMESEE CCCCCHHHHHHHHHH	25.54	30242111
191	Phosphorylation	ATDEDITSHMESEEL CCCCHHHHHHHHHHH	22.59	15869464
195	Phosphorylation	DITSHMESEELNGAY HHHHHHHHHHHCCHH	28.88	15869464
202	Phosphorylation	SEELNGAYKAIPVAQ HHHHCCHHHHCHHHH	11.44	30242111
203	Phosphorylation	EELNGAYKAIPVAQD HHHCCHHHHCHHHHC	39.03	27251275
204	Phosphorylation	ELNGAYKAIPVAQDL HHCCHHHHCHHHHCC	9.91	27251275
208	Phosphorylation	AYKAIPVAQDLNAPS HHHHCHHHHCCCCCC	7.57	27251275
215	O-linked_Glycosylation	AQDLNAPSDWDSRGK HHCCCCCCCCCCCCC	49.26	OGP
215	Phosphorylation	AQDLNAPSDWDSRGK HHCCCCCCCCCCCCC	49.26	15869464
219	Phosphorylation	NAPSDWDSRGKDSYE CCCCCCCCCCCCHHC	38.38	19664994
224	Phosphorylation	WDSRGKDSYETSQLD CCCCCCCHHCCCCCC	28.49	28355574
225	Phosphorylation	DSRGKDSYETSQLDD CCCCCCHHCCCCCCC	33.10	25072903
227	O-linked_Glycosylation	RGKDSYETSQLDDQS CCCCHHCCCCCCCCC	17.34	OGP
227	Phosphorylation	RGKDSYETSQLDDQS CCCCHHCCCCCCCCC	17.34	25072903
228	O-linked_Glycosylation	GKDSYETSQLDDQSA CCCHHCCCCCCCCCH	19.46	OGP
228	Phosphorylation	GKDSYETSQLDDQSA CCCHHCCCCCCCCCH	19.46	15869464
232	Phosphorylation	YETSQLDDQSAETHS HCCCCCCCCCHHHHH	53.58	27251275
234	O-linked_Glycosylation	TSQLDDQSAETHSHK CCCCCCCCHHHHHHH	34.76	OGP
234	Phosphorylation	TSQLDDQSAETHSHK CCCCCCCCHHHHHHH	34.76	29255136
237	O-linked_Glycosylation	LDDQSAETHSHKQSR CCCCCHHHHHHHHHH	28.53	OGP
237	Phosphorylation	LDDQSAETHSHKQSR CCCCCHHHHHHHHHH	28.53	29255136
238	Phosphorylation	DDQSAETHSHKQSRL CCCCHHHHHHHHHHH	21.29	27251275
239	O-linked_Glycosylation	DQSAETHSHKQSRLY CCCHHHHHHHHHHHH	39.54	OGP
239	Phosphorylation	DQSAETHSHKQSRLY CCCHHHHHHHHHHHH	39.54	23911959
240	Phosphorylation	QSAETHSHKQSRLYK CCHHHHHHHHHHHHH	25.27	27251275
241	Phosphorylation	SAETHSHKQSRLYKR CHHHHHHHHHHHHHH	53.64	27251275
243	Phosphorylation	ETHSHKQSRLYKRKA HHHHHHHHHHHHHHC	29.11	18702456
246	Phosphorylation	SHKQSRLYKRKANDE HHHHHHHHHHHCCCC	13.98	24505115
247	Phosphorylation	HKQSRLYKRKANDES HHHHHHHHHHCCCCC	52.60	27251275
254	Phosphorylation	KRKANDESNEHSDVI HHHCCCCCCCCCCCC	50.83	29255136
258	Phosphorylation	NDESNEHSDVIDSQE CCCCCCCCCCCCHHH	27.65	29255136
263	Phosphorylation	EHSDVIDSQELSKVS CCCCCCCHHHHHHHH	17.90	29255136
267	O-linked_Glycosylation	VIDSQELSKVSREFH CCCHHHHHHHHHHHH	30.20	OGP
267	Phosphorylation	VIDSQELSKVSREFH CCCHHHHHHHHHHHH	30.20	15869464
270	Phosphorylation	SQELSKVSREFHSHE HHHHHHHHHHHHHCC	29.81	15869464
271	Phosphorylation	QELSKVSREFHSHEF HHHHHHHHHHHHCCC	54.29	27251275
275	Phosphorylation	KVSREFHSHEFHSHE HHHHHHHHCCCCCCC	29.99	29255136
276	Phosphorylation	VSREFHSHEFHSHED HHHHHHHCCCCCCCC	32.92	27251275
280	O-linked_Glycosylation	FHSHEFHSHEDMLVV HHHCCCCCCCCEEEE	33.61	OGP
280	Phosphorylation	FHSHEFHSHEDMLVV HHHCCCCCCCCEEEE	33.61	29255136
283	Phosphorylation	HEFHSHEDMLVVDPK CCCCCCCCEEEECCC	30.23	27251275
288	Phosphorylation	HEDMLVVDPKSKEED CCCEEEECCCCHHHH	37.11	27251275
291	Phosphorylation	MLVVDPKSKEEDKHL EEEECCCCHHHHHCH	51.17	15869464
293	Phosphorylation	VVDPKSKEEDKHLKF EECCCCHHHHHCHHH	77.76	27251275
303	O-linked_Glycosylation	KHLKFRISHELDSAS HCHHHHHHHHHHCCC	13.47	OGP
303	Phosphorylation	KHLKFRISHELDSAS HCHHHHHHHHHHCCC	13.47	19664994
304	Phosphorylation	HLKFRISHELDSASS CHHHHHHHHHHCCCC	36.95	27251275
308	O-linked_Glycosylation	RISHELDSASSEVN- HHHHHHHCCCCCCC-	42.55	OGP
308	Phosphorylation	RISHELDSASSEVN- HHHHHHHCCCCCCC-	42.55	28355574
310	Phosphorylation	SHELDSASSEVN--- HHHHHCCCCCCC---	30.86	26503892
311	O-linked_Glycosylation	HELDSASSEVN---- HHHHCCCCCCC----	45.33	OGP
311	Phosphorylation	HELDSASSEVN---- HHHHCCCCCCC----	45.33	15869464
316	Phosphorylation	ASSEVN--------- CCCCCC---------		27251275
321	Phosphorylation	N-------------- C--------------		27251275
323	Phosphorylation	---------------- ----------------		27251275
324	Phosphorylation	----------------- -----------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
26	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
27	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
62	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
63	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
190	T	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
191	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
195	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
215	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
219	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
224	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
228	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
234	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
237	T	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
239	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
243	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
254	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
258	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
263	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
267	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
270	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
275	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
280	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
291	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
303	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
308	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
310	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot
311	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
59	T	Glycosylation	15869464
Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.
62	S	Glycosylation	15869464
Isoform 5 is GalNAc O-glycosylated at Thr-59 or Ser-62.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of OSTP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDLI7_HUMAN	PDLIM7	physical	16189514
CTBL1_HUMAN	CTNNBL1	physical	16189514
IBP5_HUMAN	IGFBP5	physical	10698186
BAG6_HUMAN	BAG6	physical	22779921
RBBP6_HUMAN	RBBP6	physical	22779921
EIF3K_HUMAN	EIF3K	physical	22779921
C1RL_HUMAN	C1RL	physical	22779921
COMD1_HUMAN	COMMD1	physical	22779921
CSN5_HUMAN	COPS5	physical	22779921
NICA_HUMAN	NCSTN	physical	22779921
UBP42_HUMAN	USP42	physical	22779921
CISD2_HUMAN	CISD2	physical	22779921
UBP8_HUMAN	USP8	physical	22779921
AFF4_HUMAN	AFF4	physical	22779921
AMOL2_HUMAN	AMOTL2	physical	22779921
DCX_HUMAN	DCX	physical	22779921
EF1A1_HUMAN	EEF1A1	physical	22779921
CE162_HUMAN	CEP162	physical	22779921
MAP1A_HUMAN	MAP1A	physical	22779921
MAP1B_HUMAN	MAP1B	physical	22779921
MARCS_HUMAN	MARCKS	physical	22779921
NCKP1_HUMAN	NCKAP1	physical	22779921
RANB9_HUMAN	RANBP9	physical	22779921
SC24C_HUMAN	SEC24C	physical	22779921
STAU1_HUMAN	STAU1	physical	22779921
TBB5_HUMAN	TUBB	physical	22779921
DNJB1_HUMAN	DNAJB1	physical	22779921
SGTA_HUMAN	SGTA	physical	22779921
TTC1_HUMAN	TTC1	physical	22779921
KAPCB_HUMAN	PRKACB	physical	22779921
STK39_HUMAN	STK39	physical	22779921
GRAP1_HUMAN	GRIPAP1	physical	22779921
RPGF2_HUMAN	RAPGEF2	physical	22779921
TCTP_HUMAN	TPT1	physical	22779921
TBCD8_HUMAN	TBC1D8	physical	22779921
C2D1B_HUMAN	CC2D1B	physical	22779921
CKLF3_HUMAN	CMTM3	physical	22779921
RM23_HUMAN	MRPL23	physical	22779921
RL5_HUMAN	RPL5	physical	22779921
RL13_HUMAN	RPL13	physical	22779921
RL15_HUMAN	RPL15	physical	22779921
RS13_HUMAN	RPS13	physical	22779921
RIMS4_HUMAN	RIMS4	physical	22779921
SNAPN_HUMAN	SNAPIN	physical	22779921
AT2A2_HUMAN	ATP2A2	physical	22779921
CCG4_HUMAN	CACNG4	physical	22779921
LRRC4_HUMAN	LRRC4	physical	22779921
AT5F1_HUMAN	ATP5F1	physical	22779921
CHD1_HUMAN	CHD1	physical	22779921
TDIF2_HUMAN	DNTTIP2	physical	22779921
EPAS1_HUMAN	EPAS1	physical	22779921
HMGN1_HUMAN	HMGN1	physical	22779921
S39A6_HUMAN	SLC39A6	physical	22779921
ZN638_HUMAN	ZNF638	physical	22779921
BRD3_HUMAN	BRD3	physical	22779921
CB050_HUMAN	C2orf50	physical	22779921
NB5R3_HUMAN	CYB5R3	physical	22779921
DSEL_HUMAN	DSEL	physical	22779921
FRIH_HUMAN	FTH1	physical	22779921
KCIP1_HUMAN	KCNIP1	physical	22779921
MPPD1_HUMAN	MPPED1	physical	22779921
PEMT_HUMAN	PEMT	physical	22779921
PLD3_HUMAN	PLD3	physical	22779921
NACAM_HUMAN	NACA	physical	22779921
NACA_HUMAN	NACA	physical	22779921
LA_HUMAN	SSB	physical	22779921
TM168_HUMAN	TMEM168	physical	22779921
CC50A_HUMAN	TMEM30A	physical	22779921
Z804A_HUMAN	ZNF804A	physical	22779921
ITAV_HUMAN	ITGAV	physical	7592829
ITB1_HUMAN	ITGB1	physical	7592829
ITB5_HUMAN	ITGB5	physical	7592829
THRB_HUMAN	F2	physical	25241761
TRAF3_HUMAN	TRAF3	physical	27026194

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of OSTP_HUMAN

Related Literatures of Post-Translational Modification

N-linked Glycosylation
Reference	PubMed
"Post-translationally modified residues of native human osteopontinare located in clusters: identification of 36 phosphorylation and fiveO-glycosylation sites and their biological implications."; Christensen B., Nielsen M.S., Haselmann K.F., Petersen T.E.,Sorensen E.S.; Biochem. J. 390:285-292(2005). Cited for: PHOSPHORYLATION AT SER-24; SER-26; SER-27; SER-62; SER-63; THR-66;SER-76; SER-81; SER-99; SER-102; SER-108; SER-117; SER-120; SER-123;SER-129; THR-185; SER-191; SER-195; SER-215; SER-219; SER-224;SER-228; SER-234; SER-254; SER-263; SER-267; SER-275; SER-280;SER-303; SER-308; SER-310; SER-105 AND SER-126, AND GLYCOSYLATION ATASN-79; ASN-106; THR-134; THR-138; THR-143; THR-147 AND THR-152.	15869464 [Abstract]
O-linked Glycosylation
Reference	PubMed
"Post-translationally modified residues of native human osteopontinare located in clusters: identification of 36 phosphorylation and fiveO-glycosylation sites and their biological implications."; Christensen B., Nielsen M.S., Haselmann K.F., Petersen T.E.,Sorensen E.S.; Biochem. J. 390:285-292(2005). Cited for: PHOSPHORYLATION AT SER-24; SER-26; SER-27; SER-62; SER-63; THR-66;SER-76; SER-81; SER-99; SER-102; SER-108; SER-117; SER-120; SER-123;SER-129; THR-185; SER-191; SER-195; SER-215; SER-219; SER-224;SER-228; SER-234; SER-254; SER-263; SER-267; SER-275; SER-280;SER-303; SER-308; SER-310; SER-105 AND SER-126, AND GLYCOSYLATION ATASN-79; ASN-106; THR-134; THR-138; THR-143; THR-147 AND THR-152.	15869464 [Abstract]
Phosphorylation
Reference	PubMed
"An initial characterization of the serum phosphoproteome."; Zhou W., Ross M.M., Tessitore A., Ornstein D., Vanmeter A.,Liotta L.A., Petricoin E.F. III; J. Proteome Res. 8:5523-5531(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-303; SER-308AND SER-310, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.	19824718 [Abstract]
"Phosphoproteomic analysis of the human pituitary."; Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F.; Pituitary 9:109-120(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-81, AND MASSSPECTROMETRY.	16807684 [Abstract]
"Post-translationally modified residues of native human osteopontinare located in clusters: identification of 36 phosphorylation and fiveO-glycosylation sites and their biological implications."; Christensen B., Nielsen M.S., Haselmann K.F., Petersen T.E.,Sorensen E.S.; Biochem. J. 390:285-292(2005). Cited for: PHOSPHORYLATION AT SER-24; SER-26; SER-27; SER-62; SER-63; THR-66;SER-76; SER-81; SER-99; SER-102; SER-108; SER-117; SER-120; SER-123;SER-129; THR-185; SER-191; SER-195; SER-215; SER-219; SER-224;SER-228; SER-234; SER-254; SER-263; SER-267; SER-275; SER-280;SER-303; SER-308; SER-310; SER-105 AND SER-126, AND GLYCOSYLATION ATASN-79; ASN-106; THR-134; THR-138; THR-143; THR-147 AND THR-152.	15869464 [Abstract]

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