dbPTM

CHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHD1_HUMAN
UniProt AC	O14646
Protein Name	Chromodomain-helicase-DNA-binding protein 1
Gene Name	CHD1
Organism	Homo sapiens (Human).
Sequence Length	1710
Subcellular Localization	Nucleus . Cytoplasm . Is released into the cytoplasm when cells enter mitosis and is reincorporated into chromatin during telophase-cytokinesis.
Protein Description	ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. [PubMed: 18042460]
Protein Sequence	MNGHSDEESVRNSSGESSQSDDDSGSASGSGSGSSSGSSSDGSSSQSGSSDSDSGSESGSQSESESDTSRENKVQAKPPKVDGAEFWKSSPSILAVQRSAILKKQQQQQQQQQHQASSNSGSEEDSSSSEDSDDSSSEVKRKKHKDEDWQMSGSGSPSQSGSDSESEEEREKSSCDETESDYEPKNKVKSRKPQNRSKSKNGKKILGQKKRQIDSSEEDDDEEDYDNDKRSSRRQATVNVSYKEDEEMKTDSDDLLEVCGEDVPQPEEEEFETIERFMDCRIGRKGATGATTTIYAVEADGDPNAGFEKNKEPGEIQYLIKWKGWSHIHNTWETEETLKQQNVRGMKKLDNYKKKDQETKRWLKNASPEDVEYYNCQQELTDDLHKQYQIVERIIAHSNQKSAAGYPDYYCKWQGLPYSECSWEDGALISKKFQACIDEYFSRNQSKTTPFKDCKVLKQRPRFVALKKQPSYIGGHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQREIQTWASQMNAVVYLGDINSRNMIRTHEWTHHQTKRLKFNILLTTYEILLKDKAFLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHGKGREYGYASLHKELEPFLLRRVKKDVEKSLPAKVEQILRMEMSALQKQYYKWILTRNYKALSKGSKGSTSGFLNIMMELKKCCNHCYLIKPPDNNEFYNKQEALQHLIRSSGKLILLDKLLIRLRERGNRVLIFSQMVRMLDILAEYLKYRQFPFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDWNPQNDLQAQARAHRIGQKKQVNIYRLVTKGSVEEDILERAKKKMVLDHLVIQRMDTTGKTVLHTGSAPSSSTPFNKEELSAILKFGAEELFKEPEGEEQEPQEMDIDEILKRAETHENEPGPLTVGDELLSQFKVANFSNMDEDDIELEPERNSKNWEEIIPEDQRRRLEEEERQKELEEIYMLPRMRNCAKQISFNGSEGRRSRSRRYSGSDSDSISEGKRPKKRGRPRTIPRENIKGFSDAEIRRFIKSYKKFGGPLERLDAIARDAELVDKSETDLRRLGELVHNGCIKALKDSSSGTERTGGRLGKVKGPTFRISGVQVNAKLVISHEEELIPLHKSIPSDPEERKQYTIPCHTKAAHFDIDWGKEDDSNLLIGIYEYGYGSWEMIKMDPDLSLTHKILPDDPDKKPQAKQLQTRADYLIKLLSRDLAKKEALSGAGSSKRRKARAKKNKAMKSIKVKEEIKSDSSPLPSEKSDEDDDKLSESKSDGRERSKKSSVSDAPVHITASGEPVPISEESEELDQKTFSICKERMRPVKAALKQLDRPEKGLSEREQLEHTRQCLIKIGDHITECLKEYTNPEQIKQWRKNLWIFVSKFTEFDARKLHKLYKHAIKKRQESQQNSDQNSNLNPHVIRNPDVERLKENTNHDDSSRDSYSSDRHLTQYHDHHKDRHQGDSYKKSDSRKRPYSSFSNGKDHRDWDHYKQDSRYYSDREKHRKLDDHRSRDHRSNLEGSLKDRSHSDHRSHSDHRLHSDHRSSSEYTHHKSSRDYRYHSDWQMDHRASSSGPRSPLDQRSPYGSRSPFEHSVEHKSTPEHTWSSRKT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MNGHSDEESVRN ---CCCCCCHHHHCC	48.38	23663014
9	Phosphorylation	NGHSDEESVRNSSGE CCCCCHHHHCCCCCC	25.08	27486199
77	Acetylation	RENKVQAKPPKVDGA CCCCCCCCCCCCCHH	44.77	25953088
88	Ubiquitination	VDGAEFWKSSPSILA CCHHHHHHCCHHHHH	46.51	-
89	Phosphorylation	DGAEFWKSSPSILAV CHHHHHHCCHHHHHH	37.77	23401153
90	Phosphorylation	GAEFWKSSPSILAVQ HHHHHHCCHHHHHHH	20.95	25159151
92	Phosphorylation	EFWKSSPSILAVQRS HHHHCCHHHHHHHHH	31.98	22115753
152	Phosphorylation	KDEDWQMSGSGSPSQ CCCCCCCCCCCCCCC	18.08	22210691
154	Phosphorylation	EDWQMSGSGSPSQSG CCCCCCCCCCCCCCC	28.88	22210691
162	Phosphorylation	GSPSQSGSDSESEEE CCCCCCCCCCCCHHH	43.12	22210691
164	Phosphorylation	PSQSGSDSESEEERE CCCCCCCCCCHHHHH	44.73	30576142
173	Phosphorylation	SEEEREKSSCDETES CHHHHHHHCCCCCCC	31.29	23663014
174	Phosphorylation	EEEREKSSCDETESD HHHHHHHCCCCCCCC	36.33	23663014
178	Phosphorylation	EKSSCDETESDYEPK HHHCCCCCCCCCCCC	27.77	23663014
180	Phosphorylation	SSCDETESDYEPKNK HCCCCCCCCCCCCHH	53.57	25850435
182	Phosphorylation	CDETESDYEPKNKVK CCCCCCCCCCCHHHC	43.33	27732954
215	Phosphorylation	QKKRQIDSSEEDDDE CCHHCCCCCCCCCCC	41.08	22167270
216	Phosphorylation	KKRQIDSSEEDDDEE CHHCCCCCCCCCCCC	41.06	22167270
225	Phosphorylation	EDDDEEDYDNDKRSS CCCCCCCCCCCCCCC	21.67	20363803
232	Phosphorylation	YDNDKRSSRRQATVN CCCCCCCCCCEEEEE	35.20	-
237	Phosphorylation	RSSRRQATVNVSYKE CCCCCEEEEECCCCC	12.32	18669648
241	Phosphorylation	RQATVNVSYKEDEEM CEEEEECCCCCCHHC	25.86	21082442
250	Phosphorylation	KEDEEMKTDSDDLLE CCCHHCCCCCHHHHH	39.15	17192257
252	Phosphorylation	DEEMKTDSDDLLEVC CHHCCCCCHHHHHHH	37.95	17192257
285	Ubiquitination	MDCRIGRKGATGATT HHCCCCCCCCCCCEE	47.92	-
311	Ubiquitination	NAGFEKNKEPGEIQY CCCCCCCCCCCCEEE	76.10	-
339	Ubiquitination	WETEETLKQQNVRGM CCCHHHHHHHCCCCH	58.20	-
348	Acetylation	QNVRGMKKLDNYKKK HCCCCHHHHHHCHHH	52.78	19817877
352	Phosphorylation	GMKKLDNYKKKDQET CHHHHHHCHHHHHHH	24.69	28152594
364	Ubiquitination	QETKRWLKNASPEDV HHHHHHHHHCCHHHH	43.43	-
367	Phosphorylation	KRWLKNASPEDVEYY HHHHHHCCHHHHHHH	37.91	28985074
386	Ubiquitination	ELTDDLHKQYQIVER HHCHHHHHHHHHHHH	58.98	-
388	Phosphorylation	TDDLHKQYQIVERII CHHHHHHHHHHHHHH	12.66	28152594
398	Phosphorylation	VERIIAHSNQKSAAG HHHHHHHCCCCCCCC	31.75	22817900
401	Acetylation	IIAHSNQKSAAGYPD HHHHCCCCCCCCCCC	46.44	26051181
401	Ubiquitination	IIAHSNQKSAAGYPD HHHHCCCCCCCCCCC	46.44	-
412	Ubiquitination	GYPDYYCKWQGLPYS CCCCCCCEECCCCHH	26.82	-
431	Ubiquitination	EDGALISKKFQACID CCCCHHHHHHHHHHH	51.09	-
447	Ubiquitination	YFSRNQSKTTPFKDC HHHCCCCCCCCCCCC	46.80	-
449	Phosphorylation	SRNQSKTTPFKDCKV HCCCCCCCCCCCCHH	30.39	-
455	Ubiquitination	TTPFKDCKVLKQRPR CCCCCCCHHHHCCCC	61.81	-
468	Ubiquitination	PRFVALKKQPSYIGG CCEEEECCCCCCCCC	69.19	-
471	Phosphorylation	VALKKQPSYIGGHEG EEECCCCCCCCCCCC	27.21	25159151
472	Phosphorylation	ALKKQPSYIGGHEGL EECCCCCCCCCCCCC	15.40	28450419
508	Sulfoxidation	SCILADEMGLGKTIQ CCEEECCCCCCCHHH	5.74	21406390
620	Ubiquitination	VDEAHRLKNDDSLLY CCHHHHHCCCCCHHH	59.28	-
624	Phosphorylation	HRLKNDDSLLYKTLI HHHCCCCCHHHHHHH	24.12	28555341
628	Ubiquitination	NDDSLLYKTLIDFKS CCCCHHHHHHHCCCC	36.50	-
634	Acetylation	YKTLIDFKSNHRLLI HHHHHCCCCCCCEEE	46.75	25953088
634	Ubiquitination	YKTLIDFKSNHRLLI HHHHHCCCCCCCEEE	46.75	-
667	Phosphorylation	IMPEKFSSWEDFEEE HCCHHCCCHHHHHHH	37.30	-
677	Ubiquitination	DFEEEHGKGREYGYA HHHHHHCCCCCCCCC	57.62	-
681	Phosphorylation	EHGKGREYGYASLHK HHCCCCCCCCCHHHH	17.67	-
705	Phosphorylation	VKKDVEKSLPAKVEQ HHHHHHHCCCHHHHH	26.53	-
719	Phosphorylation	QILRMEMSALQKQYY HHHHHHHHHHHHHHH	16.72	-
725	Phosphorylation	MSALQKQYYKWILTR HHHHHHHHHHHHHHH	17.66	-
726	Phosphorylation	SALQKQYYKWILTRN HHHHHHHHHHHHHHC	9.43	26657352
731	Phosphorylation	QYYKWILTRNYKALS HHHHHHHHHCHHHHH	14.03	26657352
738	Phosphorylation	TRNYKALSKGSKGST HHCHHHHHCCCCCCH	39.57	-
745	Phosphorylation	SKGSKGSTSGFLNIM HCCCCCCHHHHHHHH	41.35	-
746	Phosphorylation	KGSKGSTSGFLNIMM CCCCCCHHHHHHHHH	29.28	24114839
786	Phosphorylation	ALQHLIRSSGKLILL HHHHHHHHCCCEEHH	36.13	25690035
813	Sulfoxidation	RVLIFSQMVRMLDIL EEEEEHHHHHHHHHH	1.68	31801345
823	Phosphorylation	MLDILAEYLKYRQFP HHHHHHHHHHHCCCC	11.68	21406692
910	Phosphorylation	QKKQVNIYRLVTKGS CCCCEEEEEEECCCC	7.84	27732954
914	Phosphorylation	VNIYRLVTKGSVEED EEEEEEECCCCHHHH	33.99	27732954
915	Ubiquitination	NIYRLVTKGSVEEDI EEEEEECCCCHHHHH	41.53	-
942	Phosphorylation	LVIQRMDTTGKTVLH HHHEEECCCCCEEEE	28.27	22210691
943	Phosphorylation	VIQRMDTTGKTVLHT HHEEECCCCCEEEEC	32.20	27282143
945	Acetylation	QRMDTTGKTVLHTGS EEECCCCCEEEECCC	33.11	26051181
945	Ubiquitination	QRMDTTGKTVLHTGS EEECCCCCEEEECCC	33.11	-
950	Phosphorylation	TGKTVLHTGSAPSSS CCCEEEECCCCCCCC	28.77	22210691
952	Phosphorylation	KTVLHTGSAPSSSTP CEEEECCCCCCCCCC	37.86	22210691
957	Phosphorylation	TGSAPSSSTPFNKEE CCCCCCCCCCCCHHH	44.42	22210691
958	Phosphorylation	GSAPSSSTPFNKEEL CCCCCCCCCCCHHHH	33.57	25159151
962	Acetylation	SSSTPFNKEELSAIL CCCCCCCHHHHHHHH	53.60	26051181
962	Ubiquitination	SSSTPFNKEELSAIL CCCCCCCHHHHHHHH	53.60	-
966	Phosphorylation	PFNKEELSAILKFGA CCCHHHHHHHHHHCH	19.28	21815630
997	Ubiquitination	MDIDEILKRAETHEN CCHHHHHHHHHCCCC	56.05	-
1010	Phosphorylation	ENEPGPLTVGDELLS CCCCCCCCCCHHHHH	26.10	24114839
1025	Phosphorylation	QFKVANFSNMDEDDI HCEECCCCCCCHHHC	30.93	30576142
1040	Phosphorylation	ELEPERNSKNWEEII CCCCHHCCCCHHHHC	33.32	25159151
1041	Acetylation	LEPERNSKNWEEIIP CCCHHCCCCHHHHCC	70.41	25953088
1041	Ubiquitination	LEPERNSKNWEEIIP CCCHHCCCCHHHHCC	70.41	-
1062	Ubiquitination	LEEEERQKELEEIYM HHHHHHHHHHHHHHH	71.18	-
1068	Phosphorylation	QKELEEIYMLPRMRN HHHHHHHHHHHHHHH	8.90	21945579
1078	Acetylation	PRMRNCAKQISFNGS HHHHHHHHHHCCCCC	50.82	25953088
1081	Phosphorylation	RNCAKQISFNGSEGR HHHHHHHCCCCCCCC	15.34	25159151
1085	Phosphorylation	KQISFNGSEGRRSRS HHHCCCCCCCCCCCC	37.67	25159151
1090	Phosphorylation	NGSEGRRSRSRRYSG CCCCCCCCCCCCCCC	32.99	25159151
1092	Phosphorylation	SEGRRSRSRRYSGSD CCCCCCCCCCCCCCC	23.50	29523821
1095	Phosphorylation	RRSRSRRYSGSDSDS CCCCCCCCCCCCCCC	19.10	23927012
1096	Phosphorylation	RSRSRRYSGSDSDSI CCCCCCCCCCCCCCC	29.97	29255136
1098	Phosphorylation	RSRRYSGSDSDSISE CCCCCCCCCCCCCCC	28.18	29255136
1100	Phosphorylation	RRYSGSDSDSISEGK CCCCCCCCCCCCCCC	34.65	29255136
1102	Phosphorylation	YSGSDSDSISEGKRP CCCCCCCCCCCCCCC	31.78	25159151
1104	Phosphorylation	GSDSDSISEGKRPKK CCCCCCCCCCCCCCC	44.22	23927012
1124	Methylation	TIPRENIKGFSDAEI CCCHHHCCCCCHHHH	66.54	-
1124	Ubiquitination	TIPRENIKGFSDAEI CCCHHHCCCCCHHHH	66.54	-
1127	Phosphorylation	RENIKGFSDAEIRRF HHHCCCCCHHHHHHH	44.58	23898821
1160	Acetylation	RDAELVDKSETDLRR HCHHHCCCCHHHHHH	42.59	26051181
1160	Ubiquitination	RDAELVDKSETDLRR HCHHHCCCCHHHHHH	42.59	-
1161	Phosphorylation	DAELVDKSETDLRRL CHHHCCCCHHHHHHH	41.06	25849741
1163	Phosphorylation	ELVDKSETDLRRLGE HHCCCCHHHHHHHHH	47.64	23186163
1178	Acetylation	LVHNGCIKALKDSSS HHHHCHHHHHHCCCC	52.31	26051181
1183	Phosphorylation	CIKALKDSSSGTERT HHHHHHCCCCCCEEC	25.47	23312004
1184	Phosphorylation	IKALKDSSSGTERTG HHHHHCCCCCCEECC	42.81	28985074
1185	Phosphorylation	KALKDSSSGTERTGG HHHHCCCCCCEECCC	54.40	23312004
1187	Phosphorylation	LKDSSSGTERTGGRL HHCCCCCCEECCCCC	25.00	23312004
1190	Phosphorylation	SSSGTERTGGRLGKV CCCCCEECCCCCCCC	37.44	-
1226	Ubiquitination	EELIPLHKSIPSDPE HHHCCCCCCCCCCHH	58.73	-
1227	Phosphorylation	ELIPLHKSIPSDPEE HHCCCCCCCCCCHHH	29.05	28985074
1230	Phosphorylation	PLHKSIPSDPEERKQ CCCCCCCCCHHHHHC	65.22	21815630
1236	Ubiquitination	PSDPEERKQYTIPCH CCCHHHHHCCCCCCC	51.43	-
1283	Phosphorylation	IKMDPDLSLTHKILP EEECCCCCCCEECCC	38.30	-
1285	Phosphorylation	MDPDLSLTHKILPDD ECCCCCCCEECCCCC	20.11	-
1320	Ubiquitination	LSRDLAKKEALSGAG HHHHHHHHHHHCCCC	42.48	-
1324	Phosphorylation	LAKKEALSGAGSSKR HHHHHHHCCCCCHHH	33.38	29396449
1328	Phosphorylation	EALSGAGSSKRRKAR HHHCCCCCHHHHHHH	31.95	17192257
1329	Phosphorylation	ALSGAGSSKRRKARA HHCCCCCHHHHHHHH	29.30	28985074
1330	2-Hydroxyisobutyrylation	LSGAGSSKRRKARAK HCCCCCHHHHHHHHH	58.90	-
1330	Acetylation	LSGAGSSKRRKARAK HCCCCCHHHHHHHHH	58.90	25953088
1338	Acetylation	RRKARAKKNKAMKSI HHHHHHHHHHHHHHH	63.80	129547
1340	Acetylation	KARAKKNKAMKSIKV HHHHHHHHHHHHHHH	59.75	7661725
1343	Acetylation	AKKNKAMKSIKVKEE HHHHHHHHHHHHHHH	54.62	7661737
1346	Acetylation	NKAMKSIKVKEEIKS HHHHHHHHHHHHHCC	55.11	129551
1353	Phosphorylation	KVKEEIKSDSSPLPS HHHHHHCCCCCCCCC	48.68	20044836
1355	Phosphorylation	KEEIKSDSSPLPSEK HHHHCCCCCCCCCCC	40.73	20044836
1356	Phosphorylation	EEIKSDSSPLPSEKS HHHCCCCCCCCCCCC	35.13	25159151
1360	Phosphorylation	SDSSPLPSEKSDEDD CCCCCCCCCCCCCCC	66.40	23401153
1363	Phosphorylation	SPLPSEKSDEDDDKL CCCCCCCCCCCCHHH	42.03	25159151
1371	Phosphorylation	DEDDDKLSESKSDGR CCCCHHHCCCCCCCC	45.63	21815630
1373	Phosphorylation	DDDKLSESKSDGRER CCHHHCCCCCCCCHH	33.80	21815630
1381	Phosphorylation	KSDGRERSKKSSVSD CCCCCHHCCCCCCCC	39.42	26074081
1384	Phosphorylation	GRERSKKSSVSDAPV CCHHCCCCCCCCCCC	39.44	25159151
1385	Phosphorylation	RERSKKSSVSDAPVH CHHCCCCCCCCCCCE	34.22	25159151
1387	Phosphorylation	RSKKSSVSDAPVHIT HCCCCCCCCCCCEEE	29.97	25159151
1394	Phosphorylation	SDAPVHITASGEPVP CCCCCEEEECCCCCC	10.41	28122231
1396	Phosphorylation	APVHITASGEPVPIS CCCEEEECCCCCCCC	34.73	25159151
1403	Phosphorylation	SGEPVPISEESEELD CCCCCCCCCCHHHHC	29.28	21082442
1406	Phosphorylation	PVPISEESEELDQKT CCCCCCCHHHHCHHH	32.11	21082442
1436	Acetylation	KQLDRPEKGLSEREQ HHCCCCCCCCCHHHH	68.76	25953088
1436	Ubiquitination	KQLDRPEKGLSEREQ HHCCCCCCCCCHHHH	68.76	-
1453	Acetylation	HTRQCLIKIGDHITE HHHHHHHHHHHHHHH	27.91	25953088
1463	Acetylation	DHITECLKEYTNPEQ HHHHHHHHHCCCHHH	61.40	26051181
1483	Phosphorylation	KNLWIFVSKFTEFDA HHHHHHHHCCCHHHH	16.00	25101063
1491	Methylation	KFTEFDARKLHKLYK CCCHHHHHHHHHHHH	43.86	-
1507	Phosphorylation	AIKKRQESQQNSDQN HHHHHHHHHHCCCCC	28.82	28555341
1511	Phosphorylation	RQESQQNSDQNSNLN HHHHHHCCCCCCCCC	35.91	25159151
1515	Phosphorylation	QQNSDQNSNLNPHVI HHCCCCCCCCCHHHH	36.74	27050516
1534	Phosphorylation	VERLKENTNHDDSSR HHHHHHHCCCCCCCC	34.71	20873877
1539	Phosphorylation	ENTNHDDSSRDSYSS HHCCCCCCCCCCCCC	33.07	30576142
1540	Phosphorylation	NTNHDDSSRDSYSSD HCCCCCCCCCCCCCH	47.29	25849741
1543	Phosphorylation	HDDSSRDSYSSDRHL CCCCCCCCCCCHHCH	26.29	30576142
1544	Phosphorylation	DDSSRDSYSSDRHLT CCCCCCCCCCHHCHH	19.24	30576142
1545	Phosphorylation	DSSRDSYSSDRHLTQ CCCCCCCCCHHCHHC	29.70	28985074
1546	Phosphorylation	SSRDSYSSDRHLTQY CCCCCCCCHHCHHCC	30.36	29496963
1576	Phosphorylation	SDSRKRPYSSFSNGK CCCCCCCCCCCCCCC	22.45	28555341
1577	Phosphorylation	DSRKRPYSSFSNGKD CCCCCCCCCCCCCCC	27.82	28555341
1578	Phosphorylation	SRKRPYSSFSNGKDH CCCCCCCCCCCCCCC	27.18	25159151
1580	Phosphorylation	KRPYSSFSNGKDHRD CCCCCCCCCCCCCCC	46.77	25159151
1591	Phosphorylation	DHRDWDHYKQDSRYY CCCCCCHHHCCCCCC	14.10	-
1595	Phosphorylation	WDHYKQDSRYYSDRE CCHHHCCCCCCCCHH	21.49	25159151
1599	Phosphorylation	KQDSRYYSDREKHRK HCCCCCCCCHHHHHC	22.66	30576142
1622	Phosphorylation	HRSNLEGSLKDRSHS HHHHCCHHHCCCCCC	23.91	25159151
1641	Phosphorylation	HSDHRLHSDHRSSSE CCCCCCCCCCCCCCC	39.44	29449344
1645	Phosphorylation	RLHSDHRSSSEYTHH CCCCCCCCCCCCCCC	34.49	29449344
1646	Phosphorylation	LHSDHRSSSEYTHHK CCCCCCCCCCCCCCC	27.44	27134283
1647	Phosphorylation	HSDHRSSSEYTHHKS CCCCCCCCCCCCCCC	35.55	27251275
1649	Phosphorylation	DHRSSSEYTHHKSSR CCCCCCCCCCCCCCC	17.20	29449344
1650	Phosphorylation	HRSSSEYTHHKSSRD CCCCCCCCCCCCCCC	17.29	29449344
1662	Phosphorylation	SRDYRYHSDWQMDHR CCCCCCCCCHHCCCC	31.45	28555341
1671	Phosphorylation	WQMDHRASSSGPRSP HHCCCCCCCCCCCCC	25.62	23401153
1671 (in isoform 2)	Phosphorylation	-	25.62	25159151
1672	Phosphorylation	QMDHRASSSGPRSPL HCCCCCCCCCCCCCC	38.03	30266825
1672 (in isoform 2)	Phosphorylation	-	38.03	27762562
1673	Phosphorylation	MDHRASSSGPRSPLD CCCCCCCCCCCCCCC	50.77	30266825
1673 (in isoform 2)	Phosphorylation	-	50.77	27762562
1677	Phosphorylation	ASSSGPRSPLDQRSP CCCCCCCCCCCCCCC	32.71	22167270
1677 (in isoform 2)	Phosphorylation	-	32.71	29743597
1683	Phosphorylation	RSPLDQRSPYGSRSP CCCCCCCCCCCCCCC	19.48	25159151
1683 (in isoform 2)	Phosphorylation	-	19.48	28152594
1684 (in isoform 2)	Phosphorylation	-	39.43	28152594
1685	Phosphorylation	PLDQRSPYGSRSPFE CCCCCCCCCCCCCCC	29.04	28176443
1686 (in isoform 2)	Phosphorylation	-	21.70	23403867
1687	Phosphorylation	DQRSPYGSRSPFEHS CCCCCCCCCCCCCCC	24.60	25159151
1688 (in isoform 2)	Phosphorylation	-	43.94	25159151
1689	Phosphorylation	RSPYGSRSPFEHSVE CCCCCCCCCCCCCCC	35.32	29255136
1693 (in isoform 2)	Phosphorylation	-	37.21	28152594
1694	Phosphorylation	SRSPFEHSVEHKSTP CCCCCCCCCCCCCCC	23.23	30266825
1698 (in isoform 2)	Phosphorylation	-	42.38	29116813
1699	Phosphorylation	EHSVEHKSTPEHTWS CCCCCCCCCCCCCCC	51.61	30266825
1700	Phosphorylation	HSVEHKSTPEHTWSS CCCCCCCCCCCCCCC	37.18	30266825
1704	Phosphorylation	HKSTPEHTWSSRKT- CCCCCCCCCCCCCC-	25.94	22167270
1706	Phosphorylation	STPEHTWSSRKT--- CCCCCCCCCCCC---	22.78	25159151
1707	Phosphorylation	TPEHTWSSRKT---- CCCCCCCCCCC----	29.38	22167270

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHD1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BCLF1_HUMAN	BCLAF1	physical	12890497
SRSF3_HUMAN	SRSF3	physical	12890497
NCOR1_HUMAN	NCOR1	physical	12890497
SAFB1_HUMAN	SAFB	physical	12890497
SSRP1_HUMAN	SSRP1	physical	10199952
H31_HUMAN	HIST1H3A	physical	16372014
PAF1_HUMAN	PAF1	physical	22046413
FBW1A_HUMAN	BTRC	physical	28166537

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00445	Epirubicin

Regulatory Network of CHD1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-215; SER-216;SER-1403 AND SER-1406, AND MASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-237; SER-241; SER-1040;SER-1096; SER-1098; SER-1100 AND SER-1677, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241; THR-250; SER-252;SER-1040; SER-1081; SER-1096; SER-1098; SER-1100; SER-1102; SER-1328;SER-1353; SER-1355; SER-1356; SER-1360; SER-1387; SER-1396; SER-1622;SER-1677; SER-1689 AND THR-1700, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-92; SER-241 ANDSER-1622, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-89, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1353; SER-1355; SER-1356AND SER-1360, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215 AND SER-216, ANDMASS SPECTROMETRY.	16083285 [Abstract]
"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry."; Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.; Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1068, AND MASSSPECTROMETRY.	12522270 [Abstract]