dbPTM

SAFB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SAFB1_HUMAN
UniProt AC	Q15424
Protein Name	Scaffold attachment factor B1
Gene Name	SAFB
Organism	Homo sapiens (Human).
Sequence Length	915
Subcellular Localization	Nucleus .
Protein Description	Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity). Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity). Can inhibit cell proliferation..
Protein Sequence	MAETLSGLGDSGAAGAAALSSASSETGTRRLSDLRVIDLRAELRKRNVDSSGNKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEPSLEPENEKILDILGETCKSEPVKEESSELEQPFAQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQPGDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDACNEVPPAPKESSTSEGADQKMSSPEDDSDTKRLSKEEKGRSSCGRNFWVSGLSSTTRATDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTAEEATKCINHLHKTELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKCDRKDDAKKGDDGSGEKSKDQDDQKPGPSERSRATKSGSRGTERTVVMDKSKGVPVISVKTSGSKERASKSQDRKSASREKRSVVSFDKVKEPRKSRDSESHSRVRERSEREQRMQAQWEREERERLEIARERLAFQRQRLERERMERERLERERMHVEHERRREQERIHREREELRRQQELRYEQERRPAVRRPYDLDRRDDAYWPEAKRAALDERYHSDFNRQDRFHDFDHRDRGRYPDHSVDRREGSRSMMGEREGQHYPERHGGPERHGRDSRDGWGGYGSDKRMSEGRGLPPPPRRDWGDHGRREDDRSWQGTADGGMMDRDHKRWQGGERSMSGHSGPGHMMNRGGMSGRGSFAPGGASRGHPIPHGGMQGGFGGQSRGSRPSDARFTRRY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAETLSGLG ------CCCCCCCCC	20.62	20068231
4	Phosphorylation	----MAETLSGLGDS ----CCCCCCCCCCC	19.38	26503892
6	Phosphorylation	--MAETLSGLGDSGA --CCCCCCCCCCCHH	39.12	22115753
11	Phosphorylation	TLSGLGDSGAAGAAA CCCCCCCCHHHHHHH	28.65	23401153
20	Phosphorylation	AAGAAALSSASSETG HHHHHHHHCCCCCCC	21.09	23401153
21	Phosphorylation	AGAAALSSASSETGT HHHHHHHCCCCCCCC	32.78	25159151
23	Phosphorylation	AAALSSASSETGTRR HHHHHCCCCCCCCCC	30.56	29255136
24	Phosphorylation	AALSSASSETGTRRL HHHHCCCCCCCCCCH	38.60	23401153
26	Phosphorylation	LSSASSETGTRRLSD HHCCCCCCCCCCHHH	45.89	29255136
28	Phosphorylation	SASSETGTRRLSDLR CCCCCCCCCCHHHCE	21.75	26503892
29	Methylation	ASSETGTRRLSDLRV CCCCCCCCCHHHCEE	38.60	115386587
32	Phosphorylation	ETGTRRLSDLRVIDL CCCCCCHHHCEEEEH	32.56	23927012
35	Methylation	TRRLSDLRVIDLRAE CCCHHHCEEEEHHHH	28.47	115493137
50	Phosphorylation	LRKRNVDSSGNKSVL HHHCCCCCCCCHHHH	35.54	30108239
51	Phosphorylation	RKRNVDSSGNKSVLM HHCCCCCCCCHHHHH	41.75	30108239
54	Acetylation	NVDSSGNKSVLMERL CCCCCCCHHHHHHHH	45.53	23236377
55	Phosphorylation	VDSSGNKSVLMERLK CCCCCCHHHHHHHHH	25.20	26055452
60	Methylation	NKSVLMERLKKAIED CHHHHHHHHHHHHHC	37.53	-
78	Phosphorylation	NPDEIEITSEGNKKT CCCCEEECCCCCCCC	14.13	30108239
79	Phosphorylation	PDEIEITSEGNKKTS CCCEEECCCCCCCCC	49.52	25159151
83	Acetylation	EITSEGNKKTSKRSS EECCCCCCCCCCCCC	69.18	26051181
83	Ubiquitination	EITSEGNKKTSKRSS EECCCCCCCCCCCCC	69.18	21890473
84	Acetylation	ITSEGNKKTSKRSSK ECCCCCCCCCCCCCC	63.13	71375
85	Phosphorylation	TSEGNKKTSKRSSKG CCCCCCCCCCCCCCC	40.88	26074081
86	Phosphorylation	SEGNKKTSKRSSKGR CCCCCCCCCCCCCCC	34.64	26074081
125 (in isoform 2)	Phosphorylation	-	43.63	29116813
126 (in isoform 2)	Phosphorylation	-	2.20	29116813
127 (in isoform 2)	Phosphorylation	-	38.15	29116813
128 (in isoform 2)	Phosphorylation	-	2.46	29507054
143	Phosphorylation	EAEIDNGSVADCVED HHHCCCCCHHHHCCC	22.01	22468782
159	Phosphorylation	DADNLQESLSDSREL CHHHHHHHHHHHHHH	21.88	26074081
161	Phosphorylation	DNLQESLSDSRELVE HHHHHHHHHHHHHHH	42.70	26074081
163	Phosphorylation	LQESLSDSRELVEGE HHHHHHHHHHHHHHH	25.03	26074081
172	Sumoylation	ELVEGEMKELPEQLQ HHHHHHHHHHHHHHH	52.36	-
172	Sumoylation	ELVEGEMKELPEQLQ HHHHHHHHHHHHHHH	52.36	28112733
186	Sumoylation	QEHAIEDKETINNLD HHHHHCCHHHHHHCC	43.92	28112733
188	Phosphorylation	HAIEDKETINNLDTS HHHCCHHHHHHCCCC	34.44	30278072
194	Phosphorylation	ETINNLDTSSSDFTI HHHHHCCCCCCCCEE	33.40	30278072
195	Phosphorylation	TINNLDTSSSDFTIL HHHHCCCCCCCCEEE	27.75	30278072
196	Phosphorylation	INNLDTSSSDFTILQ HHHCCCCCCCCEEEE	35.70	26503892
197	Phosphorylation	NNLDTSSSDFTILQE HHCCCCCCCCEEEEE	36.19	26503892
200	Phosphorylation	DTSSSDFTILQEIEE CCCCCCCEEEEECCC	26.26	30278072
209	Phosphorylation	LQEIEEPSLEPENEK EEECCCCCCCCCCCH	48.95	28176443
224	Phosphorylation	ILDILGETCKSEPVK HHHHHHHHHCCCCCC	24.36	28102081
225	Ubiquitination	LDILGETCKSEPVKE HHHHHHHHCCCCCCC	3.87	21890473
225	Glutathionylation	LDILGETCKSEPVKE HHHHHHHHCCCCCCC	3.87	22555962
226	Methylation	DILGETCKSEPVKEE HHHHHHHCCCCCCCC	66.33	-
226	Sumoylation	DILGETCKSEPVKEE HHHHHHHCCCCCCCC	66.33	-
226	Sumoylation	DILGETCKSEPVKEE HHHHHHHCCCCCCCC	66.33	-
226	Ubiquitination	DILGETCKSEPVKEE HHHHHHHCCCCCCCC	66.33	-
227	Phosphorylation	ILGETCKSEPVKEES HHHHHHCCCCCCCCC	49.64	29255136
231	Sumoylation	TCKSEPVKEESSELE HHCCCCCCCCCCCCC	67.49	-
231	Ubiquitination	TCKSEPVKEESSELE HHCCCCCCCCCCCCC	67.49	21890473
231	Sumoylation	TCKSEPVKEESSELE HHCCCCCCCCCCCCC	67.49	21527249
234	Phosphorylation	SEPVKEESSELEQPF CCCCCCCCCCCCCCC	30.15	29255136
235	Phosphorylation	EPVKEESSELEQPFA CCCCCCCCCCCCCCC	49.86	29255136
245	Phosphorylation	EQPFAQDTSSVGPDR CCCCCCCCCCCCCCH	15.72	29255136
246	Phosphorylation	QPFAQDTSSVGPDRK CCCCCCCCCCCCCHH	31.17	29255136
247	Phosphorylation	PFAQDTSSVGPDRKL CCCCCCCCCCCCHHH	32.93	29255136
253	Sumoylation	SSVGPDRKLAEEEDL CCCCCCHHHHHHHHH	60.47	-
253	Sumoylation	SSVGPDRKLAEEEDL CCCCCCHHHHHHHHH	60.47	-
263	Phosphorylation	EEEDLFDSAHPEEGD HHHHHHHCCCCCCCC	22.57	30266825
275	Phosphorylation	EGDLDLASESTAHAQ CCCCCCCCCCHHHHH	39.10	30266825
277	Phosphorylation	DLDLASESTAHAQSS CCCCCCCCHHHHHHC	28.53	30266825
278	Phosphorylation	LDLASESTAHAQSSK CCCCCCCHHHHHHCC	20.57	30266825
283	Phosphorylation	ESTAHAQSSKADSLL CCHHHHHHCCHHHEE	34.29	23401153
284	Phosphorylation	STAHAQSSKADSLLA CHHHHHHCCHHHEEE	21.56	30108239
285	Ubiquitination	TAHAQSSKADSLLAV HHHHHHCCHHHEEEE	62.55	-
288	Phosphorylation	AQSSKADSLLAVVKR HHHCCHHHEEEEEEC	30.09	19664994
294	Acetylation	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	71379
294	Sumoylation	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	-
294	Ubiquitination	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	21890473
294	Sumoylation	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	21527249
294	Ubiquitination	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	21890473
294	Ubiquitination	DSLLAVVKREPAEQP HHEEEEEECCCCCCC	44.43	21890473
307	Phosphorylation	QPGDGERTDCEPVGL CCCCCCCCCCEECCC	40.47	23927012
321	Phosphorylation	LEPAVEQSSAASELA CHHHHHCCHHHHHHH	14.40	25159151
322	Phosphorylation	EPAVEQSSAASELAE HHHHHCCHHHHHHHH	27.78	23927012
325	Phosphorylation	VEQSSAASELAEASS HHCCHHHHHHHHHCH	32.62	23927012
331	Phosphorylation	ASELAEASSEELAEA HHHHHHHCHHHHHHC	29.77	26503892
332	Phosphorylation	SELAEASSEELAEAP HHHHHHCHHHHHHCC	41.98	30278072
340	Phosphorylation	EELAEAPTEAPSPEA HHHHHCCCCCCCCCC	52.40	30278072
344	Phosphorylation	EAPTEAPSPEARDSK HCCCCCCCCCCCCCC	42.28	29255136
350	Phosphorylation	PSPEARDSKEDGRKF CCCCCCCCCCCCCCC	32.18	30576142
354	Ubiquitination	ARDSKEDGRKFDFDA CCCCCCCCCCCCCCC	35.45	21890473
356	Acetylation	DSKEDGRKFDFDACN CCCCCCCCCCCCCCC	55.61	-
356	Ubiquitination	DSKEDGRKFDFDACN CCCCCCCCCCCCCCC	55.61	-
359	Ubiquitination	EDGRKFDFDACNEVP CCCCCCCCCCCCCCC	7.84	21890473
362	Glutathionylation	RKFDFDACNEVPPAP CCCCCCCCCCCCCCC	4.86	22555962
370	Ubiquitination	NEVPPAPKESSTSEG CCCCCCCCCCCCCCC	72.79	-
372	Phosphorylation	VPPAPKESSTSEGAD CCCCCCCCCCCCCCC	45.07	23927012
373	Phosphorylation	PPAPKESSTSEGADQ CCCCCCCCCCCCCCC	36.72	23927012
374	Phosphorylation	PAPKESSTSEGADQK CCCCCCCCCCCCCCC	39.82	23927012
375	Phosphorylation	APKESSTSEGADQKM CCCCCCCCCCCCCCC	35.66	22167270
381	Sumoylation	TSEGADQKMSSPEDD CCCCCCCCCCCCCCC	41.10	28112733
381	Ubiquitination	TSEGADQKMSSPEDD CCCCCCCCCCCCCCC	41.10	-
383	Phosphorylation	EGADQKMSSPEDDSD CCCCCCCCCCCCCHH	50.18	29255136
384	Phosphorylation	GADQKMSSPEDDSDT CCCCCCCCCCCCHHH	28.89	29255136
389	Phosphorylation	MSSPEDDSDTKRLSK CCCCCCCHHHHHCCH	60.55	22167270
391	Phosphorylation	SPEDDSDTKRLSKEE CCCCCHHHHHCCHHH	23.24	22167270
392	Ubiquitination	PEDDSDTKRLSKEEK CCCCHHHHHCCHHHH	57.22	-
392	Acetylation	PEDDSDTKRLSKEEK CCCCHHHHHCCHHHH	57.22	26051181
392	Sumoylation	PEDDSDTKRLSKEEK CCCCHHHHHCCHHHH	57.22	28112733
395	Phosphorylation	DSDTKRLSKEEKGRS CHHHHHCCHHHHCCC	41.89	20068231
402	Phosphorylation	SKEEKGRSSCGRNFW CHHHHCCCCCCCCCC	38.35	27174698
403	Phosphorylation	KEEKGRSSCGRNFWV HHHHCCCCCCCCCCC	21.16	27174698
406	Acetylation	KGRSSCGRNFWVSGL HCCCCCCCCCCCCCC	39.23	19608861
411	Phosphorylation	CGRNFWVSGLSSTTR CCCCCCCCCCCCCCC	25.31	30108239
414	Phosphorylation	NFWVSGLSSTTRATD CCCCCCCCCCCCHHH	29.21	30108239
415	Phosphorylation	FWVSGLSSTTRATDL CCCCCCCCCCCHHHH	38.55	25159151
416	Phosphorylation	WVSGLSSTTRATDLK CCCCCCCCCCHHHHH	19.54	25159151
417	Phosphorylation	VSGLSSTTRATDLKN CCCCCCCCCHHHHHH	21.91	30108239
423	Acetylation	TTRATDLKNLFSKYG CCCHHHHHHHHHHHC	55.18	22647301
423	Ubiquitination	TTRATDLKNLFSKYG CCCHHHHHHHHHHHC	55.18	21890473
423	Malonylation	TTRATDLKNLFSKYG CCCHHHHHHHHHHHC	55.18	26320211
423	Ubiquitination	TTRATDLKNLFSKYG CCCHHHHHHHHHHHC	55.18	21890473
423	Ubiquitination	TTRATDLKNLFSKYG CCCHHHHHHHHHHHC	55.18	21890473
427	Phosphorylation	TDLKNLFSKYGKVVG HHHHHHHHHHCCCCC	28.30	24719451
428	Acetylation	DLKNLFSKYGKVVGA HHHHHHHHHCCCCCC	51.17	22647325
428	Ubiquitination	DLKNLFSKYGKVVGA HHHHHHHHHCCCCCC	51.17	21890473
428	Ubiquitination	DLKNLFSKYGKVVGA HHHHHHHHHCCCCCC	51.17	21890473
428	Ubiquitination	DLKNLFSKYGKVVGA HHHHHHHHHCCCCCC	51.17	21890473
431	Ubiquitination	NLFSKYGKVVGAKVV HHHHHHCCCCCCEEE	30.56	-
436	Acetylation	YGKVVGAKVVTNARS HCCCCCCEEEECCCC	31.17	24649665
436	Ubiquitination	YGKVVGAKVVTNARS HCCCCCCEEEECCCC	31.17	-
436	Malonylation	YGKVVGAKVVTNARS HCCCCCCEEEECCCC	31.17	26320211
439	Phosphorylation	VVGAKVVTNARSPGA CCCCEEEECCCCCCC	26.58	25159151
443	Phosphorylation	KVVTNARSPGARCYG EEEECCCCCCCEEEE	25.85	28355574
448	Glutathionylation	ARSPGARCYGFVTMS CCCCCCEEEEEEECC	3.75	22555962
449	Phosphorylation	RSPGARCYGFVTMST CCCCCEEEEEEECCC	14.19	20068231
453	Phosphorylation	ARCYGFVTMSTAEEA CEEEEEEECCCHHHH	11.80	20860994
455	Phosphorylation	CYGFVTMSTAEEATK EEEEEECCCHHHHHH	18.33	21406692
456	Phosphorylation	YGFVTMSTAEEATKC EEEEECCCHHHHHHH	27.54	22210691
461	Phosphorylation	MSTAEEATKCINHLH CCCHHHHHHHHHHHH	29.72	22210691
469	Ubiquitination	KCINHLHKTELHGKM HHHHHHHHHCCCCEE	50.48	-
469	Acetylation	KCINHLHKTELHGKM HHHHHHHHHCCCCEE	50.48	26051181
475	Acetylation	HKTELHGKMISVEKA HHHCCCCEEEEHHHH	23.47	23749302
475	Ubiquitination	HKTELHGKMISVEKA HHHCCCCEEEEHHHH	23.47	19608861
481	Malonylation	GKMISVEKAKNEPVG CEEEEHHHHCCCCCC	63.61	26320211
483	Sumoylation	MISVEKAKNEPVGKK EEEHHHHCCCCCCCC	73.28	28112733
492	Phosphorylation	EPVGKKTSDKRDSDG CCCCCCCCCCCCCCC	50.44	-
500	Acetylation	DKRDSDGKKEKSSNS CCCCCCCCCCCCCCC	63.85	7926031
501	Acetylation	KRDSDGKKEKSSNSD CCCCCCCCCCCCCCC	75.74	7926043
504	Phosphorylation	SDGKKEKSSNSDRST CCCCCCCCCCCCHHH	35.52	18510355
505	Phosphorylation	DGKKEKSSNSDRSTN CCCCCCCCCCCHHHH	51.96	30576142
507	Phosphorylation	KKEKSSNSDRSTNLK CCCCCCCCCHHHHCC	36.03	28102081
509	Methylation	EKSSNSDRSTNLKRD CCCCCCCHHHHCCCC	45.24	115386595
510	Phosphorylation	KSSNSDRSTNLKRDD CCCCCCHHHHCCCCC	27.00	30576142
511	Phosphorylation	SSNSDRSTNLKRDDK CCCCCHHHHCCCCCC	45.52	21406692
514	Sumoylation	SDRSTNLKRDDKCDR CCHHHHCCCCCCCCC	56.71	28112733
532	Phosphorylation	AKKGDDGSGEKSKDQ HCCCCCCCCCCCCCC	51.26	29116813
536	Phosphorylation	DDGSGEKSKDQDDQK CCCCCCCCCCCCCCC	36.84	28985074
538	Acetylation	GSGEKSKDQDDQKPG CCCCCCCCCCCCCCC	65.32	19608861
543	Sumoylation	SKDQDDQKPGPSERS CCCCCCCCCCHHHHH	59.96	-
543	Sumoylation	SKDQDDQKPGPSERS CCCCCCCCCCHHHHH	59.96	28112733
543	Acetylation	SKDQDDQKPGPSERS CCCCCCCCCCHHHHH	59.96	26051181
547	Phosphorylation	DDQKPGPSERSRATK CCCCCCHHHHHHHCC	52.11	26074081
550	Phosphorylation	KPGPSERSRATKSGS CCCHHHHHHHCCCCC	23.40	26074081
553	Phosphorylation	PSERSRATKSGSRGT HHHHHHHCCCCCCCC	25.32	30576142
555	Phosphorylation	ERSRATKSGSRGTER HHHHHCCCCCCCCEE	37.33	25159151
557	Phosphorylation	SRATKSGSRGTERTV HHHCCCCCCCCEEEE	34.33	25159151
560	Phosphorylation	TKSGSRGTERTVVMD CCCCCCCCEEEEEEE	22.60	25159151
563	Phosphorylation	GSRGTERTVVMDKSK CCCCCEEEEEEECCC	15.95	26074081
568	Acetylation	ERTVVMDKSKGVPVI EEEEEEECCCCCEEE	35.65	23749302
569	Phosphorylation	RTVVMDKSKGVPVIS EEEEEECCCCCEEEE	30.31	26074081
570	Sumoylation	TVVMDKSKGVPVISV EEEEECCCCCEEEEE	70.44	28112733
576	Phosphorylation	SKGVPVISVKTSGSK CCCCEEEEEECCCCH	20.14	30266825
578	Sumoylation	GVPVISVKTSGSKER CCEEEEEECCCCHHH	30.13	25114211
578	Acetylation	GVPVISVKTSGSKER CCEEEEEECCCCHHH	30.13	25953088
579	Phosphorylation	VPVISVKTSGSKERA CEEEEEECCCCHHHH	35.84	25159151
580	Phosphorylation	PVISVKTSGSKERAS EEEEEECCCCHHHHC	35.04	25159151
582	Phosphorylation	ISVKTSGSKERASKS EEEECCCCHHHHCCC	30.98	25159151
587	Phosphorylation	SGSKERASKSQDRKS CCCHHHHCCCCCHHH	38.78	30576142
589	Phosphorylation	SKERASKSQDRKSAS CHHHHCCCCCHHHHH	34.51	30576142
594	Phosphorylation	SKSQDRKSASREKRS CCCCCHHHHHHHHHH	32.16	26074081
596	Phosphorylation	SQDRKSASREKRSVV CCCHHHHHHHHHHCC	48.33	26074081
601	Phosphorylation	SASREKRSVVSFDKV HHHHHHHHCCCHHHC	37.63	23927012
604	Phosphorylation	REKRSVVSFDKVKEP HHHHHCCCHHHCCCC	26.10	29255136
607	Acetylation	RSVVSFDKVKEPRKS HHCCCHHHCCCCCCC	53.87	19608861
607	Ubiquitination	RSVVSFDKVKEPRKS HHCCCHHHCCCCCCC	53.87	19608861
607	Malonylation	RSVVSFDKVKEPRKS HHCCCHHHCCCCCCC	53.87	26320211
609	Acetylation	VVSFDKVKEPRKSRD CCCHHHCCCCCCCCC	68.68	7307319
614	Phosphorylation	KVKEPRKSRDSESHS HCCCCCCCCCCHHHH	42.47	30576142
614 (in isoform 4)	Phosphorylation	-	42.47	21857030
617	Phosphorylation	EPRKSRDSESHSRVR CCCCCCCCHHHHHHH	39.63	29743597
617 (in isoform 4)	Phosphorylation	-	39.63	21857030
619	Phosphorylation	RKSRDSESHSRVRER CCCCCCHHHHHHHHH	30.62	29743597
619 (in isoform 4)	Phosphorylation	-	30.62	28102081
621	Phosphorylation	SRDSESHSRVRERSE CCCCHHHHHHHHHHH	41.57	20068231
627	Phosphorylation	HSRVRERSEREQRMQ HHHHHHHHHHHHHHH	35.93	30576142
702	Phosphorylation	RRQQELRYEQERRPA HHHHHHHHHHHHCCC	34.29	24043423
712	Methylation	ERRPAVRRPYDLDRR HHCCCCCCCCCCCCC	27.77	-
723	Phosphorylation	LDRRDDAYWPEAKRA CCCCCCCCCHHHHHH	28.61	20090780
728	Methylation	DAYWPEAKRAALDER CCCCHHHHHHHHHHH	40.69	115977475
728	Acetylation	DAYWPEAKRAALDER CCCCHHHHHHHHHHH	40.69	25953088
738	Phosphorylation	ALDERYHSDFNRQDR HHHHHHHCCCCCCCC	34.66	26714015
742 (in isoform 2)	Methylation	-	39.51	-
749 (in isoform 2)	Dimethylation	-	6.82	-
749 (in isoform 2)	Methylation	-	6.82	-
751 (in isoform 2)	Methylation	-	33.27	-
754	Methylation	HDFDHRDRGRYPDHS CCCCCCCCCCCCCCC	31.29	115368129
757	Phosphorylation	DHRDRGRYPDHSVDR CCCCCCCCCCCCCCC	18.81	28152594
761	Phosphorylation	RGRYPDHSVDRREGS CCCCCCCCCCCCCCC	32.85	28152594
764	Methylation	YPDHSVDRREGSRSM CCCCCCCCCCCCCCC	36.07	115493129
768	Phosphorylation	SVDRREGSRSMMGER CCCCCCCCCCCCCCC	19.21	27251275
770	Phosphorylation	DRREGSRSMMGEREG CCCCCCCCCCCCCCC	18.15	24719451
780	Phosphorylation	GEREGQHYPERHGGP CCCCCCCCCCCCCCC	10.02	28152594
783	Methylation	EGQHYPERHGGPERH CCCCCCCCCCCCCCC	29.28	115493121
794	Phosphorylation	PERHGRDSRDGWGGY CCCCCCCCCCCCCCC	30.80	30576142
801	Phosphorylation	SRDGWGGYGSDKRMS CCCCCCCCCCCCCCC	14.98	28152594
803	Phosphorylation	DGWGGYGSDKRMSEG CCCCCCCCCCCCCCC	31.32	25159151
805	Methylation	WGGYGSDKRMSEGRG CCCCCCCCCCCCCCC	52.26	130735
805	Acetylation	WGGYGSDKRMSEGRG CCCCCCCCCCCCCCC	52.26	26051181
808	Phosphorylation	YGSDKRMSEGRGLPP CCCCCCCCCCCCCCC	40.72	23401153
811	Methylation	DKRMSEGRGLPPPPR CCCCCCCCCCCCCCC	39.15	24129315
818	Methylation	RGLPPPPRRDWGDHG CCCCCCCCCCCCCCC	55.77	34666407
818	Dimethylation	RGLPPPPRRDWGDHG CCCCCCCCCCCCCCC	55.77	-
820	Methylation	LPPPPRRDWGDHGRR CCCCCCCCCCCCCCC	55.80	-
832	Phosphorylation	GRREDDRSWQGTADG CCCCCCCCCCCCCCC	30.64	23401153
834	Phosphorylation	REDDRSWQGTADGGM CCCCCCCCCCCCCCC	40.37	27251275
836	Phosphorylation	DDRSWQGTADGGMMD CCCCCCCCCCCCCCC	13.38	28985074
847	Sumoylation	GMMDRDHKRWQGGER CCCCCCCCCCCCCCC	60.67	28112733
855	Phosphorylation	RWQGGERSMSGHSGP CCCCCCCCCCCCCCC	17.01	23322592
857	Phosphorylation	QGGERSMSGHSGPGH CCCCCCCCCCCCCCC	34.30	23322592
860	Phosphorylation	ERSMSGHSGPGHMMN CCCCCCCCCCCCCCC	50.65	23322592
868	Asymmetric dimethylarginine	GPGHMMNRGGMSGRG CCCCCCCCCCCCCCC	25.75	-
868	Methylation	GPGHMMNRGGMSGRG CCCCCCCCCCCCCCC	25.75	24129315
872	Phosphorylation	MMNRGGMSGRGSFAP CCCCCCCCCCCCCCC	28.72	22210691
874	Asymmetric dimethylarginine	NRGGMSGRGSFAPGG CCCCCCCCCCCCCCC	30.21	-
874	Methylation	NRGGMSGRGSFAPGG CCCCCCCCCCCCCCC	30.21	24129315
883	Phosphorylation	SFAPGGASRGHPIPH CCCCCCCCCCCCCCC	41.91	22210691
884	Asymmetric dimethylarginine	FAPGGASRGHPIPHG CCCCCCCCCCCCCCC	47.08	-
884	Methylation	FAPGGASRGHPIPHG CCCCCCCCCCCCCCC	47.08	24129315
901	Phosphorylation	QGGFGGQSRGSRPSD CCCCCCCCCCCCCCC	41.71	22210691
902	Methylation	GGFGGQSRGSRPSDA CCCCCCCCCCCCCCC	38.94	30760949
904	Phosphorylation	FGGQSRGSRPSDARF CCCCCCCCCCCCCCC	39.65	23186163
905	Methylation	GGQSRGSRPSDARFT CCCCCCCCCCCCCCC	37.25	115391805
907	Phosphorylation	QSRGSRPSDARFTRR CCCCCCCCCCCCCCC	42.67	21601212
910	Methylation	GSRPSDARFTRRY-- CCCCCCCCCCCCC--	38.16	24387951

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SAFB1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SAFB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SAFB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SAFB2_HUMAN	SAFB2	physical	12660241
RBP56_HUMAN	TAF15	physical	15066997
ESR1_HUMAN	ESR1	physical	15066997
CHD3_HUMAN	CHD3	physical	16169070
ESR1_HUMAN	ESR1	physical	10707955
NCOR1_HUMAN	NCOR1	physical	16195251
NCOR1_HUMAN	NCOR1	physical	21527249
HDAC3_HUMAN	HDAC3	physical	21527249
PIAS1_HUMAN	PIAS1	physical	21527249
ESR1_HUMAN	ESR1	physical	21527249
SAP18_HUMAN	SAP18	physical	22939629
SMU1_HUMAN	SMU1	physical	22939629
TPBG_HUMAN	TPBG	physical	22939629
TRI55_HUMAN	TRIM55	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
SON_HUMAN	SON	physical	22939629
TR112_HUMAN	TRMT112	physical	22939629
SEPT7_HUMAN	SEPT7	physical	22939629
UT14A_HUMAN	UTP14A	physical	22939629
VTNC_HUMAN	VTN	physical	22939629
ZCH18_HUMAN	ZC3H18	physical	22939629
SNUT2_HUMAN	USP39	physical	22939629
TMOD2_HUMAN	TMOD2	physical	22939629
VASN_HUMAN	VASN	physical	22939629
SRSF7_HUMAN	SRSF7	physical	22939629
THIL_HUMAN	ACAT1	physical	22939629
U2AF2_HUMAN	U2AF2	physical	22939629
SURF4_HUMAN	SURF4	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
P53_HUMAN	TP53	physical	21130767
HNRPU_HUMAN	HNRNPU	physical	26344197
HNRL1_HUMAN	HNRNPUL1	physical	26344197
MCM4_HUMAN	MCM4	physical	26344197
PDIA1_HUMAN	P4HB	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SAFB1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-194; SER-288; SER-383 AND SER-384, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-475 AND LYS-607, AND MASSSPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235; SER-247 ANDSER-288, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-194; SER-288; SER-383 AND SER-384, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; SER-373; SER-383;SER-384; SER-601 AND SER-604, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-555 AND SER-557, ANDMASS SPECTROMETRY.	17287340 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-604, AND MASSSPECTROMETRY.	17924679 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-601 ANDSER-604, AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384; SER-589; SER-604AND SER-808, AND MASS SPECTROMETRY.	17081983 [Abstract]
Sumoylation
Reference	PubMed
"Co-repressor activity of scaffold attachment factor B1 requiressumoylation."; Garee J.P., Meyer R., Oesterreich S.; Biochem. Biophys. Res. Commun. 408:516-522(2011). Cited for: SUMOYLATION AT LYS-231 AND LYS-294.	21527249 [Abstract]