| UniProt ID | HNRPU_HUMAN | |
|---|---|---|
| UniProt AC | Q00839 | |
| Protein Name | Heterogeneous nuclear ribonucleoprotein U {ECO:0000303|PubMed:1628625} | |
| Gene Name | HNRNPU {ECO:0000312|HGNC:HGNC:5048} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 825 | |
| Subcellular Localization | Nucleus . Nucleus matrix . Chromosome . Nucleus speckle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, spindle pole . Midbody . Cytop | |
| Protein Description | DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. [PubMed: 10490622] | |
| Protein Sequence | MSSSPVNVKKLKVSELKEELKKRRLSDKGLKAELMERLQAALDDEEAGGRPAMEPGNGSLDLGGDSAGRSGAGLEQEAAAGGDEEEEEEEEEEEGISALDGDQMELGEENGAAGAADSGPMEEEEAASEDENGDDQGFQEGEDELGDEEEGAGDENGHGEQQPQPPATQQQQPQQQRGAAKEAAGKSSGPTSLFAVTVAPPGARQGQQQAGGKKKAEGGGGGGRPGAPAAGDGKTEQKGGDKKRGVKRPREDHGRGYFEYIEENKYSRAKSPQPPVEEEDEHFDDTVVCLDTYNCDLHFKISRDRLSASSLTMESFAFLWAGGRASYGVSKGKVCFEMKVTEKIPVRHLYTKDIDIHEVRIGWSLTTSGMLLGEEEFSYGYSLKGIKTCNCETEDYGEKFDENDVITCFANFESDEVELSYAKNGQDLGVAFKISKEVLAGRPLFPHVLCHNCAVEFNFGQKEKPYFPIPEEYTFIQNVPLEDRVRGPKGPEEKKDCEVVMMIGLPGAGKTTWVTKHAAENPGKYNILGTNTIMDKMMVAGFKKQMADTGKLNTLLQRAPQCLGKFIEIAARKKRNFILDQTNVSAAAQRRKMCLFAGFQRKAVVVCPKDEDYKQRTQKKAEVEGKDLPEHAVLKMKGNFTLPEVAECFDEITYVELQKEEAQKLLEQYKEESKKALPPEKKQNTGSKKSNKNKSGKNQFNRGGGHRGRGGFNMRGGNFRGGAPGNRGGYNRRGNMPQRGGGGGGSGGIGYPYPRAPVFPGRGSYSNRGNYNRGGMPNRGNYNQNFRGRGNNRGYKNQSQGYNQWQQGQFWGQKPWSQHYHQGYY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSSSPVNVK ------CCCCCCCHH | 39.25 | 20068231 | |
| 2 | Phosphorylation | ------MSSSPVNVK ------CCCCCCCHH | 39.25 | 29255136 | |
| 3 | Phosphorylation | -----MSSSPVNVKK -----CCCCCCCHHH | 37.04 | 29255136 | |
| 4 | Phosphorylation | ----MSSSPVNVKKL ----CCCCCCCHHHC | 26.09 | 29255136 | |
| 9 | Acetylation | SSSPVNVKKLKVSEL CCCCCCHHHCCHHHH | 47.38 | 23749302 | |
| 9 | Ubiquitination | SSSPVNVKKLKVSEL CCCCCCHHHCCHHHH | 47.38 | - | |
| 10 | Ubiquitination | SSPVNVKKLKVSELK CCCCCHHHCCHHHHH | 49.62 | - | |
| 12 | Malonylation | PVNVKKLKVSELKEE CCCHHHCCHHHHHHH | 53.23 | 26320211 | |
| 12 | Ubiquitination | PVNVKKLKVSELKEE CCCHHHCCHHHHHHH | 53.23 | - | |
| 14 | Phosphorylation | NVKKLKVSELKEELK CHHHCCHHHHHHHHH | 35.31 | 20068231 | |
| 17 | Sumoylation | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | - | |
| 17 | Acetylation | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | 23749302 | |
| 17 | Malonylation | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | 26320211 | |
| 17 | Succinylation | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | 23954790 | |
| 17 | Sumoylation | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | - | |
| 17 | Ubiquitination | KLKVSELKEELKKRR HCCHHHHHHHHHHCC | 45.12 | - | |
| 21 | Acetylation | SELKEELKKRRLSDK HHHHHHHHHCCCCCH | 47.73 | 23749302 | |
| 26 | Phosphorylation | ELKKRRLSDKGLKAE HHHHCCCCCHHHHHH | 35.15 | 23401153 | |
| 28 | Acetylation | KKRRLSDKGLKAELM HHCCCCCHHHHHHHH | 63.87 | 23749302 | |
| 28 | Ubiquitination | KKRRLSDKGLKAELM HHCCCCCHHHHHHHH | 63.87 | - | |
| 31 | Acetylation | RLSDKGLKAELMERL CCCCHHHHHHHHHHH | 48.78 | 25953088 | |
| 31 | Malonylation | RLSDKGLKAELMERL CCCCHHHHHHHHHHH | 48.78 | 26320211 | |
| 31 | Ubiquitination | RLSDKGLKAELMERL CCCCHHHHHHHHHHH | 48.78 | - | |
| 50 | Methylation | DDEEAGGRPAMEPGN CCHHHCCCCCCCCCC | 18.19 | 136575 | |
| 53 | Sulfoxidation | EAGGRPAMEPGNGSL HHCCCCCCCCCCCCC | 7.66 | 21406390 | |
| 59 | Phosphorylation | AMEPGNGSLDLGGDS CCCCCCCCCCCCCCC | 23.78 | 29255136 | |
| 59 (in isoform 2) | Phosphorylation | - | 23.78 | 18669648 | |
| 66 | Phosphorylation | SLDLGGDSAGRSGAG CCCCCCCCCCCCCCC | 35.58 | 25159151 | |
| 66 (in isoform 2) | Phosphorylation | - | 35.58 | 18669648 | |
| 70 | Phosphorylation | GGDSAGRSGAGLEQE CCCCCCCCCCCHHHH | 31.88 | 26074081 | |
| 128 | Phosphorylation | MEEEEAASEDENGDD CCHHHHHHCCCCCCC | 53.26 | 22468782 | |
| 181 | Acetylation | QQQRGAAKEAAGKSS HHHHHHHHHHCCCCC | 47.56 | 156585 | |
| 181 | Ubiquitination | QQQRGAAKEAAGKSS HHHHHHHHHHCCCCC | 47.56 | 21906983 | |
| 181 (in isoform 1) | Ubiquitination | - | 47.56 | 21890473 | |
| 181 (in isoform 2) | Ubiquitination | - | 47.56 | 21890473 | |
| 186 | Acetylation | AAKEAAGKSSGPTSL HHHHHCCCCCCCCCE | 36.40 | 25953088 | |
| 186 | Malonylation | AAKEAAGKSSGPTSL HHHHHCCCCCCCCCE | 36.40 | 26320211 | |
| 186 | Ubiquitination | AAKEAAGKSSGPTSL HHHHHCCCCCCCCCE | 36.40 | 21890473 | |
| 186 (in isoform 1) | Ubiquitination | - | 36.40 | 21890473 | |
| 186 (in isoform 2) | Ubiquitination | - | 36.40 | 21890473 | |
| 187 | ADP-ribosylation | AKEAAGKSSGPTSLF HHHHCCCCCCCCCEE | 39.34 | 28190768 | |
| 187 | Phosphorylation | AKEAAGKSSGPTSLF HHHHCCCCCCCCCEE | 39.34 | 30266825 | |
| 188 | O-linked_Glycosylation | KEAAGKSSGPTSLFA HHHCCCCCCCCCEEE | 52.88 | 30059200 | |
| 188 | Phosphorylation | KEAAGKSSGPTSLFA HHHCCCCCCCCCEEE | 52.88 | 30266825 | |
| 188 (in isoform 2) | Phosphorylation | - | 52.88 | 18220336 | |
| 191 | Phosphorylation | AGKSSGPTSLFAVTV CCCCCCCCCEEEEEE | 41.40 | 30266825 | |
| 191 (in isoform 2) | Phosphorylation | - | 41.40 | 18669648 | |
| 192 | Phosphorylation | GKSSGPTSLFAVTVA CCCCCCCCEEEEEEC | 25.32 | 25159151 | |
| 192 (in isoform 2) | Phosphorylation | - | 25.32 | 18669648 | |
| 197 | O-linked_Glycosylation | PTSLFAVTVAPPGAR CCCEEEEEECCCCHH | 13.92 | 30059200 | |
| 197 | Phosphorylation | PTSLFAVTVAPPGAR CCCEEEEEECCCCHH | 13.92 | 25867546 | |
| 213 | Acetylation | GQQQAGGKKKAEGGG CCCCCCCCCCCCCCC | 50.62 | 24846201 | |
| 215 | Acetylation | QQAGGKKKAEGGGGG CCCCCCCCCCCCCCC | 55.97 | 21339330 | |
| 215 | Methylation | QQAGGKKKAEGGGGG CCCCCCCCCCCCCCC | 55.97 | 116252581 | |
| 215 | Ubiquitination | QQAGGKKKAEGGGGG CCCCCCCCCCCCCCC | 55.97 | - | |
| 215 (in isoform 2) | Acetylation | - | 55.97 | 19608861 | |
| 215 (in isoform 2) | Ubiquitination | - | 55.97 | 21890473 | |
| 224 | Methylation | EGGGGGGRPGAPAAG CCCCCCCCCCCCCCC | 29.74 | 115386091 | |
| 234 | Acetylation | APAAGDGKTEQKGGD CCCCCCCCCCCCCCC | 54.34 | 23749302 | |
| 234 | Ubiquitination | APAAGDGKTEQKGGD CCCCCCCCCCCCCCC | 54.34 | 19608861 | |
| 235 | Phosphorylation | PAAGDGKTEQKGGDK CCCCCCCCCCCCCCC | 49.53 | 23312004 | |
| 246 | Acetylation | GGDKKRGVKRPREDH CCCCCCCCCCCCHHC | 5.73 | 19608861 | |
| 246 | Ubiquitination | GGDKKRGVKRPREDH CCCCCCCCCCCCHHC | 5.73 | 19608861 | |
| 246 (in isoform 2) | Ubiquitination | - | 5.73 | 21890473 | |
| 255 | Citrullination | RPREDHGRGYFEYIE CCCHHCCCCHHHHHH | 32.97 | - | |
| 255 | Citrullination | RPREDHGRGYFEYIE CCCHHCCCCHHHHHH | 32.97 | - | |
| 255 | Methylation | RPREDHGRGYFEYIE CCCHHCCCCHHHHHH | 32.97 | 115479401 | |
| 257 | Phosphorylation | REDHGRGYFEYIEEN CHHCCCCHHHHHHCC | 7.59 | 28152594 | |
| 260 | Phosphorylation | HGRGYFEYIEENKYS CCCCHHHHHHCCCCC | 12.06 | 21082442 | |
| 264 (in isoform 1) | Ubiquitination | - | 35.46 | 21890473 | |
| 265 | Sumoylation | FEYIEENKYSRAKSP HHHHHCCCCCCCCCC | 48.13 | - | |
| 265 | Acetylation | FEYIEENKYSRAKSP HHHHHCCCCCCCCCC | 48.13 | 19608861 | |
| 265 | Malonylation | FEYIEENKYSRAKSP HHHHHCCCCCCCCCC | 48.13 | 26320211 | |
| 265 | Sumoylation | FEYIEENKYSRAKSP HHHHHCCCCCCCCCC | 48.13 | 19608861 | |
| 265 | Ubiquitination | FEYIEENKYSRAKSP HHHHHCCCCCCCCCC | 48.13 | 21890473 | |
| 266 | Phosphorylation | EYIEENKYSRAKSPQ HHHHCCCCCCCCCCC | 18.25 | 27273156 | |
| 267 | Phosphorylation | YIEENKYSRAKSPQP HHHCCCCCCCCCCCC | 27.63 | 22617229 | |
| 270 | Phosphorylation | ENKYSRAKSPQPPVE CCCCCCCCCCCCCCC | 62.65 | 18669648 | |
| 271 | Phosphorylation | NKYSRAKSPQPPVEE CCCCCCCCCCCCCCC | 27.99 | 22167270 | |
| 285 | Phosphorylation | EEDEHFDDTVVCLDT CCCCCCCCEEEEEEC | 40.22 | 18669648 | |
| 286 | Phosphorylation | EDEHFDDTVVCLDTY CCCCCCCEEEEEECC | 19.38 | 23927012 | |
| 292 | Phosphorylation | DTVVCLDTYNCDLHF CEEEEEECCCCCEEE | 12.04 | 23927012 | |
| 293 | Phosphorylation | TVVCLDTYNCDLHFK EEEEEECCCCCEEEE | 17.29 | 23927012 | |
| 307 | Phosphorylation | KISRDRLSASSLTME EECCCCCCCCCCCHH | 27.31 | 20068231 | |
| 313 | Sulfoxidation | LSASSLTMESFAFLW CCCCCCCHHHHHHHH | 5.01 | 28183972 | |
| 314 (in isoform 2) | Ubiquitination | - | 37.15 | 21890473 | |
| 326 | Phosphorylation | LWAGGRASYGVSKGK HHHCCCHHCCCCCCC | 22.51 | 20068231 | |
| 327 | Phosphorylation | WAGGRASYGVSKGKV HHCCCHHCCCCCCCE | 22.14 | 24719451 | |
| 330 | Phosphorylation | GRASYGVSKGKVCFE CCHHCCCCCCCEEEE | 31.18 | 20068231 | |
| 331 | Succinylation | RASYGVSKGKVCFEM CHHCCCCCCCEEEEE | 61.41 | 23954790 | |
| 331 | Ubiquitination | RASYGVSKGKVCFEM CHHCCCCCCCEEEEE | 61.41 | - | |
| 332 (in isoform 1) | Ubiquitination | - | 21.81 | 21890473 | |
| 333 | Acetylation | SYGVSKGKVCFEMKV HCCCCCCCEEEEEEE | 39.30 | 21339330 | |
| 333 | Ubiquitination | SYGVSKGKVCFEMKV HCCCCCCCEEEEEEE | 39.30 | 19608861 | |
| 333 (in isoform 2) | Ubiquitination | - | 39.30 | 21890473 | |
| 335 | Glutathionylation | GVSKGKVCFEMKVTE CCCCCCEEEEEEECC | 2.45 | 22555962 | |
| 339 | Acetylation | GKVCFEMKVTEKIPV CCEEEEEEECCCCCC | 38.52 | 25953088 | |
| 339 | Ubiquitination | GKVCFEMKVTEKIPV CCEEEEEEECCCCCC | 38.52 | - | |
| 343 | Acetylation | FEMKVTEKIPVRHLY EEEEECCCCCCCEEE | 42.83 | 23749302 | |
| 343 | Malonylation | FEMKVTEKIPVRHLY EEEEECCCCCCCEEE | 42.83 | 26320211 | |
| 343 | Ubiquitination | FEMKVTEKIPVRHLY EEEEECCCCCCCEEE | 42.83 | - | |
| 350 | Phosphorylation | KIPVRHLYTKDIDIH CCCCCEEEECCCCEE | 12.96 | 21406692 | |
| 351 | Phosphorylation | IPVRHLYTKDIDIHE CCCCEEEECCCCEEE | 28.71 | 21406692 | |
| 351 (in isoform 1) | Ubiquitination | - | 28.71 | 21890473 | |
| 352 | Acetylation | PVRHLYTKDIDIHEV CCCEEEECCCCEEEE | 38.85 | 19608861 | |
| 352 | Malonylation | PVRHLYTKDIDIHEV CCCEEEECCCCEEEE | 38.85 | 26320211 | |
| 352 | Ubiquitination | PVRHLYTKDIDIHEV CCCEEEECCCCEEEE | 38.85 | 21890473 | |
| 382 | Phosphorylation | EEFSYGYSLKGIKTC EEECCCEECCCEEEC | 21.17 | 24719451 | |
| 387 | Ubiquitination | GYSLKGIKTCNCETE CEECCCEEECCCCCC | 56.55 | - | |
| 423 | Ubiquitination | EVELSYAKNGQDLGV EEEEEECCCCCEEEE | 54.07 | - | |
| 433 | Acetylation | QDLGVAFKISKEVLA CEEEEEEEECHHHHC | 36.01 | 25953088 | |
| 433 | Ubiquitination | QDLGVAFKISKEVLA CEEEEEEEECHHHHC | 36.01 | - | |
| 435 | Phosphorylation | LGVAFKISKEVLAGR EEEEEEECHHHHCCC | 24.29 | 21406692 | |
| 436 | Acetylation | GVAFKISKEVLAGRP EEEEEECHHHHCCCC | 56.14 | 26051181 | |
| 436 | Ubiquitination | GVAFKISKEVLAGRP EEEEEECHHHHCCCC | 56.14 | - | |
| 445 | Acetylation | VLAGRPLFPHVLCHN HHCCCCCCCCEEECC | 4.33 | 19608861 | |
| 445 | Ubiquitination | VLAGRPLFPHVLCHN HHCCCCCCCCEEECC | 4.33 | 19608861 | |
| 445 (in isoform 2) | Ubiquitination | - | 4.33 | 21890473 | |
| 463 (in isoform 1) | Ubiquitination | - | 51.91 | 21890473 | |
| 464 | Acetylation | FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC | 52.64 | 25825284 | |
| 464 | Ubiquitination | FNFGQKEKPYFPIPE ECCCCCCCCCCCCCC | 52.64 | 20639865 | |
| 466 | Phosphorylation | FGQKEKPYFPIPEEY CCCCCCCCCCCCCHH | 32.81 | 25884760 | |
| 472 | Phosphorylation | PYFPIPEEYTFIQNV CCCCCCCHHEEEECC | 44.51 | 15592455 | |
| 473 | Phosphorylation | YFPIPEEYTFIQNVP CCCCCCHHEEEECCC | 12.80 | 27273156 | |
| 474 | Phosphorylation | FPIPEEYTFIQNVPL CCCCCHHEEEECCCH | 19.97 | 21552520 | |
| 489 | Succinylation | EDRVRGPKGPEEKKD HHCCCCCCCCHHHCC | 85.14 | 23954790 | |
| 489 | Sumoylation | EDRVRGPKGPEEKKD HHCCCCCCCCHHHCC | 85.14 | - | |
| 489 | Ubiquitination | EDRVRGPKGPEEKKD HHCCCCCCCCHHHCC | 85.14 | - | |
| 491 (in isoform 2) | Ubiquitination | - | 53.34 | 21890473 | |
| 494 | Acetylation | GPKGPEEKKDCEVVM CCCCCHHHCCCEEEE | 52.85 | 25953088 | |
| 495 | Acetylation | PKGPEEKKDCEVVMM CCCCHHHCCCEEEEE | 71.53 | 25953088 | |
| 495 | Sumoylation | PKGPEEKKDCEVVMM CCCCHHHCCCEEEEE | 71.53 | 28112733 | |
| 497 | Acetylation | GPEEKKDCEVVMMIG CCHHHCCCEEEEEEC | 6.16 | 19608861 | |
| 497 | Glutathionylation | GPEEKKDCEVVMMIG CCHHHCCCEEEEEEC | 6.16 | 22555962 | |
| 497 | S-palmitoylation | GPEEKKDCEVVMMIG CCHHHCCCEEEEEEC | 6.16 | 26865113 | |
| 497 | Ubiquitination | GPEEKKDCEVVMMIG CCHHHCCCEEEEEEC | 6.16 | 19608861 | |
| 497 (in isoform 2) | Ubiquitination | - | 6.16 | 21890473 | |
| 505 | Acetylation | EVVMMIGLPGAGKTT EEEEEECCCCCCCCE | 2.15 | 19608861 | |
| 505 | Ubiquitination | EVVMMIGLPGAGKTT EEEEEECCCCCCCCE | 2.15 | 19608861 | |
| 505 (in isoform 2) | Ubiquitination | - | 2.15 | 21890473 | |
| 509 (in isoform 1) | Ubiquitination | - | 33.48 | 21890473 | |
| 510 | Ubiquitination | IGLPGAGKTTWVTKH ECCCCCCCCEEECCC | 42.10 | 21906983 | |
| 511 | Phosphorylation | GLPGAGKTTWVTKHA CCCCCCCCEEECCCC | 25.60 | 23882029 | |
| 515 | Phosphorylation | AGKTTWVTKHAAENP CCCCEEECCCCCCCC | 14.52 | 24114839 | |
| 515 (in isoform 1) | Ubiquitination | - | 14.52 | 21890473 | |
| 516 | Acetylation | GKTTWVTKHAAENPG CCCEEECCCCCCCCC | 22.94 | 19608861 | |
| 516 | Methylation | GKTTWVTKHAAENPG CCCEEECCCCCCCCC | 22.94 | 19608861 | |
| 516 | Sumoylation | GKTTWVTKHAAENPG CCCEEECCCCCCCCC | 22.94 | 28112733 | |
| 516 | Ubiquitination | GKTTWVTKHAAENPG CCCEEECCCCCCCCC | 22.94 | 21890473 | |
| 517 (in isoform 2) | Ubiquitination | - | 22.32 | 21890473 | |
| 523 (in isoform 1) | Ubiquitination | - | 57.57 | 21890473 | |
| 524 | Sumoylation | HAAENPGKYNILGTN CCCCCCCCCCCCCCC | 36.06 | - | |
| 524 | Acetylation | HAAENPGKYNILGTN CCCCCCCCCCCCCCC | 36.06 | 19608861 | |
| 524 | Sumoylation | HAAENPGKYNILGTN CCCCCCCCCCCCCCC | 36.06 | 28112733 | |
| 524 | Ubiquitination | HAAENPGKYNILGTN CCCCCCCCCCCCCCC | 36.06 | 21890473 | |
| 524 (in isoform 2) | Ubiquitination | - | 36.06 | 21890473 | |
| 525 | Nitration | AAENPGKYNILGTNT CCCCCCCCCCCCCCC | 17.22 | - | |
| 525 | Phosphorylation | AAENPGKYNILGTNT CCCCCCCCCCCCCCC | 17.22 | 28152594 | |
| 525 (in isoform 2) | Ubiquitination | - | 17.22 | 21890473 | |
| 530 | Phosphorylation | GKYNILGTNTIMDKM CCCCCCCCCCHHHHH | 26.24 | 20068231 | |
| 532 | Acetylation | YNILGTNTIMDKMMV CCCCCCCCHHHHHHH | 19.95 | 19608861 | |
| 532 | Phosphorylation | YNILGTNTIMDKMMV CCCCCCCCHHHHHHH | 19.95 | 20068231 | |
| 532 | Ubiquitination | YNILGTNTIMDKMMV CCCCCCCCHHHHHHH | 19.95 | 19608861 | |
| 532 (in isoform 2) | Ubiquitination | - | 19.95 | 21890473 | |
| 534 | Sulfoxidation | ILGTNTIMDKMMVAG CCCCCCHHHHHHHHC | 3.69 | 21406390 | |
| 536 | Sumoylation | GTNTIMDKMMVAGFK CCCCHHHHHHHHCHH | 16.12 | 28112733 | |
| 536 | Ubiquitination | GTNTIMDKMMVAGFK CCCCHHHHHHHHCHH | 16.12 | 21890473 | |
| 537 | Sulfoxidation | TNTIMDKMMVAGFKK CCCHHHHHHHHCHHH | 1.97 | 21406390 | |
| 543 | Acetylation | KMMVAGFKKQMADTG HHHHHCHHHHHCCCC | 40.97 | 25953088 | |
| 543 | Methylation | KMMVAGFKKQMADTG HHHHHCHHHHHCCCC | 40.97 | 7662963 | |
| 543 | Ubiquitination | KMMVAGFKKQMADTG HHHHHCHHHHHCCCC | 40.97 | 21890473 | |
| 543 (in isoform 1) | Ubiquitination | - | 40.97 | 21890473 | |
| 544 | Acetylation | MMVAGFKKQMADTGK HHHHCHHHHHCCCCH | 42.94 | 30583223 | |
| 544 | Methylation | MMVAGFKKQMADTGK HHHHCHHHHHCCCCH | 42.94 | 30583223 | |
| 544 | Ubiquitination | MMVAGFKKQMADTGK HHHHCHHHHHCCCCH | 42.94 | 21906983 | |
| 546 | Acetylation | VAGFKKQMADTGKLN HHCHHHHHCCCCHHH | 5.10 | 19608861 | |
| 546 | Ubiquitination | VAGFKKQMADTGKLN HHCHHHHHCCCCHHH | 5.10 | 19608861 | |
| 546 (in isoform 2) | Ubiquitination | - | 5.10 | 21890473 | |
| 549 | Phosphorylation | FKKQMADTGKLNTLL HHHHHCCCCHHHHHH | 27.03 | - | |
| 550 (in isoform 1) | Ubiquitination | - | 32.76 | 21890473 | |
| 551 | Acetylation | KQMADTGKLNTLLQR HHHCCCCHHHHHHHH | 40.43 | 19608861 | |
| 551 | Malonylation | KQMADTGKLNTLLQR HHHCCCCHHHHHHHH | 40.43 | 26320211 | |
| 551 | Ubiquitination | KQMADTGKLNTLLQR HHHCCCCHHHHHHHH | 40.43 | 21890473 | |
| 554 | Phosphorylation | ADTGKLNTLLQRAPQ CCCCHHHHHHHHHHH | 39.00 | 28857561 | |
| 562 | S-nitrosocysteine | LLQRAPQCLGKFIEI HHHHHHHHHHHHHHH | 5.42 | - | |
| 562 | S-nitrosylation | LLQRAPQCLGKFIEI HHHHHHHHHHHHHHH | 5.42 | 19483679 | |
| 564 (in isoform 1) | Ubiquitination | - | 30.38 | 21890473 | |
| 565 | Acetylation | RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH | 30.16 | 19608861 | |
| 565 | Sumoylation | RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH | 30.16 | 28112733 | |
| 565 | Ubiquitination | RAPQCLGKFIEIAAR HHHHHHHHHHHHHHH | 30.16 | 21890473 | |
| 572 | Methylation | KFIEIAARKKRNFIL HHHHHHHHHCCCEEE | 35.69 | 115479409 | |
| 574 | Sumoylation | IEIAARKKRNFILDQ HHHHHHHCCCEEECC | 47.20 | 28112733 | |
| 575 | Methylation | EIAARKKRNFILDQT HHHHHHCCCEEECCC | 46.45 | 115479433 | |
| 582 | Phosphorylation | RNFILDQTNVSAAAQ CCEEECCCCHHHHHH | 36.94 | 29255136 | |
| 585 | Phosphorylation | ILDQTNVSAAAQRRK EECCCCHHHHHHHHH | 17.79 | 29255136 | |
| 590 | Acetylation | NVSAAAQRRKMCLFA CHHHHHHHHHHHHHC | 35.15 | 19608861 | |
| 590 | Ubiquitination | NVSAAAQRRKMCLFA CHHHHHHHHHHHHHC | 35.15 | 19608861 | |
| 592 | Malonylation | SAAAQRRKMCLFAGF HHHHHHHHHHHHCCC | 35.83 | 26320211 | |
| 592 | Ubiquitination | SAAAQRRKMCLFAGF HHHHHHHHHHHHCCC | 35.83 | - | |
| 593 | Sulfoxidation | AAAQRRKMCLFAGFQ HHHHHHHHHHHCCCE | 1.97 | 28465586 | |
| 594 | Glutathionylation | AAQRRKMCLFAGFQR HHHHHHHHHHCCCEE | 2.95 | 22555962 | |
| 595 (in isoform 2) | Ubiquitination | - | 2.70 | 21890473 | |
| 602 | Acetylation | LFAGFQRKAVVVCPK HHCCCEEEEEEECCC | 34.45 | 26051181 | |
| 602 | Ubiquitination | LFAGFQRKAVVVCPK HHCCCEEEEEEECCC | 34.45 | - | |
| 607 | Acetylation | QRKAVVVCPKDEDYK EEEEEEECCCCHHHH | 2.04 | 19608861 | |
| 607 | Glutathionylation | QRKAVVVCPKDEDYK EEEEEEECCCCHHHH | 2.04 | 22555962 | |
| 607 | S-palmitoylation | QRKAVVVCPKDEDYK EEEEEEECCCCHHHH | 2.04 | 29575903 | |
| 607 | Ubiquitination | QRKAVVVCPKDEDYK EEEEEEECCCCHHHH | 2.04 | 19608861 | |
| 607 (in isoform 2) | Ubiquitination | - | 2.04 | 21890473 | |
| 609 | Sumoylation | KAVVVCPKDEDYKQR EEEEECCCCHHHHHH | 69.49 | - | |
| 609 | Acetylation | KAVVVCPKDEDYKQR EEEEECCCCHHHHHH | 69.49 | 23954790 | |
| 609 | Succinylation | KAVVVCPKDEDYKQR EEEEECCCCHHHHHH | 69.49 | 23954790 | |
| 609 | Sumoylation | KAVVVCPKDEDYKQR EEEEECCCCHHHHHH | 69.49 | 28112733 | |
| 609 | Ubiquitination | KAVVVCPKDEDYKQR EEEEECCCCHHHHHH | 69.49 | 19608861 | |
| 613 | Phosphorylation | VCPKDEDYKQRTQKK ECCCCHHHHHHHHHH | 13.63 | 28450419 | |
| 613 (in isoform 1) | Ubiquitination | - | 13.63 | 21890473 | |
| 614 | Acetylation | CPKDEDYKQRTQKKA CCCCHHHHHHHHHHH | 45.70 | 23749302 | |
| 614 | Ubiquitination | CPKDEDYKQRTQKKA CCCCHHHHHHHHHHH | 45.70 | 21906983 | |
| 616 | Acetylation | KDEDYKQRTQKKAEV CCHHHHHHHHHHHHH | 34.67 | 19608861 | |
| 616 | Ubiquitination | KDEDYKQRTQKKAEV CCHHHHHHHHHHHHH | 34.67 | 19608861 | |
| 616 (in isoform 2) | Ubiquitination | - | 34.67 | 21890473 | |
| 619 | Ubiquitination | DYKQRTQKKAEVEGK HHHHHHHHHHHHCCC | 54.03 | - | |
| 620 | Succinylation | YKQRTQKKAEVEGKD HHHHHHHHHHHCCCC | 39.71 | 23954790 | |
| 625 (in isoform 1) | Ubiquitination | - | 33.67 | 21890473 | |
| 626 | Acetylation | KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE | 42.45 | 23954790 | |
| 626 | Malonylation | KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE | 42.45 | 26320211 | |
| 626 | Sumoylation | KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE | 42.45 | 28112733 | |
| 626 | Ubiquitination | KKAEVEGKDLPEHAV HHHHHCCCCCCCHHE | 42.45 | 21890473 | |
| 634 (in isoform 1) | Ubiquitination | - | 4.68 | 21890473 | |
| 635 | Sumoylation | LPEHAVLKMKGNFTL CCCHHEEEEECCCCH | 31.78 | - | |
| 635 | Acetylation | LPEHAVLKMKGNFTL CCCHHEEEEECCCCH | 31.78 | 19608861 | |
| 635 | Malonylation | LPEHAVLKMKGNFTL CCCHHEEEEECCCCH | 31.78 | 26320211 | |
| 635 | Sumoylation | LPEHAVLKMKGNFTL CCCHHEEEEECCCCH | 31.78 | 28112733 | |
| 635 | Ubiquitination | LPEHAVLKMKGNFTL CCCHHEEEEECCCCH | 31.78 | 21890473 | |
| 637 | Sumoylation | EHAVLKMKGNFTLPE CHHEEEEECCCCHHH | 49.46 | - | |
| 637 | Ubiquitination | EHAVLKMKGNFTLPE CHHEEEEECCCCHHH | 49.46 | - | |
| 645 (in isoform 2) | Ubiquitination | - | 5.26 | 21890473 | |
| 648 | Glutathionylation | TLPEVAECFDEITYV CHHHHHHHHCEEEEE | 3.62 | 22555962 | |
| 651 | Acetylation | EVAECFDEITYVELQ HHHHHHCEEEEEECC | 19.58 | 19608861 | |
| 653 | Phosphorylation | AECFDEITYVELQKE HHHHCEEEEEECCHH | 21.33 | 26356563 | |
| 654 | Phosphorylation | ECFDEITYVELQKEE HHHCEEEEEECCHHH | 9.51 | 26356563 | |
| 655 | Acetylation | CFDEITYVELQKEEA HHCEEEEEECCHHHH | 4.42 | 19608861 | |
| 659 | Ubiquitination | ITYVELQKEEAQKLL EEEEECCHHHHHHHH | 70.87 | - | |
| 663 (in isoform 1) | Ubiquitination | - | 39.96 | 21890473 | |
| 664 | Sumoylation | LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH | 63.19 | - | |
| 664 | Acetylation | LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH | 63.19 | 23236377 | |
| 664 | Succinylation | LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH | 63.19 | 23954790 | |
| 664 | Sumoylation | LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH | 63.19 | 28112733 | |
| 664 | Ubiquitination | LQKEEAQKLLEQYKE CCHHHHHHHHHHHHH | 63.19 | 21890473 | |
| 669 | Phosphorylation | AQKLLEQYKEESKKA HHHHHHHHHHHHHHC | 15.81 | 28152594 | |
| 670 | Sumoylation | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | - | |
| 670 | Acetylation | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | 25825284 | |
| 670 | Methylation | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | 22649427 | |
| 670 | Succinylation | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | 23954790 | |
| 670 | Sumoylation | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | 28112733 | |
| 670 | Ubiquitination | QKLLEQYKEESKKAL HHHHHHHHHHHHHCC | 55.49 | 19608861 | |
| 673 | Phosphorylation | LEQYKEESKKALPPE HHHHHHHHHHCCCHH | 40.31 | 28152594 | |
| 674 | Acetylation | EQYKEESKKALPPEK HHHHHHHHHCCCHHH | 45.40 | 23749302 | |
| 674 | Ubiquitination | EQYKEESKKALPPEK HHHHHHHHHCCCHHH | 45.40 | 19608861 | |
| 675 | Ubiquitination | QYKEESKKALPPEKK HHHHHHHHCCCHHHH | 65.52 | - | |
| 690 | Phosphorylation | QNTGSKKSNKNKSGK CCCCCCCCCCCCCCC | 57.69 | - | |
| 697 | Acetylation | SNKNKSGKNQFNRGG CCCCCCCCCCCCCCC | 55.45 | 26051181 | |
| 702 | Dimethylation | SGKNQFNRGGGHRGR CCCCCCCCCCCCCCC | 46.55 | - | |
| 702 | Methylation | SGKNQFNRGGGHRGR CCCCCCCCCCCCCCC | 46.55 | 24129315 | |
| 707 | Dimethylation | FNRGGGHRGRGGFNM CCCCCCCCCCCCCCC | 39.52 | - | |
| 707 | Methylation | FNRGGGHRGRGGFNM CCCCCCCCCCCCCCC | 39.52 | 54548243 | |
| 709 | Dimethylation | RGGGHRGRGGFNMRG CCCCCCCCCCCCCCC | 41.86 | - | |
| 709 | Methylation | RGGGHRGRGGFNMRG CCCCCCCCCCCCCCC | 41.86 | 24395547 | |
| 714 | Methylation | RGRGGFNMRGGNFRG CCCCCCCCCCCCCCC | 3.83 | 15782174 | |
| 715 | Dimethylation | GRGGFNMRGGNFRGG CCCCCCCCCCCCCCC | 51.47 | - | |
| 715 | Methylation | GRGGFNMRGGNFRGG CCCCCCCCCCCCCCC | 51.47 | 24395559 | |
| 720 | Dimethylation | NMRGGNFRGGAPGNR CCCCCCCCCCCCCCC | 46.78 | - | |
| 720 | Methylation | NMRGGNFRGGAPGNR CCCCCCCCCCCCCCC | 46.78 | 24395571 | |
| 727 | Dimethylation | RGGAPGNRGGYNRRG CCCCCCCCCCCCCCC | 45.92 | - | |
| 727 | Methylation | RGGAPGNRGGYNRRG CCCCCCCCCCCCCCC | 45.92 | 24395583 | |
| 730 | Phosphorylation | APGNRGGYNRRGNMP CCCCCCCCCCCCCCC | 14.33 | 21394647 | |
| 732 | Methylation | GNRGGYNRRGNMPQR CCCCCCCCCCCCCCC | 39.12 | 24395595 | |
| 733 | Asymmetric dimethylarginine | NRGGYNRRGNMPQRG CCCCCCCCCCCCCCC | 36.88 | - | |
| 733 | Methylation | NRGGYNRRGNMPQRG CCCCCCCCCCCCCCC | 36.88 | 24129315 | |
| 739 | Asymmetric dimethylarginine | RRGNMPQRGGGGGGS CCCCCCCCCCCCCCC | 39.59 | - | |
| 739 | Methylation | RRGNMPQRGGGGGGS CCCCCCCCCCCCCCC | 39.59 | 24129315 | |
| 753 | Phosphorylation | SGGIGYPYPRAPVFP CCCCCCCCCCCCCCC | 9.25 | - | |
| 755 | Asymmetric dimethylarginine | GIGYPYPRAPVFPGR CCCCCCCCCCCCCCC | 45.76 | - | |
| 755 | Methylation | GIGYPYPRAPVFPGR CCCCCCCCCCCCCCC | 45.76 | 24129315 | |
| 762 | Asymmetric dimethylarginine | RAPVFPGRGSYSNRG CCCCCCCCCCCCCCC | 30.99 | - | |
| 762 | Methylation | RAPVFPGRGSYSNRG CCCCCCCCCCCCCCC | 30.99 | 24129315 | |
| 768 | Dimethylation | GRGSYSNRGNYNRGG CCCCCCCCCCCCCCC | 28.88 | - | |
| 768 | Methylation | GRGSYSNRGNYNRGG CCCCCCCCCCCCCCC | 28.88 | 24395607 | |
| 773 | Dimethylation | SNRGNYNRGGMPNRG CCCCCCCCCCCCCCC | 32.46 | - | |
| 773 | Methylation | SNRGNYNRGGMPNRG CCCCCCCCCCCCCCC | 32.46 | 24395619 | |
| 779 | Dimethylation | NRGGMPNRGNYNQNF CCCCCCCCCCCCCCC | 28.94 | - | |
| 779 | Methylation | NRGGMPNRGNYNQNF CCCCCCCCCCCCCCC | 28.94 | 24384407 | |
| 787 | Methylation | GNYNQNFRGRGNNRG CCCCCCCCCCCCCCC | 41.26 | 24383485 | |
| 789 | Methylation | YNQNFRGRGNNRGYK CCCCCCCCCCCCCCC | 40.17 | 115479417 | |
| 793 | Methylation | FRGRGNNRGYKNQSQ CCCCCCCCCCCCCCC | 54.54 | 115479425 | |
| 795 | Acetylation | GRGNNRGYKNQSQGY CCCCCCCCCCCCCCC | 11.97 | 19608861 | |
| 795 | Ubiquitination | GRGNNRGYKNQSQGY CCCCCCCCCCCCCCC | 11.97 | 19608861 | |
| 795 (in isoform 2) | Ubiquitination | - | 11.97 | 21890473 | |
| 799 | Phosphorylation | NRGYKNQSQGYNQWQ CCCCCCCCCCCCCHH | 34.66 | 25159151 | |
| 802 | Phosphorylation | YKNQSQGYNQWQQGQ CCCCCCCCCCHHCCC | 9.13 | 21406692 | |
| 814 | Acetylation | QGQFWGQKPWSQHYH CCCCCCCCCHHHCCC | 44.51 | 19608861 | |
| 814 | Sumoylation | QGQFWGQKPWSQHYH CCCCCCCCCHHHCCC | 44.51 | 28112733 | |
| 814 | Ubiquitination | QGQFWGQKPWSQHYH CCCCCCCCCHHHCCC | 44.51 | 19608861 | |
| 817 | Phosphorylation | FWGQKPWSQHYHQGY CCCCCCHHHCCCCCC | 18.66 | 28450419 | |
| 820 | Phosphorylation | QKPWSQHYHQGYY-- CCCHHHCCCCCCC-- | 6.54 | 28450419 | |
| 824 | Phosphorylation | SQHYHQGYY------ HHCCCCCCC------ | 10.22 | 28450419 | |
| 825 | Phosphorylation | QHYHQGYY------- HCCCCCCC------- | 20.92 | 20090780 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HNRPU_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-234; LYS-265; LYS-352;LYS-464; LYS-516; LYS-524; LYS-551; LYS-565; LYS-626; LYS-635; LYS-670AND LYS-814, AND MASS SPECTROMETRY. | |
| Methylation | |
| Reference | PubMed |
| "Identifying and quantifying in vivo methylation sites by heavy methylSILAC."; Ong S.E., Mittler G., Mann M.; Nat. Methods 1:119-126(2004). Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT ARG-50; ARG-733 AND ARG-739, ANDMASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-66 AND SER-271,AND MASS SPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-271 AND THR-286,AND MASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-66 AND SER-271,AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, AND MASSSPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59; SER-66 AND SER-188,AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, AND MASSSPECTROMETRY. | |
| "Toward a global characterization of the phosphoproteome in prostatecancer cells: identification of phosphoproteins in the LNCaP cellline."; Giorgianni F., Zhao Y., Desiderio D.M., Beranova-Giorgianni S.; Electrophoresis 28:2027-2034(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-271, AND MASSSPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-59 AND SER-271,AND MASS SPECTROMETRY. | |
| "Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-473, AND MASSSPECTROMETRY. | |
