DDX31_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DDX31_HUMAN
• UniProt AC: Q9H8H2
• Protein Name: Probable ATP-dependent RNA helicase DDX31
• Gene Name: DDX31
• Organism: Homo sapiens (Human).
• Sequence Length: 851
• Subcellular Localization: Nucleus, nucleolus . Colocalized with NPM1 in the nucleoli.
• Protein Description: Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. [PubMed: 23019224]
• Protein Sequence: MAPDLASQRHSESFPSVNSRPNVILPGREGRREGLPPGGGTRGSLVPTRPVPPSPAPLGTSPYSWSRSGPGRGGGAGSSRVPRGVPGPAVCAPGSLLHHASPTQTMAAADGSLFDNPRTFSRRPPAQASRQAKATKRKYQASSEAPPAKRRNETSFLPAKKTSVKETQRTFKGNAQKMFSPKKHSVSTSDRNQEERQCIKTSSLFKNNPDIPELHRPVVKQVQEKVFTSAAFHELGLHPHLISTINTVLKMSSMTSVQKQSIPVLLEGRDALVRSQTGSGKTLAYCIPVVQSLQAMESKIQRSDGPYALVLVPTRELALQSFDTVQKLLKPFTWIVPGVLMGGEKRKSEKARLRKGINILISTPGRLVDHIKSTKNIHFSRLRWLVFDEADRILDLGFEKDITVILNAVNAECQKRQNVLLSATLTEGVTRLADISLHDPVSISVLDKSHDQLNPKDKAVQEVCPPPAGDKLDSFAIPESLKQHVTVVPSKLRLVCLAAFILQKCKFEEDQKMVVFFSSCELVEFHYSLFLQTLLSSSGAPASGQLPSASMRLKFLRLHGGMEQEERTAVFQEFSHSRRGVLLCTDVAARGLDLPQVTWIVQYNAPSSPAEYIHRIGRTARIGCHGSSLLILAPSEAEYVNSLASHKINVSEIKMEDILCVLTRDDCFKGKRWGAQKSHAVGPQEIRERATVLQTVFEDYVHSSERRVSWAKKALQSFIQAYATYPRELKHIFHVRSLHLGHVAKSFGLRDAPRNLSALTRKKRKAHVKRPDLHKKTQSKHSLAEILRSEYSSGMEADIAKVKKQNAPGEPGGRPLQHSLQPTPCFGRGKTLKWRKTQKGVQRDSKTSQKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Ubiquitination	SFPSVNSRPNVILPG CCCCCCCCCCEEECC	22.93	24816145
23	Ubiquitination	SVNSRPNVILPGREG CCCCCCCEEECCCCC	5.43	29967540
53	Ubiquitination	VPTRPVPPSPAPLGT CCCCCCCCCCCCCCC	53.85	24816145
54	Phosphorylation	PTRPVPPSPAPLGTS CCCCCCCCCCCCCCC	27.85	-
71	Ubiquitination	SWSRSGPGRGGGAGS CCCCCCCCCCCCCCC	44.37	29967540
82	Ubiquitination	GAGSSRVPRGVPGPA CCCCCCCCCCCCCCC	26.63	29967540
104	Ubiquitination	LHHASPTQTMAAADG CCCCCCCCCCCCCCC	32.44	29967540
121	Phosphorylation	FDNPRTFSRRPPAQA CCCCCCCCCCCHHHH	27.11	-
129	Phosphorylation	RRPPAQASRQAKATK CCCHHHHHHHHHHHH	16.91	-
130	Ubiquitination	RPPAQASRQAKATKR CCHHHHHHHHHHHHH	43.42	29967540
139	Phosphorylation	AKATKRKYQASSEAP HHHHHHHHHHCCCCC	17.22	22210691
142	Phosphorylation	TKRKYQASSEAPPAK HHHHHHHCCCCCCCC	17.12	22210691
149	Ubiquitination	SSEAPPAKRRNETSF CCCCCCCCCCCCCCC	58.63	24816145
155	Phosphorylation	AKRRNETSFLPAKKT CCCCCCCCCCCCCCC	20.71	28555341
160	Acetylation	ETSFLPAKKTSVKET CCCCCCCCCCCHHHH	55.43	25953088
162	Phosphorylation	SFLPAKKTSVKETQR CCCCCCCCCHHHHHH	37.74	26074081
163	Ubiquitination	FLPAKKTSVKETQRT CCCCCCCCHHHHHHH	39.82	29967540
163	Phosphorylation	FLPAKKTSVKETQRT CCCCCCCCHHHHHHH	39.82	26074081
177	Acetylation	TFKGNAQKMFSPKKH HHCCCHHHCCCCCCC	39.23	25953088
180	Phosphorylation	GNAQKMFSPKKHSVS CCHHHCCCCCCCCCC	32.10	30576142
187	Phosphorylation	SPKKHSVSTSDRNQE CCCCCCCCCCCCCHH	25.80	-
189	Phosphorylation	KKHSVSTSDRNQEER CCCCCCCCCCCHHHH	27.37	-
195	Ubiquitination	TSDRNQEERQCIKTS CCCCCHHHHHHHHHH	37.98	29967540
200	Ubiquitination	QEERQCIKTSSLFKN HHHHHHHHHHHHHHC	50.40	29967540
203	Phosphorylation	RQCIKTSSLFKNNPD HHHHHHHHHHHCCCC	42.95	24719451
243	Ubiquitination	GLHPHLISTINTVLK CCCHHHHHHHHHHHH	29.60	29967540
259	Ubiquitination	SSMTSVQKQSIPVLL HCCCHHHHCCCCEEE	43.80	29967540
271	Ubiquitination	VLLEGRDALVRSQTG EEEECCCEEEECCCC	13.44	29967540
275	Phosphorylation	GRDALVRSQTGSGKT CCCEEEECCCCCCCC	25.31	23401153
276	Ubiquitination	RDALVRSQTGSGKTL CCEEEECCCCCCCCH	39.04	29967540
277	Phosphorylation	DALVRSQTGSGKTLA CEEEECCCCCCCCHH	34.26	23401153
279	Ubiquitination	LVRSQTGSGKTLAYC EEECCCCCCCCHHHH	40.27	29967540
281	Ubiquitination	RSQTGSGKTLAYCIP ECCCCCCCCHHHHHH	41.90	-
294	Ubiquitination	IPVVQSLQAMESKIQ HHHHHHHHHHHHHHH	43.86	29967540
303	Phosphorylation	MESKIQRSDGPYALV HHHHHHHCCCCCEEE	30.46	28152594
305	Ubiquitination	SKIQRSDGPYALVLV HHHHHCCCCCEEEEE	20.54	29967540
307	Phosphorylation	IQRSDGPYALVLVPT HHHCCCCCEEEEEEC	20.35	28152594
319	Ubiquitination	VPTRELALQSFDTVQ EECHHHHHHCHHHHH	7.38	29967540
327	Ubiquitination	QSFDTVQKLLKPFTW HCHHHHHHHHCCCCC	51.99	29967540
342	Ubiquitination	IVPGVLMGGEKRKSE CCCCCCCCCCCCHHH	36.63	29967540
352	Ubiquitination	KRKSEKARLRKGINI CCHHHHHHHHCCCCE	46.20	29967540
353	Ubiquitination	RKSEKARLRKGINIL CHHHHHHHHCCCCEE	8.73	29967540
360	Ubiquitination	LRKGINILISTPGRL HHCCCCEEECCCCHH	1.87	29967540
362	Phosphorylation	KGINILISTPGRLVD CCCCEEECCCCHHHH	25.71	26270265
363	Phosphorylation	GINILISTPGRLVDH CCCEEECCCCHHHHH	23.83	26270265
372	Ubiquitination	GRLVDHIKSTKNIHF CHHHHHHHCCCCCCH	48.96	29967540
375	Ubiquitination	VDHIKSTKNIHFSRL HHHHHCCCCCCHHHE	62.08	29967540
386	Ubiquitination	FSRLRWLVFDEADRI HHHEEEEEEECHHHH	4.51	29967540
415	Acetylation	AVNAECQKRQNVLLS HHCHHHHHHCCEEHE	68.55	26051181
422	Phosphorylation	KRQNVLLSATLTEGV HHCCEEHEEEECCCH	18.29	25690035
424	Phosphorylation	QNVLLSATLTEGVTR CCEEHEEEECCCHHH	30.73	25690035
426	Phosphorylation	VLLSATLTEGVTRLA EEHEEEECCCHHHHH	26.74	25690035
448	Ubiquitination	VSISVLDKSHDQLNP CEEEEECCCCCCCCC	45.59	29967540
448	Acetylation	VSISVLDKSHDQLNP CEEEEECCCCCCCCC	45.59	26051181
456	Ubiquitination	SHDQLNPKDKAVQEV CCCCCCCCCCHHHHH	71.44	29967540
471	Ubiquitination	CPPPAGDKLDSFAIP CCCCCCCCCCCCCCC	53.96	29967540
471	Acetylation	CPPPAGDKLDSFAIP CCCCCCCCCCCCCCC	53.96	26051181
482	Ubiquitination	FAIPESLKQHVTVVP CCCCHHHHHHCCCCC	47.87	29967540
506	Acetylation	AFILQKCKFEEDQKM HHHHHHCCCCCCCCE	63.95	26051181
518	Phosphorylation	QKMVVFFSSCELVEF CCEEEEEECCCHHHH	23.71	24043423
519	Phosphorylation	KMVVFFSSCELVEFH CEEEEEECCCHHHHH	13.37	24043423
527	Phosphorylation	CELVEFHYSLFLQTL CCHHHHHHHHHHHHH	16.64	24043423
528	Phosphorylation	ELVEFHYSLFLQTLL CHHHHHHHHHHHHHH	12.22	24043423
533	Phosphorylation	HYSLFLQTLLSSSGA HHHHHHHHHHHCCCC	31.64	24043423
536	Phosphorylation	LFLQTLLSSSGAPAS HHHHHHHHCCCCCCC	26.10	24043423
537	Phosphorylation	FLQTLLSSSGAPASG HHHHHHHCCCCCCCC	32.53	24043423
538	Phosphorylation	LQTLLSSSGAPASGQ HHHHHHCCCCCCCCC	35.28	24043423
543	Phosphorylation	SSSGAPASGQLPSAS HCCCCCCCCCCCCHH	26.47	24043423
548	Phosphorylation	PASGQLPSASMRLKF CCCCCCCCHHHHHHH	41.38	24043423
550	Phosphorylation	SGQLPSASMRLKFLR CCCCCCHHHHHHHHH	14.58	24043423
568	Phosphorylation	GMEQEERTAVFQEFS CCCHHHHHHHHHHCC	30.38	-
575	Phosphorylation	TAVFQEFSHSRRGVL HHHHHHCCCCCCCEE	21.57	24505115
577	Phosphorylation	VFQEFSHSRRGVLLC HHHHCCCCCCCEEEE	23.60	24505115
673	Ubiquitination	DCFKGKRWGAQKSHA CCCCCCCCCCCCCCC	15.23	24816145
721	Ubiquitination	ALQSFIQAYATYPRE HHHHHHHHHHHCCHH	7.36	24816145
730	Ubiquitination	ATYPRELKHIFHVRS HHCCHHHHHHEEEEE	29.87	-
737	Phosphorylation	KHIFHVRSLHLGHVA HHHEEEEEECHHHHH	21.03	27251275
746	Phosphorylation	HLGHVAKSFGLRDAP CHHHHHHHCCCCCCC	18.14	27251275
754	Ubiquitination	FGLRDAPRNLSALTR CCCCCCCCCHHHHHH	59.44	24816145
757	Phosphorylation	RDAPRNLSALTRKKR CCCCCCHHHHHHHHH	25.45	22210691
760	Phosphorylation	PRNLSALTRKKRKAH CCCHHHHHHHHHHHH	39.91	22210691
777	Ubiquitination	RPDLHKKTQSKHSLA CCCHHHHHCCHHHHH	42.76	24816145
782	Phosphorylation	KKTQSKHSLAEILRS HHHCCHHHHHHHHHH	32.77	-
791	Phosphorylation	AEILRSEYSSGMEAD HHHHHHHHHCCCHHH	14.91	27642862
823	Phosphorylation	LQHSLQPTPCFGRGK CCCCCCCCCCCCCCC	21.52	-
828	Methylation	QPTPCFGRGKTLKWR CCCCCCCCCCCCCCH	24.15	24129315
830	Methylation	TPCFGRGKTLKWRKT CCCCCCCCCCCCHHC	49.69	-
845	Phosphorylation	QKGVQRDSKTSQKV- CCCCCCCCCCCCCC-	39.77	29970186
850	Ubiquitination	RDSKTSQKV------ CCCCCCCCC------	50.07	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DDX31_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DDX31_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DDX31_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DKC1_HUMAN	DKC1	physical	26344197
NOC2L_HUMAN	NOC2L	physical	26344197
PERL_HUMAN	LPO	physical	28514442
LEG1H_HUMAN	C6orf58	physical	28514442
PROL1_HUMAN	PROL1	physical	28514442
CERU_HUMAN	CP	physical	28514442
HPT_HUMAN	HP	physical	28514442
PIGR_HUMAN	PIGR	physical	28514442
SG2A1_HUMAN	SCGB2A1	physical	28514442
DMBT1_HUMAN	DMBT1	physical	28514442
BPIA1_HUMAN	BPIFA1	physical	28514442
TRFL_HUMAN	LTF	physical	28514442
IGLL5_HUMAN	IGLL5	physical	28514442
CO3_HUMAN	C3	physical	28514442
BPIB2_HUMAN	BPIFB2	physical	28514442
PROL4_HUMAN	PRR4	physical	28514442
A1AT_HUMAN	SERPINA1	physical	28514442
BPIB1_HUMAN	BPIFB1	physical	28514442
MSLN_HUMAN	MSLN	physical	28514442
HEMO_HUMAN	HPX	physical	28514442
LACRT_HUMAN	LACRT	physical	28514442
TCO1_HUMAN	TCN1	physical	28514442
TSP1_HUMAN	THBS1	physical	28514442
NGAL_HUMAN	LCN2	physical	28514442
CYTN_HUMAN	CST1	physical	28514442
CYTT_HUMAN	CST2	physical	28514442
LCN1_HUMAN	LCN1	physical	28514442
QSOX1_HUMAN	QSOX1	physical	28514442
VTDB_HUMAN	GC	physical	28514442
SG1D2_HUMAN	SCGB1D2	physical	28514442
A1AG1_HUMAN	ORM1	physical	28514442
APOA1_HUMAN	APOA1	physical	28514442
ZA2G_HUMAN	AZGP1	physical	28514442
AACT_HUMAN	SERPINA3	physical	28514442
LYSC_HUMAN	LYZ	physical	28514442
MUC5B_HUMAN	MUC5B	physical	28514442
IGJ_HUMAN	IGJ	physical	28514442
ZG16B_HUMAN	ZG16B	physical	28514442
CYTS_HUMAN	CST4	physical	28514442
PLTP_HUMAN	PLTP	physical	28514442
TRFE_HUMAN	TF	physical	28514442
SART3_HUMAN	SART3	physical	28514442
NUCB1_HUMAN	NUCB1	physical	28514442
PIP_HUMAN	PIP	physical	28514442
CLUS_HUMAN	CLU	physical	28514442
TTHY_HUMAN	TTR	physical	28514442
ANT3_HUMAN	SERPINC1	physical	28514442
SG1D1_HUMAN	SCGB1D1	physical	28514442
CYTC_HUMAN	CST3	physical	28514442
SPB3_HUMAN	SERPINB3	physical	28514442
FETUA_HUMAN	AHSG	physical	28514442
ALBU_HUMAN	ALB	physical	28514442
RBM4_HUMAN	RBM4	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.