BPIB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BPIB1_HUMAN
• UniProt AC: Q8TDL5
• Protein Name: BPI fold-containing family B member 1
• Gene Name: BPIFB1
• Organism: Homo sapiens (Human).
• Sequence Length: 484
• Subcellular Localization: Secreted.
• Protein Description: May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS..
• Protein Sequence: MAGPWTFTLLCGLLAATLIQATLSPTAVLILGPKVIKEKLTQELKDHNATSILQQLPLLSAMREKPAGGIPVLGSLVNTVLKHIIWLKVITANILQLQVKPSANDQELLVKIPLDMVAGFNTPLVKTIVEFHMTTEAQATIRMDTSASGPTRLVLSDCATSHGSLRIQLLHKLSFLVNALAKQVMNLLVPSLPNLVKNQLCPVIEASFNGMYADLLQLVKVPISLSIDRLEFDLLYPAIKGDTIQLYLGAKLLDSQGKVTKWFNNSAASLTMPTLDNIPFSLIVSQDVVKAAVAAVLSPEEFMVLLDSVLPESAHRLKSSIGLINEKAADKLGSTQIVKILTQDTPEFFIDQGHAKVAQLIVLEVFPSSEALRPLFTLGIEASSEAQFYTKGDQLILNLNNISSDRIQLMNSGIGWFQPDVLKNIITEIIHSILLPNQNGKLRSGVPVSLVKALGFEAAESSLTKDALVLTPASLWKPSSPVSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
48	N-linked_Glycosylation	TQELKDHNATSILQQ HHHHHHCCHHHHHHH	55.86	UniProtKB CARBOHYD
48	N-linked_Glycosylation	TQELKDHNATSILQQ HHHHHHCCHHHHHHH	55.86	17623646
127	Phosphorylation	FNTPLVKTIVEFHMT CCCHHHHHHEEECCC	23.83	29759185
134	Phosphorylation	TIVEFHMTTEAQATI HHEEECCCCCCCEEE	16.96	29759185
135	Phosphorylation	IVEFHMTTEAQATIR HEEECCCCCCCEEEE	23.04	29759185
140	Phosphorylation	MTTEAQATIRMDTSA CCCCCCEEEEECCCC	9.31	29759185
145	Phosphorylation	QATIRMDTSASGPTR CEEEEECCCCCCCEE	19.49	21406692
146	Phosphorylation	ATIRMDTSASGPTRL EEEEECCCCCCCEEE	19.04	21406692
148	Phosphorylation	IRMDTSASGPTRLVL EEECCCCCCCEEEEE	45.10	21406692
151	Phosphorylation	DTSASGPTRLVLSDC CCCCCCCEEEEEEEC	39.91	21406692
156	Phosphorylation	GPTRLVLSDCATSHG CCEEEEEEECCCCCC	24.14	21406692
160	Phosphorylation	LVLSDCATSHGSLRI EEEEECCCCCCHHHH	27.82	21406692
161	Phosphorylation	VLSDCATSHGSLRIQ EEEECCCCCCHHHHH	13.81	21406692
164	Phosphorylation	DCATSHGSLRIQLLH ECCCCCCHHHHHHHH	14.73	21406692
191	Phosphorylation	VMNLLVPSLPNLVKN HHHHHCCCCCHHHHC	49.32	-
264	N-linked_Glycosylation	GKVTKWFNNSAASLT CCCCHHCCCCCCCCC	40.19	UniProtKB CARBOHYD
281	Phosphorylation	TLDNIPFSLIVSQDV CCCCCCEEEEECHHH	16.31	25332170
327	Ubiquitination	SIGLINEKAADKLGS HHHCCCHHHHHHCCC	44.37	-
401	N-linked_Glycosylation	QLILNLNNISSDRIQ EEEEECCCCCCHHHH	38.39	17623646
401	N-linked_Glycosylation	QLILNLNNISSDRIQ EEEEECCCCCCHHHH	38.39	UniProtKB CARBOHYD
444	Phosphorylation	NQNGKLRSGVPVSLV CCCCCCCCCCCHHHH	55.36	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BPIB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BPIB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BPIB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ENL_HUMAN	MLLT1	physical	28514442
AF9_HUMAN	MLLT3	physical	28514442
TIM50_HUMAN	TIMM50	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.