TIM50_HUMAN - dbPTM
TIM50_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TIM50_HUMAN
UniProt AC Q3ZCQ8
Protein Name Mitochondrial import inner membrane translocase subunit TIM50
Gene Name TIMM50
Organism Homo sapiens (Human).
Sequence Length 353
Subcellular Localization Mitochondrion inner membrane
Single-pass membrane protein .
Isoform 2: Nucleus speckle . Nuclear and enriched in speckles with snRNPs.
Protein Description Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo.; Isoform 2: May participate in the release of snRNPs and SMN from the Cajal body..
Protein Sequence MAASAAVFSRLRSGLRLGSRGLCTRLATPPRRAPDQAAEIGSRGSTKAQGPQQQPGSEGPSYAKKVALWLAGLLGAGGTVSVVYIFGNNPVDENGAKIPDEFDNDPILVQQLRRTYKYFKDYRQMIIEPTSPCLLPDPLQEPYYQPPYTLVLELTGVLLHPEWSLATGWRFKKRPGIETLFQQLAPLYEIVIFTSETGMTAFPLIDSVDPHGFISYRLFRDATRYMDGHHVKDISCLNRDPARVVVVDCKKEAFRLQPYNGVALRPWDGNSDDRVLLDLSAFLKTIALNGVEDVRTVLEHYALEDDPLAAFKQRQSRLEQEEQQRLAELSKSNKQNLFLGSLTSRLWPRSKQP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MAASAAVFSRL
----CCHHHHHHHHH		13.7620164059
6 (in isoform 2)Phosphorylation-10.6120068231
9PhosphorylationAASAAVFSRLRSGLR
CHHHHHHHHHHHCCC		24.6520068231
28PhosphorylationGLCTRLATPPRRAPD
CCHHCCCCCCCCCCC		38.1227174698
42PhosphorylationDQAAEIGSRGSTKAQ
CHHHHHHCCCCCCCC		38.8530108239
43MethylationQAAEIGSRGSTKAQG
HHHHHHCCCCCCCCC		37.56115918505
45PhosphorylationAEIGSRGSTKAQGPQ
HHHHCCCCCCCCCCC		26.1430108239
46PhosphorylationEIGSRGSTKAQGPQQ
HHHCCCCCCCCCCCC		32.9730108239
47UbiquitinationIGSRGSTKAQGPQQQ
HHCCCCCCCCCCCCC		40.1721906983
47 (in isoform 1)Ubiquitination-40.1721890473
57PhosphorylationGPQQQPGSEGPSYAK
CCCCCCCCCCCHHHH		46.1728102081
61PhosphorylationQPGSEGPSYAKKVAL
CCCCCCCHHHHHHHH		48.8820860994
62PhosphorylationPGSEGPSYAKKVALW
CCCCCCHHHHHHHHH		26.1018083107
64 (in isoform 1)Ubiquitination-39.2821890473
64UbiquitinationSEGPSYAKKVALWLA
CCCCHHHHHHHHHHH		39.2821906983
107 (in isoform 2)Phosphorylation-7.0220068231
107PhosphorylationDEFDNDPILVQQLRR
CCCCCCHHHHHHHHH		7.0220068231
112PhosphorylationDPILVQQLRRTYKYF
CHHHHHHHHHHHHHH		1.9320068231
112 (in isoform 2)Phosphorylation-1.9321406692
131PhosphorylationQMIIEPTSPCLLPDP
HHCCCCCCCCCCCCC		25.08-
145 (in isoform 2)Phosphorylation-27.0121406692
146MethylationLQEPYYQPPYTLVLE
CCCCCCCCCEEEEEE		14.03-
148PhosphorylationEPYYQPPYTLVLELT
CCCCCCCEEEEEEEE		21.27-
150UbiquitinationYYQPPYTLVLELTGV
CCCCCEEEEEEEECC		3.23-
150 (in isoform 2)Ubiquitination-3.2321890473
164PhosphorylationVLLHPEWSLATGWRF
CHHCCHHHHHCCCCC		13.38-
167UbiquitinationHPEWSLATGWRFKKR
CCHHHHHCCCCCCCC		42.44-
167 (in isoform 2)Ubiquitination-42.4421890473
223UbiquitinationYRLFRDATRYMDGHH
HHHHHCCCHHCCCCC		26.99-
223 (in isoform 2)Ubiquitination-26.99-
225PhosphorylationLFRDATRYMDGHHVK
HHHCCCHHCCCCCCC		8.6620068231
232 (in isoform 1)Ubiquitination-45.0121890473
232UbiquitinationYMDGHHVKDISCLNR
HCCCCCCCCCHHCCC		45.0121890473
235PhosphorylationGHHVKDISCLNRDPA
CCCCCCCHHCCCCCC		23.7620068231
249S-palmitoylationARVVVVDCKKEAFRL
CEEEEEECCCHHEEC		4.6021044946
250AcetylationRVVVVDCKKEAFRLQ
EEEEEECCCHHEECC		49.5425953088
280PhosphorylationDRVLLDLSAFLKTIA
CHHEEHHHHHHHHHH		19.35-
301PhosphorylationVRTVLEHYALEDDPL
HHHHHHHHCCCCCHH		11.96-
312UbiquitinationDDPLAAFKQRQSRLE
CCHHHHHHHHHHHHH		39.5820639865
312 (in isoform 1)Ubiquitination-39.5821890473
331UbiquitinationQRLAELSKSNKQNLF
HHHHHHHHHHHCHHH		71.3421906983
331 (in isoform 1)Ubiquitination-71.3421890473
334UbiquitinationAELSKSNKQNLFLGS
HHHHHHHHCHHHHHH		47.8821890473
334 (in isoform 1)Ubiquitination-47.8821890473
335 (in isoform 2)Ubiquitination-56.9921890473
335UbiquitinationELSKSNKQNLFLGSL
HHHHHHHCHHHHHHH		56.9921890473
335UbiquitinationELSKSNKQNLFLGSL
HHHHHHHCHHHHHHH		56.99-
341PhosphorylationKQNLFLGSLTSRLWP
HCHHHHHHHHHCCCC		30.5327573165
343PhosphorylationNLFLGSLTSRLWPRS
HHHHHHHHHCCCCCC		17.3127080861
344PhosphorylationLFLGSLTSRLWPRSK
HHHHHHHHCCCCCCC		30.5727080861
354 (in isoform 2)Ubiquitination--
383Phosphorylation-------------------------------------
-------------------------------------		-
404Phosphorylation----------------------------------------------------------
----------------------------------------------------------		-
415Ubiquitination---------------------------------------------------------------------
---------------------------------------------------------------------		-
415 (in isoform 2)Ubiquitination-21890473
415Ubiquitination---------------------------------------------------------------------
---------------------------------------------------------------------		21890473
434Ubiquitination----------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------		-
434 (in isoform 2)Ubiquitination-21890473
437Ubiquitination-------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------		-
437Ubiquitination-------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------		21890473
437 (in isoform 2)Ubiquitination-21890473
444Phosphorylation--------------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------------		-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TIM50_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TIM50_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TIM50_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TOM70_HUMANTOMM70Aphysical
22939629
TOM40_HUMANTOMM40physical
22939629
TOM7_HUMANTOMM7physical
22939629
VAMP2_HUMANVAMP2physical
22939629
TOM40_HUMANTOMM40physical
26344197
ZN852_HUMANZNF852physical
28514442
WASF1_HUMANWASF1physical
28514442
ABI2_HUMANABI2physical
28514442
ZN629_HUMANZNF629physical
28514442
WASF3_HUMANWASF3physical
28514442
BRK1_HUMANBRK1physical
28514442
MUC5B_HUMANMUC5Bphysical
28514442
WASF2_HUMANWASF2physical
28514442
ABI1_HUMANABI1physical
28514442
GLCNE_HUMANGNEphysical
28514442
DPP9_HUMANDPP9physical
28514442
HDAC6_HUMANHDAC6physical
28514442
NCKP1_HUMANNCKAP1physical
28514442
ZN100_HUMANZNF100physical
28514442
CYFP1_HUMANCYFIP1physical
28514442
ZN624_HUMANZNF624physical
28514442
IGJ_HUMANIGJphysical
28514442
ZKSC8_HUMANZKSCAN8physical
28514442
CYFP2_HUMANCYFIP2physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TIM50_HUMAN

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Related Literatures of Post-Translational Modification

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