dbPTM

HDAC6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HDAC6_HUMAN
UniProt AC	Q9UBN7
Protein Name	Histone deacetylase 6
Gene Name	HDAC6
Organism	Homo sapiens (Human).
Sequence Length	1215
Subcellular Localization	Nucleus. Cytoplasm. Perikaryon. Cell projection, dendrite. Cell projection, axon. It is mainly cytoplasmic, where it is associated with microtubules.
Protein Description	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.; In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy..
Protein Sequence	MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	TTTRQRRSRQNPQSP HHHHHHHHCCCCCCC	40.17	23403867
22	Phosphorylation	RSRQNPQSPPQDSSV HHCCCCCCCCCCCCC	39.54	29255136
27	Phosphorylation	PQSPPQDSSVTSKRN CCCCCCCCCCCCHHH	22.81	30266825
28	Phosphorylation	QSPPQDSSVTSKRNI CCCCCCCCCCCHHHH	37.39	30266825
30	Phosphorylation	PPQDSSVTSKRNIKK CCCCCCCCCHHHHCC	30.40	30266825
31	Phosphorylation	PQDSSVTSKRNIKKG CCCCCCCCHHHHCCC	27.71	30266825
32	Ubiquitination	QDSSVTSKRNIKKGA CCCCCCCHHHHCCCC	39.85	-
32	Acetylation	QDSSVTSKRNIKKGA CCCCCCCHHHHCCCC	39.85	22438583
33	Methylation	DSSVTSKRNIKKGAV CCCCCCHHHHCCCCC	50.28	-
36	Acetylation	VTSKRNIKKGAVPRS CCCHHHHCCCCCCCC	49.02	22438583
37	Acetylation	TSKRNIKKGAVPRSI CCHHHHCCCCCCCCC	48.59	22438583
43	Phosphorylation	KKGAVPRSIPNLAEV CCCCCCCCCCCHHHH	36.01	25159151
51	Acetylation	IPNLAEVKKKGKMKK CCCHHHHHHHCHHHH	40.03	22438583
51	Ubiquitination	IPNLAEVKKKGKMKK CCCHHHHHHHCHHHH	40.03	-
52	Acetylation	PNLAEVKKKGKMKKL CCHHHHHHHCHHHHH	72.44	22438583
53	Acetylation	NLAEVKKKGKMKKLG CHHHHHHHCHHHHHH	59.03	22438583
55	Acetylation	AEVKKKGKMKKLGQA HHHHHHCHHHHHHHH	57.32	22438583
57	Acetylation	VKKKGKMKKLGQAME HHHHCHHHHHHHHHH	48.62	22438583
58	Acetylation	KKKGKMKKLGQAMEE HHHCHHHHHHHHHHH	55.11	22438583
116	Ubiquitination	PERLHAIKEQLIQEG HHHHHHHHHHHHHCC	39.94	2190698
130	Ubiquitination	GLLDRCVSFQARFAE CCHHHHHHHHHHHCC	18.44	21906983
146	Phosphorylation	EELMLVHSLEYIDLM HHHHHHEEHHHEEHH	18.54	-
381	Phosphorylation	AGGKLILSLEGGYNL HCCEEEEEECCCCHH	19.85	29083192
386	Phosphorylation	ILSLEGGYNLRALAE EEEECCCCHHHHHHH	23.14	29083192
412	Phosphorylation	DPCPMLESPGAPCRS CCCCCCCCCCCCCCC	25.36	28348404
458	Phosphorylation	EEDNVEESEEEGPWE CCCCCCCCCCCCCCC	36.48	21486957
525	Phosphorylation	GLAGRCLTLTPRPAT CCCCEEEECCCCCCC	32.01	28348404
527	Phosphorylation	AGRCLTLTPRPATEA CCEEEECCCCCCCHH	16.41	24719451
538	Phosphorylation	ATEAELLTCHSAEYV CCHHHHHHCCCHHHH	22.31	28796482
541	Phosphorylation	AELLTCHSAEYVGHL HHHHHCCCHHHHCHH	25.58	28796482
544	Phosphorylation	LTCHSAEYVGHLRAT HHCCCHHHHCHHHHH	16.08	28796482
551	Phosphorylation	YVGHLRATEKMKTRE HHCHHHHHHHCHHHH	29.70	24719451
553	Acetylation	GHLRATEKMKTRELH CHHHHHHHCHHHHHH	41.14	22438583
555	Acetylation	LRATEKMKTRELHRE HHHHHHCHHHHHHHH	56.34	22438583
556	Phosphorylation	RATEKMKTRELHRES HHHHHCHHHHHHHHC	26.36	22210691
570	Phosphorylation	SSNFDSIYICPSTFA CCCCCEEEECCHHHH	10.62	20029029
807	Phosphorylation	GDPPPLLTLPRPPLS CCCCCCCCCCCCCCC	42.26	24719451
846	Phosphorylation	VEDREGPSSSKLVTK EECCCCCCCCCCEEC	59.09	-
847	Phosphorylation	EDREGPSSSKLVTKK ECCCCCCCCCCEECC	34.33	-
849	Ubiquitination	REGPSSSKLVTKKAP CCCCCCCCCEECCCC	49.26	-
849	Acetylation	REGPSSSKLVTKKAP CCCCCCCCCEECCCC	49.26	25953088
853	Acetylation	SSSKLVTKKAPQPAK CCCCCEECCCCCCCC	39.18	22438583
854	Ubiquitination	SSKLVTKKAPQPAKP CCCCEECCCCCCCCC	56.80	-
854	Acetylation	SSKLVTKKAPQPAKP CCCCEECCCCCCCCC	56.80	22438583
860	Ubiquitination	KKAPQPAKPRLAERM CCCCCCCCCHHHHHC	37.04	-
868	Phosphorylation	PRLAERMTTREKKVL CHHHHHCCHHHHHHH	28.99	30108239
869	Phosphorylation	RLAERMTTREKKVLE HHHHHCCHHHHHHHH	27.73	30108239
872	Acetylation	ERMTTREKKVLEAGM HHCCHHHHHHHHHCC	44.91	22438583
873	Acetylation	RMTTREKKVLEAGMG HCCHHHHHHHHHCCC	47.50	22438583
881	Acetylation	VLEAGMGKVTSASFG HHHHCCCEEEEECCC	33.19	22424773
883	Phosphorylation	EAGMGKVTSASFGEE HHCCCEEEEECCCCC	23.28	24275569
886	Phosphorylation	MGKVTSASFGEESTP CCEEEEECCCCCCCC	33.29	22468782
915	Phosphorylation	DQPSEAATGGATLAQ CCCCHHCCCCCHHHH	43.10	24275569
919	Phosphorylation	EAATGGATLAQTISE HHCCCCCHHHHHHHH	26.38	24275569
923	Phosphorylation	GGATLAQTISEAAIG CCCHHHHHHHHHHHC	22.36	24275569
925	Phosphorylation	ATLAQTISEAAIGGA CHHHHHHHHHHHCCH	25.27	24275569
993	Phosphorylation	GGATLAQTTSEAAME CCCCEEEHHHHHHHC	27.04	24275569
994	Phosphorylation	GATLAQTTSEAAMEG CCCEEEHHHHHHHCC	16.70	24275569
995	Phosphorylation	ATLAQTTSEAAMEGA CCEEEHHHHHHHCCC	28.73	24275569
1003	Phosphorylation	EAAMEGATLDQTTSE HHHHCCCCCCCCCCC	41.55	24275569
1007	Phosphorylation	EGATLDQTTSEEAPG CCCCCCCCCCCCCCC	31.77	24275569
1016	Phosphorylation	SEEAPGGTELIQTPL CCCCCCCCEEEECCC	33.27	24275569
1021	Phosphorylation	GGTELIQTPLASSTD CCCEEEECCCCCCCC	17.18	24275569
1025	Phosphorylation	LIQTPLASSTDHQTP EEECCCCCCCCCCCC	41.26	26074081
1026	Phosphorylation	IQTPLASSTDHQTPP EECCCCCCCCCCCCC	32.04	26074081
1027	Phosphorylation	QTPLASSTDHQTPPT ECCCCCCCCCCCCCC	34.70	26074081
1031	Phosphorylation	ASSTDHQTPPTSPVQ CCCCCCCCCCCCCCC	28.02	26657352
1034	Phosphorylation	TDHQTPPTSPVQGTT CCCCCCCCCCCCCCC	47.03	26657352
1035	Phosphorylation	DHQTPPTSPVQGTTP CCCCCCCCCCCCCCC	28.93	26657352
1040	Phosphorylation	PTSPVQGTTPQISPS CCCCCCCCCCCCCHH	20.43	12354939
1041	Phosphorylation	TSPVQGTTPQISPST CCCCCCCCCCCCHHH	21.74	24275569
1047	Phosphorylation	TTPQISPSTLIGSLR CCCCCCHHHHHHHEE	29.11	24275569
1048	Phosphorylation	TPQISPSTLIGSLRT CCCCCHHHHHHHEEE	26.27	24275569
1052	Phosphorylation	SPSTLIGSLRTLELG CHHHHHHHEEEEECC	14.00	24719451
1055	Phosphorylation	TLIGSLRTLELGSES HHHHHEEEEECCCCC	29.85	-
1062	Phosphorylation	TLELGSESQGASESQ EEECCCCCCCCCCCC	35.29	28348404
1066	Phosphorylation	GSESQGASESQAPGE CCCCCCCCCCCCCCC	44.60	28348404
1068	Phosphorylation	ESQGASESQAPGEEN CCCCCCCCCCCCCCC	29.19	28348404
1206	Ubiquitination	KNIAHQNKFGEDMPH HCHHHHCCCCCCCCC	48.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
22	S	Phosphorylation	Kinase	GRK5	P34947	PSP
458	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
458	S	Phosphorylation	Kinase	CK2A1	Q60737	PSP
458	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
570	Y	Phosphorylation	Kinase	EGFR	P00533	PSP
1031	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
1031	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
1035	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:28599312

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HDAC6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HDAC6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZBT16_HUMAN	ZBTB16	physical	15467736
HDA11_HUMAN	HDAC11	physical	11948178
RUNX2_HUMAN	RUNX2	physical	12391164
MTG16_HUMAN	CBFA2T3	physical	11533236
UBC_HUMAN	UBC	physical	17512543
DNJB8_HUMAN	DNAJB8	physical	20159555
DNJB6_HUMAN	DNAJB6	physical	20159555
EP300_HUMAN	EP300	physical	19344692
EGFR_HUMAN	EGFR	physical	20029029
ERBB2_HUMAN	ERBB2	physical	20029029
ERBB3_HUMAN	ERBB3	physical	20029029
ERBB4_HUMAN	ERBB4	physical	20029029
FNTA_HUMAN	FNTA	physical	19228685
FNTB_HUMAN	FNTB	physical	19228685
HS90A_HUMAN	HSP90AA1	physical	19158084
MARE1_HUMAN	MAPRE1	physical	19737819
ACTZ_HUMAN	ACTR1A	physical	19737819
FAT1_HUMAN	FAT1	physical	19033385
SMAD7_HUMAN	SMAD7	physical	15831498
HIF1A_HUMAN	HIF1A	physical	16951198
TAU_HUMAN	MAPT	physical	18636984
HS90A_HUMAN	HSP90AA1	physical	18591380
CFTR_HUMAN	CFTR	physical	14675537
PP1G_HUMAN	PPP1CC	physical	14670976
TBB2B_HUMAN	TUBB2B	physical	12606581
TBA1A_HUMAN	TUBA1A	physical	12606581
TBA1A_HUMAN	TUBA1A	physical	12486003
TBA1A_HUMAN	TUBA1A	physical	12024216
TBB2A_HUMAN	TUBB2A	physical	12024216
DIAP3_HUMAN	DIAPH3	physical	15976449
HS90A_HUMAN	HSP90AA1	physical	15916966
SMAD7_HUMAN	SMAD7	physical	15831516
G3BP1_HUMAN	G3BP1	physical	18079183
SIR2_HUMAN	SIRT2	physical	17516032
SRC8_HUMAN	CTTN	physical	17643370
GRP78_HUMAN	HSPA5	physical	20371724
GCR_HUMAN	NR3C1	physical	20018896
MIIP_HUMAN	MIIP	physical	20008322
MYD88_HUMAN	MYD88	physical	20837465
BCL3_HUMAN	BCL3	physical	15469820
DPOA2_HUMAN	POLA2	physical	21900206
HES1_HUMAN	HES1	physical	21900206
NASP_HUMAN	NASP	physical	21900206
F16P1_HUMAN	FBP1	physical	21900206
PDIP2_HUMAN	POLDIP2	physical	21900206
BBS10_HUMAN	BBS10	physical	21900206
NACAD_HUMAN	NACAD	physical	21900206
ZN205_HUMAN	ZNF205	physical	21900206
LPXN_HUMAN	LPXN	physical	21900206
PRDX4_HUMAN	PRDX4	physical	21900206
CFTR_HUMAN	CFTR	physical	22069321
CSK22_HUMAN	CSNK2A2	physical	21486957
GSK3A_HUMAN	GSK3A	physical	22022450
GSK3B_HUMAN	GSK3B	physical	22022450
KPCA_HUMAN	PRKCA	physical	21949397
FBX11_HUMAN	FBXO11	physical	21090589
PTOV1_HUMAN	PTOV1	physical	21090589
UBD_HUMAN	UBD	physical	21090589
CHIP_HUMAN	STUB1	physical	22492994
RS6_HUMAN	RPS6	physical	22367689
RL36A_HUMAN	RPL36A	physical	22367689
BIRC5_HUMAN	BIRC5	physical	22334690
XPO1_HUMAN	XPO1	physical	22334690
ARBK1_HUMAN	ADRBK1	physical	22193721
SRC8_HUMAN	CTTN	physical	21847094
JDP2_HUMAN	JDP2	physical	22989952
ATF3_HUMAN	ATF3	physical	22989952
TBA1A_HUMAN	TUBA1A	physical	19961433
TBB5_HUMAN	TUBB	physical	19961433
TBB5_RAT	Tubb5	physical	19961433
TBA1A_RAT	Tuba1a	physical	19961433
UBC_HUMAN	UBC	physical	15171253
TBB2A_HUMAN	TUBB2A	physical	19805354
IMA5_HUMAN	KPNA1	physical	22778253
ACINU_HUMAN	ACIN1	physical	23752268
DD19A_HUMAN	DDX19A	physical	23752268
BC11B_HUMAN	BCL11B	physical	23752268
CEP57_HUMAN	CEP57	physical	23752268
CPSF1_HUMAN	CPSF1	physical	23752268
BDH_HUMAN	BDH1	physical	23752268
DNJA1_HUMAN	DNAJA1	physical	23752268
HDAC6_HUMAN	HDAC6	physical	23752268
IQCB1_HUMAN	IQCB1	physical	23752268
KDM1A_HUMAN	KDM1A	physical	23752268
DIC_HUMAN	SLC25A10	physical	23752268
TIM50_HUMAN	TIMM50	physical	23752268
NUP50_HUMAN	NUP50	physical	23752268
PLAP_HUMAN	PLAA	physical	23752268
PUF60_HUMAN	PUF60	physical	23752268
DDX41_HUMAN	DDX41	physical	23752268
USP9X_HUMAN	USP9X	physical	23752268
PML_HUMAN	PML	physical	23752268
SC16A_HUMAN	SEC16A	physical	23752268
SRRM2_HUMAN	SRRM2	physical	23752268
SF3A1_HUMAN	SF3A1	physical	23752268
SMRC1_HUMAN	SMARCC1	physical	23752268
ETV6_HUMAN	ETV6	physical	23752268
UBP47_HUMAN	USP47	physical	23752268
UBP7_HUMAN	USP7	physical	23752268
ZMYM3_HUMAN	ZMYM3	physical	23752268
TRI27_HUMAN	TRIM27	physical	23752268
RD23B_HUMAN	RAD23B	physical	23703321
PYR1_HUMAN	CAD	physical	23703321
TBA1B_HUMAN	TUBA1B	physical	23703321
CNTLN_HUMAN	CNTLN	physical	23703321
CENPJ_HUMAN	CENPJ	physical	23703321
GBF1_HUMAN	GBF1	physical	23703321
NAV2_HUMAN	NAV2	physical	23703321
HDAC6_HUMAN	HDAC6	physical	23703321
XPO2_HUMAN	CSE1L	physical	23703321
MSH2_HUMAN	MSH2	physical	23703321
HSP74_HUMAN	HSPA4	physical	23703321
PSMD1_HUMAN	PSMD1	physical	23703321
NR1H4_HUMAN	NR1H4	physical	23703321
GANAB_HUMAN	GANAB	physical	23703321
HS90B_HUMAN	HSP90AB1	physical	23703321
PLAP_HUMAN	PLAA	physical	23703321
HS90A_HUMAN	HSP90AA1	physical	23703321
PFKAP_HUMAN	PFKP	physical	23703321
XRCC5_HUMAN	XRCC5	physical	23703321
PFKAL_HUMAN	PFKL	physical	23703321
ENPL_HUMAN	HSP90B1	physical	23703321
MCM7_HUMAN	MCM7	physical	23703321
DDX1_HUMAN	DDX1	physical	23703321
GRP78_HUMAN	HSPA5	physical	23703321
HSP7C_HUMAN	HSPA8	physical	23703321
HSP72_HUMAN	HSPA2	physical	23703321
HS71L_HUMAN	HSPA1L	physical	23703321
HSP76_HUMAN	HSPA6	physical	23703321
TCPE_HUMAN	CCT5	physical	23703321
KPYM_HUMAN	PKM	physical	23703321
TCPG_HUMAN	CCT3	physical	23703321
TCPA_HUMAN	TCP1	physical	23703321
TCPH_HUMAN	CCT7	physical	23703321
TBB5_HUMAN	TUBB	physical	23703321
TBA1C_HUMAN	TUBA1C	physical	23703321
TBB4B_HUMAN	TUBB4B	physical	23703321
TBB3_HUMAN	TUBB3	physical	23703321
TBB4A_HUMAN	TUBB4A	physical	23703321
TBA1A_HUMAN	TUBA1A	physical	23703321
PGK1_HUMAN	PGK1	physical	23703321
DNJA1_HUMAN	DNAJA1	physical	23703321
PRS8_HUMAN	PSMC5	physical	23703321
TADBP_HUMAN	TARDBP	physical	23703321
PELO_HUMAN	PELO	physical	23703321
PCNA_HUMAN	PCNA	physical	23703321
NEK3_HUMAN	NEK3	physical	23703321
RS6_HUMAN	RPS6	physical	23703321
KMT5A_HUMAN	SETD8	physical	23703321
ATM_HUMAN	ATM	physical	23703321
RPA2_HUMAN	POLR1B	physical	21988832
UBC_HUMAN	UBC	physical	24035499
SQSTM_HUMAN	SQSTM1	physical	24086678
TRI50_HUMAN	TRIM50	physical	24308962
ATX3_HUMAN	ATXN3	physical	24685680
RANB9_HUMAN	RANBP9	physical	24795145
MK03_HUMAN	MAPK3	physical	24089523
MK01_HUMAN	MAPK1	physical	24089523
ELAV1_HUMAN	ELAVL1	physical	18644987
DYHC1_HUMAN	DYNC1H1	physical	25342804
ACTB_HUMAN	ACTB	physical	25342804
MYH10_HUMAN	MYH10	physical	25342804
DDIT3_HUMAN	DDIT3	physical	17872950
ISG15_HUMAN	ISG15	physical	25429107
UBC_HUMAN	UBC	physical	25429107
RIPR2_HUMAN	FAM65B	physical	24687993
DYSF_HUMAN	DYSF	physical	24687993
CLIP1_HUMAN	CLIP1	physical	24474193
UBC_HUMAN	UBC	physical	25342804
KAT5_HUMAN	KAT5	physical	24302573
KHDR1_HUMAN	KHDRBS1	physical	26080397
KAD2_HUMAN	AK2	physical	26496610
ODBA_HUMAN	BCKDHA	physical	26496610
ODBB_HUMAN	BCKDHB	physical	26496610
CPT1A_HUMAN	CPT1A	physical	26496610
ODB2_HUMAN	DBT	physical	26496610
ODP2_HUMAN	DLAT	physical	26496610
DLDH_HUMAN	DLD	physical	26496610
ODO2_HUMAN	DLST	physical	26496610
DNJA1_HUMAN	DNAJA1	physical	26496610
ODO1_HUMAN	OGDH	physical	26496610
ODPA_HUMAN	PDHA1	physical	26496610
ODPB_HUMAN	PDHB	physical	26496610
IFRD2_HUMAN	IFRD2	physical	26496610
ODPX_HUMAN	PDHX	physical	26496610
TF3C5_HUMAN	GTF3C5	physical	26496610
PLAP_HUMAN	PLAA	physical	26496610
Z518A_HUMAN	ZNF518A	physical	26496610
IPO7_HUMAN	IPO7	physical	26496610
XPOT_HUMAN	XPOT	physical	26496610
GEMI5_HUMAN	GEMIN5	physical	26496610
ABT1_HUMAN	ABT1	physical	26496610
PKN3_HUMAN	PKN3	physical	26496610
T161A_HUMAN	TMEM161A	physical	26496610
ATD3A_HUMAN	ATAD3A	physical	26496610
VKOR1_HUMAN	VKORC1	physical	26496610
ZMYM1_HUMAN	ZMYM1	physical	26496610
UTP15_HUMAN	UTP15	physical	26496610
UTP4_HUMAN	CIRH1A	physical	26496610
RT36_HUMAN	MRPS36	physical	26496610
TBC16_HUMAN	TBC1D16	physical	26496610
GLOD5_HUMAN	GLOD5	physical	26496610
ABC3G_HUMAN	APOBEC3G	physical	26105074
VIF_HV1B1	vif	physical	26105074
VIF_HV1BR	vif	physical	26105074
VIF_HV1H2	vif	physical	26105074
XRCC6_HUMAN	XRCC6	physical	25299772
CEP70_HUMAN	CEP70	physical	26112604
1433Z_HUMAN	YWHAZ	physical	25770209
MA7D3_HUMAN	MAP7D3	physical	24614595
TF65_HUMAN	RELA	physical	26388610
KDM5C_HUMAN	KDM5C	genetic	28319113
IGF1R_HUMAN	IGF1R	genetic	28319113
PB1_HUMAN	PBRM1	genetic	28319113
PK3CA_HUMAN	PIK3CA	genetic	28319113
TBA1B_HUMAN	TUBA1B	physical	26382850
DDX58_HUMAN	DDX58	physical	26746851
MSH2_HUMAN	MSH2	physical	24882211
MSH3_HUMAN	MSH3	physical	24882211
MSH6_HUMAN	MSH6	physical	24882211
MLH1_HUMAN	MLH1	physical	24882211
MRE11_HUMAN	MRE11A	physical	24882211
RAD50_HUMAN	RAD50	physical	24882211
NBN_HUMAN	NBN	physical	24882211
HDAC6_HUMAN	HDAC6	physical	24882211
GDIR1_HUMAN	ARHGDIA	physical	26719334
RS15_HUMAN	RPS15	physical	26643866
RS15A_HUMAN	RPS15A	physical	26643866
RS17_HUMAN	RPS17	physical	26643866
RS18_HUMAN	RPS18	physical	26643866
RS3_HUMAN	RPS3	physical	26643866
RS5_HUMAN	RPS5	physical	26643866
RS7_HUMAN	RPS7	physical	26643866
RSSA_HUMAN	RPSA	physical	26643866
CH60_HUMAN	HSPD1	physical	26643866
RLA2_HUMAN	RPLP2	physical	26643866
RL21_HUMAN	RPL21	physical	26643866
RL3_HUMAN	RPL3	physical	26643866
ACTG_HUMAN	ACTG1	physical	26643866
ENOA_HUMAN	ENO1	physical	26643866
ATPA_HUMAN	ATP5A1	physical	26643866
ATPB_HUMAN	ATP5B	physical	26643866
DDX3X_HUMAN	DDX3X	physical	26643866
SERA_HUMAN	PHGDH	physical	26643866
RO52_HUMAN	TRIM21	physical	26643866
EF1A1_HUMAN	EEF1A1	physical	26643866
EF2_HUMAN	EEF2	physical	26643866
IF4A1_HUMAN	EIF4A1	physical	26643866
FAS_HUMAN	FASN	physical	26643866
FKB15_HUMAN	FKBP15	physical	26643866
G3P_HUMAN	GAPDH	physical	26643866
HSP7C_HUMAN	HSPA8	physical	26643866
HS90B_HUMAN	HSP90AB1	physical	26643866
HNRPK_HUMAN	HNRNPK	physical	26643866
HNRPR_HUMAN	HNRNPR	physical	26643866
HNRPU_HUMAN	HNRNPU	physical	26643866
HDAC6_HUMAN	HDAC6	physical	26643866
H2B1B_HUMAN	HIST1H2BB	physical	26643866
K1C18_HUMAN	KRT18	physical	26643866
ODB2_HUMAN	DBT	physical	26643866
BIN1_HUMAN	BIN1	physical	26643866
MYL6_HUMAN	MYL6	physical	26643866
MYH10_HUMAN	MYH10	physical	26643866
MYH9_HUMAN	MYH9	physical	26643866
NONO_HUMAN	NONO	physical	26643866
NUCL_HUMAN	NCL	physical	26643866
NPM_HUMAN	NPM1	physical	26643866
PAWR_HUMAN	PAWR	physical	26643866
PIMT_HUMAN	PCMT1	physical	26643866
KPYM_HUMAN	PKM	physical	26643866
FUS_HUMAN	FUS	physical	26643866
GRP75_HUMAN	HSPA9	physical	26643866
TCPE_HUMAN	CCT5	physical	26643866
TRRAP_HUMAN	TRRAP	physical	26643866
TBA1B_HUMAN	TUBA1B	physical	26643866
TBB5_HUMAN	TUBB	physical	26643866
TBB4B_HUMAN	TUBB4B	physical	26643866
STAT3_HUMAN	STAT3	physical	26775640
JAK2_HUMAN	JAK2	physical	26775640
PTN11_HUMAN	PTPN11	physical	26775640
PTPA_HUMAN	PPP2R4	physical	26775640

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
300863	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia (CDP-PBHM)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB02546	Vorinostat

Regulatory Network of HDAC6_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-30, AND MASSSPECTROMETRY.	17287340 [Abstract]