dbPTM

UBP7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBP7_HUMAN
UniProt AC	Q93009
Protein Name	Ubiquitin carboxyl-terminal hydrolase 7
Gene Name	USP7 {ECO:0000312\|HGNC:HGNC:12630}
Organism	Homo sapiens (Human).
Sequence Length	1102
Subcellular Localization	Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucl
Protein Description	Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. [PubMed: 11923872]
Protein Sequence	MNHQQQQQQQKAGEQQLSEPEDMEMEAGDTDDPPRITQNPVINGNVALSDGHNTAEEDMEDDTSWRSEATFQFTVERFSRLSESVLSPPCFVRNLPWKIMVMPRFYPDRPHQKSVGFFLQCNAESDSTSWSCHAQAVLKIINYRDDEKSFSRRISHLFFHKENDWGFSNFMAWSEVTDPEKGFIDDDKVTFEVFVQADAPHGVAWDSKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSVPLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAEFVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDNENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFREEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQEDELLECLSPATSRTFRIEEIPLDQVDIDKENEMLVTVAHFHKEVFGTFGIPFLLRIHQGEHFREVMKRIQSLLDIQEKEFEKFKFAIVMMGRHQYINEDEYEVNLKDFEPQPGNMSHPRPWLGLDHFNKAPKRSRYTYLEKAIKIHN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	KAGEQQLSEPEDMEM HHHHHHCCCHHHCCC	46.93	29255136
30	Phosphorylation	MEMEAGDTDDPPRIT CCCCCCCCCCCCCCC	41.19	23927012
37	Phosphorylation	TDDPPRITQNPVING CCCCCCCCCCCEECC	24.47	30576142
49	Phosphorylation	INGNVALSDGHNTAE ECCCEEECCCCCCCC	31.63	28348404
54	Phosphorylation	ALSDGHNTAEEDMED EECCCCCCCCHHCCC	29.76	28348404
63	Phosphorylation	EEDMEDDTSWRSEAT CHHCCCCCCCCCCEE	42.38	29978859
64	Phosphorylation	EDMEDDTSWRSEATF HHCCCCCCCCCCEEE	27.73	29978859
79	Phosphorylation	QFTVERFSRLSESVL EEEHHHHHHHCHHCC	38.23	28348404
82	Ubiquitination	VERFSRLSESVLSPP HHHHHHHCHHCCCCC	27.07	21890473
82	Phosphorylation	VERFSRLSESVLSPP HHHHHHHCHHCCCCC	27.07	24719451
84	Phosphorylation	RFSRLSESVLSPPCF HHHHHCHHCCCCCEE	25.61	28348404
98	Ubiquitination	FVRNLPWKIMVMPRF EECCCCEEEEEECCC	20.98	21906983
106	Phosphorylation	IMVMPRFYPDRPHQK EEEECCCCCCCCCCC	12.90	28152594
132	Ubiquitination	SDSTSWSCHAQAVLK CCCCCCEEEHHHHHH	2.22	21890473
143	Phosphorylation	AVLKIINYRDDEKSF HHHHHHCCCCCCCCH	12.66	28152594
148	Ubiquitination	INYRDDEKSFSRRIS HCCCCCCCCHHHHHH	64.89	21906983
149	Phosphorylation	NYRDDEKSFSRRISH CCCCCCCCHHHHHHH	26.80	23882029
151	Phosphorylation	RDDEKSFSRRISHLF CCCCCCHHHHHHHHH	27.95	17081983
155	Phosphorylation	KSFSRRISHLFFHKE CCHHHHHHHHHHCCC	16.60	23882029
209	Ubiquitination	GVAWDSKKHTGYVGL CEEECCCCCCCCCCC	50.80	-
211	Phosphorylation	AWDSKKHTGYVGLKN EECCCCCCCCCCCCC	38.80	28152594
213	Phosphorylation	DSKKHTGYVGLKNQG CCCCCCCCCCCCCCC	7.78	28152594
224	Ubiquitination	KNQGATCYMNSLLQT CCCCCCCHHHHHHHH	8.58	-
238	Ubiquitination	TLFFTNQLRKAVYMM HHHHHHHHHHEEEEC	7.04	21890473
240	Ubiquitination	FFTNQLRKAVYMMPT HHHHHHHHEEEECCC	51.28	-
254	Acetylation	TEGDDSSKSVPLALQ CCCCCCCCCHHHHHH	60.47	26051181
254	Ubiquitination	TEGDDSSKSVPLALQ CCCCCCCCCHHHHHH	60.47	21906983
256	Acetylation	GDDSSKSVPLALQRV CCCCCCCHHHHHHHH	5.31	-
256	Ubiquitination	GDDSSKSVPLALQRV CCCCCCCHHHHHHHH	5.31	-
272	Acetylation	YELQHSDKPVGTKKL HHHHCCCCCCCCCCH	44.62	23954790
272	Malonylation	YELQHSDKPVGTKKL HHHHCCCCCCCCCCH	44.62	26320211
272	Ubiquitination	YELQHSDKPVGTKKL HHHHCCCCCCCCCCH	44.62	-
277	2-Hydroxyisobutyrylation	SDKPVGTKKLTKSFG CCCCCCCCCHHHHHC	39.60	-
277	Acetylation	SDKPVGTKKLTKSFG CCCCCCCCCHHHHHC	39.60	25953088
281	Acetylation	VGTKKLTKSFGWETL CCCCCHHHHHCHHHH	54.98	26051181
296	Ubiquitination	DSFMQHDVQELCRVL HHHHHHCHHHHHHHH	4.46	-
310	2-Hydroxyisobutyrylation	LLDNVENKMKGTCVE HHHCCCHHCCCCCEE	28.60	-
310	Acetylation	LLDNVENKMKGTCVE HHHCCCHHCCCCCEE	28.60	25953088
312	Acetylation	DNVENKMKGTCVEGT HCCCHHCCCCCEECC	53.32	26051181
312	Ubiquitination	DNVENKMKGTCVEGT HCCCHHCCCCCEECC	53.32	-
319	Ubiquitination	KGTCVEGTIPKLFRG CCCCEECCHHHHHCC	22.17	-
322	Acetylation	CVEGTIPKLFRGKMV CEECCHHHHHCCCEE	57.30	25953088
322	Ubiquitination	CVEGTIPKLFRGKMV CEECCHHHHHCCCEE	57.30	-
327	2-Hydroxyisobutyrylation	IPKLFRGKMVSYIQC HHHHHCCCEEEEEEE	31.69	-
327	Acetylation	IPKLFRGKMVSYIQC HHHHHCCCEEEEEEE	31.69	25953088
327	Malonylation	IPKLFRGKMVSYIQC HHHHHCCCEEEEEEE	31.69	26320211
331	Phosphorylation	FRGKMVSYIQCKEVD HCCCEEEEEEEEECC	5.43	-
335	Ubiquitination	MVSYIQCKEVDYRSD EEEEEEEEECCCCCC	44.38	-
339	Ubiquitination	IQCKEVDYRSDRRED EEEEECCCCCCCCCC	19.72	21890473
355	Ubiquitination	YDIQLSIKGKKNIFE EEEEEEECCCCCHHH	62.39	21906983
357	Ubiquitination	IQLSIKGKKNIFESF EEEEECCCCCHHHHH	37.33	-
358	Acetylation	QLSIKGKKNIFESFV EEEECCCCCHHHHHC	65.04	26051181
358	Ubiquitination	QLSIKGKKNIFESFV EEEECCCCCHHHHHC	65.04	-
379	Phosphorylation	QLDGDNKYDAGEHGL ECCCCCCCCCCHHHH	19.78	-
391	2-Hydroxyisobutyrylation	HGLQEAEKGVKFLTL HHHHHHHHCCCEEEC	75.86	-
391	Ubiquitination	HGLQEAEKGVKFLTL HHHHHHHHCCCEEEC	75.86	-
404	Ubiquitination	TLPPVLHLQLMRFMY ECCCHHHHHHHHHHH	3.51	21890473
420	Ubiquitination	PQTDQNIKINDRFEF CCCCCCCEECCCCCC	42.90	21906983
423	Ubiquitination	DQNIKINDRFEFPEQ CCCCEECCCCCCCCC	61.18	21890473
424	Methylation	QNIKINDRFEFPEQL CCCEECCCCCCCCCC	28.62	115919673
439	Ubiquitination	PLDEFLQKTDPKDPA CHHHHHHHCCCCCHH	57.98	21906983
460	Ubiquitination	VLVHSGDNHGGHYVV EEEECCCCCCCEEEE	38.95	-
463	Ubiquitination	HSGDNHGGHYVVYLN ECCCCCCCEEEEEEC	11.03	21890473
474	Ubiquitination	VYLNPKGDGKWCKFD EEECCCCCCCCCCCC	62.72	-
476	Acetylation	LNPKGDGKWCKFDDD ECCCCCCCCCCCCHH	54.91	26051181
476	Ubiquitination	LNPKGDGKWCKFDDD ECCCCCCCCCCCCHH	54.91	-
479	Acetylation	KGDGKWCKFDDDVVS CCCCCCCCCCHHHHH	51.19	25953088
479	Ubiquitination	KGDGKWCKFDDDVVS CCCCCCCCCCHHHHH	51.19	21906983
490	Acetylation	DVVSRCTKEEAIEHN HHHHHCCHHHHHHHC	58.12	26051181
490	Ubiquitination	DVVSRCTKEEAIEHN HHHHHCCHHHHHHHC	58.12	-
507	Ubiquitination	GHDDDLSVRHCTNAY CCCCCCHHHHHCCEE	6.69	-
523	Ubiquitination	LVYIRESKLSEVLQA EEEEEHHHHHHHHHH	51.81	-
579	Ubiquitination	EDQFCGHQGNDMYDE CCCCCCCCCCCCCCH	37.35	-
595	Acetylation	KVKYTVFKVLKNSSL HHHHHHHHHHCCCCH	42.18	19608861
595	Ubiquitination	KVKYTVFKVLKNSSL HHHHHHHHHHCCCCH	42.18	19608861
665	Ubiquitination	WTIFLETVDPELAAS EEEEEEECCHHHHHC	9.37	-
672	Phosphorylation	VDPELAASGATLPKF CCHHHHHCCCCCCCC	24.29	21406692
675	Phosphorylation	ELAASGATLPKFDKD HHHHCCCCCCCCCCC	47.31	21406692
679	Ubiquitination	SGATLPKFDKDHDVM CCCCCCCCCCCCCEE	15.49	-
681	2-Hydroxyisobutyrylation	ATLPKFDKDHDVMLF CCCCCCCCCCCEEEE	61.16	-
681	Acetylation	ATLPKFDKDHDVMLF CCCCCCCCCCCEEEE	61.16	26051181
681	Ubiquitination	ATLPKFDKDHDVMLF CCCCCCCCCCCEEEE	61.16	-
695	Ubiquitination	FLKMYDPKTRSLNYC EEEECCCCCCCCCCC	54.39	-
696	Ubiquitination	LKMYDPKTRSLNYCG EEECCCCCCCCCCCC	30.77	-
701	Phosphorylation	PKTRSLNYCGHIYTP CCCCCCCCCCCEECC	12.71	28152594
706	Phosphorylation	LNYCGHIYTPISCKI CCCCCCEECCCCCCH	10.78	28152594
707	Phosphorylation	NYCGHIYTPISCKIR CCCCCEECCCCCCHH	17.34	28152594
710	Phosphorylation	GHIYTPISCKIRDLL CCEECCCCCCHHHHH	15.57	28152594
712	Ubiquitination	IYTPISCKIRDLLPV EECCCCCCHHHHHHH	33.70	-
730	Phosphorylation	RAGFIQDTSLILYEE CCCCCCCCCEEEEEE	14.73	27251275
731	Phosphorylation	AGFIQDTSLILYEEV CCCCCCCCEEEEEEC	23.00	28348404
735	Phosphorylation	QDTSLILYEEVKPNL CCCCEEEEEECCCCH	11.75	27273156
739	Sumoylation	LILYEEVKPNLTERI EEEEEECCCCHHHHH	31.31	-
743	Phosphorylation	EEVKPNLTERIQDYD EECCCCHHHHHHHCC	29.83	-
749	Phosphorylation	LTERIQDYDVSLDKA HHHHHHHCCCCHHHH	11.23	27642862
752	Phosphorylation	RIQDYDVSLDKALDE HHHHCCCCHHHHHHH	28.14	20873877
755	Ubiquitination	DYDVSLDKALDELMD HCCCCHHHHHHHHCC	57.02	-
761	Sulfoxidation	DKALDELMDGDIIVF HHHHHHHCCCCEEEE	5.21	21406390
770	Ubiquitination	GDIIVFQKDDPENDN CCEEEEECCCCCCCC	53.27	-
782	Phosphorylation	NDNSELPTAKEYFRD CCCCCCCCHHHHHHH	64.09	24719451
784	Ubiquitination	NSELPTAKEYFRDLY CCCCCCHHHHHHHHH	56.26	-
791	Phosphorylation	KEYFRDLYHRVDVIF HHHHHHHHHHCCEEE	7.59	28152594
801	Acetylation	VDVIFCDKTIPNDPG CCEEEECCCCCCCCC	49.92	26051181
802	O-linked_Glycosylation	DVIFCDKTIPNDPGF CEEEECCCCCCCCCE	28.54	23301498
808	Ubiquitination	KTIPNDPGFVVTLSN CCCCCCCCEEEEECC	30.74	21890473
824	Acetylation	MNYFQVAKTVAQRLN CCHHHHHHHHHHHHC	44.68	25953088
824	Ubiquitination	MNYFQVAKTVAQRLN CCHHHHHHHHHHHHC	44.68	21906983
825	Ubiquitination	NYFQVAKTVAQRLNT CHHHHHHHHHHHHCC	16.01	21890473
832	Phosphorylation	TVAQRLNTDPMLLQF HHHHHHCCCHHHHHH	46.18	27174698
835	Sulfoxidation	QRLNTDPMLLQFFKS HHHCCCHHHHHHHHH	6.94	21406390
841	Acetylation	PMLLQFFKSQGYRDG HHHHHHHHHCCCCCC	43.06	25953088
841	Methylation	PMLLQFFKSQGYRDG HHHHHHHHHCCCCCC	43.06	66726983
841	Ubiquitination	PMLLQFFKSQGYRDG HHHHHHHHHCCCCCC	43.06	21906983
842	Phosphorylation	MLLQFFKSQGYRDGP HHHHHHHHCCCCCCC	24.55	27174698
845	Phosphorylation	QFFKSQGYRDGPGNP HHHHHCCCCCCCCCC	9.63	28152594
853	Acetylation	RDGPGNPLRHNYEGT CCCCCCCCCCCCCCH	11.45	-
853	Ubiquitination	RDGPGNPLRHNYEGT CCCCCCCCCCCCCCH	11.45	21890473
859	Ubiquitination	PLRHNYEGTLRDLLQ CCCCCCCCHHHHHHH	21.49	-
866	Ubiquitination	GTLRDLLQFFKPRQP CHHHHHHHHHCCCCC	49.37	21890473
869	Acetylation	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	19608861
869	Sumoylation	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	28112733
869	Ubiquitination	RDLLQFFKPRQPKKL HHHHHHHCCCCCCCH	40.35	21906983
875	Ubiquitination	FKPRQPKKLYYQQLK HCCCCCCCHHHHHHH	48.70	21906983
877	Phosphorylation	PRQPKKLYYQQLKMK CCCCCCHHHHHHHHH	14.22	30576142
878	Phosphorylation	RQPKKLYYQQLKMKI CCCCCHHHHHHHHHC	10.54	30576142
882	Sumoylation	KLYYQQLKMKITDFE CHHHHHHHHHCCCCC	33.53	28112733
882	Ubiquitination	KLYYQQLKMKITDFE CHHHHHHHHHCCCCC	33.53	21906983
884	Ubiquitination	YYQQLKMKITDFENR HHHHHHHHCCCCCCC	40.65	-
886	Phosphorylation	QQLKMKITDFENRRS HHHHHHCCCCCCCCC	29.17	30576142
891	Methylation	KITDFENRRSFKCIW HCCCCCCCCCEEEEE	28.55	115919677
893	Phosphorylation	TDFENRRSFKCIWLN CCCCCCCCEEEEEEC	26.31	27067055
895	Acetylation	FENRRSFKCIWLNSQ CCCCCCEEEEEECCC	26.51	26051181
898	Acetylation	RRSFKCIWLNSQFRE CCCEEEEEECCCCCC	10.04	-
898	Ubiquitination	RRSFKCIWLNSQFRE CCCEEEEEECCCCCC	10.04	-
910	Ubiquitination	FREEEITLYPDKHGC CCCEEECCCCCCCCH	7.79	-
911	Ubiquitination	REEEITLYPDKHGCV CCEEECCCCCCCCHH	10.75	-
914	2-Hydroxyisobutyrylation	EITLYPDKHGCVRDL EECCCCCCCCHHHHH	37.08	-
914	Acetylation	EITLYPDKHGCVRDL EECCCCCCCCHHHHH	37.08	23749302
914	Ubiquitination	EITLYPDKHGCVRDL EECCCCCCCCHHHHH	37.08	-
918	Acetylation	YPDKHGCVRDLLEEC CCCCCCHHHHHHHHH	6.72	-
918	Ubiquitination	YPDKHGCVRDLLEEC CCCCCCHHHHHHHHH	6.72	-
926	Acetylation	RDLLEECKKAVELGE HHHHHHHHHHHHHHH	47.23	26051181
926	Ubiquitination	RDLLEECKKAVELGE HHHHHHHHHHHHHHH	47.23	-
927	Ubiquitination	DLLEECKKAVELGEK HHHHHHHHHHHHHHH	70.13	-
934	Acetylation	KAVELGEKASGKLRL HHHHHHHHHCCCCHH	46.16	23749302
934	Ubiquitination	KAVELGEKASGKLRL HHHHHHHHHCCCCHH	46.16	21906983
946	Phosphorylation	LRLLEIVSYKIIGVH CHHHHHEEEEEEEEC	26.77	20860994
963	Phosphorylation	DELLECLSPATSRTF HHHHHHCCCCCCCEE	24.93	30266825
966	Phosphorylation	LECLSPATSRTFRIE HHHCCCCCCCEEEEE	23.33	30266825
967	Phosphorylation	ECLSPATSRTFRIEE HHCCCCCCCEEEEEE	31.28	30266825
1017	Ubiquitination	RIHQGEHFREVMKRI EHHCCHHHHHHHHHH	6.57	21890473
1023	Ubiquitination	HFREVMKRIQSLLDI HHHHHHHHHHHHHHH	17.68	-
1026	Phosphorylation	EVMKRIQSLLDIQEK HHHHHHHHHHHHCHH	28.64	27050516
1033	Acetylation	SLLDIQEKEFEKFKF HHHHHCHHHHHHHHE	51.86	25953088
1033	Ubiquitination	SLLDIQEKEFEKFKF HHHHHCHHHHHHHHE	51.86	21906983
1037	Acetylation	IQEKEFEKFKFAIVM HCHHHHHHHHEEEEE	60.21	25953088
1039	Ubiquitination	EKEFEKFKFAIVMMG HHHHHHHHEEEEECC	44.98	-
1050	Phosphorylation	VMMGRHQYINEDEYE EECCCCCCCCCCCEE	10.29	-
1056	Phosphorylation	QYINEDEYEVNLKDF CCCCCCCEEEECCCC	37.18	-
1068	Acetylation	KDFEPQPGNMSHPRP CCCCCCCCCCCCCCC	36.91	-
1080	Ubiquitination	PRPWLGLDHFNKAPK CCCCCCCCCCCCCCC	42.40	21890473
1084	Acetylation	LGLDHFNKAPKRSRY CCCCCCCCCCCCHHH	66.19	19608861
1084	Malonylation	LGLDHFNKAPKRSRY CCCCCCCCCCCCHHH	66.19	26320211
1084	Ubiquitination	LGLDHFNKAPKRSRY CCCCCCCCCCCCHHH	66.19	19608861
1089	Phosphorylation	FNKAPKRSRYTYLEK CCCCCCCHHHHHHHH	35.45	24719451
1091	Phosphorylation	KAPKRSRYTYLEKAI CCCCCHHHHHHHHHH	10.86	23312004
1092	Phosphorylation	APKRSRYTYLEKAIK CCCCHHHHHHHHHHH	22.11	23312004
1093	Phosphorylation	PKRSRYTYLEKAIKI CCCHHHHHHHHHHHC	12.15	23312004
1096	Acetylation	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	19608861
1096	Ubiquitination	SRYTYLEKAIKIHN- HHHHHHHHHHHCCC-	53.46	21906983

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
18	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	ICP0	P08393	PMID:32416261

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
18	S	Phosphorylation	17651432
Isoform 1 is phosphorylated at positions Ser-18 and Ser-963.
869	K	ubiquitylation	17651432
Isoform 1: Ubiquitinated at Lys-869.
963	S	Phosphorylation	17651432
Isoform 1 is phosphorylated at positions Ser-18 and Ser-963.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBP7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P53_HUMAN	TP53	physical	11923872
TRAF1_HUMAN	TRAF1	physical	11279055
TRAF2_HUMAN	TRAF2	physical	11279055
TRAF3_HUMAN	TRAF3	physical	11279055
TRAF4_HUMAN	TRAF4	physical	11279055
TRAF5_HUMAN	TRAF5	physical	11279055
TRAF6_HUMAN	TRAF6	physical	11279055
CLSPN_HUMAN	CLSPN	physical	19124652
MDM2_HUMAN	MDM2	physical	17936559
PDC6I_HUMAN	PDCD6IP	physical	17927229
GUAA_HUMAN	GMPS	physical	15749019
H2B3B_HUMAN	HIST3H2BB	physical	15749019
P53_HUMAN	TP53	physical	17525743
CRKL_HUMAN	CRKL	physical	19615732
DNMT1_HUMAN	DNMT1	physical	19615732
IF4B_HUMAN	EIF4B	physical	19615732
GTF2I_HUMAN	GTF2I	physical	19615732
MCM4_HUMAN	MCM4	physical	19615732
MCM5_HUMAN	MCM5	physical	19615732
MCM6_HUMAN	MCM6	physical	19615732
NUP98_HUMAN	NUP98	physical	19615732
PPM1G_HUMAN	PPM1G	physical	19615732
HLTF_HUMAN	HLTF	physical	19615732
SRP68_HUMAN	SRP68	physical	19615732
ZN207_HUMAN	ZNF207	physical	19615732
CCDC6_HUMAN	CCDC6	physical	19615732
AKAP1_HUMAN	AKAP1	physical	19615732
RAE1L_HUMAN	RAE1	physical	19615732
GUAA_HUMAN	GMPS	physical	19615732
UBP14_HUMAN	USP14	physical	19615732
BUB3_HUMAN	BUB3	physical	19615732
TRIPC_HUMAN	TRIP12	physical	19615732
BABA2_HUMAN	BRE	physical	19615732
HUWE1_HUMAN	HUWE1	physical	19615732
SCML2_HUMAN	SCML2	physical	19615732
UBP19_HUMAN	USP19	physical	19615732
KIF3A_HUMAN	KIF3A	physical	19615732
ABRX2_HUMAN	FAM175B	physical	19615732
DCAF4_HUMAN	DCAF4	physical	19615732
BABA1_HUMAN	BABAM1	physical	19615732
RN220_HUMAN	RNF220	physical	19615732
YLPM1_HUMAN	YLPM1	physical	19615732
BRCC3_HUMAN	BRCC3	physical	19615732
MCMBP_HUMAN	MCMBP	physical	19615732
FBX38_HUMAN	FBXO38	physical	19615732
PPIL4_HUMAN	PPIL4	physical	19615732
DOCK7_HUMAN	DOCK7	physical	19615732
CHFR_HUMAN	CHFR	physical	17442268
UBP11_HUMAN	USP11	physical	19615732
P53_HUMAN	TP53	physical	17380154
MDM2_HUMAN	MDM2	physical	16943424
P53_HUMAN	TP53	physical	16402859
MDM2_HUMAN	MDM2	physical	16402859
PCGF2_HUMAN	PCGF2	physical	20601937
BMI1_HUMAN	BMI1	physical	20601937
RING1_HUMAN	RING1	physical	20601937
RING2_HUMAN	RNF2	physical	20601937
CBX8_HUMAN	CBX8	physical	20601937
UBP11_HUMAN	USP11	physical	20601937
RING2_HUMAN	RNF2	physical	20800574
RING1_HUMAN	RING1	physical	20800574
BMI1_HUMAN	BMI1	physical	20800574
EZH2_HUMAN	EZH2	physical	20800574
SUZ12_HUMAN	SUZ12	physical	20800574
EED_HUMAN	EED	physical	20800574
GUAA_HUMAN	GMPS	physical	19834552
MDM4_HUMAN	MDM4	physical	20713061
UHRF1_HUMAN	UHRF1	physical	21745816
DNMT1_HUMAN	DNMT1	physical	21745816
DNMT1_HUMAN	DNMT1	physical	21268065
UHRF1_HUMAN	UHRF1	physical	21268065
FOXN2_HUMAN	FOXN2	physical	21845734
P53_HUMAN	TP53	physical	21845734
CHK1_HUMAN	CHEK1	physical	21845734
DAXX_HUMAN	DAXX	physical	16845383
MDM2_HUMAN	MDM2	physical	16845383
P53_HUMAN	TP53	physical	16845383
DNMT1_HUMAN	DNMT1	physical	21045206
UBC_HUMAN	UBC	physical	20622874
UBE2S_HUMAN	UBE2S	physical	20622874
TRAF6_HUMAN	TRAF6	physical	20622874
UBP7_HUMAN	USP7	physical	16111684
UVSSA_HUMAN	UVSSA	physical	22466611
UHRF1_HUMAN	UHRF1	physical	22411829
P53_HUMAN	TP53	physical	14506283
P53_HUMAN	TP53	physical	16474402
MDM2_HUMAN	MDM2	physical	16474402
EBNA1_EBVB9	BKRF1	physical	16474402
ORF73_HHV8P	HHV8GK18_gp81	physical	22514345
UBC_HUMAN	UBC	physical	22195557
PSA5_HUMAN	PSMA5	physical	19193609
PSA3_HUMAN	PSMA3	physical	19193609
PSB6_HUMAN	PSMB6	physical	19193609
PSB5_HUMAN	PSMB5	physical	19193609
PSB8_HUMAN	PSMB8	physical	19193609
PSB4_HUMAN	PSMB4	physical	19193609
PML_HUMAN	PML	physical	20719947
PML_HUMAN	PML	physical	21305000
TBCB_HUMAN	TBCB	physical	16713569
TRI22_HUMAN	TRIM22	physical	16713569
WWP2_HUMAN	WWP2	physical	16713569
ACD_HUMAN	ACD	physical	16713569
ARNT2_HUMAN	ARNT2	physical	16713569
PKHO1_HUMAN	PLEKHO1	physical	16713569
CR3L3_HUMAN	CREB3L3	physical	16713569
DNJA3_HUMAN	DNAJA3	physical	16713569
EWS_HUMAN	EWSR1	physical	16713569
RADIL_HUMAN	RADIL	physical	16713569
RN220_HUMAN	RNF220	physical	16713569
BEND5_HUMAN	BEND5	physical	16713569
HECW1_HUMAN	HECW1	physical	16713569
HERP1_HUMAN	HERPUD1	physical	16713569
KLHL8_HUMAN	KLHL8	physical	16713569
MAGE1_HUMAN	MAGEE1	physical	16713569
MARH7_HUMAN	MARCH7	physical	16713569
PEG3_HUMAN	PEG3	physical	16713569
PICK1_HUMAN	PICK1	physical	16713569
PKCB1_HUMAN	ZMYND8	physical	16713569
HTRA2_HUMAN	HTRA2	physical	16713569
SYVN1_HUMAN	SYVN1	physical	16713569
LAP2A_HUMAN	TMPO	physical	16713569
LAP2B_HUMAN	TMPO	physical	16713569
TROP_HUMAN	TRO	physical	16713569
ZN423_HUMAN	ZNF423	physical	16713569
BCOR_HUMAN	BCOR	physical	16713569
NECA2_HUMAN	NECAB2	physical	16713569
PEPL_HUMAN	PPL	physical	16713569
UCRI_HUMAN	UQCRFS1	physical	22939629
VAMP2_HUMAN	VAMP2	physical	22939629
XPOT_HUMAN	XPOT	physical	22939629
ZCHC8_HUMAN	ZCCHC8	physical	22939629
WDR74_HUMAN	WDR74	physical	22939629
XRCC4_HUMAN	XRCC4	physical	22939629
VPS53_HUMAN	VPS53	physical	22939629
TF65_HUMAN	RELA	physical	23267096
RARA_HUMAN	RARA	physical	23208507
TRI27_HUMAN	TRIM27	physical	23105109
HOIL1_HUMAN	RBCK1	physical	23105109
TRI31_HUMAN	TRIM31	physical	23105109
MARH7_HUMAN	MARCH7	physical	23105109
TRIM8_HUMAN	TRIM8	physical	23105109
UHRF2_HUMAN	UHRF2	physical	23105109
UBC_HUMAN	UBC	physical	23287719
DAXX_HUMAN	DAXX	physical	23348568
TRAF4_HUMAN	TRAF4	physical	23388826
P53_HUMAN	TP53	physical	23388826
DAXX_HUMAN	DAXX	physical	23536002
UB2E1_HUMAN	UBE2E1	physical	23603909
KAT5_HUMAN	KAT5	physical	23775119
PPARG_HUMAN	PPARG	physical	24072712
MCMBP_HUMAN	MCMBP	physical	24190967
CDC37_HUMAN	CDC37	physical	22863883
CSN6_HUMAN	COPS6	physical	22863883
FKBP5_HUMAN	FKBP5	physical	22863883
MAGD2_HUMAN	MAGED2	physical	22863883
MMS19_HUMAN	MMS19	physical	22863883
PPP6_HUMAN	PPP6C	physical	22863883
PP6R3_HUMAN	PPP6R3	physical	22863883
TRAP1_HUMAN	TRAP1	physical	22863883
ABL1_HUMAN	ABL1	physical	24317448
PTEN_HUMAN	PTEN	physical	24270891
RB_HUMAN	RB1	physical	24823443
XPC_HUMAN	XPC	physical	25118285
PEPD_HUMAN	PEPD	physical	18330356
TPP1_HUMAN	TPP1	physical	25172512
HUWE1_HUMAN	HUWE1	physical	25147182
ABRX2_HUMAN	FAM175B	physical	25283148
RN220_HUMAN	RNF220	physical	25266658
PA2GA_HUMAN	PLA2G2A	physical	22118674
ZEB1_HUMAN	ZEB1	physical	25086746
CHK1_HUMAN	CHEK1	physical	25086746
SVIL_HUMAN	SVIL	physical	23382381
ING1_HUMAN	ING1	physical	21731648
RL40_HUMAN	UBA52	physical	14506283
UBC_HUMAN	UBC	physical	14506283
TRRAP_HUMAN	TRRAP	physical	25925205
SYDC_HUMAN	DARS	physical	25925205
CE112_HUMAN	CEP112	physical	25925205
SF3B3_HUMAN	SF3B3	physical	25925205
TM87A_HUMAN	TMEM87A	physical	25925205
LMNA_HUMAN	LMNA	physical	25925205
GIN1_HUMAN	GIN1	physical	25925205
MYNN_HUMAN	MYNN	physical	25925205
CWC22_HUMAN	CWC22	physical	25925205
TNIP2_HUMAN	TNIP2	physical	25925205
ZFP2_HUMAN	ZFP2	physical	25925205
ZN394_HUMAN	ZNF394	physical	25925205
ZN594_HUMAN	ZNF594	physical	25925205
FBF1_HUMAN	FBF1	physical	25925205
ZC11A_HUMAN	ZC3H11A	physical	25925205
MTCH1_HUMAN	MTCH1	physical	25925205
CA2D1_HUMAN	CACNA2D1	physical	25925205
DDX4_HUMAN	DDX4	physical	25925205
PIPNB_HUMAN	PITPNB	physical	25925205
SP110_HUMAN	SP110	physical	25925205
DICER_HUMAN	DICER1	physical	25925205
FA7_HUMAN	F7	physical	25925205
KLC1_HUMAN	KLC1	physical	25925205
GOGB1_HUMAN	GOLGB1	physical	25925205
K2C1_HUMAN	KRT1	physical	25925205
UTRO_HUMAN	UTRN	physical	25925205
MYO3A_HUMAN	MYO3A	physical	25925205
MYH9_HUMAN	MYH9	physical	25925205
MACF1_HUMAN	MACF1	physical	25925205
DREB_HUMAN	DBN1	physical	25925205
DYHC1_HUMAN	DYNC1H1	physical	25925205
ZN169_HUMAN	ZNF169	physical	25925205
POLH_HUMAN	POLH	physical	25435364
HNRPF_HUMAN	HNRNPF	physical	26344197
SMD1_HUMAN	SNRPD1	physical	26344197
SCML2_HUMAN	SCML2	physical	25605328
RING2_HUMAN	RNF2	physical	25605328
BMI1_HUMAN	BMI1	physical	25605328
H2A2C_HUMAN	HIST2H2AC	physical	25605328
H2B2E_HUMAN	HIST2H2BE	physical	25605328
BCL6_HUMAN	BCL6	physical	26496610
BLMH_HUMAN	BLMH	physical	26496610
DNMT1_HUMAN	DNMT1	physical	26496610
ETV6_HUMAN	ETV6	physical	26496610
PML_HUMAN	PML	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
RING1_HUMAN	RING1	physical	26496610
STIL_HUMAN	STIL	physical	26496610
TCF20_HUMAN	TCF20	physical	26496610
TMF1_HUMAN	TMF1	physical	26496610
LAP2A_HUMAN	TMPO	physical	26496610
LAP2B_HUMAN	TMPO	physical	26496610
PKP4_HUMAN	PKP4	physical	26496610
YBOX3_HUMAN	YBX3	physical	26496610
GUAA_HUMAN	GMPS	physical	26496610
KIF23_HUMAN	KIF23	physical	26496610
WDR1_HUMAN	WDR1	physical	26496610
SCML2_HUMAN	SCML2	physical	26496610
FAKD2_HUMAN	FASTKD2	physical	26496610
ZN609_HUMAN	ZNF609	physical	26496610
UHRF1_HUMAN	UHRF1	physical	26496610
VATD_HUMAN	ATP6V1D	physical	26496610
BCOR_HUMAN	BCOR	physical	26496610
BCORL_HUMAN	BCORL1	physical	26496610
DHX40_HUMAN	DHX40	physical	26496610
TCAL4_HUMAN	TCEAL4	physical	26496610
FBX38_HUMAN	FBXO38	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
PCGF1_HUMAN	PCGF1	physical	26496610
PPIL4_HUMAN	PPIL4	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
K2013_HUMAN	KIAA2013	physical	26496610
RN169_HUMAN	RNF169	physical	26496610
ANDR_HUMAN	AR	physical	26175158
CI_DROME	ci	physical	26120032
GLI1_HUMAN	GLI1	physical	26120032
GLI2_HUMAN	GLI2	physical	26120032
GLI3_HUMAN	GLI3	physical	26120032
H2A2C_HUMAN	HIST2H2AC	physical	26507658
NUCL_HUMAN	NCL	physical	25695607
KPYM_HUMAN	PKM	physical	25695607
PP2AA_HUMAN	PPP2CA	physical	25695607
ANXA1_HUMAN	ANXA1	physical	25695607
RAD18_HUMAN	RAD18	physical	25961918
CRY1_HUMAN	CRY1	physical	25756610
VIRF1_HHV8P	vIRF-1	physical	26786098
OTUD4_HUMAN	OTUD4	physical	25944111
PTEN_HUMAN	PTEN	physical	26280536
RN168_HUMAN	RNF168	physical	25894431
UHRF1_HUMAN	UHRF1	physical	26299963
UB2D3_HUMAN	UBE2D3	physical	26299963
TFP11_HUMAN	TFIP11	physical	26460617
P53_HUMAN	TP53	physical	26460617
MDM2_HUMAN	MDM2	physical	26460617
KAT5_HUMAN	KAT5	physical	25865756
KMT2E_HUMAN	KMT2E	physical	26678539
OGT1_HUMAN	OGT	physical	26678539
GUAA_HUMAN	GMPS	physical	26046769
UHRF1_HUMAN	UHRF1	physical	26046769
NUCL_HUMAN	NCL	physical	26238070
P53_HUMAN	TP53	physical	26238070
MDM2_HUMAN	MDM2	physical	26238070
MCM4_HUMAN	MCM4	physical	26950370
SUMO2_HUMAN	SUMO2	physical	26950370
DNMT1_HUMAN	DNMT1	physical	25960197
GUAA_HUMAN	GMPS	physical	24462112
MDM2_HUMAN	MDM2	physical	24462112
P53_HUMAN	TP53	physical	24462112
UVSSA_HUMAN	UVSSA	physical	27129218
SYUA_HUMAN	SNCA	physical	27444016
MYC_HUMAN	MYC	physical	27618649
TRIPC_HUMAN	TRIP12	physical	27800609
UBB_HUMAN	UBB	physical	27452404
UBP7_HUMAN	USP7	physical	27452404
PHF8_HUMAN	PHF8	physical	27183383
MARH7_HUMAN	MARCH7	physical	27302477
MDM2_HUMAN	MDM2	physical	28196907
CHK1_HUMAN	CHEK1	physical	25483066
CTNB1_HUMAN	CTNNB1	physical	29045831
ZEB1_HUMAN	ZEB1	physical	29119051
SUV91_HUMAN	SUV39H1	physical	26971997
MDM2_HUMAN	MDM2	physical	26971997
INAR1_HUMAN	IFNAR1	physical	28656291
SIR7_HUMAN	SIRT7	physical	28655758
RN169_HUMAN	RNF169	physical	28325877

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBP7_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-595; LYS-869; LYS-1084 ANDLYS-1096, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-49 AND THR-54,AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18 AND SER-963, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Biochemical characterization of USP7 reveals post-translationalmodification sites and structural requirements for substrateprocessing and subcellular localization."; Fernandez-Montalvan A., Bouwmeester T., Joberty G., Mader R.,Mahnke M., Pierrat B., Schlaeppi J.M., Worpenberg S., Gerhartz B.; FEBS J. 274:4256-4270(2007). Cited for: SUBUNIT, PHOSPHORYLATION AT SER-18 AND SER-963, UBIQUITINATION ATLYS-869, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.	17651432 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18, AND MASSSPECTROMETRY.	15302935 [Abstract]
Ubiquitylation
Reference	PubMed
"Biochemical characterization of USP7 reveals post-translationalmodification sites and structural requirements for substrateprocessing and subcellular localization."; Fernandez-Montalvan A., Bouwmeester T., Joberty G., Mader R.,Mahnke M., Pierrat B., Schlaeppi J.M., Worpenberg S., Gerhartz B.; FEBS J. 274:4256-4270(2007). Cited for: SUBUNIT, PHOSPHORYLATION AT SER-18 AND SER-963, UBIQUITINATION ATLYS-869, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.	17651432 [Abstract]

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