DOCK7_HUMAN - dbPTM
DOCK7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DOCK7_HUMAN
UniProt AC Q96N67
Protein Name Dedicator of cytokinesis protein 7
Gene Name DOCK7
Organism Homo sapiens (Human).
Sequence Length 2140
Subcellular Localization Cell projection, axon . Enriched in the developing axons of hippocampal neurons.
Protein Description Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. [PubMed: 16982419 Has a role in pigmentation (By similarity Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity]
Protein Sequence MAERRAFAQKISRTVAAEVRKQISGQYSGSPQLLKNLNIVGNISHHTTVPLTEAVDPVDLEDYLITHPLAVDSGPLRDLIEFPPDDIEVVYSPRDCRTLVSAVPEESEMDPHVRDCIRSYTEDWAIVIRKYHKLGTGFNPNTLDKQKERQKGLPKQVFESDEAPDGNSYQDDQDDLKRRSMSIDDTPRGSWACSIFDLKNSLPDALLPNLLDRTPNEEIDRQNDDQRKSNRHKELFALHPSPDEEEPIERLSVPDIPKEHFGQRLLVKCLSLKFEIEIEPIFASLALYDVKEKKKISENFYFDLNSEQMKGLLRPHVPPAAITTLARSAIFSITYPSQDVFLVIKLEKVLQQGDIGECAEPYMIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEVEISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRLSDEDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVRPTREILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVIFGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTPLETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNVEVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQLEPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRNSLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNPDISGTPTSPDDEVRSIIGSKGLDRSNSWVNTGGPKAAPWGSNPSPSAESTQAMDRSCNRMSSHTETSSFLQTLTGRLPTKKLFHEELALQWVVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLEAPRKSRFPERFMDDIAALVSTIASDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSVLVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIANMFELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQIKARVAMLYLPLIGIIMETVPQLYDFTETHNQRGRPICIATDDYESESGSMISQTVAMAIAGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLSVLQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRRSRGQLGTYTIASPPERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDGNLATEANLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRALVSKFPELLFEEETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARVKMQVTMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMILSDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVHSAALVAEYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESGLVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQSTGWERMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVIKDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRAHGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQDPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCEDALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRMSLRKMDL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationAEVRKQISGQYSGSP
HHHHHHHCCCCCCCH		19.8321945579
27PhosphorylationRKQISGQYSGSPQLL
HHHHCCCCCCCHHHH		20.6521945579
28PhosphorylationKQISGQYSGSPQLLK
HHHCCCCCCCHHHHH		25.5521945579
28 (in isoform 2)Phosphorylation-25.5518669648
30PhosphorylationISGQYSGSPQLLKNL
HCCCCCCCHHHHHHC		11.9729255136
30 (in isoform 2)Phosphorylation-11.9718669648
133UbiquitinationIVIRKYHKLGTGFNP
HHHHHHHHCCCCCCC		45.5929967540
136PhosphorylationRKYHKLGTGFNPNTL
HHHHHCCCCCCCCHH		49.3830266825
142PhosphorylationGTGFNPNTLDKQKER
CCCCCCCHHHHHHHH		37.2830266825
155UbiquitinationERQKGLPKQVFESDE
HHHCCCCHHHHCCCC		65.2229967540
160PhosphorylationLPKQVFESDEAPDGN
CCHHHHCCCCCCCCC		29.3229978859
168PhosphorylationDEAPDGNSYQDDQDD
CCCCCCCCCCCCHHH		29.6929978859
169PhosphorylationEAPDGNSYQDDQDDL
CCCCCCCCCCCHHHH		21.6929978859
177UbiquitinationQDDQDDLKRRSMSID
CCCHHHHHHHCCCCC		53.4021906983
177 (in isoform 1)Ubiquitination-53.4021906983
177 (in isoform 2)Ubiquitination-53.4021906983
177 (in isoform 3)Ubiquitination-53.4021906983
177 (in isoform 4)Ubiquitination-53.4021906983
177 (in isoform 5)Ubiquitination-53.4021906983
177 (in isoform 6)Ubiquitination-53.4021906983
177UbiquitinationQDDQDDLKRRSMSID
CCCHHHHHHHCCCCC		53.40-
180PhosphorylationQDDLKRRSMSIDDTP
HHHHHHHCCCCCCCC		22.4019664994
180 (in isoform 2)Phosphorylation-22.4018669648
182PhosphorylationDLKRRSMSIDDTPRG
HHHHHCCCCCCCCCC		24.9029255136
182 (in isoform 2)Phosphorylation-24.9018669648
186PhosphorylationRSMSIDDTPRGSWAC
HCCCCCCCCCCCCCC		15.9030266825
190O-linked_GlycosylationIDDTPRGSWACSIFD
CCCCCCCCCCCHHHH		16.8730379171
190PhosphorylationIDDTPRGSWACSIFD
CCCCCCCCCCCHHHH		16.8722617229
193GlutathionylationTPRGSWACSIFDLKN
CCCCCCCCHHHHCCC		2.3222555962
194PhosphorylationPRGSWACSIFDLKNS
CCCCCCCHHHHCCCC		20.6727050516
199UbiquitinationACSIFDLKNSLPDAL
CCHHHHCCCCCCCCC		46.4632015554
214PhosphorylationLPNLLDRTPNEEIDR
CHHHHCCCCCHHHHC		30.0821815630
233UbiquitinationQRKSNRHKELFALHP
HHHHHHHHHHEEECC		53.53-
233 (in isoform 5)Ubiquitination-53.53-
258UbiquitinationLSVPDIPKEHFGQRL
CCCCCCCHHHHHHHH		65.2429967540
358GlutathionylationQQGDIGECAEPYMIF
HCCCCCCCCCCEEEE		4.3622555962
362PhosphorylationIGECAEPYMIFKEAD
CCCCCCCEEEEECCC		8.3728796482
366UbiquitinationAEPYMIFKEADATKN
CCCEEEEECCCCCCC		40.8629967540
366 (in isoform 5)Ubiquitination-40.86-
371PhosphorylationIFKEADATKNKEKLE
EEECCCCCCCHHHHH		35.3828270605
381MethylationKEKLEKLKSQADQFC
HHHHHHHHHHHHHHH		52.1424129315
381UbiquitinationKEKLEKLKSQADQFC
HHHHHHHHHHHHHHH		52.1429967540
382PhosphorylationEKLEKLKSQADQFCQ
HHHHHHHHHHHHHHH		40.8326552605
410PhosphorylationIHLMNIVSSAGSLER
HHHHHHHHCCCCCCC		15.6329691806
411PhosphorylationHLMNIVSSAGSLERD
HHHHHHHCCCCCCCC		26.2529691806
414PhosphorylationNIVSSAGSLERDSTE
HHHHCCCCCCCCCCE		27.1229691806
426PhosphorylationSTEVEISTGERKGSW
CCEEEEECCCCCCCH		49.0428674419
432PhosphorylationSTGERKGSWSERRNS
ECCCCCCCHHHHCCC		30.3930576142
434PhosphorylationGERKGSWSERRNSSI
CCCCCCHHHHCCCCC		23.9528102081
439PhosphorylationSWSERRNSSIVGRRS
CHHHHCCCCCCCCHH		21.4530266825
440PhosphorylationWSERRNSSIVGRRSL
HHHHCCCCCCCCHHC		25.5030266825
446PhosphorylationSSIVGRRSLERTTSG
CCCCCCHHCCCCCCC		32.9722199227
450PhosphorylationGRRSLERTTSGDDAC
CCHHCCCCCCCCCCC		18.8826503892
451PhosphorylationRRSLERTTSGDDACN
CHHCCCCCCCCCCCC		36.6130266825
452PhosphorylationRSLERTTSGDDACNL
HHCCCCCCCCCCCCC		39.3429255136
452 (in isoform 2)Phosphorylation-39.3418669648
460PhosphorylationGDDACNLTSFRPATL
CCCCCCCCCCCCCEE		16.3024732914
461PhosphorylationDDACNLTSFRPATLT
CCCCCCCCCCCCEEE		23.5624732914
466PhosphorylationLTSFRPATLTVTNFF
CCCCCCCEEEEEECH		26.1624732914
468PhosphorylationSFRPATLTVTNFFKQ
CCCCCEEEEEECHHC		22.4124732914
470PhosphorylationRPATLTVTNFFKQEG
CCCEEEEEECHHCCC		22.5224732914
496PhosphorylationLADMRRPSSVLRRLR
HHHCCCCHHHHHHHC		31.1323312004
497PhosphorylationADMRRPSSVLRRLRP
HHCCCCHHHHHHHCC		28.0523312004
522PhosphorylationPAPENPHYCLTPELL
CCCCCCCCCCCHHHH		7.15-
532UbiquitinationTPELLQVKLYPDSRV
CHHHHEEEECCCCCC		29.3721963094
532 (in isoform 5)Ubiquitination-29.37-
584PhosphorylationQGSARNITVKVQFMY
CCCCCCEEEEEEEEE		20.1624702127
621PhosphorylationEAYTAVVYHNRSPDF
HHHEEEEECCCCCCC		6.1828152594
649PhosphorylationDHHHLLFTFYHVSCQ
CCHHHEEEEEEECCC		24.21-
762SulfoxidationRIGDMRIMENNLENE
EECCEEHHCCCHHHH		2.9621406390
848PhosphorylationRNSLLASYIHYVFRL
CHHHHHHHHHHHHCC		6.0130576142
851PhosphorylationLLASYIHYVFRLPNT
HHHHHHHHHHCCCCC		7.5430576142
858PhosphorylationYVFRLPNTYPNSSSP
HHHCCCCCCCCCCCC		38.1121945579
859PhosphorylationVFRLPNTYPNSSSPG
HHCCCCCCCCCCCCC		13.6821945579
862PhosphorylationLPNTYPNSSSPGPGG
CCCCCCCCCCCCCCC		27.9121945579
863PhosphorylationPNTYPNSSSPGPGGL
CCCCCCCCCCCCCCC		47.3821945579
864PhosphorylationNTYPNSSSPGPGGLG
CCCCCCCCCCCCCCC		33.4322617229
864 (in isoform 2)Phosphorylation-33.4318669648
873PhosphorylationGPGGLGGSVHYATMA
CCCCCCCCHHHHHHC		12.1521945579
876PhosphorylationGLGGSVHYATMARSA
CCCCCHHHHHHCCCC		11.1221945579
878PhosphorylationGGSVHYATMARSAVR
CCCHHHHHHCCCCCC		12.2821945579
882PhosphorylationHYATMARSAVRPASL
HHHHHCCCCCCHHHC		22.9030266825
882 (in isoform 2)Phosphorylation-22.9018669648
888PhosphorylationRSAVRPASLNLNRSR
CCCCCHHHCCCCCCC		22.0719664994
888 (in isoform 2)Phosphorylation-22.0718669648
894PhosphorylationASLNLNRSRSLSNSN
HHCCCCCCCCCCCCC		25.7523927012
894 (in isoform 2)Phosphorylation-25.7518669648
896PhosphorylationLNLNRSRSLSNSNPD
CCCCCCCCCCCCCCC		37.0829255136
896 (in isoform 2)Phosphorylation-37.0818669648
898PhosphorylationLNRSRSLSNSNPDIS
CCCCCCCCCCCCCCC		39.1929255136
898 (in isoform 2)Phosphorylation-39.1918669648
900PhosphorylationRSRSLSNSNPDISGT
CCCCCCCCCCCCCCC		46.4919664994
900 (in isoform 2)Phosphorylation-46.4918669648
905PhosphorylationSNSNPDISGTPTSPD
CCCCCCCCCCCCCCC		43.9523927012
905 (in isoform 2)Phosphorylation-43.9518669648
907PhosphorylationSNPDISGTPTSPDDE
CCCCCCCCCCCCCHH		19.3229255136
907 (in isoform 2)Phosphorylation-19.3218669648
909PhosphorylationPDISGTPTSPDDEVR
CCCCCCCCCCCHHHH		53.3729255136
909 (in isoform 2)Phosphorylation-53.3718669648
910PhosphorylationDISGTPTSPDDEVRS
CCCCCCCCCCHHHHH		27.7729255136
910 (in isoform 2)Phosphorylation-27.7718669648
910 (in isoform 3)Phosphorylation-27.7729743597
910 (in isoform 4)Phosphorylation-27.7729743597
910 (in isoform 5)Phosphorylation-27.7729743597
917PhosphorylationSPDDEVRSIIGSKGL
CCCHHHHHHHCCCCC		24.5924732914
917 (in isoform 3)Phosphorylation-24.59-
917 (in isoform 4)Phosphorylation-24.59-
917 (in isoform 5)Phosphorylation-24.59-
921PhosphorylationEVRSIIGSKGLDRSN
HHHHHHCCCCCCCCC		17.0927486199
921 (in isoform 3)Phosphorylation-17.09-
921 (in isoform 4)Phosphorylation-17.09-
921 (in isoform 5)Phosphorylation-17.09-
922 (in isoform 3)Ubiquitination-59.28-
922 (in isoform 5)Ubiquitination-59.28-
927PhosphorylationGSKGLDRSNSWVNTG
CCCCCCCCCCCCCCC		34.5830266825
929PhosphorylationKGLDRSNSWVNTGGP
CCCCCCCCCCCCCCC		33.3819664994
929 (in isoform 2)Phosphorylation-33.3818669648
932PhosphorylationDRSNSWVNTGGPKAA
CCCCCCCCCCCCCCC		27.0932142685
932 (in isoform 3)Phosphorylation-27.0918669648
932 (in isoform 4)Phosphorylation-27.0918669648
932 (in isoform 5)Phosphorylation-27.0918669648
933PhosphorylationRSNSWVNTGGPKAAP
CCCCCCCCCCCCCCC		33.6230266825
943PhosphorylationPKAAPWGSNPSPSAE
CCCCCCCCCCCCCHH		41.5230266825
946PhosphorylationAPWGSNPSPSAESTQ
CCCCCCCCCCHHHHH		35.4230266825
948PhosphorylationWGSNPSPSAESTQAM
CCCCCCCCHHHHHHH		49.3530266825
951PhosphorylationNPSPSAESTQAMDRS
CCCCCHHHHHHHHHH		26.0730266825
952PhosphorylationPSPSAESTQAMDRSC
CCCCHHHHHHHHHHH		16.3230266825
958PhosphorylationSTQAMDRSCNRMSSH
HHHHHHHHHHHCCCC		16.1030576142
963PhosphorylationDRSCNRMSSHTETSS
HHHHHHCCCCHHHHH		18.7427273156
963 (in isoform 2)Phosphorylation-18.7418669648
964PhosphorylationRSCNRMSSHTETSSF
HHHHHCCCCHHHHHH		25.7028731282
964 (in isoform 2)Phosphorylation-25.7018669648
966PhosphorylationCNRMSSHTETSSFLQ
HHHCCCCHHHHHHHH		42.7923927012
968PhosphorylationRMSSHTETSSFLQTL
HCCCCHHHHHHHHHH		30.7223927012
969PhosphorylationMSSHTETSSFLQTLT
CCCCHHHHHHHHHHH		16.9223927012
970PhosphorylationSSHTETSSFLQTLTG
CCCHHHHHHHHHHHC		37.0823927012
974PhosphorylationETSSFLQTLTGRLPT
HHHHHHHHHHCCCCC		28.5623403867
976PhosphorylationSSFLQTLTGRLPTKK
HHHHHHHHCCCCCHH		24.5223403867
981PhosphorylationTLTGRLPTKKLFHEE
HHHCCCCCHHHCCHH		45.4622964224
1072PhosphorylationEMVERLNTSLAFFLN
HHHHHHHHHHHHHHH		29.7022210691
1073PhosphorylationMVERLNTSLAFFLND
HHHHHHHHHHHHHHH		19.3422210691
1092PhosphorylationMDRGFVFSLIKSCYK
HHHHHHHHHHHHHHH		24.7124719451
1106PhosphorylationKQVSSKLYSLPNPSV
HHHHHHHHCCCCHHH		16.3423403867
1107PhosphorylationQVSSKLYSLPNPSVL
HHHHHHHCCCCHHHH		48.0320860994
1112PhosphorylationLYSLPNPSVLVSLRL
HHCCCCHHHHEEEEH		34.4220860994
1116PhosphorylationPNPSVLVSLRLDFLR
CCHHHHEEEEHHHHH		12.0120860994
1139PhosphorylationVTLNLPCSLLTPPAS
EEEECCHHHCCCCCC		25.1928348404
1142PhosphorylationNLPCSLLTPPASPSP
ECCHHHCCCCCCCCC		32.3026657352
1146PhosphorylationSLLTPPASPSPSVSS
HHCCCCCCCCCCCCC		31.5228348404
1148PhosphorylationLTPPASPSPSVSSAT
CCCCCCCCCCCCCCC		27.5828348404
1150PhosphorylationPPASPSPSVSSATSQ
CCCCCCCCCCCCCCC		38.6826657352
1152PhosphorylationASPSPSVSSATSQSS
CCCCCCCCCCCCCCC		20.7028348404
1153PhosphorylationSPSPSVSSATSQSSG
CCCCCCCCCCCCCCC		33.1528348404
1155PhosphorylationSPSVSSATSQSSGFS
CCCCCCCCCCCCCCC		29.2828348404
1156PhosphorylationPSVSSATSQSSGFST
CCCCCCCCCCCCCCC		27.9928348404
1158PhosphorylationVSSATSQSSGFSTNV
CCCCCCCCCCCCCCC		32.0028348404
1204UbiquitinationILDPDAEGLFGLHKK
HHCCCCCCCCHHHHH		28.2024816145
1235UbiquitinationRYSDPQIKARVAMLY
CCCCHHHHHHHHHHH		25.5424816145
1242PhosphorylationKARVAMLYLPLIGII
HHHHHHHHHHHHHHH		8.00-
1257PhosphorylationMETVPQLYDFTETHN
HHHCHHHHHCCHHCC		12.0818426980
1274PhosphorylationGRPICIATDDYESES
CCEEEEECCCCCCCC		14.9730576142
1281PhosphorylationTDDYESESGSMISQT
CCCCCCCCCCCHHHH		45.5130576142
1283PhosphorylationDYESESGSMISQTVA
CCCCCCCCCHHHHHH		23.4030576142
1296PhosphorylationVAMAIAGTSVPQLTR
HHHHHHCCCCCCCCC		19.96-
1297PhosphorylationAMAIAGTSVPQLTRP
HHHHHCCCCCCCCCC		30.77-
1302PhosphorylationGTSVPQLTRPGSFLL
CCCCCCCCCCCCEEE		29.5727251275
1306PhosphorylationPQLTRPGSFLLTSTS
CCCCCCCCEEEECCC		18.5319664994
1310PhosphorylationRPGSFLLTSTSGRQH
CCCCEEEECCCCCCC		31.9119691289
1311PhosphorylationPGSFLLTSTSGRQHT
CCCEEEECCCCCCCC		22.1219691289
1312PhosphorylationGSFLLTSTSGRQHTT
CCEEEECCCCCCCCE		29.9328348404
1313PhosphorylationSFLLTSTSGRQHTTF
CEEEECCCCCCCCEE		31.5728348404
1318PhosphorylationSTSGRQHTTFSAESS
CCCCCCCCEECCHHH		22.6224043423
1319PhosphorylationTSGRQHTTFSAESSR
CCCCCCCEECCHHHH		17.3024043423
1321PhosphorylationGRQHTTFSAESSRSL
CCCCCEECCHHHHHH		29.0924043423
1324PhosphorylationHTTFSAESSRSLLIC
CCEECCHHHHHHHHH		30.6724043423
1325PhosphorylationTTFSAESSRSLLICL
CEECCHHHHHHHHHH		19.8624043423
1352PhosphorylationQKWFTDLSVLQLNRL
HHHHCCCHHHHHHHH		24.4819664994
1372PhosphorylationLCVSCFEYKGKKVFE
HHHHHHHHCCHHHHH		12.5617384208
1383PhosphorylationKVFERMNSLTFKKSK
HHHHHHHHCCCCCCH		21.3119664994
1383 (in isoform 2)Phosphorylation-21.3118669648
1383 (in isoform 3)Phosphorylation-21.3123898821
1383 (in isoform 4)Phosphorylation-21.3123898821
1385PhosphorylationFERMNSLTFKKSKDM
HHHHHHCCCCCCHHH		32.9830266825
1388MethylationMNSLTFKKSKDMRAK
HHHCCCCCCHHHHHH		59.55-
1390 (in isoform 3)Phosphorylation-65.5123927012
1390 (in isoform 4)Phosphorylation-65.5123927012
1392 (in isoform 3)Phosphorylation-5.2923927012
1392 (in isoform 4)Phosphorylation-5.2923927012
1394 (in isoform 3)Phosphorylation-17.7223927012
1394 (in isoform 4)Phosphorylation-17.7223927012
1398PhosphorylationDMRAKLEEAILGSIG
HHHHHHHHHHHHHHH		51.9932142685
1398 (in isoform 3)Phosphorylation-51.9925849741
1398 (in isoform 4)Phosphorylation-51.9925849741
1401PhosphorylationAKLEEAILGSIGARQ
HHHHHHHHHHHHHHH		5.9232142685
1403PhosphorylationLEEAILGSIGARQEM
HHHHHHHHHHHHHHH		17.8821815630
1406UbiquitinationAILGSIGARQEMVRR
HHHHHHHHHHHHHHH		14.3329967540
1407PhosphorylationILGSIGARQEMVRRS
HHHHHHHHHHHHHHH		27.9832142685
1414 (in isoform 2)Phosphorylation-30.1423898821
1414 (in isoform 6)Phosphorylation-30.1423898821
1415MethylationQEMVRRSRGQLGTYT
HHHHHHHCCCCCEEE		34.76-
1415UbiquitinationQEMVRRSRGQLGTYT
HHHHHHHCCCCCEEE		34.7629967540
1417UbiquitinationMVRRSRGQLGTYTIA
HHHHHCCCCCEEEEC		35.2927667366
1420PhosphorylationRSRGQLGTYTIASPP
HHCCCCCEEEECCCC		26.5328796482
1421PhosphorylationSRGQLGTYTIASPPE
HCCCCCEEEECCCCC		8.3728796482
1421 (in isoform 2)Phosphorylation-8.3723927012
1421 (in isoform 6)Phosphorylation-8.3723927012
1422PhosphorylationRGQLGTYTIASPPER
CCCCCEEEECCCCCC		15.2028796482
1423 (in isoform 2)Phosphorylation-2.2323927012
1423 (in isoform 6)Phosphorylation-2.2323927012
1425PhosphorylationLGTYTIASPPERSPS
CCEEEECCCCCCCCC		36.8229496963
1425 (in isoform 2)Phosphorylation-36.8223927012
1425 (in isoform 6)Phosphorylation-36.8223927012
1426UbiquitinationGTYTIASPPERSPSG
CEEEECCCCCCCCCC		26.2527667366
1429PhosphorylationTIASPPERSPSGSAF
EECCCCCCCCCCCCC		60.6919664994
1429 (in isoform 2)Phosphorylation-60.6925849741
1429 (in isoform 6)Phosphorylation-60.6925849741
1430PhosphorylationIASPPERSPSGSAFG
ECCCCCCCCCCCCCC		23.0429255136
1432PhosphorylationSPPERSPSGSAFGSQ
CCCCCCCCCCCCCCH		46.7729255136
1434PhosphorylationPERSPSGSAFGSQEN
CCCCCCCCCCCCHHH		25.4323927012
1437UbiquitinationSPSGSAFGSQENLRW
CCCCCCCCCHHHCCH		28.3029967540
1438PhosphorylationPSGSAFGSQENLRWR
CCCCCCCCHHHCCHH		28.0619664994
1448UbiquitinationNLRWRKDMTHWRQNT
HCCHHHHCHHHHHCH		3.1327667366
1455PhosphorylationMTHWRQNTEKLDKSR
CHHHHHCHHHHHHHH		26.5927251275
1457UbiquitinationHWRQNTEKLDKSRAE
HHHHCHHHHHHHHHH		61.0127667366
1477PhosphorylationLIDGNLATEANLIIL
HHCCCCHHHCCEEEE		38.5022468782
1486PhosphorylationANLIILDTLEIVVQT
CCEEEEECCEEEEEE		23.8926074081
1495PhosphorylationEIVVQTVSVTESKES
EEEEEEECCCCCHHH		27.0622468782
1497PhosphorylationVVQTVSVTESKESIL
EEEEECCCCCHHHHH		27.3422468782
1570PhosphorylationSSIGTIRSHASASLY
CCCHHHHHHHHHHHH		21.3928348404
1841PhosphorylationGWERMFGTYFRVGFY
HHHHHHCCEEEEEEE		14.2825137130
1874PhosphorylationITKLAEISHRLEGFY
HHHHHHHHHHHHHCC		8.28-
1910PhosphorylationKLDPNKAYIQITYVE
CCCCCCCEEEEEEEE		8.5826552605
1914PhosphorylationNKAYIQITYVEPYFD
CCCEEEEEEEECCCC		12.7326552605
1915PhosphorylationKAYIQITYVEPYFDT
CCEEEEEEEECCCCC		12.4026552605
1919PhosphorylationQITYVEPYFDTYEMK
EEEEEECCCCCEECC		10.6926552605
1920AcetylationITYVEPYFDTYEMKD
EEEEECCCCCEECCC		9.1719608861
1922AcetylationYVEPYFDTYEMKDRI
EEECCCCCEECCCCE		16.1019608861
1922PhosphorylationYVEPYFDTYEMKDRI
EEECCCCCEECCCCE		16.1026552605
1923PhosphorylationVEPYFDTYEMKDRIT
EECCCCCEECCCCEE		18.8326552605
1931AcetylationEMKDRITYFDKNYNL
ECCCCEEEECCCCCE		13.8619608861
1951AcetylationCTPFTLDGRAHGELH
ECCCCCCCCCCHHHH		31.6119608861
1960UbiquitinationAHGELHEQFKRKTIL
CCHHHHHHHHHCEEE		38.1132015554
1961UbiquitinationHGELHEQFKRKTILT
CHHHHHHHHHCEEEE		8.2329967540
1962AcetylationGELHEQFKRKTILTT
HHHHHHHHHCEEEEE		53.3219608861
1962MalonylationGELHEQFKRKTILTT
HHHHHHHHHCEEEEE		53.3226320211
1962MethylationGELHEQFKRKTILTT
HHHHHHHHHCEEEEE		53.32-
1962UbiquitinationGELHEQFKRKTILTT
HHHHHHHHHCEEEEE		53.3232015554
1963UbiquitinationELHEQFKRKTILTTS
HHHHHHHHCEEEEEC		42.5129967540
1964MalonylationLHEQFKRKTILTTSH
HHHHHHHCEEEEECC		40.2726320211
1965PhosphorylationHEQFKRKTILTTSHA
HHHHHHCEEEEECCC		25.8323401153
1968PhosphorylationFKRKTILTTSHAFPY
HHHCEEEEECCCCCC		23.5423401153
1969PhosphorylationKRKTILTTSHAFPYI
HHCEEEEECCCCCCC		18.3123401153
1970PhosphorylationRKTILTTSHAFPYIK
HCEEEEECCCCCCCE		13.9523401153
1971UbiquitinationKTILTTSHAFPYIKT
CEEEEECCCCCCCEE		29.3332015554
1972UbiquitinationTILTTSHAFPYIKTR
EEEEECCCCCCCEEE		13.5829967540
1975PhosphorylationTTSHAFPYIKTRVNV
EECCCCCCCEEECCC		14.4823401153
1991PhosphorylationHKEEIILTPIEVAIE
CCCEEEEEEHHHHHH		16.29-
1991UbiquitinationHKEEIILTPIEVAIE
CCCEEEEEEHHHHHH		16.2932015554
1992UbiquitinationKEEIILTPIEVAIED
CCEEEEEEHHHHHHH		19.8029967540
1993UbiquitinationEEIILTPIEVAIEDM
CEEEEEEHHHHHHHH		5.8432015554
1994UbiquitinationEIILTPIEVAIEDMQ
EEEEEEHHHHHHHHH		27.4029967540
2002UbiquitinationVAIEDMQKKTQELAF
HHHHHHHHHHHHHHH		51.6732015554
2038UbiquitinationTTVNQGPLEVAQVFL
CCCCCCCHHHHHHHH		12.0632142685
2040UbiquitinationVNQGPLEVAQVFLSE
CCCCCHHHHHHHHHC		6.2632142685
2046UbiquitinationEVAQVFLSEIPSDPK
HHHHHHHHCCCCCHH		23.2424816145
2048UbiquitinationAQVFLSEIPSDPKLF
HHHHHHCCCCCHHHH		3.3924816145
2049UbiquitinationQVFLSEIPSDPKLFR
HHHHHCCCCCHHHHH		28.7332142685
2055UbiquitinationIPSDPKLFRHHNKLR
CCCCHHHHHHCCCHH		9.7324816145
2057UbiquitinationSDPKLFRHHNKLRLC
CCHHHHHHCCCHHHH		22.8724816145
2066AcetylationNKLRLCFKDFTKRCE
CCHHHHHHHHHHHHH		51.4326051181
2069UbiquitinationRLCFKDFTKRCEDAL
HHHHHHHHHHHHHHH		27.9332142685
2070UbiquitinationLCFKDFTKRCEDALR
HHHHHHHHHHHHHHH		55.8629967540
2071UbiquitinationCFKDFTKRCEDALRK
HHHHHHHHHHHHHHH		26.4632142685
2072UbiquitinationFKDFTKRCEDALRKN
HHHHHHHHHHHHHHC		6.2229967540
2077UbiquitinationKRCEDALRKNKSLIG
HHHHHHHHHCHHHCC		42.0724816145
2079UbiquitinationCEDALRKNKSLIGPD
HHHHHHHCHHHCCCC		32.4924816145
2080UbiquitinationEDALRKNKSLIGPDQ
HHHHHHCHHHCCCCH		50.0732142685
2081UbiquitinationDALRKNKSLIGPDQK
HHHHHCHHHCCCCHH		34.3129967540
2082PhosphorylationALRKNKSLIGPDQKE
HHHHCHHHCCCCHHH		5.8432645325
2083UbiquitinationLRKNKSLIGPDQKEY
HHHCHHHCCCCHHHH		10.9824816145
2084PhosphorylationRKNKSLIGPDQKEYQ
HHCHHHCCCCHHHHH		25.6532645325
2086UbiquitinationNKSLIGPDQKEYQRE
CHHHCCCCHHHHHHH		67.9524816145
2087PhosphorylationKSLIGPDQKEYQREL
HHHCCCCHHHHHHHH		43.5532142685
2088UbiquitinationSLIGPDQKEYQRELE
HHCCCCHHHHHHHHH		66.8124816145
2089PhosphorylationLIGPDQKEYQRELER
HCCCCHHHHHHHHHH		41.0632142685
2093PhosphorylationDQKEYQRELERNYHR
CHHHHHHHHHHHHHH		39.1832645325
2098PhosphorylationQRELERNYHRLKEAL
HHHHHHHHHHHHHHH		8.4432142685
2101UbiquitinationLERNYHRLKEALQPL
HHHHHHHHHHHHHHH		3.6129967540
2102MalonylationERNYHRLKEALQPLI
HHHHHHHHHHHHHHH		40.6832601280
2103UbiquitinationRNYHRLKEALQPLIN
HHHHHHHHHHHHHHH		60.2429967540
2113PhosphorylationQPLINRKIPQLYKAV
HHHHHCCCHHHHHHH		2.0732645325
2115PhosphorylationLINRKIPQLYKAVLP
HHHCCCHHHHHHHHH		61.9832645325
2117PhosphorylationNRKIPQLYKAVLPVT
HCCCHHHHHHHHHEE		7.52-
2118PhosphorylationRKIPQLYKAVLPVTC
CCCHHHHHHHHHEEC		40.3832142685
2120PhosphorylationIPQLYKAVLPVTCHR
CHHHHHHHHHEECCC		5.6232142685
2124PhosphorylationYKAVLPVTCHRDSFS
HHHHHHEECCCCCCC		10.7223927012
2129PhosphorylationPVTCHRDSFSRMSLR
HEECCCCCCCHHHCC		25.6923401153
2131PhosphorylationTCHRDSFSRMSLRKM
ECCCCCCCHHHCCCC		30.9029255136
2134PhosphorylationRDSFSRMSLRKMDL-
CCCCCHHHCCCCCC-		24.7423186163
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
1257YPhosphorylationKinaseERBB2P04626
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DOCK7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DOCK7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CRLF3_HUMANCRLF3physical
24255178
DOCK6_HUMANDOCK6physical
24255178
LRCH1_HUMANLRCH1physical
24255178
LRCH2_HUMANLRCH2physical
24255178
LRCH3_HUMANLRCH3physical
24255178
NSD3_HUMANWHSC1L1physical
23455924
CBY1_HUMANCBY1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615859Epileptic encephalopathy, early infantile, 23 (EIEE23)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DOCK7_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-1962, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180; SER-182; SER-896;SER-900; SER-905; THR-907; THR-909; SER-910; SER-929 AND SER-1438, ANDMASS SPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-896 AND SER-898, ANDMASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-30; SER-180;SER-182; SER-894; SER-896; SER-898; SER-900; THR-907; THR-909;SER-910; SER-1383; SER-1430; SER-1432 AND SER-1438, AND MASSSPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30; SER-180; SER-182;SER-882; SER-888; SER-900; THR-907; SER-910; SER-1383 AND SER-1432,AND MASS SPECTROMETRY.
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND THR-1385, ANDMASS SPECTROMETRY.
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30, AND MASSSPECTROMETRY.

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