DOCK6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOCK6_HUMAN
• UniProt AC: Q96HP0
• Protein Name: Dedicator of cytokinesis protein 6
• Gene Name: DOCK6
• Organism: Homo sapiens (Human).
• Sequence Length: 2047
• Subcellular Localization: Cytoplasm . Cytoplasm, perinuclear region . Mainly located near the cell surface.
• Protein Description: Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity)..
• Protein Sequence: MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVLLSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDAQVRAAVEMYIEDWVIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPEDTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDEDEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDLNSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMVLKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSAGQLDRDSDSEGERRPAWTDRRRRGPQDRASSGDDACSFSGFRPATLTVTNFFKQEAERLSDEDLFKFLADMRRPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGRPTKEILEFPAREVYAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTREAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIPLLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQDPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVLDKLVRLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAFRLPGTEPSLPDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVSRILASKLLHEELALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRFPGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAHYKQVATRLQSSPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQSSTFSSQAPDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVHSLLCGHDTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDTEGEGDIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWVLKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKARLEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEALVEGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHGLATQRALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFARVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQDLMFNLHMILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCMVHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTELGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQSSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVEIIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDGRAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFATEQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIPEDPKLFRHHNKLRLCFKDFCKKCEDALRKNKALIGPDQKEYHRELERNYCRLREALQPLLTQRLPQLMAPTPPGLRNSLNRASFRKADL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAASERRAFAH ----CCHHHHHHHHH	38.40	24719451
16	Phosphorylation	FAHKINRTVAAEVRK HHHHHHHHHHHHHHH	15.26	24114839
30	Phosphorylation	KQVSRERSGSPHSSR HHHHHHCCCCCCCCC	38.58	24275569
35	Phosphorylation	ERSGSPHSSRRCSSS HCCCCCCCCCCHHCC	28.99	-
40	Phosphorylation	PHSSRRCSSSLGVPL CCCCCCHHCCCCCCH	22.58	25849741
41	Phosphorylation	HSSRRCSSSLGVPLT CCCCCHHCCCCCCHH	32.96	26657352
42	Phosphorylation	SSRRCSSSLGVPLTE CCCCHHCCCCCCHHE	16.92	26657352
48	Phosphorylation	SSLGVPLTEVVEPLD CCCCCCHHEEECCCC	22.21	19276368
159	Phosphorylation	QVFEQDASGDERSGP HHHCCCCCCCCCCCC	55.88	30266825
164	Phosphorylation	DASGDERSGPEDSND CCCCCCCCCCCCCCC	57.56	28102081
169	Phosphorylation	ERSGPEDSNDSRRGS CCCCCCCCCCCCCCC	40.66	28102081
172	Phosphorylation	GPEDSNDSRRGSGSP CCCCCCCCCCCCCCC	28.29	28102081
176	Phosphorylation	SNDSRRGSGSPEDTP CCCCCCCCCCCCCCC	34.00	29255136
178	Phosphorylation	DSRRGSGSPEDTPRS CCCCCCCCCCCCCCC	27.15	29255136
182	Phosphorylation	GSGSPEDTPRSSGAS CCCCCCCCCCCCCCC	20.95	25850435
185	Phosphorylation	SPEDTPRSSGASSIF CCCCCCCCCCCCCHH	34.04	30266825
186	Phosphorylation	PEDTPRSSGASSIFD CCCCCCCCCCCCHHH	39.39	30266825
189	Phosphorylation	TPRSSGASSIFDLRN CCCCCCCCCHHHHHH	27.73	23403867
190	Phosphorylation	PRSSGASSIFDLRNL CCCCCCCCHHHHHHH	27.09	23403867
233	Phosphorylation	HRPPALLTLYPAPDE HCCCEEEEEEECCCH	25.70	26503514
248	Phosphorylation	DEAVERCSRPEPPRE HHHHHHCCCCCCCCC	58.03	26503514
302	Phosphorylation	NFYFDLNSDSMKGLL CEEEECCCCCHHHHH	38.06	21601212
358	Phosphorylation	ISECCEPYMVLKEVD HHHHCCHHHHEEECH	4.23	27642862
397	Phosphorylation	YRMPFAWTAVHLANI CCCCCCHHHHHHHHH	18.51	24719451
406	Phosphorylation	VHLANIVSSAGQLDR HHHHHHHHHCCCCCC	15.63	28348404
407	Phosphorylation	HLANIVSSAGQLDRD HHHHHHHHCCCCCCC	26.06	29460479
415	Phosphorylation	AGQLDRDSDSEGERR CCCCCCCCCCCCCCC	43.88	28348404
438	Phosphorylation	RGPQDRASSGDDACS CCCCCCCCCCCCCCC	35.43	28348404
439	Phosphorylation	GPQDRASSGDDACSF CCCCCCCCCCCCCCC	45.30	28348404
447	Phosphorylation	GDDACSFSGFRPATL CCCCCCCCCCCCCEE	22.26	24719451
483	Phosphorylation	LADMRRPSSLLRRLR HHHCCCCHHHHHHHC	31.63	28857561
484	Phosphorylation	ADMRRPSSLLRRLRP HHCCCCHHHHHHHCC	33.82	28857561
493	Phosphorylation	LRRLRPVTAQLKIDI HHHHCCEEEEEEEEC	16.03	-
529	Phosphorylation	PDPRGRPTKEILEFP CCCCCCCCHHHHHCC	39.69	22210691
545	Phosphorylation	REVYAPHTSYRNLLY CCCCCCCCCCCCEEE	26.79	22210691
547	Phosphorylation	VYAPHTSYRNLLYVY CCCCCCCCCCEEEEE	12.50	22210691
561	Phosphorylation	YPHSLNFSSRQGSVR ECCCCCCCCCCCCHH	24.44	28064214
636	Phosphorylation	ENHHLLFTFYHVSCQ CCCEEEEEEEEEECC	24.21	-
749	Phosphorylation	RLKDTVLSEGNVEQE EEECCCCCCCCHHHH	38.84	-
857	Phosphorylation	PDGAPPVTVQAATLA CCCCCCCEEEEHHHH	16.81	29255136
862	Phosphorylation	PVTVQAATLARGSGR CCEEEEHHHHCCCCC	24.78	29255136
865	Methylation	VQAATLARGSGRPAS EEEHHHHCCCCCCCH	42.81	-
867	Phosphorylation	AATLARGSGRPASLY EHHHHCCCCCCCHHE	26.52	23403867
872	Phosphorylation	RGSGRPASLYLARSK CCCCCCCHHEEECCC	21.89	22617229
874	Phosphorylation	SGRPASLYLARSKSI CCCCCHHEEECCCCC	8.88	23403867
878	Phosphorylation	ASLYLARSKSISSSN CHHEEECCCCCCCCC	25.75	26846344
879	Ubiquitination	SLYLARSKSISSSNP HHEEECCCCCCCCCC	46.37	21906983
880	Phosphorylation	LYLARSKSISSSNPD HEEECCCCCCCCCCC	29.02	26846344
882	Phosphorylation	LARSKSISSSNPDLA EECCCCCCCCCCCCC	34.50	30266825
883	Phosphorylation	ARSKSISSSNPDLAV ECCCCCCCCCCCCCC	32.25	30266825
884	Phosphorylation	RSKSISSSNPDLAVA CCCCCCCCCCCCCCC	45.66	30266825
894	Phosphorylation	DLAVAPGSVDDEVSR CCCCCCCCCCHHHHH	22.70	23403867
900	Phosphorylation	GSVDDEVSRILASKL CCCCHHHHHHHHHHH	16.14	23927012
941	Phosphorylation	FFQLMVKSMALHLLL HHHHHHHHHHHHHHH	9.62	19413330
1026	Phosphorylation	AHYKQVATRLQSSPN HHHHHHHHHHHCCCC	32.81	28348404
1065	Phosphorylation	NLPCCPLSPPASPSP ECCCCCCCCCCCCCC	17.61	28348404
1069	Phosphorylation	CPLSPPASPSPSVSS CCCCCCCCCCCCCCC	31.52	28348404
1071	Phosphorylation	LSPPASPSPSVSSTT CCCCCCCCCCCCCCC	27.58	28348404
1073	Phosphorylation	PPASPSPSVSSTTSQ CCCCCCCCCCCCCCC	38.68	28348404
1075	Phosphorylation	ASPSPSVSSTTSQSS CCCCCCCCCCCCCCC	26.72	28348404
1076	Phosphorylation	SPSPSVSSTTSQSST CCCCCCCCCCCCCCC	33.28	28348404
1077	Phosphorylation	PSPSVSSTTSQSSTF CCCCCCCCCCCCCCC	23.98	28348404
1078	Phosphorylation	SPSVSSTTSQSSTFS CCCCCCCCCCCCCCC	27.07	28348404
1079	Phosphorylation	PSVSSTTSQSSTFSS CCCCCCCCCCCCCCC	28.31	28348404
1081	Phosphorylation	VSSTTSQSSTFSSQA CCCCCCCCCCCCCCC	30.98	28348404
1082	Phosphorylation	SSTTSQSSTFSSQAP CCCCCCCCCCCCCCC	26.32	28348404
1083	Phosphorylation	STTSQSSTFSSQAPD CCCCCCCCCCCCCCC	32.55	28348404
1165	Phosphorylation	KARVAELYLPLLSIA HHHHHHHHHHHHHHH	9.59	22468782
1170	Phosphorylation	ELYLPLLSIARDTLP HHHHHHHHHHHHHCH	23.14	22468782
1175	Phosphorylation	LLSIARDTLPRLHDF HHHHHHHHCHHHHHC	32.86	22468782
1190	Phosphorylation	AEGPGQRSRLASMLD CCCCCCHHHHHHHHC	24.61	23403867
1194	Phosphorylation	GQRSRLASMLDSDTE CCHHHHHHHHCCCCC	25.19	26434776
1198	Phosphorylation	RLASMLDSDTEGEGD HHHHHHCCCCCCCCC	42.33	23403867
1200	Phosphorylation	ASMLDSDTEGEGDIA HHHHCCCCCCCCCCC	50.25	23403867
1209	Phosphorylation	GEGDIAGTINPSVAM CCCCCCCCCCHHHHH	14.46	27251275
1213	Phosphorylation	IAGTINPSVAMAIAG CCCCCCHHHHHHHCC	20.30	28102081
1230	Phosphorylation	LAPGSRASISQGPPT CCCCCCCCCCCCCCC	22.97	30266825
1232	Phosphorylation	PGSRASISQGPPTAS CCCCCCCCCCCCCCC	26.96	30266825
1237	Phosphorylation	SISQGPPTASRAGCA CCCCCCCCCCCCCCC	40.16	17924679
1239	Phosphorylation	SQGPPTASRAGCALS CCCCCCCCCCCCCCC	25.74	17924679
1246	Phosphorylation	SRAGCALSAESSRTL CCCCCCCCHHHHHHH	16.09	30387612
1249	Phosphorylation	GCALSAESSRTLLAC CCCCCHHHHHHHHHH	25.49	30387612
1308	Phosphorylation	KAFERINSLTFKKSL HHHHHHHHHHCHHHC	26.81	30266825
1310	Phosphorylation	FERINSLTFKKSLDM HHHHHHHHCHHHCCH	32.98	30266825
1314	Phosphorylation	NSLTFKKSLDMKARL HHHHCHHHCCHHHHH	30.14	24719451
1318	Acetylation	FKKSLDMKARLEEAI CHHHCCHHHHHHHHH	29.98	19820333
1318	Methylation	FKKSLDMKARLEEAI CHHHCCHHHHHHHHH	29.98	-
1339	Phosphorylation	RQEMVRRSRERSPFG HHHHHHHHHHCCCCC	28.12	23403867
1343	Phosphorylation	VRRSRERSPFGNPEN HHHHHHCCCCCCHHH	21.59	30266825
1356	Phosphorylation	ENVRWRKSVTHWKQT HHCCCHHHCCCCHHC	24.55	24719451
1371	"N6,N6-dimethyllysine"	SDRVDKTKDEMEHEA CCCCCCCHHHHHHHH	58.39	-
1371	Methylation	SDRVDKTKDEMEHEA CCCCCCCHHHHHHHH	58.39	-
1679	Phosphorylation	FCSGKHFTELGLVGL CCCCCCHHHHHHHHH	29.98	-
1819	Phosphorylation	KLDSQKAYIQITYVE HCHHCCEEEEEEEEE	10.61	18083107
1823	Phosphorylation	QKAYIQITYVEPYFD CCEEEEEEEEECCCC	12.73	25072903
1824	Phosphorylation	KAYIQITYVEPYFDT CEEEEEEEEECCCCC	12.40	25072903
1828	Phosphorylation	QITYVEPYFDTYELK EEEEEECCCCCEEEC	10.69	18083107
1831	Phosphorylation	YVEPYFDTYELKDRV EEECCCCCEEECCCE	14.70	25072903
1832	Phosphorylation	VEPYFDTYELKDRVT EECCCCCEEECCCEE	22.55	25072903
1871	Acetylation	GELPEQHKRKTLLST CCCCHHHHCHHHCCC	56.11	130075
2029	Phosphorylation	LPQLMAPTPPGLRNS CHHHCCCCCCCHHHH	32.36	28348404
2036	Phosphorylation	TPPGLRNSLNRASFR CCCCHHHHHCHHHHH	22.16	22167270
2041	Phosphorylation	RNSLNRASFRKADL- HHHHCHHHHHHCCC-	23.50	25849741

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1194	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOCK6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOCK6_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DOCK6_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614219: Adams-Oliver syndrome 2 (AOS2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.
PubMed: 18220336

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1237 AND SER-1239, ANDMASS SPECTROMETRY.
PubMed: 17924679