LRCH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRCH2_HUMAN
• UniProt AC: Q5VUJ6
• Protein Name: Leucine-rich repeat and calponin homology domain-containing protein 2
• Gene Name: LRCH2
• Organism: Homo sapiens (Human).
• Sequence Length: 765
• Protein Sequence: MAASQGGGGNSGGGGCGGGGSSGGCGTAGGGGGGAGGGGGGGGGTLVVPIPVPTLFGQPFPNGPPWNPGSLQPQHTVRSLDRALEEAGSSGILSLSGRKLRDFPGSGYDLTDTTQADLSRNRFTEIPSDVWLFAPLETLNLYHNCIKTIPEAIKNLQMLTYLNISRNLLSTLPKYLFDLPLKVLVVSNNKLVSIPEEIGKLKDLMELDISCNEIQVLPQQMGKLHSLRELNIRRNNLHVLPDELGDLPLVKLDFSCNKVTEIPVCYRKLHHLQVIILDNNPLQVPPAQICLKGKVHIFKYLNIQACCRMDKKPDSLDLPSLSKRMPSQPLTDSMEDFYPNKNHGPDSGIGSDNGEKRLSTTEPSDDDTVSLHSQVSESNREQTSRNDSHIIGSKTDSQKDQEVYDFVDPNTEDVAVPEQGNAHIGSFVSFFKGKEKCSEKSRKNEELGDEKRLEKEQLLAEEEDDDLKEVTDLRKIAAQLLQQEQKNRILNHSTSVMRNKPKQTVECEKSVSADEVNSPLSPLTWQPLENQKDQIDEQPWPESHPIIWQSEERRRSKQIRKEYFKYKSMRKSSSGNENDEQDSDNANMSTQSPVSSEEYDRTDGFSHSPFGLKPRSAFSRSSRQEYGAADPGFTMRRKMEHLREEREQIRQLRNNLESRLKVILPDDIGAALMDGVVLCHLANHIRPRSVASIHVPSPAVPKLSMAKCRRNVENFLDACKKLGVSQERLCLPHHILEERGLVKVGVTVQALLELPTTKASQLSVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
128	Phosphorylation	NRFTEIPSDVWLFAP CCCCCCCCCCEEECC	50.92	25338102
160	Phosphorylation	IKNLQMLTYLNISRN HHHHHHHHHHHHCHH	22.18	23401153
161	Phosphorylation	KNLQMLTYLNISRNL HHHHHHHHHHHCHHH	8.19	22461510
170	Phosphorylation	NISRNLLSTLPKYLF HHCHHHHHCCHHHHH	30.94	22210691
171	Phosphorylation	ISRNLLSTLPKYLFD HCHHHHHCCHHHHHC	47.23	23401153
315	Phosphorylation	RMDKKPDSLDLPSLS CCCCCCCCCCCCCHH	32.10	22199227
320	Phosphorylation	PDSLDLPSLSKRMPS CCCCCCCCHHCCCCC	53.20	29083192
322	Phosphorylation	SLDLPSLSKRMPSQP CCCCCCHHCCCCCCC	23.66	29083192
327	Phosphorylation	SLSKRMPSQPLTDSM CHHCCCCCCCCCCCH	34.78	27732954
331	Phosphorylation	RMPSQPLTDSMEDFY CCCCCCCCCCHHHHC	32.48	22199227
333	Phosphorylation	PSQPLTDSMEDFYPN CCCCCCCCHHHHCCC	20.88	22199227
338	Phosphorylation	TDSMEDFYPNKNHGP CCCHHHHCCCCCCCC	20.44	27732954
347	Phosphorylation	NKNHGPDSGIGSDNG CCCCCCCCCCCCCCC	35.13	29255136
351	Phosphorylation	GPDSGIGSDNGEKRL CCCCCCCCCCCCEEE	26.44	29255136
359	Phosphorylation	DNGEKRLSTTEPSDD CCCCEEECCCCCCCC	37.00	30266825
360	Phosphorylation	NGEKRLSTTEPSDDD CCCEEECCCCCCCCC	39.51	30266825
361	Phosphorylation	GEKRLSTTEPSDDDT CCEEECCCCCCCCCC	42.39	30266825
364	Phosphorylation	RLSTTEPSDDDTVSL EECCCCCCCCCCEEH	47.65	30266825
368	Phosphorylation	TEPSDDDTVSLHSQV CCCCCCCCEEHHHHC	20.99	30266825
370	Phosphorylation	PSDDDTVSLHSQVSE CCCCCCEEHHHHCCC	23.58	30266825
373	Phosphorylation	DDTVSLHSQVSESNR CCCEEHHHHCCCCCC	37.26	26126808
376	Phosphorylation	VSLHSQVSESNREQT EEHHHHCCCCCCHHC	27.89	27732954
378	Phosphorylation	LHSQVSESNREQTSR HHHHCCCCCCHHCCC	33.41	27732954
393	Phosphorylation	NDSHIIGSKTDSQKD CCCCCCCCCCCCCCC	23.21	22210691
510	Phosphorylation	QTVECEKSVSADEVN CEEEEEECCCHHHCC	10.06	27732954
512	Phosphorylation	VECEKSVSADEVNSP EEEEECCCHHHCCCC	36.77	29978859
518	Phosphorylation	VSADEVNSPLSPLTW CCHHHCCCCCCCCCC	32.18	22199227
521	Phosphorylation	DEVNSPLSPLTWQPL HHCCCCCCCCCCCCC	22.65	29507054
524	Phosphorylation	NSPLSPLTWQPLENQ CCCCCCCCCCCCCCC	25.99	22199227
543	Phosphorylation	DEQPWPESHPIIWQS CCCCCCCCCCCCCCC	30.40	29978859
550	Phosphorylation	SHPIIWQSEERRRSK CCCCCCCCHHHHHHH	26.82	29978859
572	Phosphorylation	KYKSMRKSSSGNEND HHHHHCCCCCCCCCC	21.26	26126808
573	Phosphorylation	YKSMRKSSSGNENDE HHHHCCCCCCCCCCC	45.35	26126808
574	Phosphorylation	KSMRKSSSGNENDEQ HHHCCCCCCCCCCCC	53.37	26126808
583	Phosphorylation	NENDEQDSDNANMST CCCCCCCCCCCCCCC	32.24	26126808
589	Phosphorylation	DSDNANMSTQSPVSS CCCCCCCCCCCCCCH	24.09	26126808
590	Phosphorylation	SDNANMSTQSPVSSE CCCCCCCCCCCCCHH	23.46	26126808
592	Phosphorylation	NANMSTQSPVSSEEY CCCCCCCCCCCHHHH	27.62	26126808
596	Phosphorylation	STQSPVSSEEYDRTD CCCCCCCHHHHCCCC	34.38	19690332
599	Phosphorylation	SPVSSEEYDRTDGFS CCCCHHHHCCCCCCC	13.48	19690332
606	Phosphorylation	YDRTDGFSHSPFGLK HCCCCCCCCCCCCCC	28.69	27732954
608	Phosphorylation	RTDGFSHSPFGLKPR CCCCCCCCCCCCCCC	22.26	27732954
617	Phosphorylation	FGLKPRSAFSRSSRQ CCCCCCCCCCHHHHH	14.02	32142685
621	Phosphorylation	PRSAFSRSSRQEYGA CCCCCCHHHHHHHCC	28.77	29978859
622	Phosphorylation	RSAFSRSSRQEYGAA CCCCCHHHHHHHCCC	36.55	29978859
626	Phosphorylation	SRSSRQEYGAADPGF CHHHHHHHCCCCCCH	12.06	29978859
634	Phosphorylation	GAADPGFTMRRKMEH CCCCCCHHHHHHHHH	18.71	25850435
636	Methylation	ADPGFTMRRKMEHLR CCCCHHHHHHHHHHH	31.82	115482233
637	Methylation	DPGFTMRRKMEHLRE CCCHHHHHHHHHHHH	31.67	115482239
638	Methylation	PGFTMRRKMEHLREE CCHHHHHHHHHHHHH	37.97	115482245
643	Methylation	RRKMEHLREEREQIR HHHHHHHHHHHHHHH	45.71	115482251
689	Phosphorylation	ANHIRPRSVASIHVP HHCCCCCCEEEEECC	25.39	28857561
692	Phosphorylation	IRPRSVASIHVPSPA CCCCCEEEEECCCCC	15.86	28857561
697	Phosphorylation	VASIHVPSPAVPKLS EEEEECCCCCCCCCC	25.13	26270265

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRCH2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRCH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRCH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.