| UniProt ID | CRLF3_HUMAN | |
|---|---|---|
| UniProt AC | Q8IUI8 | |
| Protein Name | Cytokine receptor-like factor 3 | |
| Gene Name | CRLF3 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 442 | |
| Subcellular Localization | Cytoplasm . The EGFP- and MYC-tagged protein has been shown to be cytoplasmic. | |
| Protein Description | May play a role in the negative regulation of cell cycle progression.. | |
| Protein Sequence | MRGAMELEPELLLQEARENVEAAQSYRRELGHRLEGLREARRQIKESASQTRDVLKQHFNDLKGTLGKLLDERLVTLLQEVDTIEQETIKPLDDCQKLIEHGVNTAEDLVREGEIAMLGGVGEENEKLWSFTKKASHIQLDSLPEVPLLVDVPCLSAQLDDSILNIVKDHIFKHGTVASRPPVQIEELIEKPGGIIVRWCKVDDDFTAQDYRLQFRKCTSNHFEDVYVGSETEFIVLHIDPNVDYQFRVCARGDGRQEWSPWSVPQIGHSTLVPHEWTAGFEGYSLSSRRNIALRNDSESSGVLYSRAPTYFCGQTLTFRVETVGQPDRRDSIGVCAEKQDGYDSLQRDQAVCISTNGAVFVNGKEMTNQLPAVTSGSTVTFDIEAVTLGTTSNNEGGHFKLRVTISSNNREVVFDWLLDQSCGSLYFGCSFFYPGWKVLVF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 (in isoform 2) | Acetylation | - | 8.88 | 22814378 | |
| 5 | Sulfoxidation | ---MRGAMELEPELL ---CCCCCCCCHHHH | 7.22 | 21406390 | |
| 45 | Ubiquitination | REARRQIKESASQTR HHHHHHHHHHHHHHH | 36.96 | 24816145 | |
| 56 | Ubiquitination | SQTRDVLKQHFNDLK HHHHHHHHHHHHHHH | 41.39 | - | |
| 63 | Ubiquitination | KQHFNDLKGTLGKLL HHHHHHHHHHHHHHH | 53.35 | 29967540 | |
| 68 | Acetylation | DLKGTLGKLLDERLV HHHHHHHHHHHHHHH | 49.33 | 25953088 | |
| 68 | Ubiquitination | DLKGTLGKLLDERLV HHHHHHHHHHHHHHH | 49.33 | 29967540 | |
| 97 | Acetylation | KPLDDCQKLIEHGVN CCHHHHHHHHHCCCC | 58.73 | 7962745 | |
| 117 | Sulfoxidation | VREGEIAMLGGVGEE HHHCCEEEECCCCCC | 4.37 | 21406390 | |
| 127 | Ubiquitination | GVGEENEKLWSFTKK CCCCCCHHHHHHHHC | 67.83 | 29967540 | |
| 130 | Phosphorylation | EENEKLWSFTKKASH CCCHHHHHHHHCCCC | 33.21 | 25072903 | |
| 132 | Phosphorylation | NEKLWSFTKKASHIQ CHHHHHHHHCCCCCC | 26.56 | 25072903 | |
| 162 | Phosphorylation | LSAQLDDSILNIVKD CCCCCCHHHHHHHHH | 28.74 | 25159151 | |
| 191 | Ubiquitination | QIEELIEKPGGIIVR CHHHHHCCCCEEEEE | 41.80 | 29967540 | |
| 306 | Phosphorylation | ESSGVLYSRAPTYFC CCCCCEEECCCCEEC | 20.15 | 24719451 | |
| 332 | Phosphorylation | GQPDRRDSIGVCAEK CCCCCCCCEEEECCC | 21.30 | 27067055 | |
| 339 | Ubiquitination | SIGVCAEKQDGYDSL CEEEECCCCCCCCCC | 34.85 | - | |
| 425 | O-linked_Glycosylation | LLDQSCGSLYFGCSF HHCCCCCCEEEEECE | 24.99 | 23301498 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CRLF3_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CRLF3_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CRLF3_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DOCK6_HUMAN | DOCK6 | physical | 24255178 | |
| DOCK7_HUMAN | DOCK7 | physical | 24255178 | |
| DOCK8_HUMAN | DOCK8 | physical | 24255178 | |
| LRCH2_HUMAN | LRCH2 | physical | 24255178 | |
| SMD2_HUMAN | SNRPD2 | physical | 24255178 | |
| KDM1A_HUMAN | KDM1A | physical | 23455924 | |
| CRLF3_HUMAN | CRLF3 | physical | 25416956 | |
| PPL13_HUMAN | LGALS14 | physical | 25416956 | |
| VPS25_HUMAN | VPS25 | physical | 25416956 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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