SMD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMD2_HUMAN
• UniProt AC: P62316
• Protein Name: Small nuclear ribonucleoprotein Sm D2
• Gene Name: SNRPD2
• Organism: Homo sapiens (Human).
• Sequence Length: 118
• Subcellular Localization: Cytoplasm, cytosol . Nucleus . SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP..
• Protein Sequence: MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLLNKPKS ------CCCCCCCHH	41.38	23401153
2	Acetylation	------MSLLNKPKS ------CCCCCCCHH	41.38	25944712
6	Acetylation	--MSLLNKPKSEMTP --CCCCCCCHHHCCH	54.51	23749302
6	Ubiquitination	--MSLLNKPKSEMTP --CCCCCCCHHHCCH	54.51	23000965
6	Sumoylation	--MSLLNKPKSEMTP --CCCCCCCHHHCCH	54.51	28112733
8	Acetylation	MSLLNKPKSEMTPEE CCCCCCCHHHCCHHH	61.73	23749302
8	Sumoylation	MSLLNKPKSEMTPEE CCCCCCCHHHCCHHH	61.73	-
8	Ubiquitination	MSLLNKPKSEMTPEE CCCCCCCHHHCCHHH	61.73	23000965
8	Sumoylation	MSLLNKPKSEMTPEE CCCCCCCHHHCCHHH	61.73	28112733
9	Phosphorylation	SLLNKPKSEMTPEEL CCCCCCHHHCCHHHH	40.92	25159151
11	Sulfoxidation	LNKPKSEMTPEELQK CCCCHHHCCHHHHHH	11.06	21406390
12	Phosphorylation	NKPKSEMTPEELQKR CCCHHHCCHHHHHHH	24.40	29255136
18	Ubiquitination	MTPEELQKREEEEFN CCHHHHHHHHHHHHC	74.52	21906983
18	Acetylation	MTPEELQKREEEEFN CCHHHHHHHHHHHHC	74.52	25953088
19	Dimethylation	TPEELQKREEEEFNT CHHHHHHHHHHHHCC	43.53	-
19	Methylation	TPEELQKREEEEFNT CHHHHHHHHHHHHCC	43.53	116264873
26	Phosphorylation	REEEEFNTGPLSVLT HHHHHHCCCCHHHHH	45.56	28464451
27	Ubiquitination	EEEEFNTGPLSVLTQ HHHHHCCCCHHHHHH	23.43	29967540
30	Phosphorylation	EFNTGPLSVLTQSVK HHCCCCHHHHHHHHH	20.43	22199227
33	Phosphorylation	TGPLSVLTQSVKNNT CCCHHHHHHHHHCCE	19.35	22115753
35	Phosphorylation	PLSVLTQSVKNNTQV CHHHHHHHHHCCEEE	29.80	22115753
37	Ubiquitination	SVLTQSVKNNTQVLI HHHHHHHHCCEEEEE	50.13	29967540
40	Ubiquitination	TQSVKNNTQVLINCR HHHHHCCEEEEEECC	29.46	24816145
46	Glutathionylation	NTQVLINCRNNKKLL CEEEEEECCCCCHHH	3.80	22555962
47	Ubiquitination	TQVLINCRNNKKLLG EEEEEECCCCCHHHH	45.31	27667366
50	Ubiquitination	LINCRNNKKLLGRVK EEECCCCCHHHHHHH	48.63	24816145
57	Ubiquitination	KKLLGRVKAFDRHCN CHHHHHHHHHHHHHH	41.81	27667366
61	Methylation	GRVKAFDRHCNMVLE HHHHHHHHHHHHHHH	29.79	115917393
61	Ubiquitination	GRVKAFDRHCNMVLE HHHHHHHHHHHHHHH	29.79	32015554
61	Neddylation	GRVKAFDRHCNMVLE HHHHHHHHHHHHHHH	29.79	32015554
63	Glutathionylation	VKAFDRHCNMVLENV HHHHHHHHHHHHHHH	3.51	22555962
63	S-nitrosylation	VKAFDRHCNMVLENV HHHHHHHHHHHHHHH	3.51	25040305
71	Neddylation	NMVLENVKEMWTEVP HHHHHHHHHHHHCCC	54.13	32015554
71	Acetylation	NMVLENVKEMWTEVP HHHHHHHHHHHHCCC	54.13	26051181
71	Ubiquitination	NMVLENVKEMWTEVP HHHHHHHHHHHHCCC	54.13	32015554
75	Phosphorylation	ENVKEMWTEVPKSGK HHHHHHHHCCCCCCC	26.29	29083192
79	Acetylation	EMWTEVPKSGKGKKK HHHHCCCCCCCCCCC	76.61	27452117
80	Phosphorylation	MWTEVPKSGKGKKKS HHHCCCCCCCCCCCC	39.40	-
82	Ubiquitination	TEVPKSGKGKKKSKP HCCCCCCCCCCCCCC	74.73	23000965
88	Ubiquitination	GKGKKKSKPVNKDRY CCCCCCCCCCCHHHH	62.96	23000965
92	Ubiquitination	KKSKPVNKDRYISKM CCCCCCCHHHHHHHH	43.76	23000965
92	Acetylation	KKSKPVNKDRYISKM CCCCCCCHHHHHHHH	43.76	19817991
98	Ubiquitination	NKDRYISKMFLRGDS CHHHHHHHHECCCCE	24.90	23000965
98	Acetylation	NKDRYISKMFLRGDS CHHHHHHHHECCCCE	24.90	25825284
105	Phosphorylation	KMFLRGDSVIVVLRN HHECCCCEEEEEECC	19.30	21712546
118	Ubiquitination	RNPLIAGK------- CCCCCCCC-------	48.41	-
118	Acetylation	RNPLIAGK------- CCCCCCCC-------	48.41	7609903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMD2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAT5_HUMAN	KAT5	physical	16169070
EF1G_HUMAN	EEF1G	physical	16169070
RUXE_HUMAN	SNRPE	physical	9417867
RUXF_HUMAN	SNRPF	physical	9417867
SMD1_HUMAN	SNRPD1	physical	9417867
SMD3_HUMAN	SNRPD3	physical	22939629
YBOX1_HUMAN	YBX1	physical	22939629
U520_HUMAN	SNRNP200	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22939629
SNUT1_HUMAN	SART1	physical	22939629
SNW1_HUMAN	SNW1	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
RUXF_HUMAN	SNRPF	physical	22365833
LSM2_HUMAN	LSM2	physical	22365833
LSM6_HUMAN	LSM6	physical	22365833
ICLN_HUMAN	CLNS1A	physical	22365833
ZCH10_HUMAN	ZCCHC10	physical	22365833
IL7RA_HUMAN	IL7R	physical	23151878
MARE1_HUMAN	MAPRE1	physical	22863883
LIS1_HUMAN	PAFAH1B1	physical	22863883
1433F_HUMAN	YWHAH	physical	22863883
CEP70_HUMAN	CEP70	physical	25416956
DDX23_HUMAN	DDX23	physical	26344197
LSM7_HUMAN	LSM7	physical	26344197
LC7L2_HUMAN	LUC7L2	physical	26344197
PRP31_HUMAN	PRPF31	physical	26344197
SNUT1_HUMAN	SART1	physical	26344197
SF3A3_HUMAN	SF3A3	physical	26344197
SF3B3_HUMAN	SF3B3	physical	26344197
U520_HUMAN	SNRNP200	physical	26344197
RU2A_HUMAN	SNRPA1	physical	26344197
SMD1_HUMAN	SNRPD1	physical	26344197
SMD3_HUMAN	SNRPD3	physical	26344197
RUXE_HUMAN	SNRPE	physical	26344197
RUXF_HUMAN	SNRPF	physical	26344197
RUXG_HUMAN	SNRPG	physical	26344197
SRP14_HUMAN	SRP14	physical	26344197
ZCH18_HUMAN	ZC3H18	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.