dbPTM

SP16H_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SP16H_HUMAN
UniProt AC	Q9Y5B9
Protein Name	FACT complex subunit SPT16
Gene Name	SUPT16H
Organism	Homo sapiens (Human).
Sequence Length	1047
Subcellular Localization	Nucleus . Chromosome . Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci.
Protein Description	Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)..
Protein Sequence	MAVTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLIREKNESNKSSFDKMIEAIKESKNGKKIGVFSKDKFPGEFMKSWNDCLNKEGFDKIDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKELRHGVKICDVYNAVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNKEGKKPEEKTYALFIGDTVLVDEDGPATVLTSVKKKVKNVGIFLKNEDEEEEEEEKDEAEDLLGRGSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKSNVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNIKAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPEGFFEQGGWSFLEPEGEGSDAEEGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEESDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRGSNRGSRHSSAPPKKKRK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVTLDKDA ------CCCCCCHHH	17.82	22223895
7	2-Hydroxyisobutyrylation	-MAVTLDKDAYYRRV -CCCCCCHHHHHHHH	47.58	-
7	Acetylation	-MAVTLDKDAYYRRV -CCCCCCHHHHHHHH	47.58	23749302
7	Ubiquitination	-MAVTLDKDAYYRRV -CCCCCCHHHHHHHH	47.58	24816145
10	Phosphorylation	VTLDKDAYYRRVKRL CCCCHHHHHHHHHHH	13.98	20068231
11	Phosphorylation	TLDKDAYYRRVKRLY CCCHHHHHHHHHHHH	8.15	20068231
12	Methylation	LDKDAYYRRVKRLYS CCHHHHHHHHHHHHH	25.00	30761167
13	Methylation	DKDAYYRRVKRLYSN CHHHHHHHHHHHHHC	23.37	30761173
16	Ubiquitination	AYYRRVKRLYSNWRK HHHHHHHHHHHCCCC	35.68	22817900
18	Phosphorylation	YRRVKRLYSNWRKGE HHHHHHHHHCCCCCC	12.18	23186163
19	Phosphorylation	RRVKRLYSNWRKGED HHHHHHHHCCCCCCC	34.21	23312004
21	Ubiquitination	VKRLYSNWRKGEDEY HHHHHHCCCCCCCCC	9.45	21890473
50	Ubiquitination	EIVYAKSTALQTWLF HHHCEEHHHHHHHHH	30.58	22817900
55	Ubiquitination	KSTALQTWLFGYELT EHHHHHHHHHCCCCC	4.09	21890473
78	Phosphorylation	DKIIFMASKKKVEFL CEEEEECCHHHHHHH	32.97	-
80	Ubiquitination	IIFMASKKKVEFLKQ EEEECCHHHHHHHHH	60.60	-
81	Ubiquitination	IFMASKKKVEFLKQI EEECCHHHHHHHHHH	51.22	22817900
86	Ubiquitination	KKKVEFLKQIANTKG HHHHHHHHHHHCCCC	45.00	21890473
91	Ubiquitination	FLKQIANTKGNENAN HHHHHHCCCCCCCCC	31.16	23000965
92	Ubiquitination	LKQIANTKGNENANG HHHHHCCCCCCCCCC	60.59	32015554
96	Ubiquitination	ANTKGNENANGAPAI HCCCCCCCCCCCCEE	42.58	23000965
113	Phosphorylation	LIREKNESNKSSFDK EEECCCCCCCHHHHH	59.98	30622161
115	Ubiquitination	REKNESNKSSFDKMI ECCCCCCCHHHHHHH	57.67	33845483
116	Phosphorylation	EKNESNKSSFDKMIE CCCCCCCHHHHHHHH	40.25	30622161
117	Phosphorylation	KNESNKSSFDKMIEA CCCCCCHHHHHHHHH	38.79	30622161
120	2-Hydroxyisobutyrylation	SNKSSFDKMIEAIKE CCCHHHHHHHHHHHH	39.50	-
120	Acetylation	SNKSSFDKMIEAIKE CCCHHHHHHHHHHHH	39.50	23749302
120	Ubiquitination	SNKSSFDKMIEAIKE CCCHHHHHHHHHHHH	39.50	22817900
126	Acetylation	DKMIEAIKESKNGKK HHHHHHHHHCCCCCE	64.08	25953088
126	Ubiquitination	DKMIEAIKESKNGKK HHHHHHHHHCCCCCE	64.08	-
128	Phosphorylation	MIEAIKESKNGKKIG HHHHHHHCCCCCEEE	26.81	28258704
131	Ubiquitination	AIKESKNGKKIGVFS HHHHCCCCCEEEEEE	36.05	21890473
134	Ubiquitination	ESKNGKKIGVFSKDK HCCCCCEEEEEECCC	6.92	23000965
138	Phosphorylation	GKKIGVFSKDKFPGE CCEEEEEECCCCCHH	37.22	28258704
139	Acetylation	KKIGVFSKDKFPGEF CEEEEEECCCCCHHH	54.17	19608861
139	Ubiquitination	KKIGVFSKDKFPGEF CEEEEEECCCCCHHH	54.17	19608861
141	Acetylation	IGVFSKDKFPGEFMK EEEEECCCCCHHHHH	58.14	23749302
146	Ubiquitination	KDKFPGEFMKSWNDC CCCCCHHHHHHHHHH	10.41	22817900
151	Ubiquitination	GEFMKSWNDCLNKEG HHHHHHHHHHCCCCC	36.89	22817900
156	Acetylation	SWNDCLNKEGFDKID HHHHHCCCCCCCCCC	46.39	25825284
156	Methylation	SWNDCLNKEGFDKID HHHHHCCCCCCCCCC	46.39	24818181
156	Ubiquitination	SWNDCLNKEGFDKID HHHHHCCCCCCCCCC	46.39	23000965
161	Ubiquitination	LNKEGFDKIDISAVV CCCCCCCCCCHHHEE	39.76	23000965
165	Phosphorylation	GFDKIDISAVVAYTI CCCCCCHHHEEEEEE	15.97	21601212
171	Phosphorylation	ISAVVAYTIAVKEDG HHHEEEEEEEECCCC	7.85	21601212
184	2-Hydroxyisobutyrylation	DGELNLMKKAASITS CCCCCHHHHHHHCHH	42.29	-
184	Acetylation	DGELNLMKKAASITS CCCCCHHHHHHHCHH	42.29	25953088
184	Ubiquitination	DGELNLMKKAASITS CCCCCHHHHHHHCHH	42.29	32015554
185	Malonylation	GELNLMKKAASITSE CCCCHHHHHHHCHHH	34.91	26320211
185	Ubiquitination	GELNLMKKAASITSE CCCCHHHHHHHCHHH	34.91	29967540
188	Phosphorylation	NLMKKAASITSEVFN CHHHHHHHCHHHHHH	31.12	30266825
190	Phosphorylation	MKKAASITSEVFNKF HHHHHHCHHHHHHHH	19.15	30266825
191	Phosphorylation	KKAASITSEVFNKFF HHHHHCHHHHHHHHH	30.05	30266825
196	Acetylation	ITSEVFNKFFKERVM CHHHHHHHHHHHHHH	40.49	19608861
196	Ubiquitination	ITSEVFNKFFKERVM CHHHHHHHHHHHHHH	40.49	23000965
199	Ubiquitination	EVFNKFFKERVMEIV HHHHHHHHHHHHHHC	47.98	23000965
203	Sulfoxidation	KFFKERVMEIVDADE HHHHHHHHHHCCCCH	3.49	21406390
211	Acetylation	EIVDADEKVRHSKLA HHCCCCHHHCHHHHH	45.15	23749302
211	Ubiquitination	EIVDADEKVRHSKLA HHCCCCHHHCHHHHH	45.15	21906983
216	2-Hydroxyisobutyrylation	DEKVRHSKLAESVEK CHHHCHHHHHHHHHH	45.66	-
216	Acetylation	DEKVRHSKLAESVEK CHHHCHHHHHHHHHH	45.66	23749302
216	Ubiquitination	DEKVRHSKLAESVEK CHHHCHHHHHHHHHH	45.66	22817900
220	O-linked_Glycosylation	RHSKLAESVEKAIEE CHHHHHHHHHHHHHH	29.93	23301498
223	2-Hydroxyisobutyrylation	KLAESVEKAIEEKKY HHHHHHHHHHHHHHH	53.13	-
223	Acetylation	KLAESVEKAIEEKKY HHHHHHHHHHHHHHH	53.13	19608861
223	Ubiquitination	KLAESVEKAIEEKKY HHHHHHHHHHHHHHH	53.13	19608861
263	Acetylation	KFSVVSDKNHMHFGA EEEEEECCCCCEECC	41.04	25953088
263	Ubiquitination	KFSVVSDKNHMHFGA EEEEEECCCCCEECC	41.04	-
280	Acetylation	CAMGIRFKSYCSNLV HHHCCHHHHHHHCHH	30.57	25825284
280	Malonylation	CAMGIRFKSYCSNLV HHHCCHHHHHHHCHH	30.57	26320211
280	Methylation	CAMGIRFKSYCSNLV HHHCCHHHHHHHCHH	30.57	109063049
280	Ubiquitination	CAMGIRFKSYCSNLV HHHCCHHHHHHHCHH	30.57	-
301	Ubiquitination	PSQEVQENYNFLLQL CCHHHHHHHHHHHHH	21.69	23000965
305	Ubiquitination	VQENYNFLLQLQEEL HHHHHHHHHHHHHHH	2.37	23000965
307	Ubiquitination	ENYNFLLQLQEELLK HHHHHHHHHHHHHHH	43.16	23000965
321	Acetylation	KELRHGVKICDVYNA HHHHHCCCHHHHHHH	42.06	26051181
326	Phosphorylation	GVKICDVYNAVMDVV CCCHHHHHHHHHHHH	5.55	-
334	Acetylation	NAVMDVVKKQKPELL HHHHHHHHHHCHHHH	49.70	25953088
334	Neddylation	NAVMDVVKKQKPELL HHHHHHHHHHCHHHH	49.70	32015554
334	Ubiquitination	NAVMDVVKKQKPELL HHHHHHHHHHCHHHH	49.70	32015554
335	Acetylation	AVMDVVKKQKPELLN HHHHHHHHHCHHHHH	52.52	19608861
335	Ubiquitination	AVMDVVKKQKPELLN HHHHHHHHHCHHHHH	52.52	32015554
337	Acetylation	MDVVKKQKPELLNKI HHHHHHHCHHHHHHH	49.71	19608861
337	Ubiquitination	MDVVKKQKPELLNKI HHHHHHHCHHHHHHH	49.71	29967540
357	Ubiquitination	FGMGIEFREGSLVIN CCCCEEECCCEEEEE	34.28	22817900
358	Ubiquitination	GMGIEFREGSLVINS CCCEEECCCEEEEEC	59.46	22817900
359	Ubiquitination	MGIEFREGSLVINSK CCEEECCCEEEEECC	23.25	22817900
360	Phosphorylation	GIEFREGSLVINSKN CEEECCCEEEEECCC	18.08	23312004
361	Ubiquitination	IEFREGSLVINSKNQ EEECCCEEEEECCCC	7.06	21890473
366	Acetylation	GSLVINSKNQYKLKK CEEEEECCCCEEECC	43.51	25953088
366	Malonylation	GSLVINSKNQYKLKK CEEEEECCCCEEECC	43.51	26320211
366	Ubiquitination	GSLVINSKNQYKLKK CEEEEECCCCEEECC	43.51	23000965
370	Ubiquitination	INSKNQYKLKKGMVF EECCCCEEECCCEEE	44.03	23000965
372	Ubiquitination	SKNQYKLKKGMVFSI CCCCEEECCCEEEEE	43.03	23000965
392	Acetylation	DLTNKEGKKPEEKTY HCCCCCCCCHHHCEE	67.27	12431835
408	Ubiquitination	LFIGDTVLVDEDGPA EEECCEEEECCCCCC	4.33	23000965
414	Ubiquitination	VLVDEDGPATVLTSV EEECCCCCCEEECCH	36.76	23000965
422	Sumoylation	ATVLTSVKKKVKNVG CEEECCHHHHHCEEE	46.79	-
422	Ubiquitination	ATVLTSVKKKVKNVG CEEECCHHHHHCEEE	46.79	22817900
423	Ubiquitination	TVLTSVKKKVKNVGI EEECCHHHHHCEEEE	61.72	22817900
424	Ubiquitination	VLTSVKKKVKNVGIF EECCHHHHHCEEEEE	53.36	22817900
426	Ubiquitination	TSVKKKVKNVGIFLK CCHHHHHCEEEEEEE	55.59	22817900
432	Ubiquitination	VKNVGIFLKNEDEEE HCEEEEEEECCCHHH	5.71	22817900
433	Acetylation	KNVGIFLKNEDEEEE CEEEEEEECCCHHHH	47.76	26051181
433	Sumoylation	KNVGIFLKNEDEEEE CEEEEEEECCCHHHH	47.76	-
433	Ubiquitination	KNVGIFLKNEDEEEE CEEEEEEECCCHHHH	47.76	32015554
439	Ubiquitination	LKNEDEEEEEEEKDE EECCCHHHHHHHHHH	69.53	24816145
442	Ubiquitination	EDEEEEEEEKDEAED CCHHHHHHHHHHHHH	73.88	23000965
444	Acetylation	EEEEEEEKDEAEDLL HHHHHHHHHHHHHHH	65.24	26051181
444	Ubiquitination	EEEEEEEKDEAEDLL HHHHHHHHHHHHHHH	65.24	29967540
448	Ubiquitination	EEEKDEAEDLLGRGS HHHHHHHHHHHCHHH	47.33	23000965
455	Phosphorylation	EDLLGRGSRAALLTE HHHHCHHHHHHHHHH	19.86	25159151
461	Phosphorylation	GSRAALLTERTRNEM HHHHHHHHHHHHHCC	25.03	28555341
464	Phosphorylation	AALLTERTRNEMTAE HHHHHHHHHHCCCHH	31.45	28555341
469	Phosphorylation	ERTRNEMTAEEKRRA HHHHHCCCHHHHHHH	25.41	27470641
473	Acetylation	NEMTAEEKRRAHQKE HCCCHHHHHHHHHHH	38.39	25953088
473	Ubiquitination	NEMTAEEKRRAHQKE HCCCHHHHHHHHHHH	38.39	23000965
479	Sumoylation	EKRRAHQKELAAQLN HHHHHHHHHHHHHHC	44.84	-
479	Sumoylation	EKRRAHQKELAAQLN HHHHHHHHHHHHHHC	44.84	-
479	Ubiquitination	EKRRAHQKELAAQLN HHHHHHHHHHHHHHC	44.84	23000965
490	Acetylation	AQLNEEAKRRLTEQK HHHCHHHHHHHHHHH	41.13	25953088
490	Ubiquitination	AQLNEEAKRRLTEQK HHHCHHHHHHHHHHH	41.13	32015554
494	Phosphorylation	EEAKRRLTEQKGEQQ HHHHHHHHHHHHHHH	34.26	21601212
497	Sumoylation	KRRLTEQKGEQQIQK HHHHHHHHHHHHHHH	59.17	-
497	Sumoylation	KRRLTEQKGEQQIQK HHHHHHHHHHHHHHH	59.17	28112733
497	Ubiquitination	KRRLTEQKGEQQIQK HHHHHHHHHHHHHHH	59.17	21906983
504	Acetylation	KGEQQIQKARKSNVS HHHHHHHHHHHCCCC	52.36	25953088
504	Ubiquitination	KGEQQIQKARKSNVS HHHHHHHHHHHCCCC	52.36	24816145
507	Ubiquitination	QQIQKARKSNVSYKN HHHHHHHHCCCCCCC	51.77	23000965
508	Phosphorylation	QIQKARKSNVSYKNP HHHHHHHCCCCCCCC	36.59	26055452
511	Phosphorylation	KARKSNVSYKNPSLM HHHHCCCCCCCCCCC	34.34	24732914
512	Phosphorylation	ARKSNVSYKNPSLMP HHHCCCCCCCCCCCC	15.53	24732914
513	Acetylation	RKSNVSYKNPSLMPK HHCCCCCCCCCCCCC	55.67	19608861
513	Sumoylation	RKSNVSYKNPSLMPK HHCCCCCCCCCCCCC	55.67	28112733
513	Ubiquitination	RKSNVSYKNPSLMPK HHCCCCCCCCCCCCC	55.67	23000965
516	Phosphorylation	NVSYKNPSLMPKEPH CCCCCCCCCCCCCCC	46.85	27251275
520	Ubiquitination	KNPSLMPKEPHIREM CCCCCCCCCCCCCEE	70.66	29967540
528	Acetylation	EPHIREMKIYIDKKY CCCCCEEEEEECCCC	27.83	25825284
531	Ubiquitination	IREMKIYIDKKYETV CCEEEEEECCCCCEE	7.73	21890473
533	Acetylation	EMKIYIDKKYETVIM EEEEEECCCCCEEEE	47.93	26051181
533	Neddylation	EMKIYIDKKYETVIM EEEEEECCCCCEEEE	47.93	32015554
534	Acetylation	MKIYIDKKYETVIMP EEEEECCCCCEEEEE	44.57	26051181
535	Phosphorylation	KIYIDKKYETVIMPV EEEECCCCCEEEEEC	23.67	28064214
540	Sulfoxidation	KKYETVIMPVFGIAT CCCCEEEEECCCCCC	1.69	28183972
541	Ubiquitination	KYETVIMPVFGIATP CCCEEEEECCCCCCC	13.73	24816145
547	Phosphorylation	MPVFGIATPFHIATI EECCCCCCCCEEEEE	25.27	-
558	Phosphorylation	IATIKNISMSVEGDY EEEEEEEEEEEECCE	17.88	20068231
560	Phosphorylation	TIKNISMSVEGDYTY EEEEEEEEEECCEEE	15.38	25072903
565	Phosphorylation	SMSVEGDYTYLRINF EEEEECCEEEEEEEE	14.24	27273156
566	Phosphorylation	MSVEGDYTYLRINFY EEEECCEEEEEEEEE	22.33	28152594
567	Phosphorylation	SVEGDYTYLRINFYC EEECCEEEEEEEEEE	6.43	28152594
573	Phosphorylation	TYLRINFYCPGSALG EEEEEEEEECCCCCC	8.01	28152594
577	Phosphorylation	INFYCPGSALGRNEG EEEEECCCCCCCCCC	12.88	28152594
577	Ubiquitination	INFYCPGSALGRNEG EEEEECCCCCCCCCC	12.88	22817900
582	Ubiquitination	PGSALGRNEGNIFPN CCCCCCCCCCCCCCC	60.78	21890473
593	Phosphorylation	IFPNPEATFVKEITY CCCCCCCEEEEEEEE	27.57	-
596	Acetylation	NPEATFVKEITYRAS CCCCEEEEEEEEECC	38.93	25825284
596	Ubiquitination	NPEATFVKEITYRAS CCCCEEEEEEEEECC	38.93	21963094
598	Ubiquitination	EATFVKEITYRASNI CCEEEEEEEEECCCC	3.21	21890473
599	Phosphorylation	ATFVKEITYRASNIK CEEEEEEEEECCCCC	14.19	-
600	Phosphorylation	TFVKEITYRASNIKA EEEEEEEEECCCCCC	15.16	-
603	Phosphorylation	KEITYRASNIKAPGE EEEEEECCCCCCCCC	30.04	-
606	Ubiquitination	TYRASNIKAPGEQTV EEECCCCCCCCCCCC	53.42	27667366
609	Ubiquitination	ASNIKAPGEQTVPAL CCCCCCCCCCCCCCC	44.50	21890473
626	Acetylation	QNAFRIIKEVQKRYK HHHHHHHHHHHHHHH	49.84	26051181
626	Ubiquitination	QNAFRIIKEVQKRYK HHHHHHHHHHHHHHH	49.84	29967540
631	Ubiquitination	IIKEVQKRYKTREAE HHHHHHHHHHCHHHH	22.53	21890473
632	Phosphorylation	IKEVQKRYKTREAEE HHHHHHHHHCHHHHH	24.60	19369195
634	Phosphorylation	EVQKRYKTREAEEKE HHHHHHHCHHHHHHH	25.47	-
640	Acetylation	KTREAEEKEKEGIVK HCHHHHHHHHCCCCC	66.64	25953088
640	Ubiquitination	KTREAEEKEKEGIVK HCHHHHHHHHCCCCC	66.64	-
642	2-Hydroxyisobutyrylation	REAEEKEKEGIVKQD HHHHHHHHCCCCCCC	72.77	-
642	Ubiquitination	REAEEKEKEGIVKQD HHHHHHHHCCCCCCC	72.77	22817900
647	Sumoylation	KEKEGIVKQDSLVIN HHHCCCCCCCEEEEE	46.60	-
647	Sumoylation	KEKEGIVKQDSLVIN HHHCCCCCCCEEEEE	46.60	28112733
647	Ubiquitination	KEKEGIVKQDSLVIN HHHCCCCCCCEEEEE	46.60	21906983
650	Phosphorylation	EGIVKQDSLVINLNR CCCCCCCEEEEECCC	23.26	28355574
658	Phosphorylation	LVINLNRSNPKLKDL EEEECCCCCCCHHHE	57.31	25159151
661	Ubiquitination	NLNRSNPKLKDLYIR ECCCCCCCHHHEEEC	72.86	22817900
663	Sumoylation	NRSNPKLKDLYIRPN CCCCCCHHHEEECCH	52.38	-
663	Acetylation	NRSNPKLKDLYIRPN CCCCCCHHHEEECCH	52.38	23749302
663	Malonylation	NRSNPKLKDLYIRPN CCCCCCHHHEEECCH	52.38	26320211
663	Sumoylation	NRSNPKLKDLYIRPN CCCCCCHHHEEECCH	52.38	-
663	Ubiquitination	NRSNPKLKDLYIRPN CCCCCCHHHEEECCH	52.38	21890473
666	Phosphorylation	NPKLKDLYIRPNIAQ CCCHHHEEECCHHHH	12.67	28152594
674	Acetylation	IRPNIAQKRMQGSLE ECCHHHHHHHHCCEE	40.59	23749302
674	Ubiquitination	IRPNIAQKRMQGSLE ECCHHHHHHHHCCEE	40.59	22817900
690	Phosphorylation	HVNGFRFTSVRGDKV EECCEEEEEECCCCE	23.27	23186163
691	Phosphorylation	VNGFRFTSVRGDKVD ECCEEEEEECCCCEE	13.70	23186163
696	2-Hydroxyisobutyrylation	FTSVRGDKVDILYNN EEEECCCCEEEEECC	44.63	-
696	Acetylation	FTSVRGDKVDILYNN EEEECCCCEEEEECC	44.63	25953088
696	Ubiquitination	FTSVRGDKVDILYNN EEEECCCCEEEEECC	44.63	23000965
701	Phosphorylation	GDKVDILYNNIKHAL CCCEEEEECCHHHHE	13.39	28152594
712	Ubiquitination	KHALFQPCDGEMIIV HHHEECCCCCCEEEE	7.94	22817900
716	Ubiquitination	FQPCDGEMIIVLHFH ECCCCCCEEEEEEEE	2.87	21890473
721	Ubiquitination	GEMIIVLHFHLKNAI CCEEEEEEEEHHCHH	9.37	21890473
727	Ubiquitination	LHFHLKNAIMFGKKR EEEEHHCHHHHCCCC	7.95	22817900
732	Acetylation	KNAIMFGKKRHTDVQ HCHHHHCCCCCCCCC	35.06	19608861
732	Ubiquitination	KNAIMFGKKRHTDVQ HCHHHHCCCCCCCCC	35.06	32015554
733	Ubiquitination	NAIMFGKKRHTDVQF CHHHHCCCCCCCCCE	50.20	-
741	Phosphorylation	RHTDVQFYTEVGEIT CCCCCCEEEEEEEEE	5.72	22817900
753	Ubiquitination	EITTDLGKHQHMHDR EEECCCCCCCCCCCH	47.60	29967540
760	Methylation	KHQHMHDRDDLYAEQ CCCCCCCHHHHHHHH	25.35	115917601
764	Phosphorylation	MHDRDDLYAEQMERE CCCHHHHHHHHHHHH	18.32	-
777	Ubiquitination	REMRHKLKTAFKNFI HHHHHHHHHHHHHHH	42.48	22817900
781	Acetylation	HKLKTAFKNFIEKVE HHHHHHHHHHHHHHH	48.78	23749302
781	Ubiquitination	HKLKTAFKNFIEKVE HHHHHHHHHHHHHHH	48.78	22817900
786	2-Hydroxyisobutyrylation	AFKNFIEKVEALTKE HHHHHHHHHHHHCHH	40.33	-
786	Acetylation	AFKNFIEKVEALTKE HHHHHHHHHHHHCHH	40.33	19608861
786	Ubiquitination	AFKNFIEKVEALTKE HHHHHHHHHHHHCHH	40.33	22817900
792	Ubiquitination	EKVEALTKEELEFEV HHHHHHCHHHCEEEC	50.47	21906983
839	Ubiquitination	PFVVTLDEVELIHFE CEEEEECCEEEEEEE	40.79	21890473
842	Ubiquitination	VTLDEVELIHFERVQ EEECCEEEEEEEEEE	4.44	22817900
861	Phosphorylation	NFDMVIVYKDYSKKV CCCEEEEECCCCCCE	6.24	-
864	Phosphorylation	MVIVYKDYSKKVTMI EEEEECCCCCCEEEE	20.45	21214269
865	Phosphorylation	VIVYKDYSKKVTMIN EEEECCCCCCEEEEE	35.81	21214269
867	Ubiquitination	VYKDYSKKVTMINAI EECCCCCCEEEEEEE	36.68	29967540
883	Ubiquitination	VASLDPIKEWLNSCD CCCCCHHHHHHHHCC	48.50	29967540
892	Ubiquitination	WLNSCDLKYTEGVQS HHHHCCCCCCCCCCC	36.55	32015554
893	Phosphorylation	LNSCDLKYTEGVQSL HHHCCCCCCCCCCCC	19.81	23186163
894	Phosphorylation	NSCDLKYTEGVQSLN HHCCCCCCCCCCCCC	25.36	28152594
899	Phosphorylation	KYTEGVQSLNWTKIM CCCCCCCCCCHHHHH	22.67	29978859
903	Phosphorylation	GVQSLNWTKIMKTIV CCCCCCHHHHHHHHC	15.04	19664994
904	Acetylation	VQSLNWTKIMKTIVD CCCCCHHHHHHHHCC	32.20	19608861
904	Ubiquitination	VQSLNWTKIMKTIVD CCCCCHHHHHHHHCC	32.20	22817900
907	Ubiquitination	LNWTKIMKTIVDDPE CCHHHHHHHHCCCCC	38.28	22817900
932	Phosphorylation	LEPEGEGSDAEEGDS CCCCCCCCCCCCCCC	29.37	19007248
979	Phosphorylation	ESDYSKESLGSEEES HCCCCHHHHCCCCHH	41.59	20164059
979	Ubiquitination	ESDYSKESLGSEEES HCCCCHHHHCCCCHH	41.59	24816145
982	Phosphorylation	YSKESLGSEEESGKD CCHHHHCCCCHHCCC	47.32	22167270
986	Phosphorylation	SLGSEEESGKDWDEL HHCCCCHHCCCHHHH	55.19	22167270
1004	Phosphorylation	ARKADRESRYEEEEE HHHHHHHHHHHHHHH	40.85	25159151
1006	Phosphorylation	KADRESRYEEEEEQS HHHHHHHHHHHHHHH	36.65	28796482
1013	Phosphorylation	YEEEEEQSRSMSRKR HHHHHHHHHHHCHHH	29.60	25159151
1014	Methylation	EEEEEQSRSMSRKRK HHHHHHHHHHCHHHH	35.75	115917597
1015	Phosphorylation	EEEEQSRSMSRKRKA HHHHHHHHHCHHHHH	26.76	25159151
1017	Phosphorylation	EEQSRSMSRKRKASV HHHHHHHCHHHHHHH	35.58	25159151
1023	Phosphorylation	MSRKRKASVHSSGRG HCHHHHHHHCCCCCC	24.33	26055452
1026	Phosphorylation	KRKASVHSSGRGSNR HHHHHHCCCCCCCCC	32.12	23403867
1027	Phosphorylation	RKASVHSSGRGSNRG HHHHHCCCCCCCCCC	20.03	23403867
1029	Dimethylation	ASVHSSGRGSNRGSR HHHCCCCCCCCCCCC	47.52	-
1029	Methylation	ASVHSSGRGSNRGSR HHHCCCCCCCCCCCC	47.52	54559583
1031	Phosphorylation	VHSSGRGSNRGSRHS HCCCCCCCCCCCCCC	23.22	23911959
1033	Dimethylation	SSGRGSNRGSRHSSA CCCCCCCCCCCCCCC	46.27	-
1033	Methylation	SSGRGSNRGSRHSSA CCCCCCCCCCCCCCC	46.27	54559591
1036	Methylation	RGSNRGSRHSSAPPK CCCCCCCCCCCCCCC	36.21	54559599
1038	Phosphorylation	SNRGSRHSSAPPKKK CCCCCCCCCCCCCCC	27.38	18510355
1039	Phosphorylation	NRGSRHSSAPPKKKR CCCCCCCCCCCCCCC	38.37	18510355
1044	Ubiquitination	HSSAPPKKKRK---- CCCCCCCCCCC----	64.68	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
494	T	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SP16H_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SP16H_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPA49_HUMAN	POLR1E	physical	19214185
SSRP1_HUMAN	SSRP1	physical	16902406
SSRP1_HUMAN	SSRP1	physical	16682447
TRI33_HUMAN	TRIM33	physical	20603019
TAL1_HUMAN	TAL1	physical	20603019
SP16H_HUMAN	SUPT16H	physical	20603019
CDK9_HUMAN	CDK9	physical	20603019
SSRP1_HUMAN	SSRP1	physical	22939629
TOP1_HUMAN	TOP1	physical	22939629
FRIH_HUMAN	FTH1	physical	22863883
BRE1A_HUMAN	RNF20	physical	24357716
PAF1_HUMAN	PAF1	physical	24357716
TONSL_HUMAN	TONSL	physical	25184681
BRD3_HUMAN	BRD3	physical	26344197
CDK12_HUMAN	CDK12	physical	26344197
CSK2B_HUMAN	CSNK2B	physical	26344197
CTR9_HUMAN	CTR9	physical	26344197
H2B1A_HUMAN	HIST1H2BA	physical	26344197
HMGB1_HUMAN	HMGB1	physical	26344197
IWS1_HUMAN	IWS1	physical	26344197
NP1L1_HUMAN	NAP1L1	physical	26344197
PESC_HUMAN	PES1	physical	26344197
SMRCD_HUMAN	SMARCAD1	physical	26344197
SRRM1_HUMAN	SRRM1	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197
TOP1_HUMAN	TOP1	physical	26344197
ZCH18_HUMAN	ZC3H18	physical	26344197
UBR5_HUMAN	UBR5	physical	27647897
RFA3_HUMAN	RPA3	physical	27173435
WRN_HUMAN	WRN	physical	27173435
SSRP1_HUMAN	SSRP1	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SP16H_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-979; SER-982 AND SER-986, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-139; LYS-196; LYS-223;LYS-513; LYS-732; LYS-786 AND LYS-904, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-979; SER-982 AND SER-986, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-508; SER-650 ANDSER-1015, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-932, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979; SER-982 ANDSER-986, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-632, AND MASSSPECTROMETRY.	19369195 [Abstract]