UBR5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBR5_HUMAN
• UniProt AC: O95071
• Protein Name: E3 ubiquitin-protein ligase UBR5
• Gene Name: UBR5
• Organism: Homo sapiens (Human).
• Sequence Length: 2799
• Subcellular Localization: Nucleus.
• Protein Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity). Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes..
• Protein Sequence: MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAFLLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQEPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVEAIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQSDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPTKMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTSIHFVVH ------CCEEEEEEE	47.93	19413330
28	Ubiquitination	RLREVSEKLNKYNLN HHHHHHHHHHHCCCC	50.26	27667366
31	Ubiquitination	EVSEKLNKYNLNSHP HHHHHHHHCCCCCCC	46.05	29967540
32	Phosphorylation	VSEKLNKYNLNSHPP HHHHHHHCCCCCCCC	24.65	-
36	Phosphorylation	LNKYNLNSHPPLNVL HHHCCCCCCCCCHHH	40.30	-
49	Ubiquitination	VLEQATIKQCVVGPN HHHHCEEEEEEECCC	33.03	29967540
73	Phosphorylation	RVCRIGFSVQPDRLE CEEEEEEEECCCCEE	18.03	-
76	Ubiquitination	RIGFSVQPDRLELGK EEEEEECCCCEECCC	26.91	23503661
78	Methylation	GFSVQPDRLELGKPD EEEECCCCEECCCCC	36.42	115919469
83	Ubiquitination	PDRLELGKPDNNDGS CCCEECCCCCCCCCC	62.92	32015554
90	Phosphorylation	KPDNNDGSKLNSNSG CCCCCCCCCCCCCCC	36.51	25159151
91	Ubiquitination	PDNNDGSKLNSNSGA CCCCCCCCCCCCCCC	58.16	23503661
94	O-linked_Glycosylation	NDGSKLNSNSGAGRT CCCCCCCCCCCCCCC	42.69	30379171
94	Phosphorylation	NDGSKLNSNSGAGRT CCCCCCCCCCCCCCC	42.69	21712546
96	Phosphorylation	GSKLNSNSGAGRTSR CCCCCCCCCCCCCCC	29.82	26425664
101	Phosphorylation	SNSGAGRTSRPGRTS CCCCCCCCCCCCCCC	28.33	28555341
102	Phosphorylation	NSGAGRTSRPGRTSD CCCCCCCCCCCCCCC	34.81	28555341
107	Phosphorylation	RTSRPGRTSDSPWFL CCCCCCCCCCCCCCC	42.68	21712546
108	Phosphorylation	TSRPGRTSDSPWFLS CCCCCCCCCCCCCCC	34.43	21712546
110	Phosphorylation	RPGRTSDSPWFLSGS CCCCCCCCCCCCCCC	24.65	25159151
115	Phosphorylation	SDSPWFLSGSETLGR CCCCCCCCCCHHHHH	30.69	25159151
117	Phosphorylation	SPWFLSGSETLGRLA CCCCCCCCHHHHHHC	24.83	29396449
119	Phosphorylation	WFLSGSETLGRLAGN CCCCCCHHHHHHCCC	35.89	29396449
119	Ubiquitination	WFLSGSETLGRLAGN CCCCCCHHHHHHCCC	35.89	23000965
130	Phosphorylation	LAGNTLGSRWSSGVG HCCCCCCCCCCCCCC	33.42	-
133	Phosphorylation	NTLGSRWSSGVGGSG CCCCCCCCCCCCCCC	18.99	21712546
134	Phosphorylation	TLGSRWSSGVGGSGG CCCCCCCCCCCCCCC	30.45	20068231
139	Phosphorylation	WSSGVGGSGGGSSGR CCCCCCCCCCCCCCC	28.47	26055452
143	Phosphorylation	VGGSGGGSSGRSSAG CCCCCCCCCCCCCCC	32.66	28450419
144	Phosphorylation	GGSGGGSSGRSSAGA CCCCCCCCCCCCCCC	41.31	21815630
146	Methylation	SGGGSSGRSSAGARD CCCCCCCCCCCCCCC	29.41	115919461
154	Phosphorylation	SSAGARDSRRQTRVI CCCCCCCCCCCCEEE	24.65	-
158	Phosphorylation	ARDSRRQTRVIRTGR CCCCCCCCEEEECCC	25.70	24702127
167	Methylation	VIRTGRDRGSGLLGS EEECCCCCCCCCCCC	39.55	115383913
169	Phosphorylation	RTGRDRGSGLLGSQP ECCCCCCCCCCCCCC	27.45	23663014
174	Phosphorylation	RGSGLLGSQPQPVIP CCCCCCCCCCCCCCC	38.36	23663014
183	Phosphorylation	PQPVIPASVIPEELI CCCCCCHHHCCHHHH	18.41	23663014
185	Ubiquitination	PVIPASVIPEELISQ CCCCHHHCCHHHHHH	3.09	21987572
191	Phosphorylation	VIPEELISQAQVVLQ HCCHHHHHHHHHHHC	31.89	17478428
200	Ubiquitination	AQVVLQGKSRSVIIR HHHHHCCCCHHHHHH	29.72	33845483
201	Phosphorylation	QVVLQGKSRSVIIRE HHHHCCCCHHHHHHH	36.29	29449344
203	Phosphorylation	VLQGKSRSVIIRELQ HHCCCCHHHHHHHHH	25.43	21857030
212	Phosphorylation	IIRELQRTNLDVNLA HHHHHHHCCCCHHHH	27.46	-
286	Phosphorylation	GYPSFRRSSLSRLGS CCCHHCHHHHHHHCC	31.23	20363803
287	Phosphorylation	YPSFRRSSLSRLGSS CCHHCHHHHHHHCCC	28.66	16083285
289	Phosphorylation	SFRRSSLSRLGSSRV HHCHHHHHHHCCCEE	27.66	20363803
293	Phosphorylation	SSLSRLGSSRVLLLP HHHHHHCCCEEEEEE	21.40	-
294	Phosphorylation	SLSRLGSSRVLLLPL HHHHHCCCEEEEEEC	25.30	-
305	Phosphorylation	LLPLERDSELLRERE EEECCCCHHHHHHHH	36.04	28555341
313	Phosphorylation	ELLRERESVLRLRER HHHHHHHHHHHHHHH	32.45	23401153
315	Ubiquitination	LRERESVLRLRERRW HHHHHHHHHHHHHHH	6.25	22817900
316	Ubiquitination	RERESVLRLRERRWL HHHHHHHHHHHHHHH	29.55	22817900
322	Ubiquitination	LRLRERRWLDGASFD HHHHHHHHHCCCCCC	12.67	22817900
324	Ubiquitination	LRERRWLDGASFDNE HHHHHHHCCCCCCCC	43.59	22817900
325	Ubiquitination	RERRWLDGASFDNER HHHHHHCCCCCCCCC	22.43	22817900
327	Phosphorylation	RRWLDGASFDNERGS HHHHCCCCCCCCCCC	38.37	22617229
330	Ubiquitination	LDGASFDNERGSTSK HCCCCCCCCCCCCCC	38.56	22817900
331	Ubiquitination	DGASFDNERGSTSKE CCCCCCCCCCCCCCC	61.33	22817900
334	Phosphorylation	SFDNERGSTSKEGEP CCCCCCCCCCCCCCC	35.41	23090842
335	Phosphorylation	FDNERGSTSKEGEPN CCCCCCCCCCCCCCC	46.79	23090842
336	Phosphorylation	DNERGSTSKEGEPNL CCCCCCCCCCCCCCC	30.33	23090842
337	Ubiquitination	NERGSTSKEGEPNLD CCCCCCCCCCCCCCC	70.58	21906983
345	Ubiquitination	EGEPNLDKKNTPVQS CCCCCCCCCCCCCCC	51.60	22817900
346	Ubiquitination	GEPNLDKKNTPVQSP CCCCCCCCCCCCCCC	66.76	21906983
348	Phosphorylation	PNLDKKNTPVQSPVS CCCCCCCCCCCCCCC	33.44	25159151
350	Ubiquitination	LDKKNTPVQSPVSLG CCCCCCCCCCCCCCC	9.18	21963094
352	Phosphorylation	KKNTPVQSPVSLGED CCCCCCCCCCCCCCC	27.74	19060867
361	Ubiquitination	VSLGEDLQWWPDKDG CCCCCCCCCCCCCCC	53.13	21963094
366	Ubiquitination	DLQWWPDKDGTKFIC CCCCCCCCCCCEEEE	54.71	29967540
394	Ubiquitination	KGELYQWKWSESEPY CCCEEEEECCCCCCC	25.89	29967540
421	Ubiquitination	ATFLGLTNEKIVLLS CEEECCCCCEEEEEE	54.31	21963094
422	Ubiquitination	TFLGLTNEKIVLLSA EEECCCCCEEEEEEC	38.64	27667366
423	Ubiquitination	FLGLTNEKIVLLSAN EECCCCCEEEEEECC	39.94	-
427	Ubiquitination	TNEKIVLLSANSIRA CCCEEEEEECCCCEE	2.92	21963094
442	Ubiquitination	TVATENNKVATWVDE EEEECCCEEEHHHHH	44.84	21906983
457	Ubiquitination	TLSSVASKLEHTAQT HHHHHHHHHHHHHHH	48.43	29967540
564	Phosphorylation	KVGVLMESVWNMNDS CCEEEEHHHCCCCCC	20.61	24850871
569	Ubiquitination	MESVWNMNDSCRFQL EHHHCCCCCCCCEEC	34.53	27667366
571	Phosphorylation	SVWNMNDSCRFQLRS HHCCCCCCCCEECCC	11.37	24850871
575	Ubiquitination	MNDSCRFQLRSPESL CCCCCCEECCCHHHH	19.33	27667366
578	Phosphorylation	SCRFQLRSPESLKNM CCCEECCCHHHHHHH	41.43	25159151
581	Phosphorylation	FQLRSPESLKNMEKA EECCCHHHHHHHHHH	48.29	28450419
583	Ubiquitination	LRSPESLKNMEKASK CCCHHHHHHHHHHHC	64.62	33845483
590	Ubiquitination	KNMEKASKTTEAKPE HHHHHHHCCCCCCCC	65.41	27667366
598	Phosphorylation	TTEAKPESKQEPVKT CCCCCCCCCCCCCCC	48.44	22817900
599	Ubiquitination	TEAKPESKQEPVKTE CCCCCCCCCCCCCCC	57.95	33845483
605	Phosphorylation	SKQEPVKTEMGPPPS CCCCCCCCCCCCCCC	31.29	28122231
612	Phosphorylation	TEMGPPPSPASTCSD CCCCCCCCCCCCCCC	38.58	25159151
615	Phosphorylation	GPPPSPASTCSDASS CCCCCCCCCCCCHHH	33.07	28102081
616	Phosphorylation	PPPSPASTCSDASSI CCCCCCCCCCCHHHH	20.38	21815630
618	Phosphorylation	PSPASTCSDASSIAS CCCCCCCCCHHHHHH	35.98	21815630
621	Phosphorylation	ASTCSDASSIASSAS CCCCCCHHHHHHHCC	27.54	28985074
622	Phosphorylation	STCSDASSIASSASM CCCCCHHHHHHHCCC	24.72	26074081
625	Phosphorylation	SDASSIASSASMPYK CCHHHHHHHCCCCCC	25.43	26074081
626	Phosphorylation	DASSIASSASMPYKR CHHHHHHHCCCCCCC	18.49	26074081
636	Phosphorylation	MPYKRRRSTPAPKEE CCCCCCCCCCCCHHH	36.61	23401153
637	Phosphorylation	PYKRRRSTPAPKEEE CCCCCCCCCCCHHHH	22.97	23401153
648	Ubiquitination	KEEEKVNEEQWSLRE HHHHHCCHHHHCEEE	55.33	22817900
651	Ubiquitination	EKVNEEQWSLREVVF HHCCHHHHCEEEEEE	11.56	21890473
652	Phosphorylation	KVNEEQWSLREVVFV HCCHHHHCEEEEEEE	19.76	23927012
654	Ubiquitination	NEEQWSLREVVFVED CHHHHCEEEEEEEEC	29.19	22817900
657	Ubiquitination	QWSLREVVFVEDVKN HHCEEEEEEEECCCC	3.68	21890473
663	Acetylation	VVFVEDVKNVPVGKV EEEEECCCCCCCCEE	65.63	23954790
663	Ubiquitination	VVFVEDVKNVPVGKV EEEEECCCCCCCCEE	65.63	29967540
669	Ubiquitination	VKNVPVGKVLKVDGA CCCCCCCEEEEECCE	44.63	33845483
672	Ubiquitination	VPVGKVLKVDGAYVA CCCCEEEEECCEEEE	41.07	21906983
677	Phosphorylation	VLKVDGAYVAVKFPG EEEECCEEEEEECCC	8.41	27642862
681	Ubiquitination	DGAYVAVKFPGTSSN CCEEEEEECCCCCCC	35.78	29967540
695	Phosphorylation	NTNCQNSSGPDADPS CCCCCCCCCCCCCHH	62.99	25627689
699	Ubiquitination	QNSSGPDADPSSLLQ CCCCCCCCCHHHHHH	33.47	21890473
705	Ubiquitination	DADPSSLLQDCRLLR CCCHHHHHHHCEEEC	4.33	21890473
720	Ubiquitination	IDELQVVKTGGTPKV CCEEEEEECCCCCCC	42.46	21906983
726	Ubiquitination	VKTGGTPKVPDCFQR EECCCCCCCCCHHHC	67.26	29967540
734	Phosphorylation	VPDCFQRTPKKLCIP CCCHHHCCCCCCCCC	28.77	24719451
740	Ubiquitination	RTPKKLCIPEKTEIL CCCCCCCCCCCCEEE	7.76	21890473
743	Ubiquitination	KKLCIPEKTEILAVN CCCCCCCCCEEEEEE	46.21	29967540
746	Ubiquitination	CIPEKTEILAVNVDS CCCCCCEEEEEECCC	3.47	21890473
761	Ubiquitination	KGVHAVLKTGNWVRY CCEEEEEECCCCEEE	48.03	21906983
803	Phosphorylation	ERNVAIFTAGQESPI CCCEEEEECCCCCCE	24.62	29255136
808	Phosphorylation	IFTAGQESPIILRDG EEECCCCCCEEEECC	17.32	29255136
928	Phosphorylation	NILHACVSVCFPTSN CHHHHHHHHHCCCCC	17.04	27067055
967	Phosphorylation	EAIANAISVVSSNGP HHHHHHHHHHCCCCC	17.66	26074081
970	Phosphorylation	ANAISVVSSNGPGNR HHHHHHHCCCCCCCC	18.87	28450419
971	Phosphorylation	NAISVVSSNGPGNRA HHHHHHCCCCCCCCC	33.91	28450419
977	Methylation	SSNGPGNRAGSSSSR CCCCCCCCCCCCCHH	46.36	26495091
980	Phosphorylation	GPGNRAGSSSSRSLR CCCCCCCCCCHHHHH	26.51	26074081
981	Phosphorylation	PGNRAGSSSSRSLRL CCCCCCCCCHHHHHH	31.26	26074081
982	Phosphorylation	GNRAGSSSSRSLRLR CCCCCCCCHHHHHHH	31.31	26074081
983	Phosphorylation	NRAGSSSSRSLRLRE CCCCCCCHHHHHHHH	28.03	26074081
984	Methylation	RAGSSSSRSLRLREM CCCCCCHHHHHHHHH	41.48	30987687
985	Phosphorylation	AGSSSSRSLRLREMM CCCCCHHHHHHHHHH	21.57	26074081
995	Phosphorylation	LREMMRRSLRAAGLG HHHHHHHHHHHCCCC	16.31	-
997	Methylation	EMMRRSLRAAGLGRH HHHHHHHHHCCCCCC	24.52	115919473
1009	Phosphorylation	GRHEAGASSSDHQDP CCCCCCCCCCCCCCC	29.47	21406692
1010	Phosphorylation	RHEAGASSSDHQDPV CCCCCCCCCCCCCCC	38.97	21406692
1011	Phosphorylation	HEAGASSSDHQDPVS CCCCCCCCCCCCCCC	36.29	21406692
1018	Phosphorylation	SDHQDPVSPPIAPPS CCCCCCCCCCCCCCC	30.28	20068231
1025	Phosphorylation	SPPIAPPSWVPDPPA CCCCCCCCCCCCCCC	39.38	21406692
1088	Ubiquitination	RKANAHFILKLLCDS HHCCHHHHHHHHHCH	2.08	23000965
1094	Ubiquitination	FILKLLCDSVVLQPY HHHHHHHCHHHHHHH	44.42	23000965
1109	2-Hydroxyisobutyrylation	LRELLSAKDARGMTP HHHHHCCCHHCCCCC	48.85	-
1109	Ubiquitination	LRELLSAKDARGMTP HHHHHCCCHHCCCCC	48.85	23000965
1115	Phosphorylation	AKDARGMTPFMSAVS CCHHCCCCCHHHHHC	19.05	29116813
1119	Phosphorylation	RGMTPFMSAVSGRAY CCCCCHHHHHCCCCC	26.37	23879269
1122	Phosphorylation	TPFMSAVSGRAYPAA CCHHHHHCCCCCCHH	23.44	29116813
1131	Phosphorylation	RAYPAAITILETAQK CCCCHHHHHHHHHHH	18.12	29116813
1135	Phosphorylation	AAITILETAQKIAKA HHHHHHHHHHHHHHC	30.83	29116813
1141	Ubiquitination	ETAQKIAKAEISSSE HHHHHHHHCCCCCCC	50.45	33845483
1146	Ubiquitination	IAKAEISSSEKEEDV HHHCCCCCCCCCCCC	48.45	22817900
1226	Phosphorylation	HDCKLKRTSPTAYCD CCCCCCCCCCCCCCC	37.15	28450419
1227	Phosphorylation	DCKLKRTSPTAYCDC CCCCCCCCCCCCCCH	25.04	25849741
1229	Phosphorylation	KLKRTSPTAYCDCWE CCCCCCCCCCCCHHH	29.99	28450419
1231	Phosphorylation	KRTSPTAYCDCWEKC CCCCCCCCCCHHHHC	7.41	23312004
1231	Ubiquitination	KRTSPTAYCDCWEKC CCCCCCCCCCHHHHC	7.41	22817900
1234	Ubiquitination	SPTAYCDCWEKCKCK CCCCCCCHHHHCCCC	4.51	22817900
1237	Acetylation	AYCDCWEKCKCKTLI CCCCHHHHCCCCEEE	17.94	26051181
1248	Ubiquitination	KTLIAGQKSARLDLL CEEECCCHHHHHHHH	45.20	-
1284	Ubiquitination	LFLVQTVARQTVEHC HHHHHHHHHHHHHHH	10.97	22817900
1290	Ubiquitination	VARQTVEHCQYRPPR HHHHHHHHHCCCCCC	10.31	22817900
1294	Ubiquitination	TVEHCQYRPPRIRED HHHHHCCCCCCCCCC	14.63	22817900
1305	Ubiquitination	IREDRNRKTASPEDS CCCCCCCCCCCCCCC	52.58	21906983
1306	Phosphorylation	REDRNRKTASPEDSD CCCCCCCCCCCCCCC	29.18	30266825
1308	Phosphorylation	DRNRKTASPEDSDMP CCCCCCCCCCCCCCC	33.77	23401153
1312	Phosphorylation	KTASPEDSDMPDHDL CCCCCCCCCCCCCCC	33.86	30266825
1319	Ubiquitination	SDMPDHDLEPPRFAQ CCCCCCCCCCCHHHH	10.77	21963094
1320	Ubiquitination	DMPDHDLEPPRFAQL CCCCCCCCCCHHHHH	60.35	16196087
1325	Ubiquitination	DLEPPRFAQLALERV CCCCCHHHHHHHHHH	12.54	21963094
1330	Ubiquitination	RFAQLALERVLQDWN HHHHHHHHHHHHHHH	34.83	21963094
1336	Ubiquitination	LERVLQDWNALKSMI HHHHHHHHHHHHHHH	4.50	21963094
1340	Ubiquitination	LQDWNALKSMIMFGS HHHHHHHHHHHHHCC	35.25	21906983
1347	Phosphorylation	KSMIMFGSQENKDPL HHHHHHCCCCCCCCC	24.05	-
1351	Ubiquitination	MFGSQENKDPLSASS HHCCCCCCCCCCHHH	61.03	21906983
1355	Phosphorylation	QENKDPLSASSRIGH CCCCCCCCHHHHHHH	31.34	21924388
1375	Phosphorylation	QVYLNQQSGTIRLDC HEEEECCCCEEEEEH	28.30	19060867
1391	Ubiquitination	THCLIVKCTADILLL CCHHHHHHHHHHHHH	2.35	27667366
1397	Ubiquitination	KCTADILLLDTLLGT HHHHHHHHHHHHHHH	4.09	27667366
1404	Phosphorylation	LLDTLLGTLVKELQN HHHHHHHHHHHHHHH	28.48	20068231
1412	Ubiquitination	LVKELQNKYTPGRRE HHHHHHHCCCCCCHH	37.22	27667366
1481	Phosphorylation	ELCNVAESLIVPVRM HHHCHHHHHHHCCCC	17.41	21924388
1484	Ubiquitination	NVAESLIVPVRMGIA CHHHHHHHCCCCCCC	4.32	21963094
1522	Ubiquitination	SVEPLPPRPSSDQSS CCCCCCCCCCCCCCC	41.62	22817900
1532	Phosphorylation	SDQSSSSSQSQSSYI CCCCCCCCCCCCCEE	35.48	17478428
1549	Phosphorylation	NPQQRRISQSQPVRG CHHHCCCCCCCCCCC	23.20	29255136
1551	Phosphorylation	QQRRISQSQPVRGRD HHCCCCCCCCCCCCC	29.66	23927012
1610	Phosphorylation	DEHDEDGSDMELDLL CCCCCCCCCCHHHHH	46.21	22067460
1679	Phosphorylation	SDSDSSSSQSDDIEQ CCCCCCCCCCCHHHH	35.33	17478428
1698	Phosphorylation	LDEPLERTTNSSHAN CCCCHHHCCCCCCCC	22.43	23663014
1699	Phosphorylation	DEPLERTTNSSHANG CCCHHHCCCCCCCCC	39.05	23663014
1701	Phosphorylation	PLERTTNSSHANGAA CHHHCCCCCCCCCCC	22.78	23663014
1702	Phosphorylation	LERTTNSSHANGAAQ HHHCCCCCCCCCCCC	28.79	23663014
1713	Phosphorylation	GAAQAPRSMQWAVRN CCCCCCHHHHHHHHC	17.80	28555341
1728	Phosphorylation	TQHQRAASTAPSSTS HHHHHHHCCCCCCCC	24.90	21945579
1729	Phosphorylation	QHQRAASTAPSSTST HHHHHHCCCCCCCCC	37.55	21945579
1732	Phosphorylation	RAASTAPSSTSTPAA HHHCCCCCCCCCCCC	43.73	21945579
1733	Phosphorylation	AASTAPSSTSTPAAS HHCCCCCCCCCCCCC	25.89	21945579
1734	Phosphorylation	ASTAPSSTSTPAASS HCCCCCCCCCCCCCC	40.74	21945579
1735	Phosphorylation	STAPSSTSTPAASSA CCCCCCCCCCCCCCC	34.05	21945579
1736	Phosphorylation	TAPSSTSTPAASSAG CCCCCCCCCCCCCCC	19.62	21945579
1740	Phosphorylation	STSTPAASSAGLIYI CCCCCCCCCCCEEEE	23.87	21945579
1741	Phosphorylation	TSTPAASSAGLIYID CCCCCCCCCCEEEEC	22.94	21945579
1746	Phosphorylation	ASSAGLIYIDPSNLR CCCCCEEEECHHHCC	12.33	21945579
1750	Phosphorylation	GLIYIDPSNLRRSGT CEEEECHHHCCCCCC	44.76	21945579
1755	Phosphorylation	DPSNLRRSGTISTSA CHHHCCCCCCCCHHH	33.58	28450419
1757	Phosphorylation	SNLRRSGTISTSAAA HHCCCCCCCCHHHHH	17.01	28464451
1759	Phosphorylation	LRRSGTISTSAAAAA CCCCCCCCHHHHHHH	19.02	28450419
1760	Phosphorylation	RRSGTISTSAAAAAA CCCCCCCHHHHHHHH	20.66	28450419
1761	Phosphorylation	RSGTISTSAAAAAAA CCCCCCHHHHHHHHH	14.77	28450419
1772	Phosphorylation	AAAALEASNASSYLT HHHHHHHCCHHHHHH	24.45	28450419
1775	Phosphorylation	ALEASNASSYLTSAS HHHHCCHHHHHHCHH	24.62	27080861
1776	Phosphorylation	LEASNASSYLTSASS HHHCCHHHHHHCHHH	23.04	27080861
1777	Phosphorylation	EASNASSYLTSASSL HHCCHHHHHHCHHHH	16.11	27080861
1779	Phosphorylation	SNASSYLTSASSLAR CCHHHHHHCHHHHHH	17.64	27080861
1780	Phosphorylation	NASSYLTSASSLARA CHHHHHHCHHHHHHH	24.45	21924388
1782	Phosphorylation	SSYLTSASSLARAYS HHHHHCHHHHHHHHH	26.17	-
1788	Phosphorylation	ASSLARAYSIVIRQI HHHHHHHHHHHHHHH	8.06	23312004
1789	Phosphorylation	SSLARAYSIVIRQIS HHHHHHHHHHHHHHH	14.92	23312004
1875	Phosphorylation	PNHPLHASQNSARRE CCCCCCCCCHHHHHH	21.10	26055452
1878	Phosphorylation	PLHASQNSARRERMT CCCCCCHHHHHHHHH	18.60	23917254
1902	Phosphorylation	LEGRRRATLLSARQG HHHHHHHHHHHHHHH	26.81	23879269
1905	Phosphorylation	RRRATLLSARQGMMS HHHHHHHHHHHHHHH	25.23	23917254
1914	Methylation	RQGMMSARGDFLNYA HHHHHHHCHHHHHHH	37.60	115383921
1920	Phosphorylation	ARGDFLNYALSLMRS HCHHHHHHHHHHHHH	15.86	24719451
1923	Phosphorylation	DFLNYALSLMRSHND HHHHHHHHHHHHCCC	16.37	24719451
1965	Phosphorylation	IKAMNQQTTLDTPQL HHHHCCCCCCCCHHH	21.40	29978859
1966	Phosphorylation	KAMNQQTTLDTPQLE HHHCCCCCCCCHHHH	20.49	28985074
1969	Phosphorylation	NQQTTLDTPQLERKR CCCCCCCCHHHHHHH	18.95	25159151
1977	Phosphorylation	PQLERKRTRELLELG HHHHHHHHHHHHHHC	31.37	26074081
1990	Phosphorylation	LGIDNEDSEHENDDD HCCCCCCCCCCCCCC	34.37	25159151
1998	Phosphorylation	EHENDDDTNQSATLN CCCCCCCCCCCCCCC	42.00	23663014
2001	Phosphorylation	NDDDTNQSATLNDKD CCCCCCCCCCCCCCC	25.87	23663014
2003	Phosphorylation	DDTNQSATLNDKDDD CCCCCCCCCCCCCCC	31.20	28464451
2011	Phosphorylation	LNDKDDDSLPAETGQ CCCCCCCCCCCCCCC	43.16	20164059
2016	Phosphorylation	DDSLPAETGQNHPFF CCCCCCCCCCCCCCC	46.29	23090842
2026	Phosphorylation	NHPFFRRSDSMTFLG CCCCCCCCCCEEEEE	29.76	26846344
2028	Phosphorylation	PFFRRSDSMTFLGCI CCCCCCCCEEEEEEC	22.44	26846344
2030	Phosphorylation	FRRSDSMTFLGCIPP CCCCCCEEEEEECCC	21.47	26846344
2063	Acetylation	LLQPNARKEDLFGRP CCCCCCCHHHCCCCC	53.84	26051181
2063	Ubiquitination	LLQPNARKEDLFGRP CCCCCCCHHHCCCCC	53.84	-
2071	Phosphorylation	EDLFGRPSQGLYSSS HHCCCCCCCCCCCCC	35.20	17525332
2075	Phosphorylation	GRPSQGLYSSSASSG CCCCCCCCCCCCCCC	17.21	-
2076	Phosphorylation	RPSQGLYSSSASSGK CCCCCCCCCCCCCCC	23.90	21924388
2080	Phosphorylation	GLYSSSASSGKCLME CCCCCCCCCCCEEEE	41.39	25627689
2089	Phosphorylation	GKCLMEVTVDRNCLE CCEEEEEEECCCHHH	11.90	24144214
2101	Ubiquitination	CLEVLPTKMSYAANL HHHHCCCCCHHHHHH	24.74	29967540
2103	Phosphorylation	EVLPTKMSYAANLKN HHCCCCCHHHHHHHH	17.11	28270605
2104	Phosphorylation	VLPTKMSYAANLKNV HCCCCCHHHHHHHHH	13.26	28270605
2115	Ubiquitination	LKNVMNMQNRQKKEG HHHHHHHHHHHHCCC	36.63	22817900
2121	Ubiquitination	MQNRQKKEGEEQPVL HHHHHHCCCCCCCCC	78.02	22817900
2136	Acetylation	PEETESSKPGPSAHD CCCCCCCCCCCCHHH	64.37	26051181
2136	Ubiquitination	PEETESSKPGPSAHD CCCCCCCCCCCCHHH	64.37	21906983
2140	Phosphorylation	ESSKPGPSAHDLAAQ CCCCCCCCHHHHHHH	44.12	-
2190	Dimethylation	DMLLGRWRLSLELFG HHHCCCHHHHHHHHH	17.03	-
2190	Methylation	DMLLGRWRLSLELFG HHHCCCHHHHHHHHH	17.03	115372849
2200	Ubiquitination	LELFGRVFMEDVGAE HHHHHHHHHHHCCCC	4.23	22817900
2203	Ubiquitination	FGRVFMEDVGAEPGS HHHHHHHHCCCCCCC	32.15	22817900
2206	Ubiquitination	VFMEDVGAEPGSILT HHHHHCCCCCCCHHH	21.47	22817900
2209	Ubiquitination	EDVGAEPGSILTELG HHCCCCCCCHHHHCC	20.87	22817900
2213	Phosphorylation	AEPGSILTELGGFEV CCCCCHHHHCCCCEE	27.74	19060867
2221	Ubiquitination	ELGGFEVKESKFRRE HCCCCEECHHHHHHH	49.42	22817900
2224	Ubiquitination	GFEVKESKFRREMEK CCEECHHHHHHHHHH	43.94	22817900
2241	Phosphorylation	NQQSRDLSLEVDRDR HHHHCCCCCHHHHCH	27.12	25463755
2255	Phosphorylation	RDLLIQQTMRQLNNH HHHHHHHHHHHHHCC	9.65	23898821
2259	Ubiquitination	IQQTMRQLNNHFGRR HHHHHHHHHCCCCCC	4.97	22817900
2263	Ubiquitination	MRQLNNHFGRRCATT HHHHHCCCCCCCCCC	9.89	22817900
2265	Ubiquitination	QLNNHFGRRCATTPM HHHCCCCCCCCCCCC	29.57	22817900
2267	Ubiquitination	NNHFGRRCATTPMAV HCCCCCCCCCCCCEE	3.67	22817900
2269	Phosphorylation	HFGRRCATTPMAVHR CCCCCCCCCCCEEEE	34.75	23312004
2269	Ubiquitination	HFGRRCATTPMAVHR CCCCCCCCCCCEEEE	34.75	22817900
2270	Phosphorylation	FGRRCATTPMAVHRV CCCCCCCCCCEEEEE	7.79	23312004
2278	Ubiquitination	PMAVHRVKVTFKDEP CCEEEEEEEEECCCC	35.20	22817900
2282	Ubiquitination	HRVKVTFKDEPGEGS EEEEEEECCCCCCCC	52.39	21906983
2289	Phosphorylation	KDEPGEGSGVARSFY CCCCCCCCCHHHHHH	26.28	21924388
2289	Ubiquitination	KDEPGEGSGVARSFY CCCCCCCCCHHHHHH	26.28	16196087
2293	Ubiquitination	GEGSGVARSFYTAIA CCCCCHHHHHHHHHH	25.54	16196087
2295	Ubiquitination	GSGVARSFYTAIAQA CCCHHHHHHHHHHHH	5.39	16196087
2308	Ubiquitination	QAFLSNEKLPNLECI HHHHCCCCCCCCHHH	73.77	16196087
2320	Acetylation	ECIQNANKGTHTSLM HHHHCCCCCCHHHHH	63.88	26051181
2320	Ubiquitination	ECIQNANKGTHTSLM HHHHCCCCCCHHHHH	63.88	-
2325	Phosphorylation	ANKGTHTSLMQRLRN CCCCCHHHHHHHHHH	17.78	28555341
2353	Methylation	MRRSSGLRAGSRRDR HHHHHCCCCCCCCCC	40.19	115919465
2356	Phosphorylation	SSGLRAGSRRDRDRD HHCCCCCCCCCCCHH	24.13	28102081
2369	Phosphorylation	RDFRRQLSIDTRPFR HHHHHHCCCCCCCCC	15.30	28857561
2372	Phosphorylation	RRQLSIDTRPFRPAS HHHCCCCCCCCCCCC	38.27	28857561
2379	Phosphorylation	TRPFRPASEGNPSDD CCCCCCCCCCCCCCC	49.04	29116813
2384	Phosphorylation	PASEGNPSDDPEPLP CCCCCCCCCCCCCCH	59.66	23312004
2424	Phosphorylation	TGMLLELSPAQLLLL HHHHHHCCHHHHHHH	14.60	23909892
2434	Phosphorylation	QLLLLLASEDSLRAR HHHHHHHCHHHHHHH	41.74	22496350
2437	Phosphorylation	LLLASEDSLRARVDE HHHHCHHHHHHHHHH	18.72	22496350
2453	Ubiquitination	MELIIAHGRENGADS HHHHHHHCCCCCCCC	29.58	21963094
2457	Ubiquitination	IAHGRENGADSILDL HHHCCCCCCCCCHHH	26.47	21963094
2459	Ubiquitination	HGRENGADSILDLGL HCCCCCCCCCHHHCC	37.29	21963094
2460	Phosphorylation	GRENGADSILDLGLV CCCCCCCCCHHHCCC	25.23	21712546
2469	Phosphorylation	LDLGLVDSSEKVQQE HHHCCCCCCHHHHHH	32.68	29396449
2470	Phosphorylation	DLGLVDSSEKVQQEN HHCCCCCCHHHHHHH	36.65	21815630
2472	Ubiquitination	GLVDSSEKVQQENRK CCCCCCHHHHHHHHH	47.49	21906983
2482 (in isoform 2)	Phosphorylation	-	31.20	29116813
2483	Phosphorylation	ENRKRHGSSRSVVDM HHHHHCCCCCCCCCC	19.22	25159151
2483 (in isoform 2)	Phosphorylation	-	19.22	29116813
2484	Phosphorylation	NRKRHGSSRSVVDMD HHHHCCCCCCCCCCC	32.92	25159151
2485 (in isoform 2)	Phosphorylation	-	34.86	25849741
2486	Phosphorylation	KRHGSSRSVVDMDLD HHCCCCCCCCCCCCC	28.57	25159151
2491	Ubiquitination	SRSVVDMDLDDTDDG CCCCCCCCCCCCCCC	42.35	22817900
2494	Ubiquitination	VVDMDLDDTDDGDDN CCCCCCCCCCCCCCC	60.37	22817900
2495	Phosphorylation	VDMDLDDTDDGDDNA CCCCCCCCCCCCCCC	35.34	30266825
2495	Ubiquitination	VDMDLDDTDDGDDNA CCCCCCCCCCCCCCC	35.34	22817900
2496	Ubiquitination	DMDLDDTDDGDDNAP CCCCCCCCCCCCCCC	65.96	22817900
2497	Ubiquitination	MDLDDTDDGDDNAPL CCCCCCCCCCCCCCC	65.59	22817900
2506	Phosphorylation	DDNAPLFYQPGKRGF CCCCCCEECCCCCCC	22.83	21406692
2509	Ubiquitination	APLFYQPGKRGFYTP CCCEECCCCCCCCCC	19.43	22817900
2510	Ubiquitination	PLFYQPGKRGFYTPR CCEECCCCCCCCCCC	56.91	21906983
2586	Phosphorylation	LRQLILASQSSDADA HHHHHHHCCCCCHHH	27.44	17478428
2655	Ubiquitination	EQPLHAMRKGLLDVL CCHHHHHHCCHHHCC	30.58	33845483
2656	Malonylation	QPLHAMRKGLLDVLP CHHHHHHCCHHHCCC	40.60	26320211
2656	Ubiquitination	QPLHAMRKGLLDVLP CHHHHHHCCHHHCCC	40.60	33845483
2664	Ubiquitination	GLLDVLPKNSLEDLT CHHHCCCCCCHHHCC	55.82	-
2779	Phosphorylation	LYVPLYSSKQILKQK HHHCCCCHHHHHHHH	18.28	-
2779	Ubiquitination	LYVPLYSSKQILKQK HHHCCCCHHHHHHHH	18.28	33845483
2780	Ubiquitination	YVPLYSSKQILKQKL HHCCCCHHHHHHHHH	35.10	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
174	S	Phosphorylation	Kinase	ATM	Q13315	PSP
191	S	Phosphorylation	Kinase	ATM	Q13315	PSP
637	T	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1227	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
1532	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1679	S	Phosphorylation	Kinase	ATM	Q13315	PSP
2483	S	Phosphorylation	Kinase	RPS6KA1	Q15418	GPS
2586	S	Phosphorylation	Kinase	ATM	Q13315	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBR5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBR5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK03_HUMAN	MAPK3	physical	12594221
MK01_HUMAN	MAPK1	physical	12594221
TOPB1_HUMAN	TOPBP1	physical	11714696
IMA5_HUMAN	KPNA1	physical	12011095
CIB1_HUMAN	CIB1	physical	12011095
P53_HUMAN	TP53	physical	21383020
DYRK2_HUMAN	DYRK2	physical	19287380
DCAF1_HUMAN	VPRBP	physical	19287380
GSK3B_HUMAN	GSK3B	physical	21118991
CDK9_HUMAN	CDK9	physical	21127351
TCEA1_HUMAN	TCEA1	physical	21127351
PCKGC_HUMAN	PCK1	physical	21726808
TNR6A_HUMAN	TNRC6A	physical	21726813
THIOM_HUMAN	TXN2	physical	21726813
PAIP1_HUMAN	PAIP1	physical	21726813
PAIP2_HUMAN	PAIP2	physical	21726813
ERF3A_HUMAN	GSPT1	physical	21726813
ERF3B_HUMAN	GSPT2	physical	21726813
TOB1_HUMAN	TOB1	physical	21726813
TOB2_HUMAN	TOB2	physical	21726813
UBC_HUMAN	UBC	physical	17897937
UBR5_HUMAN	UBR5	physical	22496338
UB2D2_HUMAN	UBE2D2	physical	19287380
UB2D2_HUMAN	UBE2D2	physical	11714696
UB2D3_HUMAN	UBE2D3	physical	11714696
UB2D2_HUMAN	UBE2D2	physical	21127351
MCRS1_HUMAN	MCRS1	physical	23069210
UTP15_HUMAN	UTP15	physical	22939629
WDR43_HUMAN	WDR43	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
TERT_HUMAN	TERT	physical	23362280
IGBP1_HUMAN	IGBP1	physical	24145130
NR1I2_HUMAN	NR1I2	physical	24438055
UBE2A_HUMAN	UBE2A	physical	11714696
UBE2B_HUMAN	UBE2B	physical	11714696
UB2L3_HUMAN	UBE2L3	physical	11714696
ATMIN_HUMAN	ATMIN	physical	25092319
MRS2_HUMAN	MRS2	physical	25833949
C1QBP_HUMAN	C1QBP	physical	25833949
BUB3_HUMAN	BUB3	physical	25833949
XPP3_HUMAN	XPNPEP3	physical	25833949
ACTZ_HUMAN	ACTR1A	physical	26344197
EIF3I_HUMAN	EIF3I	physical	26344197
T2FB_HUMAN	GTF2F2	physical	26344197
RAGP1_HUMAN	RANGAP1	physical	26344197
SET_HUMAN	SET	physical	26344197
SRSF1_HUMAN	SRSF1	physical	26344197
TPD53_HUMAN	TPD52L1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
ZN207_HUMAN	ZNF207	physical	26438829
BUB3_HUMAN	BUB3	physical	26438829
PAIP2_HUMAN	PAIP2	physical	26224628
UBR5_HUMAN	UBR5	physical	26949039
UB2D2_HUMAN	UBE2D2	physical	26949039
GKN1_HUMAN	GKN1	physical	27590582
MOAP1_HUMAN	MOAP1	physical	27721409
RING1_HUMAN	RING1	physical	27647897
RING2_HUMAN	RNF2	physical	27647897
BMI1_HUMAN	BMI1	physical	27647897
UBP2L_HUMAN	UBAP2L	physical	27647897
SP16H_HUMAN	SUPT16H	physical	27647897
SSRP1_HUMAN	SSRP1	physical	27647897
TCP4_HUMAN	SUB1	physical	27647897
SPT5H_HUMAN	SUPT5H	physical	27647897
NONO_HUMAN	NONO	physical	27647897
APC_HUMAN	APC	physical	18076571
UBR5_HUMAN	UBR5	physical	28425671
AUGN_HUMAN	C2orf40	physical	28856538

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Identification of phosphorylation sites on the E3 ubiquitin ligaseUBR5/EDD.";
Bethard J.R., Zheng H., Roberts L., Eblen S.T.;
J. Proteomics 75:603-609(2011).
Cited for: PHOSPHORYLATION AT SER-110; SER-327; SER-352; SER-578; SER-612;THR-637; SER-808; SER-928; SER-1018; THR-1115; THR-1135; SER-1227;SER-1308; SER-1355; SER-1375; SER-1481; THR-1736; SER-1741; SER-1780;THR-1969; SER-2026; SER-2028; THR-2030; SER-2076; THR-2213; SER-2289AND SER-2484.
PubMed: 21924388

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327 AND SER-2486, ANDMASS SPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549, AND MASSSPECTROMETRY.
PubMed: 19369195

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327; SER-1308; SER-1549;THR-1969 AND SER-2486, AND MASS SPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-139; SER-1549 ANDTHR-1969, AND MASS SPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549, AND MASSSPECTROMETRY.
PubMed: 18220336

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-598, AND MASSSPECTROMETRY.
PubMed: 18088087

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549 AND SER-1551, ANDMASS SPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2071, AND MASSSPECTROMETRY.
PubMed: 17525332

"Phosphoproteome analysis of the human mitotic spindle.";
Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.;
Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-327, AND MASSSPECTROMETRY.
PubMed: 16565220

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1549, AND MASSSPECTROMETRY.
PubMed: 17081983

"Global phosphoproteome of HT-29 human colon adenocarcinoma cells.";
Kim J.-E., Tannenbaum S.R., White F.M.;
J. Proteome Res. 4:1339-1346(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-287, AND MASSSPECTROMETRY.
PubMed: 16083285

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1746, AND MASSSPECTROMETRY.
PubMed: 15592455