TPD53_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPD53_HUMAN
• UniProt AC: Q16890
• Protein Name: Tumor protein D53
• Gene Name: TPD52L1
• Organism: Homo sapiens (Human).
• Sequence Length: 204
• Protein Sequence: MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELVQLEDEITTLRQVLSAKERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHETLSHAGQKATAAFSNVGTAISKKFGDMSYSIRHSISMPAMRNSPTFKSFEERVETTVTSLKTKVGGTNPNGGSFEEVLSSTAHASAQSLAGGSRRTKEEELQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	QAQGLLETEPLQGTD HHCCCCCCCCCCCCC	42.76	24043423
17	Phosphorylation	ETEPLQGTDEDAVAS CCCCCCCCCHHHHHH	24.21	24043423
24	Phosphorylation	TDEDAVASADFSSML CCHHHHHHCCHHHHC	23.05	24043423
28	Phosphorylation	AVASADFSSMLSEEE HHHHCCHHHHCCHHH	18.52	24043423
29	Phosphorylation	VASADFSSMLSEEEK HHHCCHHHHCCHHHH	24.60	24043423
32	Phosphorylation	ADFSSMLSEEEKEEL CCHHHHCCHHHHHHH	34.03	20068231
60	Ubiquitination	LRQVLSAKERHLVEI HHHHHCHHHHHHHHH	52.48	-
68	Ubiquitination	ERHLVEIKQKLGMNL HHHHHHHHHHHCCHH	28.07	-
80	Ubiquitination	MNLMNELKQNFSKSW CHHHHHHHHHHHHHH	36.70	-
84	Phosphorylation	NELKQNFSKSWHDMQ HHHHHHHHHHHHHHH	33.07	28857561
86	Phosphorylation	LKQNFSKSWHDMQTT HHHHHHHHHHHHHHH	28.57	22617229
92	Phosphorylation	KSWHDMQTTTAYKKT HHHHHHHHHHHHHHH	21.34	27251275
93	Phosphorylation	SWHDMQTTTAYKKTH HHHHHHHHHHHHHHH	7.79	27251275
94	Phosphorylation	WHDMQTTTAYKKTHE HHHHHHHHHHHHHHH	31.23	27251275
96	Phosphorylation	DMQTTTAYKKTHETL HHHHHHHHHHHHHHH	15.78	26552605
97	Ubiquitination	MQTTTAYKKTHETLS HHHHHHHHHHHHHHH	49.05	-
98	Ubiquitination	QTTTAYKKTHETLSH HHHHHHHHHHHHHHH	42.30	-
98	Acetylation	QTTTAYKKTHETLSH HHHHHHHHHHHHHHH	42.30	24469547
99	Phosphorylation	TTTAYKKTHETLSHA HHHHHHHHHHHHHHH	22.31	-
102	Phosphorylation	AYKKTHETLSHAGQK HHHHHHHHHHHHHHH	26.42	18212344
109	Ubiquitination	TLSHAGQKATAAFSN HHHHHHHHHHHHHCC	46.95	-
115	Phosphorylation	QKATAAFSNVGTAIS HHHHHHHCCHHHHHH	26.36	20068231
119	Phosphorylation	AAFSNVGTAISKKFG HHHCCHHHHHHHHHC	19.28	26434776
122	Phosphorylation	SNVGTAISKKFGDMS CCHHHHHHHHHCCCC	27.59	26434776
123	Methylation	NVGTAISKKFGDMSY CHHHHHHHHHCCCCH	46.11	115979683
123	Ubiquitination	NVGTAISKKFGDMSY CHHHHHHHHHCCCCH	46.11	-
129	Phosphorylation	SKKFGDMSYSIRHSI HHHHCCCCHHHHHCC	22.07	28857561
130	Phosphorylation	KKFGDMSYSIRHSIS HHHCCCCHHHHHCCC	11.07	28857561
131	Phosphorylation	KFGDMSYSIRHSISM HHCCCCHHHHHCCCC	13.07	28857561
133	Methylation	GDMSYSIRHSISMPA CCCCHHHHHCCCCCC	16.15	24129315
133	Dimethylation	GDMSYSIRHSISMPA CCCCHHHHHCCCCCC	16.15	-
135	Phosphorylation	MSYSIRHSISMPAMR CCHHHHHCCCCCCCC	13.40	25849741
137 (in isoform 2)	Phosphorylation	-	23.02	20166139
137	Phosphorylation	YSIRHSISMPAMRNS HHHHHCCCCCCCCCC	23.02	22617229
144	Phosphorylation	SMPAMRNSPTFKSFE CCCCCCCCCCCCCHH	18.23	23927012
146	Phosphorylation	PAMRNSPTFKSFEER CCCCCCCCCCCHHHH	43.44	30266825
149	Phosphorylation	RNSPTFKSFEERVET CCCCCCCCHHHHHHH	33.43	23927012
156	Phosphorylation	SFEERVETTVTSLKT CHHHHHHHHHHHCCC	24.57	21955146
157	Phosphorylation	FEERVETTVTSLKTK HHHHHHHHHHHCCCC	14.31	21955146
159	Phosphorylation	ERVETTVTSLKTKVG HHHHHHHHHCCCCCC	26.67	28857561
160	Phosphorylation	RVETTVTSLKTKVGG HHHHHHHHCCCCCCC	24.43	22617229
162	Ubiquitination	ETTVTSLKTKVGGTN HHHHHHCCCCCCCCC	46.17	-
163	Phosphorylation	TTVTSLKTKVGGTNP HHHHHCCCCCCCCCC	35.93	-
168	Phosphorylation	LKTKVGGTNPNGGSF CCCCCCCCCCCCCCH	41.39	23090842
174	Phosphorylation	GTNPNGGSFEEVLSS CCCCCCCCHHHHHHH	30.77	9484778
180	Phosphorylation	GSFEEVLSSTAHASA CCHHHHHHHHCHHHH	30.71	23090842
181	Phosphorylation	SFEEVLSSTAHASAQ CHHHHHHHHCHHHHH	26.00	23186163
182	Phosphorylation	FEEVLSSTAHASAQS HHHHHHHHCHHHHHH	21.06	23186163
186	Phosphorylation	LSSTAHASAQSLAGG HHHHCHHHHHHHCCC	19.58	23186163
189	Phosphorylation	TAHASAQSLAGGSRR HCHHHHHHHCCCCCC	21.65	23898821
194	Phosphorylation	AQSLAGGSRRTKEEE HHHHCCCCCCCHHHH	20.06	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPD53_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPD53_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPD53_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GP135_HUMAN	GPR135	physical	16169070
HDAC1_HUMAN	HDAC1	physical	16169070
YAED1_HUMAN	YAE1D1	physical	16169070
EIF3J_HUMAN	EIF3J	physical	16169070
MAL2_HUMAN	MAL2	physical	11549320
TPD52_HUMAN	TPD52	physical	9484778
TPD53_HUMAN	TPD52L1	physical	9484778
TPD54_HUMAN	TPD52L2	physical	9484778
INO1_HUMAN	ISYNA1	physical	26344197
UCHL3_HUMAN	UCHL3	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149, AND MASSSPECTROMETRY.
PubMed: 18669648