INO1_HUMAN - dbPTM
INO1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INO1_HUMAN
UniProt AC Q9NPH2
Protein Name Inositol-3-phosphate synthase 1
Gene Name ISYNA1
Organism Homo sapiens (Human).
Sequence Length 558
Subcellular Localization Cytoplasm.
Protein Description Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds..
Protein Sequence MEAAAQFFVESPDVVYGPEAIEAQYEYRTTRVSREGGVLKVHPTSTRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLSWPTRSGRKEANYYGSLTQAGTVSLGLDAEGQEVFVPFSAVLPMVAPNDLVFDGWDISSLNLAEAMRRAKVLDWGLQEQLWPHMEALRPRPSVYIPEFIAANQSARADNLIPGSRAQQLEQIRRDIRDFRSSAGLDKVIVLWTANTERFCEVIPGLNDTAENLLRTIELGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQHRVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGENLSAPLQFRSKEVSKSNVVDDMVQSNPVLYTPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLALLTELCQRVSFCTDMDPEPQTFHPVLSLLSFLFKAPLVPPGSPVVNALFRQRSCIENILRACVGLPPQNHMLLEHKMERPGPSLKRVGPVAATYPMLNKKGPVPAATNGCTGDANGHLQEEPPMPTT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27 (in isoform 2)Ubiquitination-14.3421890473
40UbiquitinationSREGGVLKVHPTSTR
EEECCEEEECCCCCC		35.7721906983
40 (in isoform 1)Ubiquitination-35.7721890473
72PhosphorylationGWGGNNGSTLTAAVL
EECCCCHHHHHHHHH		23.5122210691
73PhosphorylationWGGNNGSTLTAAVLA
ECCCCHHHHHHHHHH		29.5322210691
75PhosphorylationGNNGSTLTAAVLANR
CCCHHHHHHHHHHHH		16.8022210691
86PhosphorylationLANRLRLSWPTRSGR
HHHHCCCCCCCCCCC		25.2823403867
89PhosphorylationRLRLSWPTRSGRKEA
HCCCCCCCCCCCCEE		31.0725002506
91PhosphorylationRLSWPTRSGRKEANY
CCCCCCCCCCCEEEE		45.4825002506
94 (in isoform 2)Ubiquitination-65.7821890473
101UbiquitinationKEANYYGSLTQAGTV
CEEEEEECCCCCEEE		16.4821890473
155UbiquitinationAEAMRRAKVLDWGLQ
HHHHHHHCCCCHHHH		41.3321890473
155 (in isoform 1)Ubiquitination-41.3321890473
168UbiquitinationLQEQLWPHMEALRPR
HHHHHHHHHHHHCCC		18.3521890473
177 (in isoform 2)Ubiquitination-28.9121890473
182 (in isoform 2)Ubiquitination-39.8821890473
184 (in isoform 2)Ubiquitination-3.1821890473
208MethylationAQQLEQIRRDIRDFR
HHHHHHHHHHHHHHH		29.88115480665
222UbiquitinationRSSAGLDKVIVLWTA
HHHCCCCEEEEEEEC		38.6121890473
222 (in isoform 1)Ubiquitination-38.6121890473
258UbiquitinationTIELGLEVSPSTLFA
HHHHCCCCCHHHHHH		14.1721890473
265 (in isoform 2)Ubiquitination-10.0821890473
305UbiquitinationFVGGDDFKSGQTKVK
EECCCCCCCCCHHHH		61.7521906983
305 (in isoform 1)Ubiquitination-61.7521890473
310UbiquitinationDFKSGQTKVKSVLVD
CCCCCCHHHHHHHHH		39.5121906983
310 (in isoform 1)Ubiquitination-39.5121890473
312UbiquitinationKSGQTKVKSVLVDFL
CCCCHHHHHHHHHHH		36.0821890473
312 (in isoform 1)Ubiquitination-36.0821890473
351PhosphorylationSAPLQFRSKEVSKSN
CCCCEECCHHHCCCC		34.1625693802
355PhosphorylationQFRSKEVSKSNVVDD
EECCHHHCCCCCCCH		31.3025693802
356UbiquitinationFRSKEVSKSNVVDDM
ECCHHHCCCCCCCHH		51.75-
357PhosphorylationRSKEVSKSNVVDDMV
CCHHHCCCCCCCHHH		27.6125693802
385PhosphorylationDHCVVIKYVPYVGDS
CCEEEEEECCCCCCH		8.7821406692
388PhosphorylationVVIKYVPYVGDSKRA
EEEEECCCCCCHHHH		13.6621406692
392PhosphorylationYVPYVGDSKRALDEY
ECCCCCCHHHHHHHH		20.3621406692
393 (in isoform 1)Ubiquitination-46.5621890473
393UbiquitinationVPYVGDSKRALDEYT
CCCCCCHHHHHHHHC		46.5621906983
402 (in isoform 2)Ubiquitination-30.3321890473
473PhosphorylationAPLVPPGSPVVNALF
CCCCCCCCHHHHHHH		21.9427050516
476UbiquitinationVPPGSPVVNALFRQR
CCCCCHHHHHHHHCH		3.8321890473
484PhosphorylationNALFRQRSCIENILR
HHHHHCHHHHHHHHH		15.8823911959
514PhosphorylationKMERPGPSLKRVGPV
HCCCCCCCCCCCCCC		53.0626434776
516MethylationERPGPSLKRVGPVAA
CCCCCCCCCCCCCCC		49.7573915073
516UbiquitinationERPGPSLKRVGPVAA
CCCCCCCCCCCCCCC		49.75-
524PhosphorylationRVGPVAATYPMLNKK
CCCCCCCCCCCCCCC		20.5821945579
525PhosphorylationVGPVAATYPMLNKKG
CCCCCCCCCCCCCCC		5.0621945579
530UbiquitinationATYPMLNKKGPVPAA
CCCCCCCCCCCCCCC		55.9621890473
530 (in isoform 1)Ubiquitination-55.9621890473
538PhosphorylationKGPVPAATNGCTGDA
CCCCCCCCCCCCCCC		33.96-
557PhosphorylationQEEPPMPTT------
CCCCCCCCC------		38.60-
558PhosphorylationEEPPMPTT-------
CCCCCCCC-------		30.64-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INO1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INO1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INO1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PP2AA_HUMANPPP2CAphysical
16169070
THIM_HUMANACAA2physical
26344197
ALDOA_HUMANALDOAphysical
26344197
GDIR1_HUMANARHGDIAphysical
26344197
ECHM_HUMANECHS1physical
26344197
ERN2_HUMANERN2physical
26344197
HNRH2_HUMANHNRNPH2physical
26344197
NACA2_HUMANNACA2physical
26344197
6PGD_HUMANPGDphysical
26344197
PLSI_HUMANPLS1physical
26344197
PPIB_HUMANPPIBphysical
26344197
PPCE_HUMANPREPphysical
26344197
PSMD9_HUMANPSMD9physical
26344197
UCHL3_HUMANUCHL3physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INO1_HUMAN

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Related Literatures of Post-Translational Modification

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