| UniProt ID | ERN2_HUMAN | |
|---|---|---|
| UniProt AC | Q76MJ5 | |
| Protein Name | Serine/threonine-protein kinase/endoribonuclease IRE2 | |
| Gene Name | ERN2 {ECO:0000312|HGNC:HGNC:16942} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 926 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein . |
|
| Protein Description | Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.. | |
| Protein Sequence | MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDLKWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNTTYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRPCPGATGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 247 | Phosphorylation | LRQLPHLTLARDTLH HHCCCCCHHHHHHHH | 18.48 | 24719451 | |
| 268 | Phosphorylation | GHIRLPASGPRDTAT CCEECCCCCCCCHHH | 47.60 | - | |
| 324 | Phosphorylation | LAPADGPTTDEVTLQ ECCCCCCCCCEEEEE | 53.03 | 29759185 | |
| 325 | Phosphorylation | APADGPTTDEVTLQV CCCCCCCCCEEEEEE | 33.04 | 29759185 | |
| 329 | Phosphorylation | GPTTDEVTLQVSGER CCCCCEEEEEECCCC | 14.93 | 29759185 | |
| 333 | Phosphorylation | DEVTLQVSGEREGSP CEEEEEECCCCCCCC | 23.21 | 29759185 | |
| 341 | Phosphorylation | GEREGSPSTAVRYPS CCCCCCCCCCEECCC | 30.60 | 22985185 | |
| 404 | Phosphorylation | AFFLELLSLSREKLW HHHHHHHHHCHHHHH | 36.60 | 24719451 | |
| 406 | Phosphorylation | FLELLSLSREKLWDS HHHHHHHCHHHHHCC | 34.71 | 17081983 | |
| 413 | Phosphorylation | SREKLWDSELHPEEK CHHHHHCCCCCCCCC | 30.40 | 29449344 | |
| 802 | Phosphorylation | SDWLEKESEQEPLVR HHHHHHHCCCCHHHH | 56.50 | - | |
| 860 | Phosphorylation | VRNKKHHYRELPVEV HHCCCCCCCCCCHHH | 12.90 | 20886841 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ERN2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ERN2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ERN2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of ERN2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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