PSMD9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSMD9_HUMAN
• UniProt AC: O00233
• Protein Name: 26S proteasome non-ATPase regulatory subunit 9
• Gene Name: PSMD9
• Organism: Homo sapiens (Human).
• Sequence Length: 223
• Protein Description: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process..
• Protein Sequence: MSDEEARQSGGSSQAGVVTVSDVQELMRRKEEIEAQIKANYDVLESQKGIGMNEPLVDCEGYPRSDVDLYQVRTARHNIICLQNDHKAVMKQVEEALHQLHARDKEKQARDMAEAHKEAMSRKLGQSESQGPPRAFAKVNSISPGSPASIAGLQVDDEIVEFGSVNTQNFQSLHNIGSVVQHSEGKPLNVTVIRRGEKHQLRLVPTRWAGKGLLGCNIIPLQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDEEARQS ------CCHHHHHHC	54.45	28450419
9	Phosphorylation	SDEEARQSGGSSQAG CHHHHHHCCCCCCCC	39.30	28450419
12	Phosphorylation	EARQSGGSSQAGVVT HHHHCCCCCCCCEEE	23.85	28450419
13	Phosphorylation	ARQSGGSSQAGVVTV HHHCCCCCCCCEEEH	27.59	28450419
30	Ubiquitination	VQELMRRKEEIEAQI HHHHHHCHHHHHHHH	49.70	29967540
30	2-Hydroxyisobutyrylation	VQELMRRKEEIEAQI HHHHHHCHHHHHHHH	49.70	-
38	Ubiquitination	EEIEAQIKANYDVLE HHHHHHHHHCHHHHH	20.64	32015554
41	Phosphorylation	EAQIKANYDVLESQK HHHHHHCHHHHHHCC	16.58	28796482
46	Phosphorylation	ANYDVLESQKGIGMN HCHHHHHHCCCCCCC	32.79	21815630
48	Ubiquitination	YDVLESQKGIGMNEP HHHHHHCCCCCCCCC	62.87	32015554
52	Sulfoxidation	ESQKGIGMNEPLVDC HHCCCCCCCCCCCCC	4.92	30846556
59	Glutathionylation	MNEPLVDCEGYPRSD CCCCCCCCCCCCCCC	3.22	22555962
62	Phosphorylation	PLVDCEGYPRSDVDL CCCCCCCCCCCCCCE	3.53	-
65	Phosphorylation	DCEGYPRSDVDLYQV CCCCCCCCCCCEEEE	37.17	-
70	Phosphorylation	PRSDVDLYQVRTARH CCCCCCEEEEEECCC	10.66	21945579
73	Methylation	DVDLYQVRTARHNII CCCEEEEEECCCCEE	13.72	115489483
81	S-nitrosylation	TARHNIICLQNDHKA ECCCCEEEECCHHHH	2.57	22178444
87	Acetylation	ICLQNDHKAVMKQVE EEECCHHHHHHHHHH	45.60	26051181
87	Ubiquitination	ICLQNDHKAVMKQVE EEECCHHHHHHHHHH	45.60	29967540
91	Ubiquitination	NDHKAVMKQVEEALH CHHHHHHHHHHHHHH	44.59	32015554
93	Ubiquitination	HKAVMKQVEEALHQL HHHHHHHHHHHHHHH	6.31	22053931
105	Ubiquitination	HQLHARDKEKQARDM HHHHHHHHHHHHHHH	62.35	29967540
106	Ubiquitination	QLHARDKEKQARDMA HHHHHHHHHHHHHHH	55.48	23000965
112	Sulfoxidation	KEKQARDMAEAHKEA HHHHHHHHHHHHHHH	2.79	30846556
117	Ubiquitination	RDMAEAHKEAMSRKL HHHHHHHHHHHHHHH	54.97	23000965
121	Phosphorylation	EAHKEAMSRKLGQSE HHHHHHHHHHHCCCC	33.05	20068231
123	Ubiquitination	HKEAMSRKLGQSESQ HHHHHHHHHCCCCCC	50.06	23000965
123 (in isoform 1)	Ubiquitination	-	50.06	21890473
123 (in isoform 2)	Ubiquitination	-	50.06	21906983
127	Phosphorylation	MSRKLGQSESQGPPR HHHHHCCCCCCCCCC	37.10	25159151
129	Phosphorylation	RKLGQSESQGPPRAF HHHCCCCCCCCCCCE	45.76	28857561
198	Ubiquitination	TVIRRGEKHQLRLVP EEEECCCCCCEEEEE	39.20	22053931
198 (in isoform 1)	Ubiquitination	-	39.20	21890473
211	Ubiquitination	VPTRWAGKGLLGCNI EECCCCCCCCCCCEE	38.34	23000965
211	Acetylation	VPTRWAGKGLLGCNI EECCCCCCCCCCCEE	38.34	26051181
211 (in isoform 1)	Ubiquitination	-	38.34	21890473
216	S-nitrosocysteine	AGKGLLGCNIIPLQR CCCCCCCCEEEECCC	3.14	-
216	S-nitrosylation	AGKGLLGCNIIPLQR CCCCCCCCEEEECCC	3.14	19483679

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SKP2	Q13309	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSMD9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSMD9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKP2_HUMAN	SKP2	physical	17409098
CKS1_HUMAN	CKS1B	physical	17409098
TYY1_HUMAN	YY1	physical	22440256
PRS10_HUMAN	PSMC6	physical	19490896
PRS6A_HUMAN	PSMC3	physical	19490896
UBC9_HUMAN	UBE2I	physical	22939629
TNIP2_HUMAN	TNIP2	physical	21988832
HNRPF_HUMAN	HNRNPF	physical	22863883
HNRH1_HUMAN	HNRNPH1	physical	22863883
PFKAL_HUMAN	PFKL	physical	22863883
ROA1_HUMAN	HNRNPA1	physical	24720748
IKKA_HUMAN	CHUK	physical	24720748
IKKA_HUMAN	CHUK	genetic	24720748
TNFA_HUMAN	TNF	genetic	24720748
PRS10_HUMAN	PSMC6	physical	24720748
ROA1_HUMAN	HNRNPA1	physical	25009770
CSH1_HUMAN	CSH1	physical	25009770
CSH2_HUMAN	CSH1	physical	25009770
ESPB1_HUMAN	ELSPBP1	physical	25009770
SAHH2_HUMAN	AHCYL1	physical	25416956
SPN90_HUMAN	NCKIPSD	physical	25416956
BANP_HUMAN	BANP	physical	25416956
TRI39_HUMAN	TRIM39	physical	25416956
CC136_HUMAN	CCDC136	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
BRCA1_HUMAN	BRCA1	physical	25184681
PRS6A_HUMAN	PSMC3	physical	26186194
PRS10_HUMAN	PSMC6	physical	26186194
AKT2_HUMAN	AKT2	physical	26186194
PP2BA_HUMAN	PPP3CA	physical	26344197
PRS7_HUMAN	PSMC2	physical	26344197
PRS6A_HUMAN	PSMC3	physical	26344197
PRS8_HUMAN	PSMC5	physical	26344197
PSD12_HUMAN	PSMD12	physical	26344197
PSD13_HUMAN	PSMD13	physical	26344197
PSDE_HUMAN	PSMD14	physical	26344197
PSMD2_HUMAN	PSMD2	physical	26344197
PSMD4_HUMAN	PSMD4	physical	26344197
PSMD6_HUMAN	PSMD6	physical	26344197
PSMD7_HUMAN	PSMD7	physical	26344197
PSMD8_HUMAN	PSMD8	physical	26344197
PRS6A_HUMAN	PSMC3	physical	28514442
PRS10_HUMAN	PSMC6	physical	28514442
AKT2_HUMAN	AKT2	physical	28514442
ERI3_HUMAN	ERI3	physical	28514442
PKN3_HUMAN	PKN3	physical	27173435
YETS4_HUMAN	YEATS4	physical	27173435
CLOCK_HUMAN	CLOCK	physical	27173435
VPS50_HUMAN	CCDC132	physical	27173435
CAVN1_HUMAN	PTRF	physical	27173435
RPR1A_HUMAN	RPRD1A	physical	27173435
RABX5_HUMAN	RABGEF1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.