PSMD8_HUMAN - dbPTM
PSMD8_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSMD8_HUMAN
UniProt AC P48556
Protein Name 26S proteasome non-ATPase regulatory subunit 8
Gene Name PSMD8
Organism Homo sapiens (Human).
Sequence Length 350
Subcellular Localization
Protein Description Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
Protein Sequence MFIKGRAPRAPPRERRRATRGGLRQVVAPPRALGSTSRPHFRRASVCRRRCRKSGGLLAASRKMAAAAVNGAAGFSSSGPAATSGAVLQAATGMYEQLKGEWNRKSPNLSKCGEELGRLKLVLLELNFLPTTGTKLTKQQLILARDILEIGAQWSILRKDIPSFERYMAQLKCYYFDYKEQLPESAYMHQLLGLNLLFLLSQNRVAEFHTELERLPAKDIQTNVYIKHPVSLEQYLMEGSYNKVFLAKGNIPAESYTFFIDILLDTIRDEIAGCIEKAYEKILFTEATRILFFNTPKKMTDYAKKRGWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYARQLEMIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35PhosphorylationAPPRALGSTSRPHFR
CCCCCCCCCCCCCHH		24.8621406692
36PhosphorylationPPRALGSTSRPHFRR
CCCCCCCCCCCCHHH		27.2721406692
37PhosphorylationPRALGSTSRPHFRRA
CCCCCCCCCCCHHHH		45.5821406692
54PhosphorylationCRRRCRKSGGLLAAS
HHHHHHHHCCHHHHC		20.8120363803
61PhosphorylationSGGLLAASRKMAAAA
HCCHHHHCHHHHHHH		27.1620363803
84PhosphorylationSSGPAATSGAVLQAA
CCCHHHHHHHHHHHH		21.7428857561
92PhosphorylationGAVLQAATGMYEQLK
HHHHHHHHCHHHHHC		26.0428857561
99UbiquitinationTGMYEQLKGEWNRKS
HCHHHHHCCCHHCCC		55.25-
105UbiquitinationLKGEWNRKSPNLSKC
HCCCHHCCCCCHHHH		68.0321906983
106PhosphorylationKGEWNRKSPNLSKCG
CCCHHCCCCCHHHHH		18.7821712546
111AcetylationRKSPNLSKCGEELGR
CCCCCHHHHHHHHHH		49.8026051181
111MalonylationRKSPNLSKCGEELGR
CCCCCHHHHHHHHHH		49.8026320211
111UbiquitinationRKSPNLSKCGEELGR
CCCCCHHHHHHHHHH		49.80-
120UbiquitinationGEELGRLKLVLLELN
HHHHHHHHHEEHHHC		34.8821906983
132PhosphorylationELNFLPTTGTKLTKQ
HHCCCCCCCCCCCHH		40.7028348404
135UbiquitinationFLPTTGTKLTKQQLI
CCCCCCCCCCHHHHH		56.3421890473
135UbiquitinationFLPTTGTKLTKQQLI
CCCCCCCCCCHHHHH		56.3421906983
138UbiquitinationTTGTKLTKQQLILAR
CCCCCCCHHHHHHHH		46.62-
138UbiquitinationTTGTKLTKQQLILAR
CCCCCCCHHHHHHHH		46.6221890473
138MalonylationTTGTKLTKQQLILAR
CCCCCCCHHHHHHHH		46.6226320211
1382-HydroxyisobutyrylationTTGTKLTKQQLILAR
CCCCCCCHHHHHHHH		46.62-
138AcetylationTTGTKLTKQQLILAR
CCCCCCCHHHHHHHH		46.6226051181
155PhosphorylationLEIGAQWSILRKDIP
HHHHHHHHHHHCCCC		10.3224719451
155O-linked_GlycosylationLEIGAQWSILRKDIP
HHHHHHHHHHHCCCC		10.3231373491
159UbiquitinationAQWSILRKDIPSFER
HHHHHHHCCCCHHHH		57.47-
159MalonylationAQWSILRKDIPSFER
HHHHHHHCCCCHHHH		57.4726320211
1592-HydroxyisobutyrylationAQWSILRKDIPSFER
HHHHHHHCCCCHHHH		57.47-
172UbiquitinationERYMAQLKCYYFDYK
HHHHHHHCHHHCCHH		14.22-
218UbiquitinationELERLPAKDIQTNVY
HHHHCCCCCCCCCEE		54.1221890473
222PhosphorylationLPAKDIQTNVYIKHP
CCCCCCCCCEEECCC		27.3028152594
225PhosphorylationKDIQTNVYIKHPVSL
CCCCCCEEECCCCCH		13.3128152594
227AcetylationIQTNVYIKHPVSLEQ
CCCCEEECCCCCHHH		24.9521466224
227UbiquitinationIQTNVYIKHPVSLEQ
CCCCEEECCCCCHHH		24.9521906983
237SulfoxidationVSLEQYLMEGSYNKV
CCHHHHHHHCCCCEE		4.7030846556
241PhosphorylationQYLMEGSYNKVFLAK
HHHHHCCCCEEEEEC		29.8427642862
243UbiquitinationLMEGSYNKVFLAKGN
HHHCCCCEEEEECCC		26.5721906983
281AcetylationCIEKAYEKILFTEAT
HHHHHHHHHHHCHHH		31.8425953088
2812-HydroxyisobutyrylationCIEKAYEKILFTEAT
HHHHHHHHHHHCHHH		31.84-
281UbiquitinationCIEKAYEKILFTEAT
HHHHHHHHHHHCHHH		31.8421906983
285PhosphorylationAYEKILFTEATRILF
HHHHHHHCHHHEEEE		22.6729978859
288PhosphorylationKILFTEATRILFFNT
HHHHCHHHEEEEECC		16.4129978859
295PhosphorylationTRILFFNTPKKMTDY
HEEEEECCCCCCCHH		31.1821044959
297UbiquitinationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.8121890473
297MalonylationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.8126320211
2972-HydroxyisobutyrylationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.81-
297SumoylationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.8128112733
297AcetylationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.8126051181
297UbiquitinationILFFNTPKKMTDYAK
EEEECCCCCCCHHHH		53.8121906983
298UbiquitinationLFFNTPKKMTDYAKK
EEECCCCCCCHHHHH		48.51-
300PhosphorylationFNTPKKMTDYAKKRG
ECCCCCCCHHHHHHC		34.4427362937
315PhosphorylationWVLGPNNYYSFASQQ
CEECCCCCCCCCCCC		13.7120090780
316PhosphorylationVLGPNNYYSFASQQQ
EECCCCCCCCCCCCC		10.2321253578
324UbiquitinationSFASQQQKPEDTTIP
CCCCCCCCCCCCCCC		46.1421906983
337UbiquitinationIPSTELAKQVIEYAR
CCHHHHHHHHHHHHH		58.692190698
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSMD8_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSMD8_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSMD8_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PFD5_HUMANPFDN5physical
17786314
PSMD4_HUMANPSMD4physical
22906049
PSME3_HUMANPSME3physical
22939629
ADRM1_HUMANADRM1physical
22863883
DHX9_HUMANDHX9physical
22863883
DC1I2_HUMANDYNC1I2physical
22863883
LIPA1_HUMANPPFIA1physical
22863883
PRS4_HUMANPSMC1physical
22863883
PRS7_HUMANPSMC2physical
22863883
PRS6B_HUMANPSMC4physical
22863883
PRS8_HUMANPSMC5physical
22863883
PRS10_HUMANPSMC6physical
22863883
PSD11_HUMANPSMD11physical
22863883
PSD13_HUMANPSMD13physical
22863883
PSMD1_HUMANPSMD1physical
22863883
PSMD2_HUMANPSMD2physical
22863883
PSMD3_HUMANPSMD3physical
22863883
PSMD4_HUMANPSMD4physical
22863883
PSMD6_HUMANPSMD6physical
22863883
PSMD7_HUMANPSMD7physical
22863883
RS8_HUMANRPS8physical
22863883
PSMD7_HUMANPSMD7physical
26186194
DVL2_HUMANDVL2physical
26186194
HEAT1_HUMANHEATR1physical
26344197
NAL13_HUMANNLRP13physical
26344197
PSA1_HUMANPSMA1physical
26344197
PSA2_HUMANPSMA2physical
26344197
PSA3_HUMANPSMA3physical
26344197
PSA5_HUMANPSMA5physical
26344197
PSA6_HUMANPSMA6physical
26344197
PSB3_HUMANPSMB3physical
26344197
PSB5_HUMANPSMB5physical
26344197
PSB6_HUMANPSMB6physical
26344197
PSB8_HUMANPSMB8physical
26344197
PRS7_HUMANPSMC2physical
26344197
PSMD1_HUMANPSMD1physical
26344197
PSD10_HUMANPSMD10physical
26344197
PSMD2_HUMANPSMD2physical
26344197
PSMD3_HUMANPSMD3physical
26344197
PSMD4_HUMANPSMD4physical
26344197
TRUA_HUMANPUS1physical
26344197
SIL1_HUMANSIL1physical
26344197
PSD12_HUMANPSMD12physical
28514442
DVL2_HUMANDVL2physical
28514442
PSMD7_HUMANPSMD7physical
28514442
BBS5_HUMANBBS5physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSMD8_HUMAN

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Related Literatures of Post-Translational Modification

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