SIL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SIL1_HUMAN
• UniProt AC: Q9H173
• Protein Name: Nucleotide exchange factor SIL1
• Gene Name: SIL1
• Organism: Homo sapiens (Human).
• Sequence Length: 461
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5..
• Protein Sequence: MAPQSLPSSRMAPLGMLLGLLMAACFTFCLSHQNLKEFALTNPEKSSTKETERKETKAEEELDAEVLEVFHPTHEWQALQPGQAVPAGSHVRLNLQTGEREAKLQYEDKFRNNLKGKRLDINTNTYTSQDLKSALAKFKEGAEMESSKEDKARQAEVKRLFRPIEELKKDFDELNVVIETDMQIMVRLINKFNSSSSSLEEKIAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLTAKKKVLFALCSLLRHFPYAQRQFLKLGGLQVLRTLVQEKGTEVLAVRVVTLLYDLVTEKMFAEEEAELTQEMSPEKLQQYRQVHLLPGLWEQGWCEITAHLLALPEHDAREKVLQTLGVLLTTCRDRYRQDPQLGRTLASLQAEYQVLASLELQDGEDEGYFQELLGSVNSLLKELR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAPQSLPSSRMA ---CCCCCCCCCCHH	40.98	29255136
8	Phosphorylation	MAPQSLPSSRMAPLG CCCCCCCCCCHHHHH	35.55	29255136
8	O-linked_Glycosylation	MAPQSLPSSRMAPLG CCCCCCCCCCHHHHH	35.55	23301498
9	Phosphorylation	APQSLPSSRMAPLGM CCCCCCCCCHHHHHH	24.92	29255136
41	O-linked_Glycosylation	NLKEFALTNPEKSST CHHHHHHHCCCCCCC	45.35	55828421
45	Ubiquitination	FALTNPEKSSTKETE HHHHCCCCCCCHHHH	51.46	-
46	O-linked_Glycosylation	ALTNPEKSSTKETER HHHCCCCCCCHHHHH	41.39	55828427
47	O-linked_Glycosylation	LTNPEKSSTKETERK HHCCCCCCCHHHHHH	55.34	55828433
48	O-linked_Glycosylation	TNPEKSSTKETERKE HCCCCCCCHHHHHHH	39.74	55828437
49	Ubiquitination	NPEKSSTKETERKET CCCCCCCHHHHHHHH	65.67	-
54	Acetylation	STKETERKETKAEEE CCHHHHHHHHHHHHH	64.60	11412715
73	O-linked_Glycosylation	VLEVFHPTHEWQALQ HHHHHCCCCCCCCCC	24.69	OGP
97	O-linked_Glycosylation	HVRLNLQTGEREAKL EEEEECCCCCCCHHH	44.14	55828761
106	Phosphorylation	EREAKLQYEDKFRNN CCCHHHHHHHHHHHH	36.21	-
109	Methylation	AKLQYEDKFRNNLKG HHHHHHHHHHHHCCC	33.99	23644510
109	Ubiquitination	AKLQYEDKFRNNLKG HHHHHHHHHHHHCCC	33.99	-
123	O-linked_Glycosylation	GKRLDINTNTYTSQD CCEEECCCCCCCHHH	29.31	OGP
123	Phosphorylation	GKRLDINTNTYTSQD CCEEECCCCCCCHHH	29.31	20873877
125	Phosphorylation	RLDINTNTYTSQDLK EEECCCCCCCHHHHH	26.58	20873877
126	Phosphorylation	LDINTNTYTSQDLKS EECCCCCCCHHHHHH	13.38	20873877
127	O-linked_Glycosylation	DINTNTYTSQDLKSA ECCCCCCCHHHHHHH	20.20	55825063
127	Phosphorylation	DINTNTYTSQDLKSA ECCCCCCCHHHHHHH	20.20	20873877
128	O-linked_Glycosylation	INTNTYTSQDLKSAL CCCCCCCHHHHHHHH	15.98	55825069
128	Phosphorylation	INTNTYTSQDLKSAL CCCCCCCHHHHHHHH	15.98	20873877
132	Ubiquitination	TYTSQDLKSALAKFK CCCHHHHHHHHHHHH	41.81	-
146	Phosphorylation	KEGAEMESSKEDKAR HHHCCCCCCHHHHHH	45.45	29255136
147	Phosphorylation	EGAEMESSKEDKARQ HHCCCCCCHHHHHHH	27.10	26657352
193	N-linked_Glycosylation	VRLINKFNSSSSSLE HHHHHHCCCCCCCHH	42.46	19159218
236	N-linked_Glycosylation	QVVINGLNSTEPLVK EEEECCCCCCCHHHH	48.56	UniProtKB CARBOHYD
286	2-Hydroxyisobutyrylation	TEQPLTAKKKVLFAL CCCCCCHHHHHHHHH	48.14	-
309	Ubiquitination	YAQRQFLKLGGLQVL HHHHHHHHHCCHHHH	46.50	21890473
323	Ubiquitination	LRTLVQEKGTEVLAV HHHHHHHCCCHHHHH	54.78	21890473
396	Ubiquitination	PEHDAREKVLQTLGV CCCHHHHHHHHHHHH	42.57	-
400	Phosphorylation	AREKVLQTLGVLLTT HHHHHHHHHHHHHHH	22.71	20068231
406	Phosphorylation	QTLGVLLTTCRDRYR HHHHHHHHHHHHHHH	21.49	20068231
407	Phosphorylation	TLGVLLTTCRDRYRQ HHHHHHHHHHHHHHH	12.91	20068231
455	Phosphorylation	ELLGSVNSLLKELR- HHHHHHHHHHHHHC-	32.68	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SIL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SIL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SIL1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRP78_HUMAN	HSPA5	physical	25877869
POC1A_HUMAN	POC1A	physical	28514442
POC1B_HUMAN	POC1B	physical	28514442
EDRF1_HUMAN	EDRF1	physical	28514442
CNTP1_HUMAN	CNTNAP1	physical	28514442
ERGI2_HUMAN	ERGIC2	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
PON2_HUMAN	PON2	physical	28514442
UBR1_HUMAN	UBR1	physical	28514442
UBR2_HUMAN	UBR2	physical	28514442
COEA1_HUMAN	COL14A1	physical	28514442
OMA1_HUMAN	OMA1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 248800: Marinesco-Sjoegren syndrome (MSS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-193, AND MASSSPECTROMETRY.
PubMed: 19159218