OMA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: OMA1_HUMAN
• UniProt AC: Q96E52
• Protein Name: Metalloendopeptidase OMA1, mitochondrial
• Gene Name: OMA1
• Organism: Homo sapiens (Human).
• Sequence Length: 524
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions..
• Protein Sequence: MSFICGLQSAARNHVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	FFRFNSLSNWRKCNT EEEECCCCCHHHHCC	33.88	24719451
129	Phosphorylation	LHPLSPASIRAIRNF CCCCCHHHHHHHHCC	18.91	27535140
192	Acetylation	KENIRKNKWKLFLGL HHHHHHCCHHHHHHH	49.06	7307393
223	Phosphorylation	VSPITGRSKLLLLGK CCCCCCCCHHHCCCH	29.06	-
230	Ubiquitination	SKLLLLGKEQFRLLS CHHHCCCHHHHHHHH	48.59	-
230	2-Hydroxyisobutyrylation	SKLLLLGKEQFRLLS CHHHCCCHHHHHHHH	48.59	-
237	Phosphorylation	KEQFRLLSELEYEAW HHHHHHHHHHHHHHH	44.73	-
407	S-palmitoylation	LLLAAKACADIRASS HHHHHHHHCHHHHHH	3.26	29575903
448	Phosphorylation	SHGNRVEYLDRLIPQ CCCCHHHHHHHHHHH	15.85	29083192
478	Ubiquitination	PDPRLLFKLSTKHFL CCHHHHHHHHHHHHH	41.31	-
480	Phosphorylation	PRLLFKLSTKHFLEE HHHHHHHHHHHHHHH	35.68	27251275
481	Phosphorylation	RLLFKLSTKHFLEES HHHHHHHHHHHHHHH	38.69	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of OMA1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of OMA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of OMA1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of OMA1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.