CNTP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTP1_HUMAN
• UniProt AC: P78357
• Protein Name: Contactin-associated protein 1
• Gene Name: CNTNAP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1384
• Subcellular Localization: Membrane ; Single-pass type I membrane protein . Cell junction, paranodal septate junction .
• Protein Description: Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells..
• Protein Sequence: MMHLRLFCILLAAVSGAEGWGYYGCDEELVGPLYARSLGASSYYSLLTAPRFARLHGISGWSPRIGDPNPWLQIDLMKKHRIRAVATQGSFNSWDWVTRYMLLYGDRVDSWTPFYQRGHNSTFFGNVNESAVVRHDLHFHFTARYIRIVPLAWNPRGKIGLRLGLYGCPYKADILYFDGDDAISYRFPRGVSRSLWDVFAFSFKTEEKDGLLLHAEGAQGDYVTLELEGAHLLLHMSLGSSPIQPRPGHTTVSAGGVLNDQHWHYVRVDRFGRDVNFTLDGYVQRFILNGDFERLNLDTEMFIGGLVGAARKNLAYRHNFRGCIENVIFNRVNIADLAVRRHSRITFEGKVAFRCLDPVPHPINFGGPHNFVQVPGFPRRGRLAVSFRFRTWDLTGLLLFSRLGDGLGHVELTLSEGQVNVSIAQSGRKKLQFAAGYRLNDGFWHEVNFVAQENHAVISIDDVEGAEVRVSYPLLIRTGTSYFFGGCPKPASRWDCHSNQTAFHGCMELLKVDGQLVNLTLVEGRRLGFYAEVLFDTCGITDRCSPNMCEHDGRCYQSWDDFICYCELTGYKGETCHTPLYKESCEAYRLSGKTSGNFTIDPDGSGPLKPFVVYCDIRENRAWTVVRHDRLWTTRVTGSSMERPFLGAIQYWNASWEEVSALANASQHCEQWIEFSCYNSRLLNTAGGYPYSFWIGRNEEQHFYWGGSQPGIQRCACGLDRSCVDPALYCNCDADQPQWRTDKGLLTFVDHLPVTQVVIGDTNRSTSEAQFFLRPLRCYGDRNSWNTISFHTGAALRFPPIRANHSLDVSFYFRTSAPSGVFLENMGGPYCQWRRPYVRVELNTSRDVVFAFDVGNGDENLTVHSDDFEFNDDEWHLVRAEINVKQARLRVDHRPWVLRPMPLQTYIWMEYDQPLYVGSAELKRRPFVGCLRAMRLNGVTLNLEGRANASEGTSPNCTGHCAHPRLPCFHGGRCVERYSYYTCDCDLTAFDGPYCNHDIGGFFEPGTWMRYNLQSALRSAAREFSHMLSRPVPGYEPGYIPGYDTPGYVPGYHGPGYRLPDYPRPGRPVPGYRGPVYNVTGEEVSFSFSTSSAPAVLLYVSSFVRDYMAVLIKDDGTLQLRYQLGTSPYVYQLTTRPVTDGQPHSINITRVYRNLFIQVDYFPLTEQKFSLLVDSQLDSPKALYLGRVMETGVIDPEIQRYNTPGFSGCLSGVRFNNVAPLKTHFRTPRPMTAELAEALRVQGELSESNCGAMPRLVSEVPPELDPWYLPPDFPYYHDEGWVAILLGFLVAFLLLGLVGMLVLFYLQNHRYKGSYHTNEPKAAHEYHPGSKPPLPTSGPAQVPTPTAAPNQAPASAPAPAPTPAPAPGPRDQNLPQILEESRSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	VGPLYARSLGASSYY CHHHHHHHCCCHHHH	24.00	22617229
43	Phosphorylation	RSLGASSYYSLLTAP HHCCCHHHHHHHHHH	8.45	22617229
45	Phosphorylation	LGASSYYSLLTAPRF CCCHHHHHHHHHHHH	14.52	22617229
48	Phosphorylation	SSYYSLLTAPRFARL HHHHHHHHHHHHHHH	39.65	22617229
59	Phosphorylation	FARLHGISGWSPRIG HHHHCCCCCCCCCCC	38.51	-
62	Phosphorylation	LHGISGWSPRIGDPN HCCCCCCCCCCCCCC	14.07	24719451
120	N-linked_Glycosylation	PFYQRGHNSTFFGNV CCEECCCCCCCCCCC	45.64	UniProtKB CARBOHYD
128	N-linked_Glycosylation	STFFGNVNESAVVRH CCCCCCCCCCCEEEC	41.32	UniProtKB CARBOHYD
202	Phosphorylation	LWDVFAFSFKTEEKD HHHEEEEEEECCCCC	23.54	24719451
276	N-linked_Glycosylation	DRFGRDVNFTLDGYV ECCCCEEEEECCHHE	28.60	UniProtKB CARBOHYD
299	Phosphorylation	FERLNLDTEMFIGGL HHHCCCCHHHHHHHH	32.30	-
316	Phosphorylation	AARKNLAYRHNFRGC HHHHHHHHHCCCCHH	18.64	28509920
420	N-linked_Glycosylation	TLSEGQVNVSIAQSG EECCCEEEEEEECCC	17.58	UniProtKB CARBOHYD
437	Phosphorylation	KLQFAAGYRLNDGFW EEEEEEEEECCCCCC	13.75	23403867
489	Methylation	YFFGGCPKPASRWDC EECCCCCCCCCCCCC	58.24	-
499	N-linked_Glycosylation	SRWDCHSNQTAFHGC CCCCCCCCCHHHCHH	21.40	UniProtKB CARBOHYD
518	N-linked_Glycosylation	KVDGQLVNLTLVEGR EECCEEEEEEEECCC	35.58	UniProtKB CARBOHYD
597	N-linked_Glycosylation	LSGKTSGNFTIDPDG CCCCCCCCEEECCCC	30.56	UniProtKB CARBOHYD
653	N-linked_Glycosylation	LGAIQYWNASWEEVS HHEEEHHHCCHHHHH	21.11	UniProtKB CARBOHYD
664	N-linked_Glycosylation	EEVSALANASQHCEQ HHHHHHHHHHHHHHH	40.76	UniProtKB CARBOHYD
763	N-linked_Glycosylation	QVVIGDTNRSTSEAQ EEEECCCCCCCCHHH	40.42	UniProtKB CARBOHYD
779	Phosphorylation	FLRPLRCYGDRNSWN EEEEEEECCCCCCCE	18.67	29978859
784	Phosphorylation	RCYGDRNSWNTISFH EECCCCCCCEEEEEE	23.69	29978859
787	Phosphorylation	GDRNSWNTISFHTGA CCCCCCEEEEEECCC	16.25	29978859
789	Phosphorylation	RNSWNTISFHTGAAL CCCCEEEEEECCCCC	14.67	29978859
792	Phosphorylation	WNTISFHTGAALRFP CEEEEEECCCCCCCC	26.89	29978859
804	N-linked_Glycosylation	RFPPIRANHSLDVSF CCCCCCCCCCEEEEE	18.55	UniProtKB CARBOHYD
843	N-linked_Glycosylation	PYVRVELNTSRDVVF CEEEEEECCCCEEEE	23.62	UniProtKB CARBOHYD
860	N-linked_Glycosylation	DVGNGDENLTVHSDD ECCCCCCCEEEEECC	45.83	UniProtKB CARBOHYD
885	Ubiquitination	VRAEINVKQARLRVD EEEEEECCCCEEECC	33.48	-
940	Phosphorylation	AMRLNGVTLNLEGRA EEEECCEEEEEECCC	16.01	-
948	N-linked_Glycosylation	LNLEGRANASEGTSP EEEECCCCCCCCCCC	42.51	UniProtKB CARBOHYD
950	Phosphorylation	LEGRANASEGTSPNC EECCCCCCCCCCCCC	36.04	22210691
953	Phosphorylation	RANASEGTSPNCTGH CCCCCCCCCCCCCCC	36.64	22210691
954	Phosphorylation	ANASEGTSPNCTGHC CCCCCCCCCCCCCCC	25.60	22210691
956	N-linked_Glycosylation	ASEGTSPNCTGHCAH CCCCCCCCCCCCCCC	35.43	UniProtKB CARBOHYD
1011	Phosphorylation	EPGTWMRYNLQSALR CCCCHHHHHHHHHHH	12.24	27642862
1015	Phosphorylation	WMRYNLQSALRSAAR HHHHHHHHHHHHHHH	32.22	30206219
1019	Phosphorylation	NLQSALRSAAREFSH HHHHHHHHHHHHHHH	27.42	30206219
1078	N-linked_Glycosylation	GYRGPVYNVTGEEVS CCCCCEEECCCCEEE	25.71	UniProtKB CARBOHYD
1087	Phosphorylation	TGEEVSFSFSTSSAP CCCEEEEEEECCCCC	15.69	-
1122	Phosphorylation	DGTLQLRYQLGTSPY CCEEEEEEECCCCCE	19.38	23663014
1126	Phosphorylation	QLRYQLGTSPYVYQL EEEEECCCCCEEEEE	34.81	23663014
1127	Phosphorylation	LRYQLGTSPYVYQLT EEEECCCCCEEEEEE	16.66	23663014
1129	Phosphorylation	YQLGTSPYVYQLTTR EECCCCCEEEEEECC	16.14	23663014
1131	Phosphorylation	LGTSPYVYQLTTRPV CCCCCEEEEEECCCC	7.61	23663014
1134	Phosphorylation	SPYVYQLTTRPVTDG CCEEEEEECCCCCCC	12.77	23663014
1135	Phosphorylation	PYVYQLTTRPVTDGQ CEEEEEECCCCCCCC	41.38	23663014
1147	N-linked_Glycosylation	DGQPHSINITRVYRN CCCCCEEEEEEEEEC	32.37	UniProtKB CARBOHYD
1149	Phosphorylation	QPHSINITRVYRNLF CCCEEEEEEEEECEE	15.03	-
1170	Phosphorylation	PLTEQKFSLLVDSQL ECCCHHEEEHHHCCC	28.03	26471730
1211	Phosphorylation	PGFSGCLSGVRFNNV CCCCCCCCCCEECCC	39.04	24719451
1331	Ubiquitination	HEYHPGSKPPLPTSG CCCCCCCCCCCCCCC	57.48	30230243
1381	Phosphorylation	LPQILEESRSE---- HHHHHHHHHCC----	31.56	30108239
1383	Phosphorylation	QILEESRSE------ HHHHHHHCC------	57.86	30108239

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RTN4_HUMAN	RTN4	physical	14592966
KCNA1_HUMAN	KCNA1	physical	14592966
KCNA2_HUMAN	KCNA2	physical	14592966

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.