dbPTM

KCNA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	KCNA1_HUMAN
UniProt AC	Q09470
Protein Name	Potassium voltage-gated channel subfamily A member 1
Gene Name	KCNA1
Organism	Homo sapiens (Human).
Sequence Length	495
Subcellular Localization	Cell membrane Multi-pass membrane protein . Membrane . Cell projection, axon . Cytoplasmic vesicle . Perikaryon . Endoplasmic reticulum . Cell projection, dendrite . Cell junction . Cell junction, synapse . Cell junction, synapse, presynaptic cell membr
Protein Description	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. [PubMed: 19903818 Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability]
Protein Sequence	MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	PGHPQDGSYPRQADH CCCCCCCCCCCCCCC	40.01	-
44	Phosphorylation	ERVVINISGLRFETQ CEEEEEECCCCHHHH	27.56	24719451
53	Ubiquitination	LRFETQLKTLAQFPN CCHHHHHHHHHHCCC	31.51	30230243
80	Phosphorylation	FDPLRNEYFFDRNRP CCCCCCCCCCCCCCC	17.07	-
88	Phosphorylation	FFDRNRPSFDAILYY CCCCCCCCCCEEEEE	32.30	-
94	Phosphorylation	PSFDAILYYYQSGGR CCCCEEEEEECCCCC	8.26	22817900
95	Phosphorylation	SFDAILYYYQSGGRL CCCEEEEEECCCCCC	7.50	22817900
96	Phosphorylation	FDAILYYYQSGGRLR CCEEEEEECCCCCCC	5.22	22817900
207	N-linked_Glycosylation	GTVHRIDNTTVIYNS CEEEEECCCEEEECC	34.97	UniProtKB CARBOHYD
243	S-palmitoylation	LVVRFFACPSKTDFF HHHHHHCCCCCCHHH	3.10	15837928
306	Phosphorylation	VFRIFKLSRHSKGLQ HHHHHHHCCCCCHHH	28.65	26074081
322	Phosphorylation	LGQTLKASMRELGLL HHHHHHHHHHHHHHH	19.45	-
413	Phosphorylation	VIVSNFNYFYHRETE EEEECCCEEEECCCC	11.02	12151401
415	Phosphorylation	VSNFNYFYHRETEGE EECCCEEEECCCCCH	6.93	12151401
437	Phosphorylation	VSSPNLASDSDLSRR CCCCCCCCCCCCCHH	40.59	-
439	Phosphorylation	SPNLASDSDLSRRSS CCCCCCCCCCCHHCC	37.65	-
445	Phosphorylation	DSDLSRRSSSTMSKS CCCCCHHCCCCCCHH	27.77	23909892
446	Phosphorylation	SDLSRRSSSTMSKSE CCCCHHCCCCCCHHH	28.19	23774215
447	Phosphorylation	DLSRRSSSTMSKSEY CCCHHCCCCCCHHHH	29.40	23909892
448	Phosphorylation	LSRRSSSTMSKSEYM CCHHCCCCCCHHHHC	27.67	23909892
450	Phosphorylation	RRSSSTMSKSEYMEI HHCCCCCCHHHHCHH	32.87	23909892

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
322	S	Phosphorylation	Kinase	PKA	-	Uniprot
446	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
446	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
243	C	Palmitoylation	15837928
Palmitoylated on Cys-243; which may be required for membrane targeting.
446	S	Phosphorylation	23774215
Phosphorylation at Ser-446 regulates channel activity by down-regulating expression at the cell membrane.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of KCNA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCNA2_HUMAN	KCNA2	physical	10428084
KCNA4_HUMAN	KCNA4	physical	10428084
KCNRG_HUMAN	KCNRG	physical	19968958

Drug and Disease Associations

Kegg Disease
H00749	Episodic ataxias
OMIM Disease
160120	Episodic ataxia 1 (EA1)
160120	Myokymia isolated 1 (MK1)
Kegg Drug
D01554	Pilsicainide hydrochloride hydrate (JAN); Pilsicainide hydrochloride; SUN 1165 (TN); Sunrythm (TN)
D08377	Pilsicainide (INN)
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of KCNA1_HUMAN

Related Literatures of Post-Translational Modification

Palmitoylation
Reference	PubMed
"The human Kv1.1 channel is palmitoylated, modulating voltage sensing:Identification of a palmitoylation consensus sequence."; Gubitosi-Klug R.A., Mancuso D.J., Gross R.W.; Proc. Natl. Acad. Sci. U.S.A. 102:5964-5968(2005). Cited for: PALMITOYLATION AT CYS-243, AND MUTAGENESIS OF 35-CYS--CYS-36 ANDCYS-243.	15837928 [Abstract]