| UniProt ID | KCNA4_HUMAN | |
|---|---|---|
| UniProt AC | P22459 | |
| Protein Name | Potassium voltage-gated channel subfamily A member 4 | |
| Gene Name | KCNA4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 653 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . Cell projection, axon . |
|
| Protein Description | Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. [PubMed: 19912772] | |
| Protein Sequence | MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 90 | Phosphorylation | RRRRRQRSEKKKAHY HHHHHHHHHHHHHHH | 45.49 | - | |
| 122 | Phosphorylation | EKILRELSEEEEDEE HHHHHHHCHHCCCHH | 37.90 | - | |
| 219 | Phosphorylation | FDPLRNEYFFDRNRP CCHHHCCCCCCCCCC | 17.07 | - | |
| 227 | Phosphorylation | FFDRNRPSFDAILYY CCCCCCCCCCEEEEE | 32.30 | - | |
| 233 | Phosphorylation | PSFDAILYYYQSGGR CCCCEEEEEECCCCC | 8.26 | - | |
| 352 | N-linked_Glycosylation | GGHGGLLNDTSAPHL CCCCCCCCCCCCCCH | 56.40 | UniProtKB CARBOHYD | |
| 458 | Phosphorylation | VFRIFKLSRHSKGLQ HHHHHHHCCCCCHHH | 28.65 | 26074081 | |
| 542 | Phosphorylation | VGGKIVGSLCAIAGV ECCEEHHHHHHHHHH | 14.91 | - | |
| 565 | Phosphorylation | VIVSNFNYFYHRETE EEEECCCEEEECCCC | 11.02 | 12151401 | |
| 571 | Phosphorylation | NYFYHRETENEEQTQ CEEEECCCCCHHHHH | 44.03 | 28270605 | |
| 577 | Phosphorylation | ETENEEQTQLTQNAV CCCCHHHHHHHHHHH | 28.91 | 28270605 | |
| 580 | Phosphorylation | NEEQTQLTQNAVSCP CHHHHHHHHHHHCCC | 15.23 | 28270605 | |
| 585 | Phosphorylation | QLTQNAVSCPYLPSN HHHHHHHCCCCCCHH | 13.63 | 28270605 | |
| 588 | Phosphorylation | QNAVSCPYLPSNLLK HHHHCCCCCCHHHHH | 35.26 | 28270605 | |
| 591 | Phosphorylation | VSCPYLPSNLLKKFR HCCCCCCHHHHHHHH | 37.20 | 28270605 | |
| 599 | Phosphorylation | NLLKKFRSSTSSSLG HHHHHHHHCCCCCCC | 40.89 | - | |
| 601 | Phosphorylation | LKKFRSSTSSSLGDK HHHHHHCCCCCCCCH | 33.60 | 15955806 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 90 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 599 | S | Phosphorylation | Kinase | PKA | - | Uniprot |
| 601 | T | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| - | K | Ubiquitination | E3 ubiquitin ligase | LNX1 | Q8TBB1 | PMID:22889411 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCNA4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCNA4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DLG1_HUMAN | DLG1 | physical | 12860415 | |
| DLG4_HUMAN | DLG4 | physical | 11997254 | |
| DLG2_HUMAN | DLG2 | physical | 11997254 | |
| DLG1_HUMAN | DLG1 | physical | 11997254 | |
| KCNA2_HUMAN | KCNA2 | physical | 10428084 | |
| KCNA1_HUMAN | KCNA1 | physical | 10428084 | |
| DLG4_HUMAN | DLG4 | physical | 9581762 | |
| DLG4_HUMAN | DLG4 | physical | 8938729 | |
| DLG1_HUMAN | DLG1 | physical | 8938729 | |
| DLG4_HUMAN | DLG4 | physical | 8601796 | |
| SRC_HUMAN | SRC | physical | 11149959 | |
| KCNRG_HUMAN | KCNRG | physical | 19968958 | |
| DLG4_HUMAN | DLG4 | physical | 11723117 | |
| DLG4_HUMAN | DLG4 | physical | 7477295 | |
| DLG1_HUMAN | DLG1 | physical | 7477295 | |
| KCAB2_HUMAN | KCNAB2 | physical | 23390957 | |
| SIR1_HUMAN | SIRT1 | physical | 23390957 |
| Kegg Disease | |
|---|---|
| There are no disease associations of PTM sites. | |
| OMIM Disease | |
| There are no disease associations of PTM sites. | |
| Kegg Drug | |
| There are no disease associations of PTM sites. | |
| DrugBank | |
| DB06637 | Dalfampridine |
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