DLG2_HUMAN - dbPTM
DLG2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DLG2_HUMAN
UniProt AC Q15700
Protein Name Disks large homolog 2
Gene Name DLG2
Organism Homo sapiens (Human).
Sequence Length 870
Subcellular Localization Cell membrane
Lipid-anchor . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse. Membrane . Cell projection, axon . Concentrated in soma and postsynaptic density of a subset of neurons.
Protein Description Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity)..
Protein Sequence MFFACYCALRTNVKKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENVHGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPEPVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKEKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5S-palmitoylation---MFFACYCALRTN
---CCCHHHHHHHHC		2.12-
5 (in isoform 3)Phosphorylation-2.1224043423
6 (in isoform 4)Phosphorylation-4.19-
7S-palmitoylation-MFFACYCALRTNVK
-CCCHHHHHHHHCCC		2.64-
7 (in isoform 3)Phosphorylation-2.6424043423
10 (in isoform 4)Phosphorylation-13.01-
10 (in isoform 5)Phosphorylation-13.0125159151
12 (in isoform 3)Phosphorylation-36.8624043423
12 (in isoform 5)Phosphorylation-36.8625159151
15 (in isoform 4)Phosphorylation-30.58-
18PhosphorylationTNVKKYRYQDEDAPH
HCCCCCCCCCCCCCC		19.7523312004
28PhosphorylationEDAPHDHSLPRLTHE
CCCCCCCCCCCCCCC		46.2419060867
45PhosphorylationGPELVHVSEKNLSQI
CCEEEEECCCCHHHH		28.1625332170
46 (in isoform 4)Phosphorylation-44.8922210691
47 (in isoform 4)Phosphorylation-56.5322210691
48 (in isoform 4)Phosphorylation-40.6522210691
50 (in isoform 4)Phosphorylation-38.2122210691
53 (in isoform 4)Phosphorylation-45.6322210691
54 (in isoform 4)Phosphorylation-32.49-
58PhosphorylationQIENVHGYVLQSHIS
HHCCHHHHEEECCCC		5.3225332170
61 (in isoform 4)Phosphorylation-23.95-
62PhosphorylationVHGYVLQSHISPLKA
HHHHEEECCCCCCCC		20.7325332170
65PhosphorylationYVLQSHISPLKASPA
HEEECCCCCCCCCCC		20.8225307156
68 (in isoform 4)Phosphorylation-50.6422210691
72 (in isoform 4)Phosphorylation-12.8724719451
85 (in isoform 4)Phosphorylation-29.1624719451
86 (in isoform 4)Phosphorylation-11.6024719451
106PhosphorylationITLERGNSGLGFSIA
EEECCCCCCCCEEEC		37.9112933808
111PhosphorylationGNSGLGFSIAGGTDN
CCCCCCEEECCCCCC		15.1024114839
118 (in isoform 5)Phosphorylation-29.86-
120 (in isoform 5)Phosphorylation-42.81-
130PhosphorylationDDPGIFITKIIPGGA
CCCCEEEEEECCCCH		12.87-
159PhosphorylationRVNEVDVSEVSHSKA
EECEECHHHCCCHHH		28.0225072903
162PhosphorylationEVDVSEVSHSKAVEA
EECHHHCCCHHHHHH		20.2825072903
164PhosphorylationDVSEVSHSKAVEALK
CHHHCCCHHHHHHHH		18.1425072903
165UbiquitinationVSEVSHSKAVEALKE
HHHCCCHHHHHHHHH		51.53-
171UbiquitinationSKAVEALKEAGSIVR
HHHHHHHHHHCCCHH		53.19-
175PhosphorylationEALKEAGSIVRLYVR
HHHHHHCCCHHEEHH		25.5928857561
180PhosphorylationAGSIVRLYVRRRRPI
HCCCHHEEHHCCCCC		4.95-
201UbiquitinationIKLFKGPKGLGFSIA
EEECCCCCCCCEEEC		75.36-
221PhosphorylationQHIPGDNSIYVTKII
CCCCCCCEEEEEEEE		21.7519690332
225PhosphorylationGDNSIYVTKIIDGGA
CCCEEEEEEEEECCC		10.2719690332
235UbiquitinationIDGGAAQKDGRLQVG
EECCCCCCCCCCEEC		58.38-
257PhosphorylationNYSLEEVTHEEAVAI
CCCHHHCCHHHHHHH		27.18-
266 (in isoform 3)Phosphorylation-52.6621406692
267 (in isoform 3)Phosphorylation-45.4521406692
272 (in isoform 3)Phosphorylation-3.9821406692
276 (in isoform 3)Phosphorylation-12.6021406692
277 (in isoform 3)Phosphorylation-28.7421406692
289 (in isoform 3)Phosphorylation-32.4321406692
290 (in isoform 3)Phosphorylation-19.9721406692
291 (in isoform 3)Phosphorylation-41.0721406692
293 (in isoform 3)Phosphorylation-4.6221406692
296 (in isoform 3)Phosphorylation-20.7521406692
297 (in isoform 3)Phosphorylation-20.0021406692
299 (in isoform 3)Phosphorylation-24.8321406692
307PhosphorylationPMENHLLSGNNGTLE
CCCCCEECCCCCCEE		45.92-
317PhosphorylationNGTLEYKTSLPPISP
CCCEEEECCCCCCCC		34.3020860994
318PhosphorylationGTLEYKTSLPPISPG
CCEEEECCCCCCCCC		34.4220860994
323PhosphorylationKTSLPPISPGRYSPI
ECCCCCCCCCCCCCC		27.3722618309
327PhosphorylationPPISPGRYSPIPKHM
CCCCCCCCCCCCCHH		25.3927732954
328PhosphorylationPISPGRYSPIPKHML
CCCCCCCCCCCCHHC		18.2627732954
340PhosphorylationHMLVDDDYTRPPEPV
HHCCCCCCCCCCCCC		16.19-
348PhosphorylationTRPPEPVYSTVNKLC
CCCCCCCCHHHHHHC		14.8924927040
360PhosphorylationKLCDKPASPRHYSPV
HHCCCCCCCCCCCCC		30.8725332170
365PhosphorylationPASPRHYSPVECDKS
CCCCCCCCCCCCCCC		19.1515822905
406PhosphorylationSTATRQPSMTLQRAV
CCCCCCCCCCEEHHH		18.96-
414PhosphorylationMTLQRAVSLEGEPRK
CCEEHHHHCCCCCCE		21.5126657352
493PhosphorylationALKGAGQTVTIIAQY
HHCCCCCEEEEEEEE		20.7824043423
495PhosphorylationKGAGQTVTIIAQYQP
CCCCCEEEEEEEECH		15.2824043423
500PhosphorylationTVTIIAQYQPEDYAR
EEEEEEEECHHHHHH		19.6024043423
505PhosphorylationAQYQPEDYARFEAKI
EEECHHHHHHHHHHH		9.6727196784
511UbiquitinationDYARFEAKIHDLREQ
HHHHHHHHHHHHHHH		33.12-
523PhosphorylationREQMMNHSMSSGSGS
HHHHHHCCCCCCCCC		18.5029978859
525PhosphorylationQMMNHSMSSGSGSLR
HHHHCCCCCCCCCCC		34.2622210691
526PhosphorylationMMNHSMSSGSGSLRT
HHHCCCCCCCCCCCC		28.4728348404
528PhosphorylationNHSMSSGSGSLRTNQ
HCCCCCCCCCCCCCC		27.4429978859
530PhosphorylationSMSSGSGSLRTNQKR
CCCCCCCCCCCCCCC		19.1729978859
533PhosphorylationSGSGSLRTNQKRSLY
CCCCCCCCCCCCEEE		47.5022210691
533 (in isoform 3)Phosphorylation-47.50-
535 (in isoform 3)Phosphorylation-41.76-
538PhosphorylationLRTNQKRSLYVRAMF
CCCCCCCEEEEEEEE		30.9622210691
540PhosphorylationTNQKRSLYVRAMFDY
CCCCCEEEEEEEEEC		6.8022210691
553PhosphorylationDYDKSKDSGLPSQGL
ECCCCCCCCCCCCCE		46.0624719451
561PhosphorylationGLPSQGLSFKYGDIL
CCCCCCEEEECCCEE		26.9024719451
574PhosphorylationILHVINASDDEWWQA
EEEEEECCCCHHHHH		40.9018220336
598PhosphorylationEEMGVIPSKRRVERK
CCCCCCCCCCCCCHH		27.8924719451
624PhosphorylationAKPGVIDSKGSFNDK
CCCCCCCCCCCCCCH		28.0021406692
627PhosphorylationGVIDSKGSFNDKRKK
CCCCCCCCCCCHHCC		25.3120873877
635PhosphorylationFNDKRKKSFIFSRKF
CCCHHCCEEEEECCC		26.9823186163
655PhosphorylationKEQSEQETSDPERGQ
HHHCCCCCCCCCCCC		37.8225627689
656PhosphorylationEQSEQETSDPERGQE
HHCCCCCCCCCCCCC		50.8725627689
690UbiquitinationVIILGPMKDRINDDL
EEEEEECCCCCCHHH		47.17-
707PhosphorylationEFPDKFGSCVPHTTR
HCCCCCCCCCCCCCC		18.31-
719PhosphorylationTTRPKRDYEVDGRDY
CCCCCCCEEECCCEE		23.14-
726PhosphorylationYEVDGRDYHFVISRE
EEECCCEEEEEEEHH		8.8725159151
750PhosphorylationKFIEAGQYNDNLYGT
CEEECCCCCCCCCCC		24.46-
755PhosphorylationGQYNDNLYGTSVQSV
CCCCCCCCCCCHHEE		25.3127196784
800PhosphorylationAIFIKPRSLEPLMEM
EEEECCCCCHHHHHH		45.6829978859
866PhosphorylationGPFIWIPSKEKL---
CCEEEECCCCCC---		44.2924719451
867UbiquitinationPFIWIPSKEKL----
CEEEECCCCCC----		54.21-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
323SPhosphorylationKinaseMAPK1P28482
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DLG2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DLG2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DLG4_HUMANDLG4physical
9182804
MAP1A_HUMANMAP1Aphysical
9786987
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DLG2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of synaptosomes from human cerebralcortex.";
DeGiorgis J.A., Jaffe H., Moreira J.E., Carlotti C.G. Jr., Leite J.P.,Pant H.C., Dosemeci A.;
J. Proteome Res. 4:306-315(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365, AND MASSSPECTROMETRY.

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