dbPTM

DLG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DLG1_HUMAN
UniProt AC	Q12959
Protein Name	Disks large homolog 1 {ECO:0000305}
Gene Name	DLG1 {ECO:0000312\|HGNC:HGNC:2900}
Organism	Homo sapiens (Human).
Sequence Length	904
Subcellular Localization	Membrane Peripheral membrane protein . Basolateral cell membrane . Endoplasmic reticulum membrane . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . Cell junction, synapse . Cell membrane, sarcolemma . Apical cell membrane . Ce
Protein Description	Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel..
Protein Sequence	MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 8)	Phosphorylation	-	13.26	29438985
3 (in isoform 9)	Phosphorylation	-	13.26	29438985
9 (in isoform 8)	Phosphorylation	-	36.62	20068231
9 (in isoform 9)	Phosphorylation	-	36.62	20068231
12 (in isoform 8)	Phosphorylation	-	2.97	24719451
12 (in isoform 9)	Phosphorylation	-	2.97	24719451
13 (in isoform 8)	Phosphorylation	-	27.64	20068231
13 (in isoform 9)	Phosphorylation	-	27.64	20068231
16 (in isoform 8)	Phosphorylation	-	60.38	25954137
16 (in isoform 9)	Phosphorylation	-	60.38	25954137
18	Phosphorylation	ALHLLEEYRSKLSQT HHHHHHHHHHHCCHH	15.71	-
21 (in isoform 8)	Phosphorylation	-	43.06	25954137
21 (in isoform 9)	Phosphorylation	-	43.06	25954137
22 (in isoform 8)	Phosphorylation	-	4.90	25954137
22 (in isoform 9)	Phosphorylation	-	4.90	25954137
23	Phosphorylation	EEYRSKLSQTEDRQL HHHHHHCCHHHHHHH	38.50	20068231
25	Phosphorylation	YRSKLSQTEDRQLRS HHHHCCHHHHHHHHH	36.16	20068231
32	Phosphorylation	TEDRQLRSSIERVIN HHHHHHHHHHHHHHH	44.23	28102081
33	Phosphorylation	EDRQLRSSIERVINI HHHHHHHHHHHHHHH	23.26	28102081
40 (in isoform 8)	Phosphorylation	-	1.98	25332170
40 (in isoform 9)	Phosphorylation	-	1.98	25332170
41 (in isoform 8)	Phosphorylation	-	5.87	25332170
41 (in isoform 9)	Phosphorylation	-	5.87	25332170
56	Phosphorylation	LIDIQEFYEVTLLDN HHHHHHHHEEEECCC	14.56	24275569
70	Phosphorylation	NPKCIDRSKPSEPIQ CCCCCCCCCCCCCCC	45.21	27080861
73	Phosphorylation	CIDRSKPSEPIQPVN CCCCCCCCCCCCCCC	60.79	27080861
81	Phosphorylation	EPIQPVNTWEISSLP CCCCCCCEEEEECCC	25.39	27080861
85	Phosphorylation	PVNTWEISSLPSSTV CCCEEEEECCCCCCC	17.82	29514088
86	Phosphorylation	VNTWEISSLPSSTVT CCEEEEECCCCCCCC	50.38	26657352
89	Phosphorylation	WEISSLPSSTVTSET EEEECCCCCCCCCCC	43.89	29514088
90	Phosphorylation	EISSLPSSTVTSETL EEECCCCCCCCCCCC	25.59	29514088
91	Phosphorylation	ISSLPSSTVTSETLP EECCCCCCCCCCCCC	31.94	29514088
93	Phosphorylation	SLPSSTVTSETLPSS CCCCCCCCCCCCCCC	22.42	28450419
94	Phosphorylation	LPSSTVTSETLPSSL CCCCCCCCCCCCCCC	25.01	28450419
96	Phosphorylation	SSTVTSETLPSSLSP CCCCCCCCCCCCCCC	43.68	28450419
99	Phosphorylation	VTSETLPSSLSPSVE CCCCCCCCCCCCCCE	47.20	28450419
100	Phosphorylation	TSETLPSSLSPSVEK CCCCCCCCCCCCCEE	30.81	28450419
102	Phosphorylation	ETLPSSLSPSVEKYR CCCCCCCCCCCEEEC	19.65	25159151
104	Phosphorylation	LPSSLSPSVEKYRYQ CCCCCCCCCEEECCC	39.26	28387310
107	Ubiquitination	SLSPSVEKYRYQDED CCCCCCEEECCCCCC	32.64	21906983
107 (in isoform 1)	Ubiquitination	-	32.64	21890473
107 (in isoform 2)	Ubiquitination	-	32.64	21890473
107 (in isoform 3)	Ubiquitination	-	32.64	21890473
107 (in isoform 4)	Ubiquitination	-	32.64	21890473
107 (in isoform 5)	Ubiquitination	-	32.64	21890473
107 (in isoform 6)	Ubiquitination	-	32.64	21890473
107 (in isoform 7)	Ubiquitination	-	32.64	21890473
108	Phosphorylation	LSPSVEKYRYQDEDT CCCCCEEECCCCCCC	10.88	30576142
110	Phosphorylation	PSVEKYRYQDEDTPP CCCEEECCCCCCCCC	19.75	30266825
115	Phosphorylation	YRYQDEDTPPQEHIS ECCCCCCCCCHHCCC	34.52	30266825
122	Phosphorylation	TPPQEHISPQITNEV CCCHHCCCHHHHCCC	16.80	30266825
126	Phosphorylation	EHISPQITNEVIGPE HCCCHHHHCCCCCHH	21.78	30266825
138	Phosphorylation	GPELVHVSEKNLSEI CHHHEECCCCCHHHH	28.16	25159151
140	Ubiquitination	ELVHVSEKNLSEIEN HHEECCCCCHHHHCC	56.53	-
143	Phosphorylation	HVSEKNLSEIENVHG ECCCCCHHHHCCCCC	46.02	28176443
153	Phosphorylation	ENVHGFVSHSHISPI CCCCCCCCCCCCCCC	19.60	30266825
155	Phosphorylation	VHGFVSHSHISPIKP CCCCCCCCCCCCCCC	18.27	30266825
158	Phosphorylation	FVSHSHISPIKPTEA CCCCCCCCCCCCCCC	18.36	30266825
158 (in isoform 3)	Phosphorylation	-	18.36	25849741
158 (in isoform 4)	Phosphorylation	-	18.36	25849741
158 (in isoform 5)	Phosphorylation	-	18.36	25849741
204	Phosphorylation	PPPVLVNTDSLETPT CCCEEEECCCCCCCC	21.34	28348404
206	Phosphorylation	PVLVNTDSLETPTYV CEEEECCCCCCCCEE	26.51	28348404
209	Phosphorylation	VNTDSLETPTYVNGT EECCCCCCCCEECCC	26.65	28348404
211	Phosphorylation	TDSLETPTYVNGTDA CCCCCCCCEECCCCC	47.74	28348404
212	Phosphorylation	DSLETPTYVNGTDAD CCCCCCCEECCCCCC	7.97	28348404
216	Phosphorylation	TPTYVNGTDADYEYE CCCEECCCCCCCEEE	23.86	28348404
220	Phosphorylation	VNGTDADYEYEEITL ECCCCCCCEEEEEEE	23.33	28102081
222	Phosphorylation	GTDADYEYEEITLER CCCCCCEEEEEEEEC	16.78	28102081
232	Phosphorylation	ITLERGNSGLGFSIA EEEECCCCCCCEEEC	37.91	19060867
285	Ubiquitination	RVNEVDVRDVTHSKA EECEEEHHHCCHHHH	28.37	21890473
291	Ubiquitination	VRDVTHSKAVEALKE HHHCCHHHHHHHHHH	49.17	-
301	Phosphorylation	EALKEAGSIVRLYVK HHHHHHCCEEEEEEE	25.59	28857561
321	Ubiquitination	SEKIMEIKLIKGPKG CHHHHEEEEEECCCC	30.74	-
321 (in isoform 2)	Ubiquitination	-	30.74	-
347	Phosphorylation	QHIPGDNSIYVTKII CCCCCCCCEEEEEEE	21.75	19690332
350 (in isoform 5)	Ubiquitination	-	4.13	21890473
351	Phosphorylation	GDNSIYVTKIIEGGA CCCCEEEEEEEECCC	10.27	19690332
361	Ubiquitination	IEGGAAHKDGKLQIG EECCCCCCCCCCCCC	64.55	-
368 (in isoform 3)	Ubiquitination	-	17.03	21890473
368 (in isoform 4)	Ubiquitination	-	17.03	21890473
370	Ubiquitination	GKLQIGDKLLAVNNV CCCCCCCEEEEEECE	39.94	-
395	Phosphorylation	VTALKNTSDFVYLKV HHHHHCCCCEEEEEE	38.14	28442448
399	Phosphorylation	KNTSDFVYLKVAKPT HCCCCEEEEEEECCC	10.78	28152594
401	Ubiquitination	TSDFVYLKVAKPTSM CCCEEEEEEECCCCC	23.59	21890473
401	Ubiquitination	TSDFVYLKVAKPTSM CCCEEEEEEECCCCC	23.59	21890473
401 (in isoform 1)	Ubiquitination	-	23.59	21890473
401 (in isoform 2)	Ubiquitination	-	23.59	21890473
401 (in isoform 6)	Ubiquitination	-	23.59	21890473
401 (in isoform 7)	Ubiquitination	-	23.59	21890473
406	Phosphorylation	YLKVAKPTSMYMNDG EEEEECCCCCCCCCC	25.97	25002506
407	Phosphorylation	LKVAKPTSMYMNDGY EEEECCCCCCCCCCC	19.22	25002506
409	Phosphorylation	VAKPTSMYMNDGYAP EECCCCCCCCCCCCC	7.79	19901323
414	Phosphorylation	SMYMNDGYAPPDITN CCCCCCCCCCCCCCC	20.85	27259358
420	Phosphorylation	GYAPPDITNSSSQPV CCCCCCCCCCCCCCC	36.11	25002506
422	Phosphorylation	APPDITNSSSQPVDN CCCCCCCCCCCCCCC	23.79	25002506
423	Phosphorylation	PPDITNSSSQPVDNH CCCCCCCCCCCCCCC	34.75	25002506
424	Phosphorylation	PDITNSSSQPVDNHV CCCCCCCCCCCCCCC	38.02	30576142
432	Phosphorylation	QPVDNHVSPSSFLGQ CCCCCCCCHHHHCCC	16.12	25002506
434	Phosphorylation	VDNHVSPSSFLGQTP CCCCCCHHHHCCCCC	26.64	25002506
435	Phosphorylation	DNHVSPSSFLGQTPA CCCCCHHHHCCCCCC	28.07	26074081
440	Phosphorylation	PSSFLGQTPASPARY HHHHCCCCCCCCCCC	21.01	26074081
443	Phosphorylation	FLGQTPASPARYSPV HCCCCCCCCCCCCCC	21.94	28188228
447	Phosphorylation	TPASPARYSPVSKAV CCCCCCCCCCCCHHH	21.31	26074081
448	Phosphorylation	PASPARYSPVSKAVL CCCCCCCCCCCHHHH	17.17	30576142
451	Phosphorylation	PARYSPVSKAVLGDD CCCCCCCCHHHHCCC	20.48	26074081
452	Ubiquitination	ARYSPVSKAVLGDDE CCCCCCCHHHHCCCC	42.63	-
503	Phosphorylation	AGGPADLSGELRKGD ECCCCCCCCCCCCCC	30.67	22210691
514	Phosphorylation	RKGDRIISVNSVDLR CCCCEEEEECCEECH	16.93	30266825
517	Phosphorylation	DRIISVNSVDLRAAS CEEEEECCEECHHCC	18.17	30266825
533 (in isoform 2)	Malonylation	-	39.77	30639696
556	Ubiquitination	EYSRFEAKIHDLREQ HHHHHHHHHHHHHHH	33.12	-
567	Phosphorylation	LREQMMNSSISSGSG HHHHHHHCCCCCCCC	15.91	30266825
568	Phosphorylation	REQMMNSSISSGSGS HHHHHHCCCCCCCCC	22.83	30266825
570	Phosphorylation	QMMNSSISSGSGSLR HHHHCCCCCCCCCCC	30.51	23401153
571	Phosphorylation	MMNSSISSGSGSLRT HHHCCCCCCCCCCCC	35.00	29255136
573	Phosphorylation	NSSISSGSGSLRTSQ HCCCCCCCCCCCCCC	27.44	29255136
575	Phosphorylation	SISSGSGSLRTSQKR CCCCCCCCCCCCCCC	19.17	29255136
578	Phosphorylation	SGSGSLRTSQKRSLY CCCCCCCCCCCCEEE	40.58	30576142
579	Phosphorylation	GSGSLRTSQKRSLYV CCCCCCCCCCCEEEE	27.54	23927012
583	Phosphorylation	LRTSQKRSLYVRALF CCCCCCCEEEEEHHC	30.96	22496350
585	Phosphorylation	TSQKRSLYVRALFDY CCCCCEEEEEHHCCC	6.80	-
592	Phosphorylation	YVRALFDYDKTKDSG EEEHHCCCCCCCCCC	16.41	23312004
593 (in isoform 5)	Ubiquitination	-	54.73	21890473
595	Phosphorylation	ALFDYDKTKDSGLPS HHCCCCCCCCCCCCC	36.87	20873877
598	Phosphorylation	DYDKTKDSGLPSQGL CCCCCCCCCCCCCCC	43.73	25159151
602	Phosphorylation	TKDSGLPSQGLNFKF CCCCCCCCCCCCEEC	41.75	20873877
611 (in isoform 3)	Ubiquitination	-	43.33	21890473
611 (in isoform 4)	Ubiquitination	-	43.33	21890473
619	Phosphorylation	ILHVINASDDEWWQA EEEEEECCCCHHHHC	40.90	22617229
619 (in isoform 2)	Phosphorylation	-	40.90	18220336
630	Phosphorylation	WWQARQVTPDGESDE HHHCEEECCCCCCCC	13.81	28985074
635	Phosphorylation	QVTPDGESDEVGVIP EECCCCCCCCCCCCC	44.60	24719451
636	Phosphorylation	VTPDGESDEVGVIPS ECCCCCCCCCCCCCC	50.74	24719451
637 (in isoform 4)	Phosphorylation	-	50.91	22167270
643	Phosphorylation	DEVGVIPSKRRVEKK CCCCCCCCCCCCCHH	27.89	24719451
644	Acetylation	EVGVIPSKRRVEKKE CCCCCCCCCCCCHHH	38.58	11921265
644	Ubiquitination	EVGVIPSKRRVEKKE CCCCCCCCCCCCHHH	38.58	2190698
644 (in isoform 1)	Ubiquitination	-	38.58	21890473
644 (in isoform 2)	Ubiquitination	-	38.58	21890473
644 (in isoform 6)	Ubiquitination	-	38.58	21890473
644 (in isoform 7)	Ubiquitination	-	38.58	21890473
657	Phosphorylation	KERARLKTVKFNSKT HHHHHCEEEECCCCC	33.26	22027822
657 (in isoform 4)	Ubiquitination	-	33.26	21890473
659	Ubiquitination	RARLKTVKFNSKTRD HHHCEEEECCCCCCC	44.02	-
660 (in isoform 4)	Phosphorylation	-	12.40	28450419
662	Phosphorylation	LKTVKFNSKTRDKGE CEEEECCCCCCCCCC	38.24	23312004
664	Phosphorylation	TVKFNSKTRDKGEIP EEECCCCCCCCCCCC	43.87	24719451
664 (in isoform 4)	Phosphorylation	-	43.87	23663014
665 (in isoform 4)	Phosphorylation	-	47.59	25849741
670 (in isoform 2)	Phosphorylation	-	6.55	22167270
672 (in isoform 4)	Phosphorylation	-	65.28	23927012
673 (in isoform 4)	Phosphorylation	-	37.68	23927012
676 (in isoform 4)	Phosphorylation	-	19.53	26503892
677	Acetylation	IPDDMGSKGLKHVTS CCCCCCCCCCCCHHC	63.63	7427837
678 (in isoform 4)	Phosphorylation	-	41.47	23663014
680 (in isoform 4)	Phosphorylation	-	44.70	23663014
681 (in isoform 4)	Phosphorylation	-	32.88	23663014
682 (in isoform 4)	Phosphorylation	-	6.33	28450419
683	Phosphorylation	SKGLKHVTSNASDSE CCCCCCHHCCCCCCC	18.91	29255136
684	Phosphorylation	KGLKHVTSNASDSES CCCCCHHCCCCCCCC	29.34	29255136
687	Phosphorylation	KHVTSNASDSESSYR CCHHCCCCCCCCCCC	46.01	29255136
689	Phosphorylation	VTSNASDSESSYRGQ HHCCCCCCCCCCCCC	36.56	29255136
690 (in isoform 2)	Ubiquitination	-	49.01	21890473
691	Phosphorylation	SNASDSESSYRGQEE CCCCCCCCCCCCCEE	36.30	29255136
692	Phosphorylation	NASDSESSYRGQEEY CCCCCCCCCCCCEEE	18.13	29255136
693	Phosphorylation	ASDSESSYRGQEEYV CCCCCCCCCCCEEEE	28.21	23927012
693 (in isoform 2)	Phosphorylation	-	28.21	28450419
697 (in isoform 2)	Phosphorylation	-	54.87	23663014
698 (in isoform 2)	Phosphorylation	-	32.81	25849741
705 (in isoform 2)	Phosphorylation	-	23.33	23927012
706 (in isoform 2)	Phosphorylation	-	7.25	23927012
709 (in isoform 2)	Phosphorylation	-	51.94	26503892
711 (in isoform 2)	Phosphorylation	-	6.04	23663014
713 (in isoform 2)	Phosphorylation	-	14.86	23663014
714 (in isoform 2)	Phosphorylation	-	24.24	23663014
715 (in isoform 2)	Phosphorylation	-	17.09	28450419
724	Ubiquitination	VIILGPMKDRINDDL EEEECCCCCCCCHHH	47.17	-
741	Phosphorylation	EFPDKFGSCVPHTTR HCCCCCCCCCCCCCC	18.31	-
753	Phosphorylation	TTRPKRDYEVDGRDY CCCCCCCEEECCCEE	23.14	28152594
760	Phosphorylation	YEVDGRDYHFVTSRE EEECCCEEEEECCHH	8.87	30183078
764	Phosphorylation	GRDYHFVTSREQMEK CCEEEEECCHHHHHH	22.56	28152594
765	Phosphorylation	RDYHFVTSREQMEKD CEEEEECCHHHHHHH	28.63	28152594
782	Phosphorylation	EHKFIEAGQYNNHLY HHCEEECCCCCCCCC	20.09	17389395
784	Phosphorylation	KFIEAGQYNNHLYGT CEEECCCCCCCCCCC	19.60	28796482
789	Phosphorylation	GQYNNHLYGTSVQSV CCCCCCCCCCCHHHH	15.71	28796482
791	Phosphorylation	YNNHLYGTSVQSVRE CCCCCCCCCHHHHHH	16.50	28796482
792	Phosphorylation	NNHLYGTSVQSVREV CCCCCCCCHHHHHHH	17.50	28442448
795	Phosphorylation	LYGTSVQSVREVAEK CCCCCHHHHHHHHHC	22.46	28442448
824	Phosphorylation	RLQIAQLYPISIFIK HHHHEEEEEEEEEEC	6.09	-
834	Phosphorylation	SIFIKPKSMENIMEM EEEECHHHHHHHHHH	39.60	28270605
843	Ubiquitination	ENIMEMNKRLTEEQA HHHHHHHHHCCHHHH	47.69	-
853	Phosphorylation	TEEQARKTFERAMKL CHHHHHHHHHHHHHH	25.77	24719451
865 (in isoform 2)	Ubiquitination	-	28.00	-
892	Phosphorylation	KQIIEEQSGSYIWVP HHHHHHCCCCEEEEE	32.74	-
895	Phosphorylation	IEEQSGSYIWVPAKE HHHCCCCEEEEECCC	11.43	-
901	Ubiquitination	SYIWVPAKEKL---- CEEEEECCCCC----	49.68	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
122	S	Phosphorylation	Kinase	P38D	Q9Z1B7	PSP
122	S	Phosphorylation	Kinase	P38G	Q63538	PSP
158	S	Phosphorylation	Kinase	CDK1	P06493	PSP
158	S	Phosphorylation	Kinase	P38D	Q9Z1B7	PSP
158	S	Phosphorylation	Kinase	P38G	Q63538	PSP
158	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
158	S	Phosphorylation	Kinase	MAPK7	Q13164	GPS
158	S	Phosphorylation	Kinase	CDK2	P24941	PSP
209	T	Phosphorylation	Kinase	MAPK12	P53778	GPS
209	T	Phosphorylation	Kinase	P38G	Q63538	PSP
209	T	Phosphorylation	Kinase	P38D	Q9Z1B7	PSP
232	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
232	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM
443	S	Phosphorylation	Kinase	MAPK12	P53778	GPS
443	S	Phosphorylation	Kinase	CDK2	P24941	PSP
443	S	Phosphorylation	Kinase	CDK1	P06493	PSP
657	T	Phosphorylation	Kinase	PRKCA	P17252	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW11	Q9UKB1	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	BTRC	Q9Y297	PMID:12902344
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:16482544
-	K	Ubiquitination	E3 ubiquitin ligase	MARCHF2	Q9P0N8	PMID:22199232
-	K	Ubiquitination	E3 ubiquitin ligase	E6	P03126	PMID:22199232

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
232	S	Phosphorylation		-
Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DLG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AGRA2_HUMAN	GPR124	physical	15021905
CSKP_HUMAN	CASK	physical	14960569
LIN7A_HUMAN	LIN7A	physical	14960569
LIN7C_HUMAN	LIN7C	physical	14960569
APBA1_HUMAN	APBA1	physical	14960569
KCJ12_HUMAN	KCNJ12	physical	14960569
NMDE1_HUMAN	GRIN2A	physical	12933808
GRIA1_HUMAN	GRIA1	physical	12933808
FBW1A_HUMAN	BTRC	physical	12902344
ACTN2_HUMAN	ACTN2	physical	12860415
ADA17_HUMAN	ADAM17	physical	12668732
41_HUMAN	EPB41	physical	7937897
DLGP1_HUMAN	DLGAP1	physical	9115257
KCNJ6_HUMAN	KCNJ6	physical	10619846
DLGP1_HUMAN	DLGAP1	physical	9286858
GRIK2_HUMAN	GRIK2	physical	11279111
DLGP1_HUMAN	DLGAP1	physical	11060025
DLGP1_HUMAN	DLGAP1	physical	9024696
KI13B_HUMAN	KIF13B	physical	10859302
KCNJ2_HUMAN	KCNJ2	physical	11181181
KCJ12_HUMAN	KCNJ12	physical	11181181
KCNJ4_HUMAN	KCNJ4	physical	11181181
CSKP_HUMAN	CASK	physical	10993877
LCK_HUMAN	LCK	physical	9341123
KCNA3_HUMAN	KCNA3	physical	9341123
MARH2_HUMAN	MARCH2	physical	17980554
ARHG8_HUMAN	NET1	physical	19586902
KCNA5_HUMAN	KCNA5	physical	16466689
MAP1A_HUMAN	MAP1A	physical	9786987
ARHG8_HUMAN	NET1	physical	17938206
ADA17_HUMAN	ADAM17	physical	18930083
TGFA_HUMAN	TGFA	physical	18930083

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DLG1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-575, AND MASSSPECTROMETRY.	19690332 [Abstract]
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