KCNJ6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCNJ6_HUMAN
• UniProt AC: P48051
• Protein Name: G protein-activated inward rectifier potassium channel 2
• Gene Name: KCNJ6
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium..
• Protein Sequence: MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENESKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	AKLTESMTNVLEGDS CCCCHHHHHHHCCCC		32142685
16	Phosphorylation	TNVLEGDSMDQDVES HHHHCCCCCCCCCCC		-
23	Phosphorylation	SMDQDVESPVAIHQP CCCCCCCCCCEECCC		-
78	Phosphorylation	RETYRYLTDIFTTLV HHHHHHHHHHHHHHH		-
202	Phosphorylation	QPKKRAETLVFSTHA CCCCHHHEEEEEEEE		26434552
212	Phosphorylation	FSTHAVISMRDGKLC EEEEEEEECCCCCEE		26434552
323	Phosphorylation	GMTCQARSSYITSEI CCCEEEECCEECEEE		19845377
382	Phosphorylation	SRAELPLSWSVSSKL HCCCCCCCCCHHHHH		28348404
384	Phosphorylation	AELPLSWSVSSKLNQ CCCCCCCCHHHHHHH		32142685
386	Phosphorylation	LPLSWSVSSKLNQHA CCCCCCHHHHHHHHC		28348404
387	Phosphorylation	PLSWSVSSKLNQHAE CCCCCHHHHHHHHCC		32142685
397	Phosphorylation	NQHAELETEEEEKNL HHHCCCCCHHHHHCH		32142685
421	Phosphorylation	VANLENESKV----- CCCCCCCCCC-----		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KCNJ6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCNJ6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCNJ6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DLG1_HUMAN	DLG1	physical	10619846
KCNJ9_HUMAN	KCNJ9	physical	10956667
KCNJ9_HUMAN	KCNJ9	physical	12297500
BIRC5_HUMAN	BIRC5	physical	15218035
GABR1_HUMAN	GABBR1	physical	17185339
M21D2_HUMAN	MB21D2	physical	28514442
HPF1_HUMAN	C4orf27	physical	28514442
CA043_HUMAN	C1orf43	physical	28514442
UFSP2_HUMAN	UFSP2	physical	28514442
LRRC1_HUMAN	LRRC1	physical	28514442
HSDL1_HUMAN	HSDL1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.