HSDL1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSDL1_HUMAN
• UniProt AC: Q3SXM5
• Protein Name: Inactive hydroxysteroid dehydrogenase-like protein 1
• Gene Name: HSDL1
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MAAVDSFYLLYREIARSCNCYMEALALVGAWYTARKSITVICDFYSLIRLHFIPRLGSRADLIKQYGRWAVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDIIVADFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQLSEDKLWDIINVNIAAASLMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIFVQSLIPFYVATSMTAPSNFLHRCSWLVPSPKVYAHHAVSTLGISKRTTGYWSHSIQFLFAQYMPEWLWVWGANILNRSLRKEALSCTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAVDSFYL ------CCHHHHHHH	19.05	-
17	Phosphorylation	LYREIARSCNCYMEA HHHHHHHHCCCHHHH	10.72	-
21	Phosphorylation	IARSCNCYMEALALV HHHHCCCHHHHHHHH	5.52	-
64	Ubiquitination	GSRADLIKQYGRWAV CCHHHHHHHHCCCHH	44.77	21890473
66	Phosphorylation	RADLIKQYGRWAVVS HHHHHHHHCCCHHHC	12.03	-
81	Ubiquitination	GATDGIGKAYAEELA CCCCCHHHHHHHHHH	35.98	21890473
83	Phosphorylation	TDGIGKAYAEELASR CCCHHHHHHHHHHHC	20.31	28102081
103	2-Hydroxyisobutyrylation	LISRNEEKLQVVAKD EEECCHHHHHHHEHH	37.73	-
103	Ubiquitination	LISRNEEKLQVVAKD EEECCHHHHHHHEHH	37.73	-
109	Ubiquitination	EKLQVVAKDIADTYK HHHHHHEHHHHHHCE	37.75	21890473
109	2-Hydroxyisobutyrylation	EKLQVVAKDIADTYK HHHHHHEHHHHHHCE	37.75	-
115	Phosphorylation	AKDIADTYKVETDII EHHHHHHCEEEEEEE	17.37	25599653
116	Ubiquitination	KDIADTYKVETDIIV HHHHHHCEEEEEEEE	35.37	-
119	Phosphorylation	ADTYKVETDIIVADF HHHCEEEEEEEEEEC	35.17	29038488
143	Ubiquitination	IREALKDKDVGILVN HHHHHCCCCCEEEEC	53.37	21890473
236	Phosphorylation	SRALQYEYASKGIFV HHHHHHHHHCCCCCC	15.96	29496907
266	Phosphorylation	SNFLHRCSWLVPSPK CCHHHCCCEECCCCC	24.33	28857561
271	Phosphorylation	RCSWLVPSPKVYAHH CCCEECCCCCEEEEH	29.85	21815630
287	Ubiquitination	VSTLGISKRTTGYWS HHHCCCCCCCCCCCH	52.41	-
287	2-Hydroxyisobutyrylation	VSTLGISKRTTGYWS HHHCCCCCCCCCCCH	52.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSDL1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSDL1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HSDL1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of HSDL1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.