HPF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HPF1_HUMAN
• UniProt AC: Q9NWY4
• Protein Name: Histone PARylation factor 1 {ECO:0000303|PubMed:27067600, ECO:0000312|HGNC:HGNC:26051}
• Gene Name: HPF1 {ECO:0000303|PubMed:27067600, ECO:0000312|HGNC:HGNC:26051}
• Organism: Homo sapiens (Human).
• Sequence Length: 346
• Protein Description: Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP1 and is able to change amino acid specificity toward serine. [PubMed: 28190768 Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability]
• Protein Sequence: MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENHYKLSLPEDFYHFWKFCEELDPEKPSDSLSASLGLQLVGPYDILAGKHKTKKKSTGLNFNLHWRFYYDPPEFQTIIIGDNKTQYHMGYFRDSPDEFPVYVGINEAKKNCIIVPNGDNVFAAVKLFLTKKLREITDKKKINLLKNIDEKLTEAARELGYSLEQRTVKMKQRDKKVVTKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKTIVEAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLLKRNLFAEIIEEHLANRSQENIDQLAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MVGGGGKR -------CCCCCCCC		22814378
7	Acetylation	-MVGGGGKRRPGGEG -CCCCCCCCCCCCCC		25953088
19	Acetylation	GEGPQCEKTTDVKKS CCCCCCCCCCCCCHH		25953088
19	Ubiquitination	GEGPQCEKTTDVKKS CCCCCCCCCCCCCHH		29967540
25	Acetylation	EKTTDVKKSKFCEAD CCCCCCCHHHCCCCC		25953088
27	Acetylation	TTDVKKSKFCEADVS CCCCCHHHCCCCCCC		19608861
27	Ubiquitination	TTDVKKSKFCEADVS CCCCCHHHCCCCCCC		19608861
39	Ubiquitination	DVSSDLRKEVENHYK CCCHHHHHHHHHHHC		29967540
46	Ubiquitination	KEVENHYKLSLPEDF HHHHHHHCCCCCHHH		29967540
90	Ubiquitination	PYDILAGKHKTKKKS HHHHHCCCCCCCCCC		29967540
97	ADP-ribosylation	KHKTKKKSTGLNFNL CCCCCCCCCCCCCEE		30257210
149	Ubiquitination	YVGINEAKKNCIIVP EEECCCCCCCEEEEC		29967540
149	Acetylation	YVGINEAKKNCIIVP EEECCCCCCCEEEEC		26051181
150	Ubiquitination	VGINEAKKNCIIVPN EECCCCCCCEEEECC		-
186	Acetylation	KKKINLLKNIDEKLT HHHHHHHHCHHHHHH		19608861
186	Ubiquitination	KKKINLLKNIDEKLT HHHHHHHHCHHHHHH		19608861
191	Ubiquitination	LLKNIDEKLTEAARE HHHCHHHHHHHHHHH		29967540
191	Acetylation	LLKNIDEKLTEAARE HHHCHHHHHHHHHHH		25953088
193	O-linked_Glycosylation	KNIDEKLTEAARELG HCHHHHHHHHHHHHC		30379171
220	Ubiquitination	RDKKVVTKTFHGAGL CCCCEEEEEECCCCE		29967540
233	Ubiquitination	GLVVPVDKNDVGYRE CEEEEECCCCCCCCC		32015554
233	Acetylation	GLVVPVDKNDVGYRE CEEEEECCCCCCCCC		19608861
238	ADP-ribosylation	VDKNDVGYRELPETD ECCCCCCCCCCCCCH		30257210
249	Ubiquitination	PETDADLKRICKTIV CCCHHHHHHHHHHHH		24816145
249	Acetylation	PETDADLKRICKTIV CCCHHHHHHHHHHHH		25953088
253	Ubiquitination	ADLKRICKTIVEAAS HHHHHHHHHHHHHCC		29967540
253	Acetylation	ADLKRICKTIVEAAS HHHHHHHHHHHHHCC		25953088
260	Phosphorylation	KTIVEAASDEERLKA HHHHHHCCCHHHHHH		-
321	Acetylation	PLAYNLLKRNLFAEI HHHHHHHHHHHHHHH		26051181
321	Ubiquitination	PLAYNLLKRNLFAEI HHHHHHHHHHHHHHH		22505724
337	Phosphorylation	EEHLANRSQENIDQL HHHHHHCCHHCHHHH		27690223

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HPF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HPF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HPF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMPPB_HUMAN	GMPPB	physical	26344197
PFKAM_HUMAN	PFKM	physical	26344197
THIO_HUMAN	TXN	physical	26344197
PARP1_HUMAN	PARP1	physical	27067600
H2A2C_HUMAN	HIST2H2AC	physical	27067600
H2B2E_HUMAN	HIST2H2BE	physical	27067600
H31T_HUMAN	HIST3H3	physical	27067600
H2AY_HUMAN	H2AFY	physical	27067600
PARP2_HUMAN	PARP2	physical	27067600
PARP1_HUMAN	PARP1	physical	28190768
PARP2_HUMAN	PARP2	physical	28190768
H10_HUMAN	H1F0	physical	28190768
H33_HUMAN	H3F3A	physical	28190768
H31_HUMAN	HIST1H3A	physical	28190768
HMGN4_HUMAN	HMGN4	physical	28190768
HMGN2_HUMAN	HMGN2	physical	28190768
HMGN1_HUMAN	HMGN1	physical	28190768
HMGB1_HUMAN	HMGB1	physical	28190768
HMGA1_HUMAN	HMGA1	physical	28190768
H15_HUMAN	HIST1H1B	physical	28190768
H31T_HUMAN	HIST3H3	physical	28190768
H15_HUMAN	HIST1H1B	physical	27067600
MKLN1_HUMAN	MKLN1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.