GMPPB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMPPB_HUMAN
• UniProt AC: Q9Y5P6
• Protein Name: Mannose-1-phosphate guanyltransferase beta
• Gene Name: GMPPB {ECO:0000312|HGNC:HGNC:22932}
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids..
• Protein Sequence: MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQVLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLQPTSIEKEVFPIMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKQPERLCSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDARIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ALILVGGYGTRLRPL EEEEECCCCCCCEEC	14.92	-
137	Ubiquitination	EGSILVTKVEEPSKY CCEEEEEECCCCCCC	39.92	21963094
143	Ubiquitination	TKVEEPSKYGVVVCE EECCCCCCCEEEEEE	57.66	21963094
143 (in isoform 2)	Ubiquitination	-	57.66	-
162	Ubiquitination	RIHRFVEKPQVFVSN CEEEEECCCEEEEEC	35.13	29967540
179	Phosphorylation	NAGMYILSPAVLQRI CCCEEECCHHHHHHH	10.97	27251275
191	Phosphorylation	QRIQLQPTSIEKEVF HHHCCCCCCCCCCHH	29.40	20068231
192	Phosphorylation	RIQLQPTSIEKEVFP HHCCCCCCCCCCHHH	35.12	20068231
195	Acetylation	LQPTSIEKEVFPIMA CCCCCCCCCHHHEEE	58.47	23236377
195	Ubiquitination	LQPTSIEKEVFPIMA CCCCCCCCCHHHEEE	58.47	-
195 (in isoform 2)	Ubiquitination	-	58.47	-
201	Sulfoxidation	EKEVFPIMAKEGQLY CCCHHHEEEECCCEE	4.42	30846556
245	Glutathionylation	QKQPERLCSGPGIVG HHCCHHHCCCCCCCC	5.75	22555962
246	Phosphorylation	KQPERLCSGPGIVGN HCCHHHCCCCCCCCE	53.25	27251275
357	Methylation	GESVPEPRIIM---- CCCCCCCCCCC----	29.42	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GMPPB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMPPB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMPPB_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMPPA_HUMAN	GMPPA	physical	16189514
VATH_HUMAN	ATP6V1H	physical	22863883
DBLOH_HUMAN	DIABLO	physical	22863883
PLAK_HUMAN	JUP	physical	22863883
LMNA_HUMAN	LMNA	physical	22863883
RNBP6_HUMAN	RANBP6	physical	22863883
GMPPA_HUMAN	GMPPA	physical	25416956
TXND5_HUMAN	TXNDC5	physical	25416956
GMPPA_HUMAN	GMPPA	physical	26186194
CCNB2_HUMAN	CCNB2	physical	26186194
ANM3_HUMAN	PRMT3	physical	26186194
EIF2D_HUMAN	EIF2D	physical	26186194
HACL1_HUMAN	HACL1	physical	26186194
P4K2B_HUMAN	PI4K2B	physical	26186194
PRUN1_HUMAN	PRUNE	physical	26186194
PYRD_HUMAN	DHODH	physical	26186194
PUSL1_HUMAN	PUSL1	physical	26186194
CCS_HUMAN	CCS	physical	26344197
FKB1B_HUMAN	FKBP1B	physical	26344197
GMPPA_HUMAN	GMPPA	physical	26344197
MPI_HUMAN	MPI	physical	26344197
SCLY_HUMAN	SCLY	physical	26344197
UB2V1_HUMAN	UBE2V1	physical	26344197
WDR1_HUMAN	WDR1	physical	26344197
GMPPA_HUMAN	GMPPA	physical	28514442
PRUN1_HUMAN	PRUNE	physical	28514442
P4K2B_HUMAN	PI4K2B	physical	28514442
ANM3_HUMAN	PRMT3	physical	28514442
CCNB2_HUMAN	CCNB2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615350: Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A14 (MDDGA14)
• 615351: Muscular dystrophy-dystroglycanopathy congenital with mental retardation B14 (MDDGB14)
• 615352: Muscular dystrophy-dystroglycanopathy limb-girdle C14 (MDDGC14)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.