GMPPA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GMPPA_HUMAN
• UniProt AC: Q96IJ6
• Protein Name: Mannose-1-phosphate guanyltransferase alpha
• Gene Name: GMPPA
• Organism: Homo sapiens (Human).
• Sequence Length: 420
• Subcellular Localization: Cytoplasm . Myc-tagged GMPPA shows a diffuse cytoplasmic and nuclear pattern in transfected COS-7 cells.
• Protein Description: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose..
• Protein Sequence: MLKAVILIGGPQKGTRFRPLSFEVPKPLFPVAGVPMIQHHIEACAQVPGMQEILLIGFYQPDEPLTQFLEAAQQEFNLPVRYLQEFAPLGTGGGLYHFRDQILAGSPEAFFVLNADVCSDFPLSAMLEAHRRQRHPFLLLGTTANRTQSLNYGCIVENPQTHEVLHYVEKPSTFISDIINCGIYLFSPEALKPLRDVFQRNQQDGQLEDSPGLWPGAGTIRLEQDVFSALAGQGQIYVHLTDGIWSQIKSAGSALYASRLYLSRYQDTHPERLAKHTPGGPWIRGNVYIHPTAKVAPSAVLGPNVSIGKGVTVGEGVRLRESIVLHGATLQEHTCVLHSIVGWGSTVGRWARVEGTPSDPNPNDPRARMDSESLFKDGKLLPAITILGCRVRIPAEVLILNSIVLPHKELSRSFTNQIIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Ubiquitination	ILIGGPQKGTRFRPL EEECCCCCCCCEEEE	66.44	21906983
13 (in isoform 1)	Ubiquitination	-	66.44	21890473
13 (in isoform 2)	Ubiquitination	-	66.44	21890473
96	Phosphorylation	LGTGGGLYHFRDQIL CCCCCCCCHHHHHHH	11.37	-
176	Phosphorylation	EKPSTFISDIINCGI CCCCCHHHHHHHCCE	20.68	-
210	Phosphorylation	QDGQLEDSPGLWPGA CCCCCCCCCCCCCCC	16.11	21712546
250	Phosphorylation	GIWSQIKSAGSALYA CHHHHHHHHHHHHHH	39.22	21712546
256	Phosphorylation	KSAGSALYASRLYLS HHHHHHHHHHHHHHH	11.40	29496907
258	Phosphorylation	AGSALYASRLYLSRY HHHHHHHHHHHHHHC	14.84	21712546
275 (in isoform 2)	Ubiquitination	-	53.23	-
275	Ubiquitination	THPERLAKHTPGGPW CCHHHHHHCCCCCCC	53.23	-
288	Phosphorylation	PWIRGNVYIHPTAKV CCCCCCEEECCCCCC	9.49	28152594
294 (in isoform 1)	Ubiquitination	-	41.21	21890473
294	Ubiquitination	VYIHPTAKVAPSAVL EEECCCCCCCCCCEE	41.21	21906983
306	Phosphorylation	AVLGPNVSIGKGVTV CEECCCCEECCCCCC	32.06	28857561
309 (in isoform 1)	Ubiquitination	-	48.84	21890473
309	Ubiquitination	GPNVSIGKGVTVGEG CCCCEECCCCCCCCC	48.84	21906983
312	Phosphorylation	VSIGKGVTVGEGVRL CEECCCCCCCCCCEE	31.31	-
347 (in isoform 2)	Ubiquitination	-	5.40	-
362 (in isoform 2)	Ubiquitination	-	52.57	21890473
371	Phosphorylation	DPRARMDSESLFKDG CHHHCCCHHHHHCCC	21.53	24719451
373	Phosphorylation	RARMDSESLFKDGKL HHCCCHHHHHCCCCC	42.95	24719451
376	Ubiquitination	MDSESLFKDGKLLPA CCHHHHHCCCCCCCE	71.51	21906983
376 (in isoform 1)	Ubiquitination	-	71.51	21890473
379	Ubiquitination	ESLFKDGKLLPAITI HHHHCCCCCCCEEEE	57.91	-
408	Ubiquitination	NSIVLPHKELSRSFT ECEECCCHHHCHHHC	59.41	21890473
408 (in isoform 1)	Ubiquitination	-	59.41	21890473
413	Phosphorylation	PHKELSRSFTNQIIL CCHHHCHHHCCCCCC	32.80	28348404
415	Phosphorylation	KELSRSFTNQIIL-- HHHCHHHCCCCCC--	27.71	28348404
429 (in isoform 2)	Ubiquitination	-		21890473
432 (in isoform 2)	Ubiquitination	-		-
461 (in isoform 2)	Ubiquitination	-		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GMPPA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GMPPA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GMPPA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GMPPB_HUMAN	GMPPB	physical	22939629
GMPPB_HUMAN	GMPPB	physical	22863883
GMPPA_HUMAN	GMPPA	physical	25416956
LPP_HUMAN	LPP	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615510: Alacrima, achalasia, and mental retardation syndrome (AAMR)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.