DBLOH_HUMAN - dbPTM
DBLOH_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DBLOH_HUMAN
UniProt AC Q9NR28
Protein Name Diablo homolog, mitochondrial
Gene Name DIABLO
Organism Homo sapiens (Human).
Sequence Length 239
Subcellular Localization Mitochondrion . Released into the cytosol when cells undergo apoptosis.
Protein Description Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance..
Protein Sequence MAALKSWLSRSVTSFFRYRQCLCVPVVANFKKRCFSELIRPWHKTVTIGFGVTLCAVPIAQKSEPHSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGARAEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKTQEEGEERAESEQEAYLRED
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MAALKSWLSRSVT
--CHHHHHHHHHHHH		33.8121712546
9PhosphorylationAALKSWLSRSVTSFF
HHHHHHHHHHHHHHH		19.0921712546
11PhosphorylationLKSWLSRSVTSFFRY
HHHHHHHHHHHHHHH		26.7727251275
13PhosphorylationSWLSRSVTSFFRYRQ
HHHHHHHHHHHHHHH		22.5121712546
14PhosphorylationWLSRSVTSFFRYRQC
HHHHHHHHHHHHHHH		21.8924719451
62UbiquitinationCAVPIAQKSEPHSLS
EECCCCCCCCCCCCC		48.00-
67PhosphorylationAQKSEPHSLSSEALM
CCCCCCCCCCHHHHH		40.4327251275
69PhosphorylationKSEPHSLSSEALMRR
CCCCCCCCHHHHHHH		29.1928857561
70 (in isoform 2)Ubiquitination-31.9821890473
70PhosphorylationSEPHSLSSEALMRRA
CCCCCCCHHHHHHHH		31.9827251275
93 (in isoform 2)Ubiquitination-10.1221890473
108PhosphorylationTEYTKAVYTLTSLYR
HHHHHHHHHHHHHHH		10.8228442448
109PhosphorylationEYTKAVYTLTSLYRQ
HHHHHHHHHHHHHHH		19.5728442448
111PhosphorylationTKAVYTLTSLYRQYT
HHHHHHHHHHHHHHH		14.6428442448
112PhosphorylationKAVYTLTSLYRQYTS
HHHHHHHHHHHHHHH		26.9028442448
114PhosphorylationVYTLTSLYRQYTSLL
HHHHHHHHHHHHHHH		8.7428442448
123UbiquitinationQYTSLLGKMNSEEED
HHHHHHHCCCCCCHH		34.5720639865
124SulfoxidationYTSLLGKMNSEEEDE
HHHHHHCCCCCCHHH		6.7330846556
126PhosphorylationSLLGKMNSEEEDEVW
HHHHCCCCCCHHHHH		42.7727251275
138 (in isoform 2)Ubiquitination-9.6321890473
146AcetylationARAEMTSKHQEYLKL
HHHHCCHHHHHHHHH		39.8925825284
146UbiquitinationARAEMTSKHQEYLKL
HHHHCCHHHHHHHHH		39.8921906983
147UbiquitinationRAEMTSKHQEYLKLE
HHHCCHHHHHHHHHH		26.0221890473
150 (in isoform 2)Ubiquitination-11.5421890473
154 (in isoform 2)Ubiquitination-42.4721890473
159UbiquitinationKLETTWMTAVGLSEM
HHHHHHHHHHHHHHH		15.1121890473
163UbiquitinationTWMTAVGLSEMAAEA
HHHHHHHHHHHHHHH		2.9321890473
164PhosphorylationWMTAVGLSEMAAEAA
HHHHHHHHHHHHHHH		21.2830175587
166 (in isoform 2)Ubiquitination-3.7321890473
191UbiquitinationRNHIQLVKLQVEEVH
HHHHEEEEEHHHHHH		41.6221890473
199 (in isoform 1)Ubiquitination-46.4321890473
203UbiquitinationEVHQLSRKAETKLAE
HHHHHHHHHHHHHHH		47.3921890473
207AcetylationLSRKAETKLAEAQIE
HHHHHHHHHHHHHHH		36.8925953088
207UbiquitinationLSRKAETKLAEAQIE
HHHHHHHHHHHHHHH		36.8921890473
219UbiquitinationQIEELRQKTQEEGEE
HHHHHHHHHHHHHHH		45.8221906983
220PhosphorylationIEELRQKTQEEGEER
HHHHHHHHHHHHHHH		32.6422817900
222 (in isoform 1)Ubiquitination-73.5221890473
230PhosphorylationEGEERAESEQEAYLR
HHHHHHHHHHHHHHC		43.5325849741
235PhosphorylationAESEQEAYLRED---
HHHHHHHHHCCC---		12.9223186163
267 (in isoform 1)Ubiquitination-21890473
279 (in isoform 1)Ubiquitination-21890473
283 (in isoform 1)Ubiquitination-21890473
295 (in isoform 1)Ubiquitination-21890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
6SPhosphorylationKinaseMAPK8P45983
GPS
9SPhosphorylationKinaseMAPK8P45983
GPS
67SPhosphorylationKinaseAKT1P31749
PSP
-KUbiquitinationE3 ubiquitin ligaseBIRC3Q13489
PMID:12525502
-KUbiquitinationE3 ubiquitin ligaseBIRC6Q9NR09
PMID:15300255
-KUbiquitinationE3 ubiquitin ligaseBIRC7Q96CA5
PMID:16729033
-KUbiquitinationE3 ubiquitin ligaseXIAPP98170
PMID:12121969
-KUbiquitinationE3 ubiquitin ligaseBIRC2Q13490
PMID:14960576
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DBLOH_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DBLOH_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XIAP_HUMANXIAPphysical
12660240
BIRC5_HUMANBIRC5physical
12660240
DBLOH_HUMANDIABLOphysical
10972280
TNR3_HUMANLTBRphysical
12571250
BIRC2_HUMANBIRC2physical
10929712
XIAP_HUMANXIAPphysical
10929712
BIRC3_HUMANBIRC3physical
10929712
BIRC7_HUMANBIRC7physical
16729033
BIRC2_HUMANBIRC2physical
16282325
BIRC5_HUMANBIRC5physical
15541727
XIAP_HUMANXIAPphysical
15541727
BEX3_MOUSENgfrap1physical
15178455
XIAP_HUMANXIAPphysical
14523016
BIRC6_HUMANBIRC6physical
15300255
UFM1_HUMANUFM1physical
21900206
EF1A1_HUMANEEF1A1physical
21900206
ZN746_HUMANZNF746physical
21900206
UBE2K_HUMANUBE2Kphysical
20537984
DBLOH_HUMANDIABLOphysical
20957035
XIAP_HUMANXIAPphysical
20957035
BIRC2_HUMANBIRC2physical
20957035
BIRC3_HUMANBIRC3physical
20957035
BIRC6_HUMANBIRC6physical
20957035
BIRC6_HUMANBIRC6physical
15507451
XIAP_HUMANXIAPphysical
15507451
XIAP_HUMANXIAPphysical
11242052
XIAP_HUMANXIAPphysical
14512414
XIAP_HUMANXIAPphysical
12218061
BIRC2_HUMANBIRC2physical
12218061
AREL1_HUMANAREL1physical
23479728
NR4A1_HUMANNR4A1physical
21988832
MAML2_HUMANMAML2physical
21988832
AP1B1_HUMANAP1B1physical
22863883
KPCD_HUMANPRKCDphysical
22465666
BIRC5_HUMANBIRC5physical
23251006
XIAP_HUMANXIAPphysical
27476169
BIRC2_HUMANBIRC2physical
27476169
BIRC3_HUMANBIRC3physical
27476169
BIRC2_HUMANBIRC2physical
28514442
XIAP_HUMANXIAPphysical
28514442
DUS22_HUMANDUSP22physical
28514442
TRAF2_HUMANTRAF2physical
28514442
MTFR1_HUMANMTFR1physical
28514442
BIRC6_HUMANBIRC6physical
28514442
TRAF1_HUMANTRAF1physical
28514442
ALR_HUMANGFERphysical
28514442
BIRC5_HUMANBIRC5physical
14699067
XIAP_HUMANXIAPphysical
11140638
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
614152Deafness, autosomal dominant, 64 (DFNA64)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DBLOH_HUMAN

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Related Literatures of Post-Translational Modification

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