MAML2_HUMAN - dbPTM
MAML2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAML2_HUMAN
UniProt AC Q8IZL2
Protein Name Mastermind-like protein 2
Gene Name MAML2
Organism Homo sapiens (Human).
Sequence Length 1156
Subcellular Localization Nucleus speckle . Nuclear, in a punctate manner.
Protein Description Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3..
Protein Sequence MGDTAPPQAPAGGLGGASGAGLLGGGSVTPRVHSAIVERLRARIAVCRQHHLSCEGRYERGRAESSDRERESTLQLLSLVQHGQGARKAGKHTKATATAATTTAPPPPPAAPPAASQAAATAAPPPPPDYHHHHQQHLLNSSNNGGSGGINGEQQPPASTPGDQRNSALIALQGSLKRKQVVNLSPANSKRPNGFVDNSFLDIKRIRVGENLSAGQGGLQINNGQSQIMSGTLPMSQAPLRKTNTLPSHTHSPGNGLFNMGLKEVKKEPGETLSCSKHMDGQMTQENIFPNRYGDDPGEQLMDPELQELFNELTNISVPPMSDLELENMINATIKQDDPFNIDLGQQSQRSTPRPSLPMEKIVIKSEYSPGLTQGPSGSPQLRPPSAGPAFSMANSALSTSSPIPSVPQSQAQPQTGSGASRALPSWQEVSHAQQLKQIAANRQQHARMQQHQQQHQPTNWSALPSSAGPSPGPFGQEKIPSPSFGQQTFSPQSSPMPGVAGGSGQSKVMANYMYKAGPSAQGGHLDVLMQQKPQDLSRSFINNPHPAMEPRQGNTKPLFHFNSDQANQQMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNPNTGSGYMNSQQSLLNQQLMGKKQTLQRQIMEQKQQLLLQQQMLADAEKIAPQDQINRHLSRPPPDYKDQRRNVGNMQPTAQYSGGSSTISLNSNQALANPVSTHTILTPNSSLLSTSHGTRMPSLSTAVQNMGMYGNLPCNQPNTYSVTSGMNQLTQQRNPKQLLANQNNPMMPRPPTLGPSNNNNVATFGAGSVGNSQQLRPNLTHSMASMPPQRTSNVMITSNTTAPNWASQEGTSKQQEALTSAGVRFPTGTPAAYTPNQSLQQAVGSQQFSQRAVAPPNQLTPAVQMRPMNQMSQTLNGQTMGPLRGLNLRPNQLSTQILPNLNQSGTGLNQSRTGINQPPSLTPSNFPSPNQSSRAFQGTDHSSDLAFDFLSQQNDNMGPALNSDADFIDSLLKTEPGNDDWMKDINLDEILGNNS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
53PhosphorylationVCRQHHLSCEGRYER
HHHHHCCCCCCCCCC		13.0327251275
72PhosphorylationSSDRERESTLQLLSL
CCHHHHHHHHHHHHH		40.4121406692
73PhosphorylationSDRERESTLQLLSLV
CHHHHHHHHHHHHHH		17.4821406692
78PhosphorylationESTLQLLSLVQHGQG
HHHHHHHHHHHHCCH		34.7821406692
175PhosphorylationALIALQGSLKRKQVV
HHHHHHCCCCCCCEE		20.1123403867
185PhosphorylationRKQVVNLSPANSKRP
CCCEECCCCCCCCCC		19.4322199227
189PhosphorylationVNLSPANSKRPNGFV
ECCCCCCCCCCCCCC		31.9521406692
199PhosphorylationPNGFVDNSFLDIKRI
CCCCCCCCCEEEEEE		23.7926657352
230PhosphorylationNGQSQIMSGTLPMSQ
CCCCCEEECCCCCCC		30.2022210691
232PhosphorylationQSQIMSGTLPMSQAP
CCCEEECCCCCCCCC		22.0022210691
236PhosphorylationMSGTLPMSQAPLRKT
EECCCCCCCCCCCCC		22.6622210691
248PhosphorylationRKTNTLPSHTHSPGN
CCCCCCCCCCCCCCC		44.1022617229
250PhosphorylationTNTLPSHTHSPGNGL
CCCCCCCCCCCCCCC		28.5228857561
252PhosphorylationTLPSHTHSPGNGLFN
CCCCCCCCCCCCCCC		35.3428857561
335SumoylationNMINATIKQDDPFNI
HHHHCEECCCCCCCC		43.23-
348PhosphorylationNIDLGQQSQRSTPRP
CCCCCCCCCCCCCCC		21.4828674419
351PhosphorylationLGQQSQRSTPRPSLP
CCCCCCCCCCCCCCC		34.8228348404
352PhosphorylationGQQSQRSTPRPSLPM
CCCCCCCCCCCCCCH		26.0424719451
365SumoylationPMEKIVIKSEYSPGL
CHHHEEEEECCCCCC		26.75-
482PhosphorylationFGQEKIPSPSFGQQT
CCCCCCCCCCCCCCC		36.3328348404
484PhosphorylationQEKIPSPSFGQQTFS
CCCCCCCCCCCCCCC		46.4728348404
489PhosphorylationSPSFGQQTFSPQSSP
CCCCCCCCCCCCCCC		20.4228348404
491PhosphorylationSFGQQTFSPQSSPMP
CCCCCCCCCCCCCCC		25.9728348404
494PhosphorylationQQTFSPQSSPMPGVA
CCCCCCCCCCCCCCC		39.5328348404
495PhosphorylationQTFSPQSSPMPGVAG
CCCCCCCCCCCCCCC		21.7028857561
513PhosphorylationQSKVMANYMYKAGPS
CHHHHHHHHHHCCCC		7.7119658100
515PhosphorylationKVMANYMYKAGPSAQ
HHHHHHHHHCCCCCC		6.3219658100
533AcetylationLDVLMQQKPQDLSRS
HHHHCCCCCCHHHHH		27.9626051181
540PhosphorylationKPQDLSRSFINNPHP
CCCHHHHHHHCCCCC		27.4028555341
682PhosphorylationPSQPLLRSPLPLQQK
CCCCCCCCCCHHHHH		30.6628674419
795PhosphorylationDQINRHLSRPPPDYK
HHHHHHHCCCCCCHH		36.2928188228
870PhosphorylationAVQNMGMYGNLPCNQ
HHHHCCCCCCCCCCC		9.3525332170
881PhosphorylationPCNQPNTYSVTSGMN
CCCCCCCEECCCCHH		14.0525332170
941PhosphorylationQQLRPNLTHSMASMP
CCCCCCCCHHHHCCC		20.6728787133
943PhosphorylationLRPNLTHSMASMPPQ
CCCCCCHHHHCCCCC		15.7130576142
946PhosphorylationNLTHSMASMPPQRTS
CCCHHHHCCCCCCCC		24.1528787133
959PhosphorylationTSNVMITSNTTAPNW
CCCEEEECCCCCCCC		22.6630576142
1083PhosphorylationINQPPSLTPSNFPSP
CCCCCCCCCCCCCCC		29.0727080861
1085PhosphorylationQPPSLTPSNFPSPNQ
CCCCCCCCCCCCCCC		45.9627080861
1089PhosphorylationLTPSNFPSPNQSSRA
CCCCCCCCCCCCCCC		32.1429507054
1093PhosphorylationNFPSPNQSSRAFQGT
CCCCCCCCCCCCCCC		28.5628857561
1094PhosphorylationFPSPNQSSRAFQGTD
CCCCCCCCCCCCCCC		20.1928857561
1131PhosphorylationSDADFIDSLLKTEPG
CCHHHHHHHHCCCCC		30.6824719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAML2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAML2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAML2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MAML1_HUMANMAML1physical
12370315
SUH_HUMANRBPJphysical
12370315
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAML2_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory