| UniProt ID | SUH_HUMAN | |
|---|---|---|
| UniProt AC | Q06330 | |
| Protein Name | Recombining binding protein suppressor of hairless | |
| Gene Name | RBPJ {ECO:0000312|HGNC:HGNC:5724} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 500 | |
| Subcellular Localization | Nucleus. Cytoplasm. Mainly nuclear, upon interaction with RITA/C12orf52, translocates to the cytoplasm, down-regulating the Notch signaling pathway. | |
| Protein Description | Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. [PubMed: 21991380 Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen)] | |
| Protein Sequence | MDHTEGSPAEEPPAHAPSPGKFGERPPPKRLTREAMRNYLKERGDQTVLILHAKVAQKSYGNEKRFFCPPPCVYLMGSGWKKKKEQMERDGCSEQESQPCAFIGIGNSDQEMQQLNLEGKNYCTAKTLYISDSDKRKHFMLSVKMFYGNSDDIGVFLSKRIKVISKPSKKKQSLKNADLCIASGTKVALFNRLRSQTVSTRYLHVEGGNFHASSQQWGAFFIHLLDDDESEGEEFTVRDGYIHYGQTVKLVCSVTGMALPRLIIRKVDKQTALLDADDPVSQLHKCAFYLKDTERMYLCLSQERIIQFQATPCPKEPNKEMINDGASWTIISTDKAEYTFYEGMGPVLAPVTPVPVVESLQLNGGGDVAMLELTGQNFTPNLRVWFGDVEAETMYRCGESMLCVVPDISAFREGWRWVRQPVQVPVTLVRNDGIIYSTSLTFTYTPEPGPRPHCSAAGAILRANSSQVPPNESNTNSEGSYTNASTNSTSVTSSTATVVS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 4 | Phosphorylation | ----MDHTEGSPAEE ----CCCCCCCCCCC | 37.46 | 29255136 | |
| 7 | Phosphorylation | -MDHTEGSPAEEPPA -CCCCCCCCCCCCCC | 18.07 | 29255136 | |
| 18 | Phosphorylation | EPPAHAPSPGKFGER CCCCCCCCCCCCCCC | 47.25 | 23401153 | |
| 21 | Acetylation | AHAPSPGKFGERPPP CCCCCCCCCCCCCCC | 54.29 | 25953088 | |
| 43 | Ubiquitination | MRNYLKERGDQTVLI HHHHHHHCCCEEEEE | 53.02 | 27667366 | |
| 44 | Ubiquitination | RNYLKERGDQTVLIL HHHHHHCCCEEEEEE | 32.25 | 27667366 | |
| 45 | Ubiquitination | NYLKERGDQTVLILH HHHHHCCCEEEEEEE | 47.39 | 27667366 | |
| 58 | Ubiquitination | LHAKVAQKSYGNEKR EEEEEEHHHHCCCCC | 35.59 | 27667366 | |
| 59 | Ubiquitination | HAKVAQKSYGNEKRF EEEEEHHHHCCCCCE | 26.62 | 27667366 | |
| 64 | Ubiquitination | QKSYGNEKRFFCPPP HHHHCCCCCEECCCC | 59.51 | 27667366 | |
| 111 | Ubiquitination | GIGNSDQEMQQLNLE ECCCCHHHHHHHCCC | 43.90 | 29967540 | |
| 112 | Ubiquitination | IGNSDQEMQQLNLEG CCCCHHHHHHHCCCC | 2.27 | 29967540 | |
| 113 | Ubiquitination | GNSDQEMQQLNLEGK CCCHHHHHHHCCCCC | 43.80 | 29967540 | |
| 120 | Ubiquitination | QQLNLEGKNYCTAKT HHHCCCCCCCEEEEE | 35.05 | 29967540 | |
| 121 | Ubiquitination | QLNLEGKNYCTAKTL HHCCCCCCCEEEEEE | 48.22 | 29967540 | |
| 122 | Phosphorylation | LNLEGKNYCTAKTLY HCCCCCCCEEEEEEE | 8.48 | - | |
| 122 | Ubiquitination | LNLEGKNYCTAKTLY HCCCCCCCEEEEEEE | 8.48 | 29967540 | |
| 124 | Phosphorylation | LEGKNYCTAKTLYIS CCCCCCEEEEEEEEE | 22.34 | 22461510 | |
| 126 | Ubiquitination | GKNYCTAKTLYISDS CCCCEEEEEEEEECC | 22.40 | 29967540 | |
| 126 | Acetylation | GKNYCTAKTLYISDS CCCCEEEEEEEEECC | 22.40 | 7609869 | |
| 129 | Phosphorylation | YCTAKTLYISDSDKR CEEEEEEEEECCCCC | 12.01 | 22461510 | |
| 131 | Phosphorylation | TAKTLYISDSDKRKH EEEEEEEECCCCCCE | 19.94 | - | |
| 133 | Phosphorylation | KTLYISDSDKRKHFM EEEEEECCCCCCEEE | 37.94 | - | |
| 135 | Acetylation | LYISDSDKRKHFMLS EEEECCCCCCEEEEE | 68.26 | 26051181 | |
| 135 | Ubiquitination | LYISDSDKRKHFMLS EEEECCCCCCEEEEE | 68.26 | 29967540 | |
| 142 | Phosphorylation | KRKHFMLSVKMFYGN CCCEEEEEEEECCCC | 14.12 | 24719451 | |
| 160 | Ubiquitination | IGVFLSKRIKVISKP HHHHHHHEEEEECCC | 30.50 | 29967540 | |
| 161 | Ubiquitination | GVFLSKRIKVISKPS HHHHHHEEEEECCCC | 4.86 | 29967540 | |
| 162 | Ubiquitination | VFLSKRIKVISKPSK HHHHHEEEEECCCCC | 37.23 | 29967540 | |
| 175 | Ubiquitination | SKKKQSLKNADLCIA CCCCHHHCCCCEEEE | 56.17 | 29967540 | |
| 175 | Acetylation | SKKKQSLKNADLCIA CCCCHHHCCCCEEEE | 56.17 | - | |
| 195 | Phosphorylation | ALFNRLRSQTVSTRY HHHHHHHCCCCCEEE | 34.49 | 23403867 | |
| 197 | Phosphorylation | FNRLRSQTVSTRYLH HHHHHCCCCCEEEEE | 20.05 | 23403867 | |
| 199 | Phosphorylation | RLRSQTVSTRYLHVE HHHCCCCCEEEEEEE | 15.56 | 23403867 | |
| 200 | Phosphorylation | LRSQTVSTRYLHVEG HHCCCCCEEEEEEEC | 20.99 | 23403867 | |
| 215 (in isoform 4) | Phosphorylation | - | 40.32 | - | |
| 216 (in isoform 6) | Phosphorylation | - | 42.38 | - | |
| 217 (in isoform 7) | Phosphorylation | - | 7.76 | - | |
| 230 | Phosphorylation | HLLDDDESEGEEFTV EEECCCCCCCCEEEE | 58.87 | 26657352 | |
| 253 | Phosphorylation | QTVKLVCSVTGMALP CEEEEEEEECCCCCC | 18.42 | 21406692 | |
| 254 | Ubiquitination | TVKLVCSVTGMALPR EEEEEEEECCCCCCH | 4.54 | 29967540 | |
| 255 | Phosphorylation | VKLVCSVTGMALPRL EEEEEEECCCCCCHH | 12.63 | 21406692 | |
| 255 | Ubiquitination | VKLVCSVTGMALPRL EEEEEEECCCCCCHH | 12.63 | 29967540 | |
| 256 | Ubiquitination | KLVCSVTGMALPRLI EEEEEECCCCCCHHH | 9.37 | 29967540 | |
| 266 | Acetylation | LPRLIIRKVDKQTAL CCHHHEEECCCCCEE | 44.36 | 20167786 | |
| 269 | Ubiquitination | LIIRKVDKQTALLDA HHEEECCCCCEECCC | 53.16 | 29967540 | |
| 270 | Ubiquitination | IIRKVDKQTALLDAD HEEECCCCCEECCCC | 27.78 | 29967540 | |
| 271 | Ubiquitination | IRKVDKQTALLDADD EEECCCCCEECCCCC | 25.64 | 29967540 | |
| 272 | Ubiquitination | RKVDKQTALLDADDP EECCCCCEECCCCCH | 12.02 | 29967540 | |
| 285 | Ubiquitination | DPVSQLHKCAFYLKD CHHHHHHHCEEEECC | 35.53 | 29967540 | |
| 291 | Acetylation | HKCAFYLKDTERMYL HHCEEEECCCCEEEE | 51.75 | 26051181 | |
| 291 | Ubiquitination | HKCAFYLKDTERMYL HHCEEEECCCCEEEE | 51.75 | - | |
| 300 | Ubiquitination | TERMYLCLSQERIIQ CCEEEEEECHHHEEE | 5.67 | 29967540 | |
| 301 | Ubiquitination | ERMYLCLSQERIIQF CEEEEEECHHHEEEE | 29.06 | 33845483 | |
| 302 | Ubiquitination | RMYLCLSQERIIQFQ EEEEEECHHHEEEEE | 30.92 | 33845483 | |
| 315 | Ubiquitination | FQATPCPKEPNKEMI EECCCCCCCCCHHHC | 86.50 | 33845483 | |
| 339 | Phosphorylation | STDKAEYTFYEGMGP ECCCCEEEEEECCCC | 15.96 | 22302987 | |
| 409 | Phosphorylation | LCVVPDISAFREGWR EEEECCHHHHHCCCC | 28.83 | 24719451 | |
| 427 | Phosphorylation | QPVQVPVTLVRNDGI CCCCCEEEEEECCCE | 17.29 | 29978859 | |
| 436 | Phosphorylation | VRNDGIIYSTSLTFT EECCCEEEEEEEEEE | 12.18 | 29978859 | |
| 437 | Phosphorylation | RNDGIIYSTSLTFTY ECCCEEEEEEEEEEE | 10.91 | 29978859 | |
| 438 | Phosphorylation | NDGIIYSTSLTFTYT CCCEEEEEEEEEEEC | 15.70 | 29978859 | |
| 439 | Phosphorylation | DGIIYSTSLTFTYTP CCEEEEEEEEEEECC | 21.33 | 29978859 | |
| 441 | Phosphorylation | IIYSTSLTFTYTPEP EEEEEEEEEEECCCC | 17.44 | 29978859 | |
| 443 | Phosphorylation | YSTSLTFTYTPEPGP EEEEEEEEECCCCCC | 22.65 | 29978859 | |
| 444 | Phosphorylation | STSLTFTYTPEPGPR EEEEEEEECCCCCCC | 18.99 | 29978859 | |
| 445 | Phosphorylation | TSLTFTYTPEPGPRP EEEEEEECCCCCCCC | 20.37 | 29978859 | |
| 455 | O-linked_Glycosylation | PGPRPHCSAAGAILR CCCCCCCCHHHHHHC | 20.37 | 30059200 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 339 | T | Phosphorylation | Kinase | MAPK14 | Q16539 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SUH_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SUH_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 614814 | Adams-Oliver syndrome 3 (AOS3) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
