COT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COT2_HUMAN
• UniProt AC: P24468
• Protein Name: COUP transcription factor 2
• Gene Name: NR2F2
• Organism: Homo sapiens (Human).
• Sequence Length: 414
• Subcellular Localization: Nucleus.
• Protein Description: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A..
• Protein Sequence: MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAMVVSTWRDPQDE -CCCEEEEECCCCCC	16.95	24719451
39	Phosphorylation	PPPGAPHTPQTPGQG CCCCCCCCCCCCCCC	18.94	24275569
50	Phosphorylation	PGQGGPASTPAQTAA CCCCCCCCCHHCCCC	37.75	24275569
51	Phosphorylation	GQGGPASTPAQTAAG CCCCCCCCHHCCCCC	25.42	14702039
55	Phosphorylation	PASTPAQTAAGGQGG CCCCHHCCCCCCCCC	22.15	24275569
89	Ubiquitination	CGDKSSGKHYGQFTC ECCCCCCCEEEEEEC	35.28	-
112	Phosphorylation	RSVRRNLSYTCRANR HHHHHHHHHHHCCCC	23.19	21712546
133	Phosphorylation	HHRNQCQYCRLKKCL HHHCHHHHHHHHHHH	6.28	28152594
141	Methylation	CRLKKCLKVGMRREA HHHHHHHHHCCHHHH	46.33	-
148	Ubiquitination	KVGMRREAVQRGRMP HHCCHHHHHHCCCCC	10.84	21890473
168	Ubiquitination	HGQFALTNGDPLNCH CCCEECCCCCCCCCH	54.44	21890473
236	Ubiquitination	NIPFFPDLQITDQVA CCCCCCCCCCCCHHH	3.95	21890473
256	Ubiquitination	WSELFVLNAAQCSMP HHHHHHHHHHHCCCC	28.11	21890473
301	Ubiquitination	IFQEQVEKLKALHVD HHHHHHHHHHHCCCC	57.33	21890473
301	Ubiquitination	IFQEQVEKLKALHVD HHHHHHHHHHHCCCC	57.33	21890473
348	Phosphorylation	SQCALEEYVRSQYPN HHHHHHHHHHHHCCC	7.56	-
362	Ubiquitination	NQPTRFGKLLLRLPS CCCCHHHHHHHHCCC	33.00	-
369	Phosphorylation	KLLLRLPSLRTVSSS HHHHHCCCCCCCCHH	34.77	24719451
374	Phosphorylation	LPSLRTVSSSVIEQL CCCCCCCCHHHHHHH	19.11	22210691
375	Phosphorylation	PSLRTVSSSVIEQLF CCCCCCCHHHHHHHH	25.04	22210691
389	Ubiquitination	FFVRLVGKTPIETLI HHHHHHCCCCHHHHH	43.58	21890473
389	Ubiquitination	FFVRLVGKTPIETLI HHHHHHCCCCHHHHH	43.58	21890473
394	Phosphorylation	VGKTPIETLIRDMLL HCCCCHHHHHHHHHH	28.36	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC1_HUMAN	HDAC1	physical	10704340
HDAC1_HUMAN	HDAC1	genetic	10704340
NR2F6_HUMAN	NR2F6	physical	10318855
TRIP4_HUMAN	TRIP4	physical	20211142
GCR_HUMAN	NR3C1	physical	14739255
SETD7_HUMAN	SETD7	physical	21988832
COT2_HUMAN	NR2F2	physical	23975195
BC11A_HUMAN	BCL11A	physical	23975195
RPGR_HUMAN	RPGR	physical	28514442
AKT1_HUMAN	AKT1	physical	28514442
NR2F6_HUMAN	NR2F6	physical	28514442
VTDB_HUMAN	GC	physical	28514442
AKT2_HUMAN	AKT2	physical	28514442
SHPK_HUMAN	SHPK	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.