BC11A_HUMAN - dbPTM
BC11A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID BC11A_HUMAN
UniProt AC Q9H165
Protein Name B-cell lymphoma/leukemia 11A
Gene Name BCL11A
Organism Homo sapiens (Human).
Sequence Length 835
Subcellular Localization Cytoplasm . Nucleus . Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles (By similarity)..
Isoform 2: Cytoplasm . Nucleus . Predominantly localized in the nucleus in nuclear paraspeckles.
Isoform 3: Cytoplas
Protein Description Transcription factor associated with the BAF SWI/SNF chromatin remodeling complex (By similarity). Repressor of fetal hemoglobin (HbF) level. [PubMed: 26375765 Involved in brain development]
Protein Sequence MSRRKQGKPQHLSKREFSPEPLEAILTDDEPDHGPLGAPEGDHDLLTCGQCQMNFPLGDILIFIEHKRKQCNGSLCLEKAVDKPPSPSPIEMKKASNPVEVGIQVTPEDDDCLSTSSRGICPKQEHIADKLLHWRGLSSPRSAHGALIPTPGMSAEYAPQGICKDEPSSYTCTTCKQPFTSAWFLLQHAQNTHGLRIYLESEHGSPLTPRVGIPSGLGAECPSQPPLHGIHIADNNPFNLLRIPGSVSREASGLAEGRFPPTPPLFSPPPRHHLDPHRIERLGAEEMALATHHPSAFDRVLRLNPMAMEPPAMDFSRRLRELAGNTSSPPLSPGRPSPMQRLLQPFQPGSKPPFLATPPLPPLQSAPPPSQPPVKSKSCEFCGKTFKFQSNLVVHRRSHTGEKPYKCNLCDHACTQASKLKRHMKTHMHKSSPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEEEEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDESRALPDVMQGMVLSSMQHFSEAFHQVLGEKHKRGHLAEAEGHRDTCDEDSVAGESDRIDDGTVNGRGCSPGESASGGLSKKLLLGSPSSLSPFSKRIKLEKEFDLPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDGGISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYACAQSSKLTRHMKTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLNNDIKTE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
74PhosphorylationKRKQCNGSLCLEKAV
CCCCCCCCEEHHHHC		11.2628111955
86PhosphorylationKAVDKPPSPSPIEMK
HHCCCCCCCCCCCCC		46.6823401153
88PhosphorylationVDKPPSPSPIEMKKA
CCCCCCCCCCCCCCC		42.7330266825
96PhosphorylationPIEMKKASNPVEVGI
CCCCCCCCCCEEEEE		51.0126074081
106PhosphorylationVEVGIQVTPEDDDCL
EEEEEEECCCCCCCC		12.4626074081
114PhosphorylationPEDDDCLSTSSRGIC
CCCCCCCCCCCCCCC		32.3530576142
115PhosphorylationEDDDCLSTSSRGICP
CCCCCCCCCCCCCCC		20.1330576142
116PhosphorylationDDDCLSTSSRGICPK
CCCCCCCCCCCCCCC		18.0530576142
117PhosphorylationDDCLSTSSRGICPKQ
CCCCCCCCCCCCCCC		34.3230576142
123SumoylationSSRGICPKQEHIADK
CCCCCCCCCHHHHHH		65.0028112733
123UbiquitinationSSRGICPKQEHIADK
CCCCCCCCCHHHHHH		65.00-
130UbiquitinationKQEHIADKLLHWRGL
CCHHHHHHHHHHCCC		43.8821890473
130 (in isoform 1)Ubiquitination-43.8821890473
130 (in isoform 2)Ubiquitination-43.8821890473
130 (in isoform 3)Ubiquitination-43.8821890473
138PhosphorylationLLHWRGLSSPRSAHG
HHHHCCCCCCCHHCC		40.9117081983
139PhosphorylationLHWRGLSSPRSAHGA
HHHCCCCCCCHHCCC		29.4024719451
142PhosphorylationRGLSSPRSAHGALIP
CCCCCCCHHCCCCCC		28.1828348404
150PhosphorylationAHGALIPTPGMSAEY
HCCCCCCCCCCCCCC		26.02-
164SumoylationYAPQGICKDEPSSYT
CCCCCCCCCCCCCCE		64.3128112733
168PhosphorylationGICKDEPSSYTCTTC
CCCCCCCCCCEECCC		33.6526552605
169PhosphorylationICKDEPSSYTCTTCK
CCCCCCCCCEECCCC		34.8726552605
170PhosphorylationCKDEPSSYTCTTCKQ
CCCCCCCCEECCCCC		15.3526552605
171PhosphorylationKDEPSSYTCTTCKQP
CCCCCCCEECCCCCC		12.8126552605
173PhosphorylationEPSSYTCTTCKQPFT
CCCCCEECCCCCCCC		27.6826552605
174PhosphorylationPSSYTCTTCKQPFTS
CCCCEECCCCCCCCC		21.6126552605
198PhosphorylationNTHGLRIYLESEHGS
HCCCEEEEEECCCCC		9.6630576142
201PhosphorylationGLRIYLESEHGSPLT
CEEEEEECCCCCCCC		32.0923927012
205PhosphorylationYLESEHGSPLTPRVG
EEECCCCCCCCCCCC		20.7423401153
205 (in isoform 3)Phosphorylation-20.74-
208PhosphorylationSEHGSPLTPRVGIPS
CCCCCCCCCCCCCCC		16.6628355574
208 (in isoform 3)Phosphorylation-16.66-
214 (in isoform 3)Phosphorylation-19.2023684312
262PhosphorylationAEGRFPPTPPLFSPP
CCCCCCCCCCCCCCC		37.4630301811
267PhosphorylationPPTPPLFSPPPRHHL
CCCCCCCCCCCCCCC		44.1526329039
271Asymmetric dimethylargininePLFSPPPRHHLDPHR
CCCCCCCCCCCCHHH		35.31-
271MethylationPLFSPPPRHHLDPHR
CCCCCCCCCCCCHHH		35.31-
326PhosphorylationLRELAGNTSSPPLSP
HHHHHCCCCCCCCCC		29.6630266825
327PhosphorylationRELAGNTSSPPLSPG
HHHHCCCCCCCCCCC		44.8623401153
328PhosphorylationELAGNTSSPPLSPGR
HHHCCCCCCCCCCCC		28.6223401153
332PhosphorylationNTSSPPLSPGRPSPM
CCCCCCCCCCCCCHH		30.9623401153
337PhosphorylationPLSPGRPSPMQRLLQ
CCCCCCCCHHHHHCC		31.4823927012
350PhosphorylationLQPFQPGSKPPFLAT
CCCCCCCCCCCCCCC		48.9828122231
357PhosphorylationSKPPFLATPPLPPLQ
CCCCCCCCCCCCCCC		27.8228122231
365PhosphorylationPPLPPLQSAPPPSQP
CCCCCCCCCCCCCCC		50.8828122231
376PhosphorylationPSQPPVKSKSCEFCG
CCCCCCCCCCCCCCC		29.9930631047
377UbiquitinationSQPPVKSKSCEFCGK
CCCCCCCCCCCCCCC		54.10-
378PhosphorylationQPPVKSKSCEFCGKT
CCCCCCCCCCCCCCE		26.4330631047
384AcetylationKSCEFCGKTFKFQSN
CCCCCCCCEEEEECC		52.55-
384UbiquitinationKSCEFCGKTFKFQSN
CCCCCCCCEEEEECC		52.55-
400PhosphorylationVVHRRSHTGEKPYKC
EEECCCCCCCCCCCC		48.5624719451
426PhosphorylationKLKRHMKTHMHKSSP
HHHHHHHHHCCCCCC		19.50-
431PhosphorylationMKTHMHKSSPMTVKS
HHHHCCCCCCCEEEC		25.6223312004
432PhosphorylationKTHMHKSSPMTVKSD
HHHCCCCCCCEEECC		24.4023312004
435PhosphorylationMHKSSPMTVKSDDGL
CCCCCCCEEECCCCC		28.3223312004
438PhosphorylationSSPMTVKSDDGLSTA
CCCCEEECCCCCCCC		36.2828450419
443PhosphorylationVKSDDGLSTASSPEP
EECCCCCCCCCCCCC		27.7028450419
444PhosphorylationKSDDGLSTASSPEPG
ECCCCCCCCCCCCCC		35.2828450419
446PhosphorylationDDGLSTASSPEPGTS
CCCCCCCCCCCCCCC		46.6522617229
447PhosphorylationDGLSTASSPEPGTSD
CCCCCCCCCCCCCCC		30.7122617229
452PhosphorylationASSPEPGTSDLVGSA
CCCCCCCCCCHHCCH		29.7728450419
453PhosphorylationSSPEPGTSDLVGSAS
CCCCCCCCCHHCCHH		34.5628450419
458PhosphorylationGTSDLVGSASSALKS
CCCCHHCCHHHHHHH		19.9426074081
460PhosphorylationSDLVGSASSALKSVV
CCHHCCHHHHHHHHH		20.1726074081
461PhosphorylationDLVGSASSALKSVVA
CHHCCHHHHHHHHHH		37.0226074081
471SumoylationKSVVAKFKSENDPNL
HHHHHHHHCCCCCCC		57.04-
518PhosphorylationVDYGFGLSLEAARHH
CCHHCCCCHHHHHHC		25.2524719451
528PhosphorylationAARHHENSSRGAVVG
HHHHCCCCCCCCEEE		20.5924247654
529PhosphorylationARHHENSSRGAVVGV
HHHCCCCCCCCEEEC		46.4430576142
540PhosphorylationVVGVGDESRALPDVM
EEECCCHHHCCHHHH		27.8230301811
584PhosphorylationEAEGHRDTCDEDSVA
HHCCCCCCCCCCCCC		23.0830576142
589PhosphorylationRDTCDEDSVAGESDR
CCCCCCCCCCCCCCC		16.3023401153
594PhosphorylationEDSVAGESDRIDDGT
CCCCCCCCCCCCCCC		31.1326471730
601PhosphorylationSDRIDDGTVNGRGCS
CCCCCCCCCCCCCCC		20.1426471730
608PhosphorylationTVNGRGCSPGESASG
CCCCCCCCCCCCCCC		38.4723401153
612PhosphorylationRGCSPGESASGGLSK
CCCCCCCCCCCCCCH		33.3830266825
614PhosphorylationCSPGESASGGLSKKL
CCCCCCCCCCCCHHH		42.5530266825
618PhosphorylationESASGGLSKKLLLGS
CCCCCCCCHHHHCCC		30.9023927012
619UbiquitinationSASGGLSKKLLLGSP
CCCCCCCHHHHCCCH		53.11-
620SumoylationASGGLSKKLLLGSPS
CCCCCCHHHHCCCHH		40.7828112733
620UbiquitinationASGGLSKKLLLGSPS
CCCCCCHHHHCCCHH		40.78-
625PhosphorylationSKKLLLGSPSSLSPF
CHHHHCCCHHHCCCH		22.9023401153
627PhosphorylationKLLLGSPSSLSPFSK
HHHCCCHHHCCCHHH		45.6823927012
628PhosphorylationLLLGSPSSLSPFSKR
HHCCCHHHCCCHHHH		35.9323927012
630PhosphorylationLGSPSSLSPFSKRIK
CCCHHHCCCHHHHCC		26.3323401153
633PhosphorylationPSSLSPFSKRIKLEK
HHHCCCHHHHCCHHH		25.1423401153
634UbiquitinationSSLSPFSKRIKLEKE
HHCCCHHHHCCHHHC		59.53-
670UbiquitinationYAASRQLKDPFLSFG
HHHHHCCCCCCCCCC		55.83-
675PhosphorylationQLKDPFLSFGDSRQS
CCCCCCCCCCCCCCC		27.8030301811
679PhosphorylationPFLSFGDSRQSPFAS
CCCCCCCCCCCCCCC		32.3827732954
696PhosphorylationEHSSENGSLRFSTPP
CCCCCCCCEEECCCC		28.14-
700PhosphorylationENGSLRFSTPPGELD
CCCCEEECCCCCCCC		33.3023401153
701PhosphorylationNGSLRFSTPPGELDG
CCCEEECCCCCCCCC		30.6923401153
711PhosphorylationGELDGGISGRSGTGS
CCCCCCCCCCCCCCC		31.2826074081
714PhosphorylationDGGISGRSGTGSGGS
CCCCCCCCCCCCCCC		44.2028450419
716PhosphorylationGISGRSGTGSGGSTP
CCCCCCCCCCCCCCC		29.4428450419
718PhosphorylationSGRSGTGSGGSTPHI
CCCCCCCCCCCCCCC		39.5623401153
721PhosphorylationSGTGSGGSTPHISGP
CCCCCCCCCCCCCCC		42.1423401153
722PhosphorylationGTGSGGSTPHISGPG
CCCCCCCCCCCCCCC		23.3530576142
726PhosphorylationGGSTPHISGPGPGRP
CCCCCCCCCCCCCCC		35.5823927012
734PhosphorylationGPGPGRPSSKEGRRS
CCCCCCCCCCCCCCC		53.3223927012
735PhosphorylationPGPGRPSSKEGRRSD
CCCCCCCCCCCCCCC		37.0930576142
736UbiquitinationGPGRPSSKEGRRSDT
CCCCCCCCCCCCCCC		69.40-
741PhosphorylationSSKEGRRSDTCEYCG
CCCCCCCCCCCHHHH		35.5930576142
741 (in isoform 2)Phosphorylation-35.59-
743PhosphorylationKEGRRSDTCEYCGKV
CCCCCCCCCHHHHHH		14.4228111955
743 (in isoform 2)Phosphorylation-14.4228348404
745 (in isoform 2)Phosphorylation-46.0528348404
746 (in isoform 2)Phosphorylation-14.5128348404
748 (in isoform 2)Phosphorylation-28.4124719451
749UbiquitinationDTCEYCGKVFKNCSN
CCCHHHHHHHHHCCC		40.72-
752UbiquitinationEYCGKVFKNCSNLTV
HHHHHHHHHCCCCEE		61.09-
755PhosphorylationGKVFKNCSNLTVHRR
HHHHHHCCCCEEECC		44.24-
763PhosphorylationNLTVHRRSHTGERPY
CCEEECCCCCCCCCE		25.9223882029
765PhosphorylationTVHRRSHTGERPYKC
EEECCCCCCCCCEEC		41.8228464451
771UbiquitinationHTGERPYKCELCNYA
CCCCCCEECEECCHH		24.74-
784UbiquitinationYACAQSSKLTRHMKT
HHHHCCHHHHHHHHH		60.16-
810PhosphorylationEICKMPFSVYSTLEK
EECCCCCHHHHHHHH		17.8021406692
812PhosphorylationCKMPFSVYSTLEKHM
CCCCCHHHHHHHHHH		8.5021406692
813PhosphorylationKMPFSVYSTLEKHMK
CCCCHHHHHHHHHHH		25.1021406692
814PhosphorylationMPFSVYSTLEKHMKK
CCCHHHHHHHHHHHH		22.6521406692
833SumoylationRVLNNDIKTE-----
HHHCCCCCCC-----		49.8428112733
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of BC11A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of BC11A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of BC11A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CHD4_HUMANCHD4physical
16091750
MTA2_HUMANMTA2physical
16091750
MTA1_HUMANMTA1physical
16091750
HDAC1_HUMANHDAC1physical
16091750
MBD3_HUMANMBD3physical
16091750
SIR1_HUMANSIRT1physical
15639232
BC11A_HUMANBCL11Aphysical
16704730
A4_HUMANAPPphysical
21832049
YMEL1_HUMANYME1L1physical
21988832
CDCA3_HUMANCDCA3physical
21988832
COT2_HUMANNR2F2physical
23975195
NR2E1_HUMANNR2E1physical
23975195
NR2E3_HUMANNR2E3physical
23975195
COT1_HUMANNR2F1physical
23975195
NR2F6_HUMANNR2F6physical
23975195
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of BC11A_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205; THR-208; SER-332;SER-625; SER-630 AND THR-701, AND MASS SPECTROMETRY.
"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-205 AND SER-608,AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-608, AND MASSSPECTROMETRY.

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