COT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COT1_HUMAN
• UniProt AC: P10589
• Protein Name: COUP transcription factor 1
• Gene Name: NR2F1
• Organism: Homo sapiens (Human).
• Sequence Length: 423
• Subcellular Localization: Nucleus .
• Protein Description: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG..
• Protein Sequence: MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGAPATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLNGHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFFPDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSIQCS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
46	Phosphorylation	EQQQQAGSGAPHTPQ HHHHHCCCCCCCCCC	34.49	30177828
51	Phosphorylation	AGSGAPHTPQTPGQP CCCCCCCCCCCCCCC	18.94	26657352
54	Phosphorylation	GAPHTPQTPGQPGAP CCCCCCCCCCCCCCC	30.50	28985074
63	Phosphorylation	GQPGAPATPGTAGDK CCCCCCCCCCCCCCC	22.61	27050516
66	Phosphorylation	GAPATPGTAGDKGQG CCCCCCCCCCCCCCC	28.77	21955146
70	Acetylation	TPGTAGDKGQGPPGS CCCCCCCCCCCCCCC	52.82	26051181
77	Phosphorylation	KGQGPPGSGQSQQHI CCCCCCCCCCCCCEE	39.16	25159151
80	Phosphorylation	GPPGSGQSQQHIECV CCCCCCCCCCEEEEE	35.02	28985074
96	Acetylation	CGDKSSGKHYGQFTC ECCCCCCCEEEEEEC	35.28	26051181
96	Ubiquitination	CGDKSSGKHYGQFTC ECCCCCCCEEEEEEC	35.28	29967540
119	Phosphorylation	RSVRRNLTYTCRANR HHHHHHCEEEECCCC	21.97	-
121	Phosphorylation	VRRNLTYTCRANRNC HHHHCEEEECCCCCC	7.12	22210691
140	Phosphorylation	HHRNQCQYCRLKKCL HHHCHHHHHHHHHHH	6.28	28152594
148	Methylation	CRLKKCLKVGMRREA HHHHHHHHHCCHHHH	46.33	23644510
158	Ubiquitination	MRREAVQRGRMPPTQ CHHHHHHCCCCCCCC	28.25	21890473
160	Ubiquitination	REAVQRGRMPPTQPN HHHHHCCCCCCCCCC	36.30	22817900
200	Phosphorylation	LRAEPYPTSRYGSQC HCCCCCCCCCCCCCC	21.72	-
219	Ubiquitination	NIMGIENICELAARL CCCCHHHHHHHHHHH	0.94	21890473
246	Ubiquitination	FFPDLQITDQVSLLR CCCCCCCCCCHHHHH	13.86	21890473
308	Ubiquitination	IFQEQVEKLKALHVD HHHHHHHHHHHCCCC	57.33	21890473
310	Ubiquitination	QEQVEKLKALHVDSA HHHHHHHHHCCCCHH	61.03	22817900
355	Phosphorylation	SQCALEEYVRSQYPN HHHHHHHHHHHHCCC	7.56	-
366	Methylation	QYPNQPSRFGKLLLR HCCCCCCHHHHHHHH	51.53	115485527
369	Ubiquitination	NQPSRFGKLLLRLPS CCCCHHHHHHHHCCC	33.00	21890473
376	Phosphorylation	KLLLRLPSLRTVSSS HHHHHCCCCCCCCHH	34.77	22210691
381	Phosphorylation	LPSLRTVSSSVIEQL CCCCCCCCHHHHHHH	19.11	22210691
382	Phosphorylation	PSLRTVSSSVIEQLF CCCCCCCHHHHHHHH	25.04	22210691
396	Ubiquitination	FFVRLVGKTPIETLI HHHHHHCCCCHHHHH	43.58	22817900
401	Phosphorylation	VGKTPIETLIRDMLL HCCCCHHHHHHHHHH	28.36	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA3_HUMAN	NCOA3	physical	10652338
ESR1_HUMAN	ESR1	physical	12093745
SP1_HUMAN	SP1	physical	9388268
BC11A_HUMAN	BCL11A	physical	10744719
BC11B_HUMAN	BCL11B	physical	10744719
TF2B_HUMAN	GTF2B	physical	1517211
BC11B_HUMAN	BCL11B	physical	15849318
CBX5_HUMAN	CBX5	physical	15849318
PHB2_HUMAN	PHB2	physical	15140878
ESR1_HUMAN	ESR1	physical	9395481
BC11A_HUMAN	BCL11A	physical	23975195
NCOA2_HUMAN	NCOA2	physical	10652338
AHR_HUMAN	AHR	physical	11368516

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.