dbPTM

NCOA3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCOA3_HUMAN
UniProt AC	Q9Y6Q9
Protein Name	Nuclear receptor coactivator 3
Gene Name	NCOA3
Organism	Homo sapiens (Human).
Sequence Length	1424
Subcellular Localization	Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
Protein Description	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit..
Protein Sequence	MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTISNDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDIIRRCIQRFFSLNDGQSWSQKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPVTNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGGMSMSPNQGLQMPSSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPGLAPNQQNIMISPRNRGSPKIASHQFSPVAGVHSPMASSGNTGNHSFSSSSLSALQAISEGVGTSLLSTLSSPGPKLDNSPNMNITQPSKVSNQDSKSPLGFYCDQNPVESSMCQSNSRDHLSDKESKESSVEGAENQRGPLESKGHKKLLQLLTCSSDDRGHSSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNSPAEVAKITAEATGKDTSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDALSKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSDFYNNSISSNGSHLGTKQQVFQGTNSLGLKSSQSVQSIRPPYNRAVSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSMGGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSIPTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYGQAAASNQLGSWPDGMLSMEQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALGIPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQGGFHLQGQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQALELKMENPTAGGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQSSEMKGWPSGNLARNSSFSQQQFAHQGNPAVYSMVHMNGSSGHMGQMNMNPMPMSGMPMGPDQKYC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGLGENLD ------CCCCCCCCC	54.77	22814378
13	Phosphorylation	ENLDPLASDSRKRKL CCCCCCCCCHHCCCC	43.75	25627689
24	Phosphorylation	KRKLPCDTPGQGLTC CCCCCCCCCCCCCCC	35.72	22817900
30	Phosphorylation	DTPGQGLTCSGEKRR CCCCCCCCCCCHHHH	16.08	30576142
32	Phosphorylation	PGQGLTCSGEKRRRE CCCCCCCCCHHHHHH	44.76	21815630
35	Acetylation	GLTCSGEKRRREQES CCCCCCHHHHHHHHH	55.52	25953088
65	Ubiquitination	DIDNFNVKPDKCAIL CCCCCCCCCHHHHHH	48.91	-
73	Acetylation	PDKCAILKETVRQIR CHHHHHHHHHHHHHH	45.27	26051181
87	Acetylation	RQIKEQGKTISNDDD HHHHHHCCCCCCCHH	42.24	25953088
90	O-linked_Glycosylation	KEQGKTISNDDDVQK HHHCCCCCCCHHHHH	39.16	23301498
97	Ubiquitination	SNDDDVQKADVSSTG CCCHHHHHCCCCCCC	46.53	-
101	Phosphorylation	DVQKADVSSTGQGVI HHHHCCCCCCCCCCC	23.80	21577200
102	Phosphorylation	VQKADVSSTGQGVID HHHCCCCCCCCCCCC	36.08	21577200
167	Ubiquitination	ILHEEDRKDFLKNLP HCCHHHHHHHHHHCC	66.22	-
184	Phosphorylation	TVNGVSWTNETQRQK HCCCCCCCCHHHHHH	18.70	-
191	Ubiquitination	TNETQRQKSHTFNCR CCHHHHHHHCCEEEE	46.52	-
203	Phosphorylation	NCRMLMKTPHDILED EEEEECCCHHHHHHH	16.34	23403867
214	Phosphorylation	ILEDINASPEMRQRY HHHHCCCCHHHHHHH	19.53	29255136
230	Phosphorylation	TMQCFALSQPRAMME HHHHHHHHCCHHHHH	34.41	24719451
244	Phosphorylation	EEGEDLQSCMICVAR HCCCCHHHHHHHHHC	16.98	-
251	Methylation	SCMICVARRITTGER HHHHHHHCCCCCCCC	15.33	5172407
274	Phosphorylation	FITRHDLSGKVVNID CCCHHHCCCCEEEEC	42.50	20068231
276	Acetylation	TRHDLSGKVVNIDTN CHHHCCCCEEEECCH	39.37	22424773
282	Phosphorylation	GKVVNIDTNSLRSSM CCEEEECCHHHHHHC	23.94	20068231
284	Phosphorylation	VVNIDTNSLRSSMRP EEEECCHHHHHHCCC	27.53	20068231
287	Phosphorylation	IDTNSLRSSMRPGFE ECCHHHHHHCCCCHH	33.50	20068231
288	Phosphorylation	DTNSLRSSMRPGFED CCHHHHHHCCCCHHH	16.63	20068231
306	Phosphorylation	RCIQRFFSLNDGQSW HHHHHHHCCCCCCCH	24.45	27251275
316	Ubiquitination	DGQSWSQKRHYQEAY CCCCHHHHHHHHHHH	35.31	-
413	Phosphorylation	NQGLQMPSSRAYGLA CCCCCCCCCCCCCCC	27.41	22210691
414	Phosphorylation	QGLQMPSSRAYGLAD CCCCCCCCCCCCCCC	18.30	22210691
417	Phosphorylation	QMPSSRAYGLADPST CCCCCCCCCCCCCCC	16.15	20068231
423	Phosphorylation	AYGLADPSTTGQMSG CCCCCCCCCCCCCCC	38.87	20068231
424	Phosphorylation	YGLADPSTTGQMSGA CCCCCCCCCCCCCCC	40.09	20068231
425	Phosphorylation	GLADPSTTGQMSGAR CCCCCCCCCCCCCCC	29.74	20068231
429	Phosphorylation	PSTTGQMSGARYGGS CCCCCCCCCCCCCCC	22.78	20068231
450	Phosphorylation	TPGPGMQSPSSYQNN CCCCCCCCCHHHCCC	20.18	28348404
452	Phosphorylation	GPGMQSPSSYQNNNY CCCCCCCHHHCCCCC	47.10	28348404
453	Phosphorylation	PGMQSPSSYQNNNYG CCCCCCHHHCCCCCC	33.84	28348404
454	Phosphorylation	GMQSPSSYQNNNYGL CCCCCHHHCCCCCCC	21.43	28348404
459	Phosphorylation	SSYQNNNYGLNMSSP HHHCCCCCCCCCCCC	25.72	28348404
464	Phosphorylation	NNYGLNMSSPPHGSP CCCCCCCCCCCCCCC	38.32	26074081
465	Phosphorylation	NYGLNMSSPPHGSPG CCCCCCCCCCCCCCC	31.51	26074081
470	Phosphorylation	MSSPPHGSPGLAPNQ CCCCCCCCCCCCCCC	16.86	26074081
505	Phosphorylation	SPVAGVHSPMASSGN CCCCCCCCCCCCCCC	17.60	16760465
509	Phosphorylation	GVHSPMASSGNTGNH CCCCCCCCCCCCCCC	32.31	17574025
543	Phosphorylation	SLLSTLSSPGPKLDN HHHHHHCCCCCCCCC	36.67	16760465
551	Phosphorylation	PGPKLDNSPNMNITQ CCCCCCCCCCCCCCC	19.81	29255136
557	Phosphorylation	NSPNMNITQPSKVSN CCCCCCCCCCHHCCC	29.44	23403867
560	Phosphorylation	NMNITQPSKVSNQDS CCCCCCCHHCCCCCC	35.55	23403867
561	Acetylation	MNITQPSKVSNQDSK CCCCCCHHCCCCCCC	57.26	25953088
563	Phosphorylation	ITQPSKVSNQDSKSP CCCCHHCCCCCCCCC	32.29	23927012
567	Phosphorylation	SKVSNQDSKSPLGFY HHCCCCCCCCCCCEE	25.85	23927012
569	Phosphorylation	VSNQDSKSPLGFYCD CCCCCCCCCCCEECC	29.34	23401153
574	Phosphorylation	SKSPLGFYCDQNPVE CCCCCCEECCCCCCC	8.04	23927012
582	Phosphorylation	CDQNPVESSMCQSNS CCCCCCCCCCCCCCC	24.49	23403867
583	Phosphorylation	DQNPVESSMCQSNSR CCCCCCCCCCCCCCC	15.29	23403867
587	Phosphorylation	VESSMCQSNSRDHLS CCCCCCCCCCCCCCC	31.67	25627689
589	Phosphorylation	SSMCQSNSRDHLSDK CCCCCCCCCCCCCHH	44.31	25627689
598	Phosphorylation	DHLSDKESKESSVEG CCCCHHHHHHHHHCC	47.68	29083192
601	Phosphorylation	SDKESKESSVEGAEN CHHHHHHHHHCCHHH	43.34	22817900
602	Phosphorylation	DKESKESSVEGAENQ HHHHHHHHHCCHHHC	25.86	21815630
615	Phosphorylation	NQRGPLESKGHKKLL HCCCCCCCHHHHHHH	52.17	20068231
616	Acetylation	QRGPLESKGHKKLLQ CCCCCCCHHHHHHHH	56.51	10490106
619	Acetylation	PLESKGHKKLLQLLT CCCCHHHHHHHHHHH	54.51	10490106
620	Acetylation	LESKGHKKLLQLLTC CCCHHHHHHHHHHHC	49.07	10490106
620	Ubiquitination	LESKGHKKLLQLLTC CCCHHHHHHHHHHHC	49.07	10490106
626	Phosphorylation	KKLLQLLTCSSDDRG HHHHHHHHCCCCCCC	20.95	23401153
628	Phosphorylation	LLQLLTCSSDDRGHS HHHHHHCCCCCCCCC	31.41	23898821
629	Phosphorylation	LQLLTCSSDDRGHSS HHHHHCCCCCCCCCC	45.75	21815630
635	Phosphorylation	SSDDRGHSSLTNSPL CCCCCCCCCCCCCCC	29.84	25849741
636	Phosphorylation	SDDRGHSSLTNSPLD CCCCCCCCCCCCCCC	33.27	23927012
638	Phosphorylation	DRGHSSLTNSPLDSS CCCCCCCCCCCCCCC	35.28	25849741
640	Phosphorylation	GHSSLTNSPLDSSCK CCCCCCCCCCCCCCC	22.92	22167270
644	Phosphorylation	LTNSPLDSSCKESSV CCCCCCCCCCCCCCC	45.37	23927012
645	Phosphorylation	TNSPLDSSCKESSVS CCCCCCCCCCCCCCE	28.95	23927012
649	Phosphorylation	LDSSCKESSVSVTSP CCCCCCCCCCEEECC	22.87	27080861
650	Phosphorylation	DSSCKESSVSVTSPS CCCCCCCCCEEECCC	21.36	27080861
652	Phosphorylation	SCKESSVSVTSPSGV CCCCCCCEEECCCCC	22.94	27080861
654	Phosphorylation	KESSVSVTSPSGVSS CCCCCEEECCCCCCC	27.67	25850435
655	Phosphorylation	ESSVSVTSPSGVSSS CCCCEEECCCCCCCC	18.21	30576142
657	Phosphorylation	SVSVTSPSGVSSSTS CCEEECCCCCCCCCC	52.15	25850435
660	Phosphorylation	VTSPSGVSSSTSGGV EECCCCCCCCCCCCC	23.30	27080861
661	Phosphorylation	TSPSGVSSSTSGGVS ECCCCCCCCCCCCCC	34.92	27080861
662	Phosphorylation	SPSGVSSSTSGGVSS CCCCCCCCCCCCCCC	21.06	27080861
663	Phosphorylation	PSGVSSSTSGGVSST CCCCCCCCCCCCCCC	33.08	27080861
664	Phosphorylation	SGVSSSTSGGVSSTS CCCCCCCCCCCCCCC	35.18	27080861
681	Acetylation	HGSLLQEKHRILHKL CCHHHHHHHHHHHHH	25.81	26051181
687	Acetylation	EKHRILHKLLQNGNS HHHHHHHHHHHCCCC	47.66	19608861
694	Phosphorylation	KLLQNGNSPAEVAKI HHHHCCCCHHHHHHE	27.21	30266825
697	Acetylation	QNGNSPAEVAKITAE HCCCCHHHHHHEEEE	46.52	19608861
702	Phosphorylation	PAEVAKITAEATGKD HHHHHHEEEEHHCCC	20.10	23312004
706	Phosphorylation	AKITAEATGKDTSSI HHEEEEHHCCCCCCC	35.95	23312004
708	Acetylation	ITAEATGKDTSSITS EEEEHHCCCCCCCEE	54.18	25953088
710	Phosphorylation	AEATGKDTSSITSCG EEHHCCCCCCCEECC	28.05	23403867
711	Phosphorylation	EATGKDTSSITSCGD EHHCCCCCCCEECCC	29.85	23403867
712	Phosphorylation	ATGKDTSSITSCGDG HHCCCCCCCEECCCC	31.79	23403867
714	Phosphorylation	GKDTSSITSCGDGNV CCCCCCCEECCCCCC	21.66	23403867
715	Phosphorylation	KDTSSITSCGDGNVV CCCCCCEECCCCCCC	17.90	23927012
723	Sumoylation	CGDGNVVKQEQLSPK CCCCCCCCHHHCCCC	43.78	-
723	Sumoylation	CGDGNVVKQEQLSPK CCCCCCCCHHHCCCC	43.78	-
723	Ubiquitination	CGDGNVVKQEQLSPK CCCCCCCCHHHCCCC	43.78	-
728	Phosphorylation	VVKQEQLSPKKKENN CCCHHHCCCCHHHCH	34.07	29255136
753	Ubiquitination	DPSDALSKELQPQVE CHHHHHHHHHHHHHC	64.39	-
767	Phosphorylation	EGVDNKMSQCTSSTI CCCCCCHHHHCCCCC	24.58	28674151
770	Phosphorylation	DNKMSQCTSSTIPSS CCCHHHHCCCCCCCC	20.34	28674151
771	Phosphorylation	NKMSQCTSSTIPSSS CCHHHHCCCCCCCCC	32.86	28674151
772	Phosphorylation	KMSQCTSSTIPSSSQ CHHHHCCCCCCCCCC	16.53	28674151
773	Phosphorylation	MSQCTSSTIPSSSQE HHHHCCCCCCCCCCC	36.35	28674151
776	Phosphorylation	CTSSTIPSSSQEKDP HCCCCCCCCCCCCCC	38.48	25627689
777	Phosphorylation	TSSTIPSSSQEKDPK CCCCCCCCCCCCCCC	30.59	25627689
778	Phosphorylation	SSTIPSSSQEKDPKI CCCCCCCCCCCCCCC	46.85	25159151
781	Acetylation	IPSSSQEKDPKIKTE CCCCCCCCCCCCCCC	72.23	25953088
786	Sumoylation	QEKDPKIKTETSEEG CCCCCCCCCCCCCCC	46.57	-
786	Sumoylation	QEKDPKIKTETSEEG CCCCCCCCCCCCCCC	46.57	-
786	Ubiquitination	QEKDPKIKTETSEEG CCCCCCCCCCCCCCC	46.57	-
834	Phosphorylation	KQQVFQGTNSLGLKS CCCEEECCCCCCCCC	15.73	27251275
836	Phosphorylation	QVFQGTNSLGLKSSQ CEEECCCCCCCCCCC	24.53	25159151
840	Methylation	GTNSLGLKSSQSVQS CCCCCCCCCCCCHHC	46.38	-
841	Phosphorylation	TNSLGLKSSQSVQSI CCCCCCCCCCCHHCC	38.36	23186163
842	Phosphorylation	NSLGLKSSQSVQSIR CCCCCCCCCCHHCCC	25.53	23186163
844	Phosphorylation	LGLKSSQSVQSIRPP CCCCCCCCHHCCCCC	24.87	23186163
849	Methylation	SQSVQSIRPPYNRAV CCCHHCCCCCCCCCC	31.24	4726625
857	O-linked_Glycosylation	PPYNRAVSLDSPVSV CCCCCCCCCCCCCCC	26.02	23301498
857	Phosphorylation	PPYNRAVSLDSPVSV CCCCCCCCCCCCCCC	26.02	29255136
860	Phosphorylation	NRAVSLDSPVSVGSS CCCCCCCCCCCCCCC	32.28	30266825
863	O-linked_Glycosylation	VSLDSPVSVGSSPPV CCCCCCCCCCCCCCC	24.93	23301498
863	Phosphorylation	VSLDSPVSVGSSPPV CCCCCCCCCCCCCCC	24.93	30266825
866	Phosphorylation	DSPVSVGSSPPVKNI CCCCCCCCCCCCCCC	37.20	30266825
867	Phosphorylation	SPVSVGSSPPVKNIS CCCCCCCCCCCCCCC	27.56	29255136
871	Acetylation	VGSSPPVKNISAFPM CCCCCCCCCCCCCCC	55.10	25953088
894 (in isoform 2)	Phosphorylation	-	22.84	22210691
904 (in isoform 3)	Phosphorylation	-	13.99	22210691
910	O-linked_Glycosylation	GGPNRNVTVTQTPSS CCCCCCEEEEECCCC	22.76	23301498
912	O-linked_Glycosylation	PNRNVTVTQTPSSGD CCCCEEEEECCCCCC	19.84	23301498
912	Phosphorylation	PNRNVTVTQTPSSGD CCCCEEEEECCCCCC	19.84	28555341
914	Phosphorylation	RNVTVTQTPSSGDWG CCEEEEECCCCCCCC	18.77	28555341
916	Phosphorylation	VTVTQTPSSGDWGLP EEEEECCCCCCCCCC	50.79	25627689
917	O-linked_Glycosylation	TVTQTPSSGDWGLPN EEEECCCCCCCCCCC	41.81	23301498
917	Phosphorylation	TVTQTPSSGDWGLPN EEEECCCCCCCCCCC	41.81	25627689
926	Acetylation	DWGLPNSKAGRMEPM CCCCCCCCCCCCCCC	62.59	25953088
926	Ubiquitination	DWGLPNSKAGRMEPM CCCCCCCCCCCCCCC	62.59	-
945	Phosphorylation	MGRPGGDYNTSLPRP CCCCCCCCCCCCCCC	24.50	20873877
947	Phosphorylation	RPGGDYNTSLPRPAL CCCCCCCCCCCCCCC	25.97	20873877
948	Phosphorylation	PGGDYNTSLPRPALG CCCCCCCCCCCCCCC	32.51	20873877
951	Dimethylation	DYNTSLPRPALGGSI CCCCCCCCCCCCCCC	34.12	-
951	Methylation	DYNTSLPRPALGGSI CCCCCCCCCCCCCCC	34.12	54561831
1033	Phosphorylation	NRPLLRNSLDDLVGP CCHHHHCCHHHHCCC	27.09	25849741
1042	Phosphorylation	DDLVGPPSNLEGQSD HHHCCCCHHCCCCCH	58.12	22817900
1048	Phosphorylation	PSNLEGQSDERALLD CHHCCCCCHHHHHHH	52.90	22817900
1059	Phosphorylation	ALLDQLHTLLSNTDA HHHHHHHHHHHCCCC	37.68	22817900
1062	Phosphorylation	DQLHTLLSNTDATGL HHHHHHHHCCCCCCH	40.57	22817900
1064	Phosphorylation	LHTLLSNTDATGLEE HHHHHHCCCCCCHHH	24.52	22817900
1067	Phosphorylation	LLSNTDATGLEEIDR HHHCCCCCCHHHHHH	45.14	22817900
1091	Methylation	QGQALEPKQDAFQGQ CCCCCCCCCCCCCCC	51.97	-
1114	Phosphorylation	KAGLYGQTYPAQGPP CCCCCCCCCCCCCCC	27.40	22817900
1171	Asymmetric dimethylarginine	TNTPKQLRMQLQQRL CCCHHHHHHHHHHHH	14.33	-
1171	Methylation	TNTPKQLRMQLQQRL CCCHHHHHHHHHHHH	14.33	24129315
1177	Asymmetric dimethylarginine	LRMQLQQRLQGQQFL HHHHHHHHHHHHHHH	18.93	-
1177	Methylation	LRMQLQQRLQGQQFL HHHHHHHHHHHHHHH	18.93	24129315
1188	Asymmetric dimethylarginine	QQFLNQSRQALELKM HHHHHHHHHHHHHHC	18.94	-
1188	Methylation	QQFLNQSRQALELKM HHHHHHHHHHHHHHC	18.94	24129315
1194	Sumoylation	SRQALELKMENPTAG HHHHHHHHCCCCCCC	34.49	-
1194	Sumoylation	SRQALELKMENPTAG HHHHHHHHCCCCCCC	34.49	-
1329	Phosphorylation	DPAFGRVSSPPNAMM CCCCCCCCCCCCHHH	35.45	30266825
1330	Phosphorylation	PAFGRVSSPPNAMMS CCCCCCCCCCCHHHC	41.33	30266825
1337	Phosphorylation	SPPNAMMSSRMGPSQ CCCCHHHCCCCCCCC	11.16	30266825
1338	Phosphorylation	PPNAMMSSRMGPSQN CCCHHHCCCCCCCCC	14.37	30266825
1357	Phosphorylation	HPQAASIYQSSEMKG CCCHHHHHHCCCCCC	10.39	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
24	T	Phosphorylation	Kinase	MAPK8	P45983	GPS
24	T	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
102	S	Phosphorylation	Kinase	CSNK1E	P49674	GPS
505	S	Phosphorylation	Kinase	ERK-SUBFAMILY	-	GPS
505	S	Phosphorylation	Kinase	GSK-FAMILY	-	GPS
505	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
505	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
505	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
505	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
505	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
509	S	Phosphorylation	Kinase	GSK3A	P49840	PSP
543	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
543	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
543	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
543	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
601	S	Phosphorylation	Kinase	CSNK1D	P48730	GPS
601	S	Phosphorylation	Kinase	CK1	-	Uniprot
728	S	Phosphorylation	Kinase	CDK1	P06493	PSP
857	S	Phosphorylation	Kinase	MAPK6	Q16659	GPS
857	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
857	S	Phosphorylation	Kinase	CHUK	O15111	GPS
857	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
857	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
860	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
860	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
860	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
860	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
867	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
867	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
867	S	Phosphorylation	Kinase	P38-SUBFAMILY	-	GPS
867	S	Phosphorylation	Kinase	MAPK14	Q16539	GPS
867	S	Phosphorylation	Kinase	CDK1	P06493	PSP
1033	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1042	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1048	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1059	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1062	S	Phosphorylation	Kinase	KIS	Q8TAS1	PSP
1062	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1064	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1067	T	Phosphorylation	Kinase	KIS	Q8TAS1	PSP
1067	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1114	T	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
1330	S	Phosphorylation	Kinase	DYRK3	O43781	PSP
1357	Y	Phosphorylation	Kinase	ABL1	P00519	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	SPOP	O43791	PMID:21577200
-	K	Ubiquitination	E3 ubiquitin ligase	FBXW7	Q969H0	PMID:24658274
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:19198599
-	K	Ubiquitination	E3 ubiquitin ligase	UBE3A	Q05086	PMID:16951183

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
601	S	Phosphorylation		19339517
Phosphorylation at Ser-601 by CK1 promotes coactivator function.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCOA3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EP300_HUMAN	EP300	physical	10655477
ANR11_HUMAN	ANKRD11	physical	15184363
RXRA_HUMAN	RXRA	physical	9267036
CCND1_HUMAN	CCND1	physical	9832502
ERR1_HUMAN	ESRRA	physical	10598588
ERR2_HUMAN	ESRRB	physical	10598588
CBP_HUMAN	CREBBP	physical	11076796
ESR1_HUMAN	ESR1	physical	11389589
ESR2_HUMAN	ESR2	physical	11389589
NR0B2_HUMAN	NR0B2	physical	11668176
NR5A2_HUMAN	NR5A2	physical	11668176
NCOA2_HUMAN	NCOA2	physical	11971985
CBP_HUMAN	CREBBP	physical	11971985
RO52_HUMAN	TRIM21	physical	11971985
NEMO_HUMAN	IKBKG	physical	11971985
IKKB_HUMAN	IKBKB	physical	11971985
IKKA_HUMAN	CHUK	physical	11971985
ESR2_HUMAN	ESR2	physical	10681591
VDR_HUMAN	VDR	physical	10681591
PRGR_HUMAN	PGR	physical	10757795
H31T_HUMAN	HIST3H3	physical	11163245
CARM1_HUMAN	CARM1	physical	17043108
CBP_HUMAN	CREBBP	physical	17043108
CARM1_HUMAN	CARM1	physical	16923966
EP300_HUMAN	EP300	physical	16923966
ESR1_HUMAN	ESR1	physical	16923966
BRCA1_HUMAN	BRCA1	physical	16860316
ABL1_HUMAN	ABL1	physical	18765637
NCOR1_HUMAN	NCOR1	physical	12089344
EP300_HUMAN	EP300	physical	11823864
ETS1_HUMAN	ETS1	physical	15788656
ETS2_HUMAN	ETS2	physical	15788656
NCOA2_HUMAN	NCOA2	physical	18267973
NCOA1_HUMAN	NCOA1	physical	18267973
VDR_HUMAN	VDR	physical	10224118
ESR1_HUMAN	ESR1	physical	14766010
CBP_HUMAN	CREBBP	physical	9192892
RARA_HUMAN	RARA	physical	17475621
NCOR2_HUMAN	NCOR2	physical	20392877
SPOP_HUMAN	SPOP	physical	21577200
CDKN3_HUMAN	CDKN3	physical	21577200
IQCK_HUMAN	IQCK	physical	21577200
BABA2_HUMAN	BRE	physical	21577200
DCTN6_HUMAN	DCTN6	physical	21577200
KC1E_HUMAN	CSNK1E	physical	21577200
RARA_HUMAN	RARA	physical	15604093
RARG_HUMAN	RARG	physical	15604093
ERR1_HUMAN	ESRRA	physical	15604093
NR1H3_HUMAN	NR1H3	physical	15604093
NR1H2_HUMAN	NR1H2	physical	15604093
PPARG_HUMAN	PPARG	physical	15604093
SPTA1_HUMAN	SPTA1	physical	16051665
MYH9_HUMAN	MYH9	physical	16051665
ACTS_HUMAN	ACTA1	physical	16051665
ANXA2_HUMAN	ANXA2	physical	16051665
TPR_HUMAN	TPR	physical	16051665
MORC2_HUMAN	MORC2	physical	16051665
NFAC3_HUMAN	NFATC3	physical	16051665
PSME3_HUMAN	PSME3	physical	16051665
IKKA_HUMAN	CHUK	physical	16051665
IKKB_HUMAN	IKBKB	physical	16051665
NEMO_HUMAN	IKBKG	physical	16051665
RO52_HUMAN	TRIM21	physical	16051665
KAT2B_HUMAN	KAT2B	physical	9346901
CBP_HUMAN	CREBBP	physical	9346901
EP300_HUMAN	EP300	physical	10866661
NFKB1_HUMAN	NFKB1	physical	15383283
EP300_HUMAN	EP300	physical	20368990
ESR1_HUMAN	ESR1	physical	20181721
RFX1_HUMAN	RFX1	physical	20181721
ESR1_HUMAN	ESR1	physical	19491275
CBP_HUMAN	CREBBP	physical	21914189
TP53B_HUMAN	TP53BP1	physical	21914189
ANDR_HUMAN	AR	physical	21047772
PRS8_HUMAN	PSMC5	physical	19144644
KPCZ_HUMAN	PRKCZ	physical	18313384
TFF1_HUMAN	TFF1	genetic	18313384
MYCD_HUMAN	MYOCD	physical	17360478
MYCD_HUMAN	MYOCD	genetic	17360478
ESR1_HUMAN	ESR1	physical	17158759
ESR2_HUMAN	ESR2	physical	17158759
CEBPA_HUMAN	CEBPA	genetic	17098861
CEBPD_HUMAN	CEBPD	genetic	17098861
UBE3A_HUMAN	UBE3A	physical	16951183
E2F1_HUMAN	E2F1	physical	16648476
PSME3_HUMAN	PSME3	physical	16439211
PIN1_HUMAN	PIN1	physical	16227615
CBP_HUMAN	CREBBP	physical	16227615
EP300_HUMAN	EP300	physical	16227615
MMS19_HUMAN	MMS19	physical	11279242
E2F1_HUMAN	E2F1	physical	15169882
PTEN_HUMAN	PTEN	physical	23514585
FBXW7_HUMAN	FBXW7	physical	23514585
SPOP_HUMAN	SPOP	physical	23559371
H31T_HUMAN	HIST3H3	physical	14747462
ETV1_HUMAN	ETV1	physical	14747462
ESR1_HUMAN	ESR1	physical	10490106
MKL1_HUMAN	MKL1	physical	17360478
MKL2_HUMAN	MKL2	physical	17360478
CBP_HUMAN	CREBBP	physical	21632823
HNF1A_HUMAN	HNF1A	physical	10777539
TF65_HUMAN	RELA	physical	16331275
PIAS1_HUMAN	PIAS1	physical	22283414
EP300_HUMAN	EP300	physical	25728767
NKX21_HUMAN	NKX2-1	physical	15449938

Drug and Disease Associations

Kegg Disease
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCOA3_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-687, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551 AND SER-857, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"CK1delta modulates the transcriptional activity of ERalpha via AIB1in an estrogen-dependent manner and regulates ERalpha-AIB1interactions."; Giamas G., Castellano L., Feng Q., Knippschild U., Jacob J.,Thomas R.S., Coombes R.C., Smith C.L., Jiao L.R., Stebbing J.; Nucleic Acids Res. 37:3110-3123(2009). Cited for: PHOSPHORYLATION AT SER-601 BY CSNK1D/CK1, AND INTERACTION WITH CSNK1D.	19339517 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551; SER-857 ANDSER-867, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214; SER-551; SER-728;SER-857 AND SER-867, AND MASS SPECTROMETRY.	18669648 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857 AND SER-867, ANDMASS SPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-857, AND MASSSPECTROMETRY.	15302935 [Abstract]

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