dbPTM

NCOA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCOA1_HUMAN
UniProt AC	Q15788
Protein Name	Nuclear receptor coactivator 1
Gene Name	NCOA1
Organism	Homo sapiens (Human).
Sequence Length	1441
Subcellular Localization	Nucleus .
Protein Description	Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3..
Protein Sequence	MSGLGDSSSDPANPDSHKRKGSPCDTLASSTEKRRREQENKYLEELAELLSANISDIDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLLLEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKSLVNGVPWPQEATRRNSHTFNCRMLIHPPDEPGTENQEACQRYEVMQCFTVSQPKSIQEDGEDFQSCLICIARRLPRPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDLVRKCIYAFFQPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQSPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSNSNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGTGISLAQFMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEMIQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSHKLVQLLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVKVKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQLLPTLEKAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEAIDNQFGQPGTGDQIPWTNNTVTAINQSKSEDQCISSQLDELLCPPTTVEGRNDEKALLEQLVSFLSGKDETELAELDRALGIDKLVQGGGLDVLSERFPPQQATPPLIMEERPNLYSQPYSSPSPTANLPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQPRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQITPQPPLNAQMLAQRQRELYSQQHRQRQLIQQQRAMLMRQQSFGNNLPPSSGLPVQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTGNIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQTPPASGYQSPDMKAWQQGAIGNNNVFSQAVQNQPTPAQPGVYNNMSITVSMAGGNTNVQNMNPMMAQMQMSSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADGTQQVQQVQVFADVQCTVNLVGGDPYLNQPGPLGTQKPTSGPQTPQAQQKSLLQQLLTE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGLGDSSS ------CCCCCCCCC	54.77	20068231
2	Phosphorylation	------MSGLGDSSS ------CCCCCCCCC	54.77	20068231
7	Phosphorylation	-MSGLGDSSSDPANP -CCCCCCCCCCCCCC	29.91	25159151
8	Phosphorylation	MSGLGDSSSDPANPD CCCCCCCCCCCCCCC	43.42	26074081
9	Phosphorylation	SGLGDSSSDPANPDS CCCCCCCCCCCCCCC	52.11	26074081
16	Phosphorylation	SDPANPDSHKRKGSP CCCCCCCCCCCCCCC	31.97	26074081
18	Acetylation	PANPDSHKRKGSPCD CCCCCCCCCCCCCCH	60.81	25953088
22	Phosphorylation	DSHKRKGSPCDTLAS CCCCCCCCCCHHHCH	25.95	23401153
26	Phosphorylation	RKGSPCDTLASSTEK CCCCCCHHHCHHHHH	30.82	30266825
29	Phosphorylation	SPCDTLASSTEKRRR CCCHHHCHHHHHHHH	40.69	23403867
30	Phosphorylation	PCDTLASSTEKRRRE CCHHHCHHHHHHHHH	34.67	23403867
31	Phosphorylation	CDTLASSTEKRRREQ CHHHCHHHHHHHHHH	42.93	23403867
59	Phosphorylation	ANISDIDSLSVKPDK CCCCHHHHCCCCHHH	23.91	24719451
88	Phosphorylation	KRMEQEKSTTDDDVQ HHHHHHCCCCCHHHH	35.47	28450419
89	Phosphorylation	RMEQEKSTTDDDVQK HHHHHCCCCCHHHHH	45.36	28450419
90	Phosphorylation	MEQEKSTTDDDVQKS HHHHCCCCCHHHHHH	44.51	28450419
97	Phosphorylation	TDDDVQKSDISSSSQ CCHHHHHHHHCCCCC	24.08	28450419
102	Phosphorylation	QKSDISSSSQGVIEK HHHHHCCCCCCCCCH	21.64	27282143
103	Phosphorylation	KSDISSSSQGVIEKE HHHHCCCCCCCCCHH	32.66	17525332
192	Phosphorylation	QEATRRNSHTFNCRM HHHHCCCCCEEEEEE	23.30	26091039
209	Phosphorylation	HPPDEPGTENQEACQ CCCCCCCCCCHHHHH	42.34	20068231
269	Phosphorylation	FMTKQDTTGKIISID EECCCCCCCCEEEEE	44.78	22210691
274	Phosphorylation	DTTGKIISIDTSSLR CCCCCEEEEEHHHHH	20.20	-
277	Phosphorylation	GKIISIDTSSLRAAG CCEEEEEHHHHHHCC	20.67	22210691
278	Phosphorylation	KIISIDTSSLRAAGR CEEEEEHHHHHHCCC	24.51	22210691
279	Phosphorylation	IISIDTSSLRAAGRT EEEEEHHHHHHCCCC	24.78	29457462
308	Phosphorylation	QPQGREPSYARQLFQ CCCCCCCHHHHHHHH	27.03	24719451
325	Phosphorylation	MTRGTASSPSYRFIL HHHCCCCCCCEEEEC	18.53	21550420
369	Phosphorylation	HIIDREHSGLSPQDD EEECCCCCCCCCCCC	36.35	23401153
372	Phosphorylation	DREHSGLSPQDDTNS CCCCCCCCCCCCCCC	24.84	23401153
377	Phosphorylation	GLSPQDDTNSGMSIP CCCCCCCCCCCCCCC	39.30	30108239
389	Phosphorylation	SIPRVNPSVNPSISP CCCCCCCCCCCCCCC	29.35	23403867
393	Phosphorylation	VNPSVNPSISPAHGV CCCCCCCCCCCCCCC	30.41	30266825
395	Phosphorylation	PSVNPSISPAHGVAR CCCCCCCCCCCCCCC	22.00	29255136
405	Phosphorylation	HGVARSSTLPPSNSN CCCCCCCCCCCCCCC	44.52	24260401
411	Phosphorylation	STLPPSNSNMVSTRI CCCCCCCCCCCCCEE	30.55	24260401
416	Phosphorylation	SNSNMVSTRINRQQS CCCCCCCCEECCHHC	24.94	24260401
423	Phosphorylation	TRINRQQSSDLHSSS CEECCHHCCCCCCCC	19.92	-
488	Phosphorylation	ISLAQFMSPRRQVTS CCHHHHCCCCCCCCC	19.28	21550420
517	Phosphorylation	PNISTLSSPVGMTSS CCCCCCCCCCCCCCH	27.07	22817900
532	Phosphorylation	ACNNNNRSYSNIPVT HHCCCCCCCCCCCCE	34.73	29978859
533	Phosphorylation	CNNNNRSYSNIPVTS HCCCCCCCCCCCCEE	11.51	29978859
534	Phosphorylation	NNNNRSYSNIPVTSL CCCCCCCCCCCCEEE	29.54	29978859
539	Phosphorylation	SYSNIPVTSLQGMNE CCCCCCCEEECCCCC	20.54	29978859
540	Phosphorylation	YSNIPVTSLQGMNEG CCCCCCEEECCCCCC	20.94	29978859
551	Phosphorylation	MNEGPNNSVGFSASS CCCCCCCCCCCCCCH	30.20	27080861
555	Phosphorylation	PNNSVGFSASSPVLR CCCCCCCCCCHHHHH	22.70	27080861
557	Phosphorylation	NSVGFSASSPVLRQM CCCCCCCCHHHHHHH	33.70	29978859
558	Phosphorylation	SVGFSASSPVLRQMS CCCCCCCHHHHHHHH	20.81	29978859
565	Phosphorylation	SPVLRQMSSQNSPSR HHHHHHHHCCCCCCC	22.04	29978859
566	Phosphorylation	PVLRQMSSQNSPSRL HHHHHHHCCCCCCCC	28.21	29978859
569	Phosphorylation	RQMSSQNSPSRLNIQ HHHHCCCCCCCCCCC	19.33	21550420
571	Phosphorylation	MSSQNSPSRLNIQPA HHCCCCCCCCCCCCC	49.58	29978859
579	Acetylation	RLNIQPAKAESKDNK CCCCCCCCCCCCCHH	60.41	25953088
582	Phosphorylation	IQPAKAESKDNKEIA CCCCCCCCCCHHHHH	50.60	18077418
590	Phosphorylation	KDNKEIASILNEMIQ CCHHHHHHHHHHHHH	33.02	27732954
598	Phosphorylation	ILNEMIQSDNSSSDG HHHHHHHCCCCCCCC	28.03	27732954
601	Phosphorylation	EMIQSDNSSSDGKPL HHHHCCCCCCCCCCC	35.89	27732954
602	Phosphorylation	MIQSDNSSSDGKPLD HHHCCCCCCCCCCCC	38.41	27732954
603	Phosphorylation	IQSDNSSSDGKPLDS HHCCCCCCCCCCCCC	50.64	27732954
620	Phosphorylation	LHNNDRLSDGDSKYS CCCCCCCCCCCCCCH	40.20	25159151
624	Phosphorylation	DRLSDGDSKYSQTSH CCCCCCCCCCHHHHH	38.74	29449344
632	Acetylation	KYSQTSHKLVQLLTT CCHHHHHHHHHHHHH	50.55	23954790
639	O-linked_Glycosylation	KLVQLLTTTAEQQLR HHHHHHHHCHHHHHH	24.79	28657654
640	O-linked_Glycosylation	LVQLLTTTAEQQLRH HHHHHHHCHHHHHHH	23.98	28657654
659	Phosphorylation	TSCKDVLSCTGTSNS CCHHHHHHCCCCCCC	14.96	20068231
661	Phosphorylation	CKDVLSCTGTSNSAS HHHHHHCCCCCCCCC	39.87	20068231
663	Phosphorylation	DVLSCTGTSNSASAN HHHHCCCCCCCCCCC	13.44	20068231
664	Phosphorylation	VLSCTGTSNSASANS HHHCCCCCCCCCCCC	30.08	20068231
666	Phosphorylation	SCTGTSNSASANSSG HCCCCCCCCCCCCCC	24.30	20068231
668	Phosphorylation	TGTSNSASANSSGGS CCCCCCCCCCCCCCC	28.01	20068231
671	Phosphorylation	SNSASANSSGGSCPS CCCCCCCCCCCCCCC	30.03	20068231
672	Phosphorylation	NSASANSSGGSCPSS CCCCCCCCCCCCCCC	47.16	20068231
675	Phosphorylation	SANSSGGSCPSSHSS CCCCCCCCCCCCCCH	26.78	20068231
678	Phosphorylation	SSGGSCPSSHSSLTE CCCCCCCCCCCHHHH	45.04	20068231
679	Phosphorylation	SGGSCPSSHSSLTER CCCCCCCCCCHHHHH	16.72	20068231
681	Phosphorylation	GSCPSSHSSLTERHK CCCCCCCCHHHHHHH	29.05	20068231
682	Phosphorylation	SCPSSHSSLTERHKI CCCCCCCHHHHHHHH	33.61	20068231
684	Phosphorylation	PSSHSSLTERHKILH CCCCCHHHHHHHHHH	32.68	20068231
698	Phosphorylation	HRLLQEGSPSDITTL HHHHHCCCCCCCEEE	22.07	23401153
700	Phosphorylation	LLQEGSPSDITTLSV HHHCCCCCCCEEEEE	43.26	30266825
703	Phosphorylation	EGSPSDITTLSVEPD CCCCCCCEEEEECCC	27.03	30266825
704	Phosphorylation	GSPSDITTLSVEPDK CCCCCCEEEEECCCC	19.85	30266825
706	Phosphorylation	PSDITTLSVEPDKKD CCCCEEEEECCCCCC	23.49	30266825
716	Phosphorylation	PDKKDSASTSVSVTG CCCCCCCCCEEEEEE	25.76	30576142
720	Phosphorylation	DSASTSVSVTGQVQG CCCCCEEEEEEEECC	17.46	30576142
729	Phosphorylation	TGQVQGNSSIKLELD EEEECCCCEEEEEEE	40.02	30576142
732	Sumoylation	VQGNSSIKLELDASK ECCCCEEEEEEECCC	37.55	-
732	Sumoylation	VQGNSSIKLELDASK ECCCCEEEEEEECCC	37.55	12529333
758	Acetylation	YLLDKDEKDLRSTPN HHHCCCHHHHHCCCC	72.67	23236377
762	Phosphorylation	KDEKDLRSTPNLSLD CCHHHHHCCCCCCHH	56.36	30576142
763	Phosphorylation	DEKDLRSTPNLSLDD CHHHHHCCCCCCHHH	15.12	30576142
767	Phosphorylation	LRSTPNLSLDDVKVK HHCCCCCCHHHCEEE	36.07	27732954
774	Sumoylation	SLDDVKVKVEKKEQM CHHHCEEEEEEHHHC	38.67	-
774	Sumoylation	SLDDVKVKVEKKEQM CHHHCEEEEEEHHHC	38.67	12529333
789	Phosphorylation	DPCNTNPTPMTKPTP CCCCCCCCCCCCCCH	27.97	21550420
793	Acetylation	TNPTPMTKPTPEEIK CCCCCCCCCCHHHHH	40.41	26051181
820	Phosphorylation	QFDQLLPTLEKAAQL HHHHHHHHHHHHHCC	47.74	24173317
841	O-linked_Glycosylation	DRMDGAVTSVTIKSE CCCCCCEEEEEEECC	19.56	28657654
844	O-linked_Glycosylation	DGAVTSVTIKSEILP CCCEEEEEEECCCCC	23.58	28657654
846	Sumoylation	AVTSVTIKSEILPAS CEEEEEEECCCCCHH	32.44	28112733
853	Phosphorylation	KSEILPASLQSATAR ECCCCCHHHHHCCCC	25.63	23312004
856	Phosphorylation	ILPASLQSATARPTS CCCHHHHHCCCCCCC	32.64	28348404
858	Phosphorylation	PASLQSATARPTSRL CHHHHHCCCCCCCHH	28.57	28348404
862	Phosphorylation	QSATARPTSRLNRLP HHCCCCCCCHHHCCC	22.41	28348404
863	Phosphorylation	SATARPTSRLNRLPE HCCCCCCCHHHCCCH	37.14	28348404
959	Ubiquitination	DRALGIDKLVQGGGL HHHHCHHHHHCCCCC	48.95	29967540
979	Phosphorylation	RFPPQQATPPLIMEE CCCCHHCCCCCEECC	22.54	21550420
996	Phosphorylation	NLYSQPYSSPSPTAN CCCCCCCCCCCCCCC	42.32	26074081
997	Phosphorylation	LYSQPYSSPSPTANL CCCCCCCCCCCCCCC	24.45	26074081
999	Phosphorylation	SQPYSSPSPTANLPS CCCCCCCCCCCCCCC	36.51	26074081
1001	Phosphorylation	PYSSPSPTANLPSPF CCCCCCCCCCCCCCC	32.30	26074081
1006	Phosphorylation	SPTANLPSPFQGMVR CCCCCCCCCCCCCCC	41.32	21550420
1026	Phosphorylation	GTMPVQVTPPRGAFS CCCCCEECCCCCCCC	15.52	21550420
1029	Dimethylation	PVQVTPPRGAFSPGM CCEECCCCCCCCCCC	50.72	-
1029	Methylation	PVQVTPPRGAFSPGM CCEECCCCCCCCCCC	50.72	30763205
1033	Phosphorylation	TPPRGAFSPGMGMQP CCCCCCCCCCCCCCC	21.73	22817900
1041	Dimethylation	PGMGMQPRQTLNRPP CCCCCCCCCCCCCCC	25.81	-
1041	Methylation	PGMGMQPRQTLNRPP CCCCCCCCCCCCCCC	25.81	30763211
1073	Asymmetric dimethylarginine	QQLIHQNRQAILNQF HHHHHHHHHHHHHHH	22.27	-
1073	Methylation	QQLIHQNRQAILNQF HHHHHHHHHHHHHHH	22.27	-
1091	Asymmetric dimethylarginine	APVGINMRSGMQQQI CCCCEECCCCCCCCC	26.10	-
1091	Methylation	APVGINMRSGMQQQI CCCCEECCCCCCCCC	26.10	-
1092	Phosphorylation	PVGINMRSGMQQQIT CCCEECCCCCCCCCC	28.05	24043423
1099	Phosphorylation	SGMQQQITPQPPLNA CCCCCCCCCCCCCCH	16.13	24043423
1114	Methylation	QMLAQRQRELYSQQH HHHHHHHHHHHHHHH	37.77	115917689
1117	Phosphorylation	AQRQRELYSQQHRQR HHHHHHHHHHHHHHH	10.32	27174698
1118	Phosphorylation	QRQRELYSQQHRQRQ HHHHHHHHHHHHHHH	35.67	27174698
1124	Asymmetric dimethylarginine	YSQQHRQRQLIQQQR HHHHHHHHHHHHHHH	32.98	-
1124	Methylation	YSQQHRQRQLIQQQR HHHHHHHHHHHHHHH	32.98	-
1131	Asymmetric dimethylarginine	RQLIQQQRAMLMRQQ HHHHHHHHHHHHHHH	20.02	-
1131	Methylation	RQLIQQQRAMLMRQQ HHHHHHHHHHHHHHH	20.02	30763217
1179	Phosphorylation	NYGTNPGTPPASTSP CCCCCCCCCCCCCCC	27.62	22817900
1185	Phosphorylation	GTPPASTSPFSQLAA CCCCCCCCCHHHHHC	22.81	22817900
1250	Phosphorylation	ANFAPSLSPGSSMVP CCCCCCCCCCCCCCC	31.39	21550420
1271	Phosphorylation	QSSLLQQTPPASGYQ CCHHHCCCCCCCCCC	20.48	21550420
1279	Phosphorylation	PPASGYQSPDMKAWQ CCCCCCCCCCHHHHH	17.87	21550420
1364	Phosphorylation	NDPALRHTGLYCNQL CCHHHHHCCEECCCC	23.58	23186163
1367	Phosphorylation	ALRHTGLYCNQLSST HHHHCCEECCCCCCC	7.24	23186163
1372	Phosphorylation	GLYCNQLSSTDLLKT CEECCCCCCCCCCCC	22.79	7481822
1373	Phosphorylation	LYCNQLSSTDLLKTE EECCCCCCCCCCCCC	34.24	28450419
1374	Phosphorylation	YCNQLSSTDLLKTEA ECCCCCCCCCCCCCC	27.56	28450419
1394 (in isoform 2)	Phosphorylation	-	19.74	29083192
1397 (in isoform 2)	Phosphorylation	-	20.08	29083192
1398 (in isoform 2)	Phosphorylation	-	4.63	29083192
1426	Phosphorylation	KPTSGPQTPQAQQKS CCCCCCCCHHHHHHH	22.09	21550420

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
22	S	Phosphorylation	Kinase	CDK2	P24941	PSP
325	S	Phosphorylation	Kinase	CDK2	P24941	PSP
395	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
395	S	Phosphorylation	Kinase	CDK2	P24941	PSP
488	S	Phosphorylation	Kinase	CDK2	P24941	PSP
569	S	Phosphorylation	Kinase	CDK2	P24941	PSP
789	T	Phosphorylation	Kinase	CDK2	P24941	PSP
979	T	Phosphorylation	Kinase	CDK2	P24941	PSP
997	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1006	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1026	T	Phosphorylation	Kinase	CDK2	P24941	PSP
1033	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1179	T	Phosphorylation	Kinase	CDK2	P24941	PSP
1179	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
1179	T	Phosphorylation	Kinase	MAPK3	P27361	GPS
1185	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1185	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
1185	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
1250	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1271	T	Phosphorylation	Kinase	CDK2	P24941	PSP
1279	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1426	T	Phosphorylation	Kinase	CDK1	P06493	PSP
1426	T	Phosphorylation	Kinase	CDK2	P24941	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCOA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCOA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FOS_HUMAN	FOS	physical	10847592
JUN_HUMAN	JUN	physical	10567404
JUN_HUMAN	JUN	physical	10847592
NFKB1_HUMAN	NFKB1	physical	10847592
SMCE1_MOUSE	Smarce1	physical	12145209
SMCE1_HUMAN	SMARCE1	physical	12145209
TRIP4_HUMAN	TRIP4	physical	10454579
CBP_HUMAN	CREBBP	physical	11113179
KAT2B_HUMAN	KAT2B	physical	9296499
FOXA2_HUMAN	FOXA2	physical	11069927
RARB_HUMAN	RARB	physical	8754792
TF2B_HUMAN	GTF2B	physical	8754792
TBP_HUMAN	TBP	physical	8754792
TEAD2_HUMAN	TEAD2	physical	10934189
TEAD1_HUMAN	TEAD1	physical	10934189
STAT3_HUMAN	STAT3	physical	11773079
CCND1_HUMAN	CCND1	physical	9832502
ANDR_HUMAN	AR	physical	10567563
ESR2_HUMAN	ESR2	physical	10809226
NCOA2_HUMAN	NCOA2	physical	11971985
CBP_HUMAN	CREBBP	physical	11971985
RO52_HUMAN	TRIM21	physical	11971985
GCR_HUMAN	NR3C1	physical	12118039
PRGC1_HUMAN	PPARGC1A	physical	10558993
THB_HUMAN	THRB	genetic	9171239
THB_HUMAN	THRB	physical	9171239
ESR1_HUMAN	ESR1	physical	12574227
NCOA3_HUMAN	NCOA3	physical	18267973
STAT6_HUMAN	STAT6	physical	18267973
ESR1_HUMAN	ESR1	physical	11358671
RARA_HUMAN	RARA	physical	10760302
GCR_HUMAN	NR3C1	physical	10659697
ESR1_HUMAN	ESR1	physical	10598586
RARA_HUMAN	RARA	physical	10082574
RXRA_HUMAN	RXRA	physical	10082574
THA_HUMAN	THRA	physical	9849963
THA_HUMAN	THRA	physical	9804773
NCOA2_HUMAN	NCOA2	physical	9751728
STAT6_HUMAN	STAT6	physical	14993689
ESR1_HUMAN	ESR1	physical	9192902
CBP_HUMAN	CREBBP	physical	9192892
RARA_HUMAN	RARA	physical	17475621
STAT3_HUMAN	STAT3	physical	17471507
EP300_HUMAN	EP300	physical	14722092
ESR1_HUMAN	ESR1	physical	14715875
ESR2_HUMAN	ESR2	physical	14715875
RBBP6_HUMAN	RBBP6	physical	20184719
PRGR_HUMAN	PGR	physical	21273440
EP300_HUMAN	EP300	physical	20368990
PPARG_HUMAN	PPARG	physical	17468099
NCOA1_HUMAN	NCOA1	physical	9774463
NCOA2_HUMAN	NCOA2	physical	9774463
TIF1A_HUMAN	TRIM24	physical	9774463
KANK2_HUMAN	KANK2	physical	17476305
ESR1_HUMAN	ESR1	physical	10731636
ESR2_HUMAN	ESR2	physical	10731636
ESR2_RAT	Esr2	physical	10731636
ANDR_HUMAN	AR	physical	10731636
GCR_HUMAN	NR3C1	physical	10731636
PPARA_HUMAN	PPARA	physical	10731636
PPARG_HUMAN	PPARG	physical	10731636
PPARG_HUMAN	PPARG	physical	17449869
NR1I2_HUMAN	NR1I2	physical	19171678
PPARG_HUMAN	PPARG	physical	9744270
PPARG_HUMAN	PPARG	physical	20717101
PPARG_HUMAN	PPARG	physical	17312272
CBP_HUMAN	CREBBP	physical	11003650
ESR1_HUMAN	ESR1	physical	17363140
RARA_HUMAN	RARA	physical	17363140
RARB_HUMAN	RARB	physical	17363140
RARG_HUMAN	RARG	physical	17363140
RXRA_HUMAN	RXRA	physical	17363140
EZH2_HUMAN	EZH2	physical	17502350
NR1H4_HUMAN	NR1H4	physical	20338915
RARA_HUMAN	RARA	physical	20338915
BRCA1_HUMAN	BRCA1	physical	16860316
KAT2B_HUMAN	KAT2B	physical	9223281
RXRA_HUMAN	RXRA	physical	10517671
HNF1A_HUMAN	HNF1A	physical	10777539
FOXO1_HUMAN	FOXO1	physical	10973497
EP300_HUMAN	EP300	physical	10973497
ARNT_HUMAN	ARNT	physical	12024042
AHR_HUMAN	AHR	physical	12024042
CBP_HUMAN	CREBBP	physical	15615775
VDR_HUMAN	VDR	physical	12796488
THA_HUMAN	THRA	physical	15140878
RXRA_HUMAN	RXRA	physical	15140878
ESR1_HUMAN	ESR1	physical	15140878
ETS2_HUMAN	ETS2	physical	15788656
ETS1_HUMAN	ETS1	physical	15788656
NR4A1_HUMAN	NR4A1	physical	16002533
SF01_HUMAN	SF1	physical	16002533
WDHD1_HUMAN	WDHD1	physical	16051665
SYTL2_HUMAN	SYTL2	physical	16051665
HSP72_HUMAN	HSPA2	physical	16051665
GRP78_HUMAN	HSPA5	physical	16051665
KCTD3_HUMAN	KCTD3	physical	16051665
TERA_HUMAN	VCP	physical	16051665
ITCH_HUMAN	ITCH	physical	16051665
TRIPB_HUMAN	TRIP11	physical	16051665
RBBP6_HUMAN	RBBP6	physical	16051665
UBR5_HUMAN	UBR5	physical	16051665
NR1I2_HUMAN	NR1I2	physical	17429319
NR4A2_HUMAN	NR4A2	physical	21757690
NR1I2_HUMAN	NR1I2	physical	15331348
NKX21_HUMAN	NKX2-1	physical	15449938

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCOA1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY.	19413330 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphorylation of steroid receptor coactivator-1. Identification ofthe phosphorylation sites and phosphorylation through the mitogen-activated protein kinase pathway."; Rowan B.G., Weigel N.L., O'Malley B.W.; J. Biol. Chem. 275:4475-4483(2000). Cited for: PHOSPHORYLATION AT SER-372; SER-395; SER-517; SER-569; SER-1033;THR-1179 AND SER-1185.	10660621 [Abstract]
Sumoylation
Reference	PubMed
"Sumoylation of the progesterone receptor and of the steroid receptorcoactivator SRC-1."; Chauchereau A., Amazit L., Quesne M., Guiochon-Mantel A., Milgrom E.; J. Biol. Chem. 278:12335-12343(2003). Cited for: SUMOYLATION AT LYS-732 AND LYS-774, UBIQUITINATION, AND MUTAGENESIS OFLYS-732; LYS-774; LYS-800; LYS-846 AND LYS-1378.	12529333 [Abstract]