SMCE1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMCE1_MOUSE
• UniProt AC: O54941
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
• Gene Name: Smarce1
• Organism: Mus musculus (Mouse).
• Sequence Length: 411
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. [PubMed: 12110891 Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth]
• Protein Sequence: MSKRPSYAPPPTPAPATQMPSTPGFVGYNPYSHLAYNNYRLGGNPGTNSRVTASSGITIPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYEAEKIEYNESMKAYHNSPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPDDYDDGFSMKHTATARFQRNHRLISEILSESVVPDVRSVVTTARMQVLKRQVQSLMVHQRKLEAELLQIEERHQEKKRKFLESTDSFNNELKRLCGLKVEVDMEKIAAEIAQAEEQARKRQEEREKEAAEQAERSQSSMAPEEEQVANKAEEKKDEESIPMETEETHLEDTAESQQNGEEGTSTPEDKESGQEGVDSMEVEGTSDSNTGSESNSATVEEPPTDPVPEDEKKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Methylation	----MSKRPSYAPPP ----CCCCCCCCCCC	20.35	-
21	Phosphorylation	APATQMPSTPGFVGY CCCCCCCCCCCCCCC	41.72	-
22	Ubiquitination	PATQMPSTPGFVGYN CCCCCCCCCCCCCCC	22.89	27667366
40	Methylation	HLAYNNYRLGGNPGT CEEECCCCCCCCCCC	29.04	-
57	Ubiquitination	RVTASSGITIPKPPK CEEECCCCCCCCCCC	3.22	27667366
73	Phosphorylation	PDKPLMPYMRYSRKV CCCCCCCCCHHCHHH	4.73	-
92	Ubiquitination	KASNPDLKLWEIGKI HHHCCCCHHHHHHHH	59.96	27667366
146	Acetylation	YLAYINAKSRAEAAL HHHHHCHHHHHHHHH	35.67	22826441
157	Phosphorylation	EAALEEESRQRQSRM HHHHHHHHHHHHHHH	36.67	-
189	Ubiquitination	YDDGFSMKHTATARF CCCCCCCCHHHHHHH	36.28	-
201	Ubiquitination	ARFQRNHRLISEILS HHHHHHHHHHHHHHC	36.95	27667366
204	Phosphorylation	QRNHRLISEILSESV HHHHHHHHHHHCCCC	24.15	29514104
236	Ubiquitination	RQVQSLMVHQRKLEA HHHHHHHHHHHHHHH	4.16	27667366
240	Ubiquitination	SLMVHQRKLEAELLQ HHHHHHHHHHHHHHH	44.07	-
262	Phosphorylation	KKRKFLESTDSFNNE HHHHHHHCCHHHHHH	39.39	29899451
263	Phosphorylation	KRKFLESTDSFNNEL HHHHHHCCHHHHHHH	26.70	26643407
265	Phosphorylation	KFLESTDSFNNELKR HHHHCCHHHHHHHHH	29.93	26643407
271	Ubiquitination	DSFNNELKRLCGLKV HHHHHHHHHHHCCCE	36.83	27667366
316	Phosphorylation	EQAERSQSSMAPEEE HHHHHHHHCCCHHHH	24.27	28973931
328	Acetylation	EEEQVANKAEEKKDE HHHHHHHHHHHHCCC	47.65	23236377
353	Phosphorylation	HLEDTAESQQNGEEG HHHHHHHHHHCCCCC	34.30	28285833
361	Phosphorylation	QQNGEEGTSTPEDKE HHCCCCCCCCHHHHH	32.48	26643407
362	Phosphorylation	QNGEEGTSTPEDKES HCCCCCCCCHHHHHC	53.47	25521595
363	Phosphorylation	NGEEGTSTPEDKESG CCCCCCCCHHHHHCC	30.45	27087446
369	Phosphorylation	STPEDKESGQEGVDS CCHHHHHCCCCCCCE	52.06	25367039
376	Phosphorylation	SGQEGVDSMEVEGTS CCCCCCCEEEEECCC	17.90	25367039
382	Phosphorylation	DSMEVEGTSDSNTGS CEEEEECCCCCCCCC	18.82	25367039
383	Phosphorylation	SMEVEGTSDSNTGSE EEEEECCCCCCCCCC	50.31	25367039
385	Phosphorylation	EVEGTSDSNTGSESN EEECCCCCCCCCCCC	35.74	25367039
387	Phosphorylation	EGTSDSNTGSESNSA ECCCCCCCCCCCCCC	46.14	25367039
389	Phosphorylation	TSDSNTGSESNSATV CCCCCCCCCCCCCCC	35.49	25367039
391	Phosphorylation	DSNTGSESNSATVEE CCCCCCCCCCCCCCC	37.47	25367039
393	Phosphorylation	NTGSESNSATVEEPP CCCCCCCCCCCCCCC	34.30	25367039
395	Phosphorylation	GSESNSATVEEPPTD CCCCCCCCCCCCCCC	28.42	25367039
401	Phosphorylation	ATVEEPPTDPVPEDE CCCCCCCCCCCCHHH	64.75	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMCE1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMCE1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMCE1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NCOA1_HUMAN	NCOA1	physical	12145209
NCOA2_HUMAN	NCOA2	physical	12145209
ESR1_MOUSE	Esr1	physical	12145209
SMCA4_MOUSE	Smarca4	physical	19781646
NCOA3_HUMAN	NCOA3	physical	12145209

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.