dbPTM

NCOA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NCOA2_HUMAN
UniProt AC	Q15596
Protein Name	Nuclear receptor coactivator 2
Gene Name	NCOA2
Organism	Homo sapiens (Human).
Sequence Length	1464
Subcellular Localization	Nucleus.
Protein Description	Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity)..
Protein Sequence	MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTRKYC

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGMGENTS ------CCCCCCCCC	49.11	19413330
2	O-linked_Glycosylation	------MSGMGENTS ------CCCCCCCCC	49.11	30059200
2	Phosphorylation	------MSGMGENTS ------CCCCCCCCC	49.11	19413330
8	Phosphorylation	MSGMGENTSDPSRAE CCCCCCCCCCHHHHH	30.15	-
29	Phosphorylation	CPDQLGPSPKRNTEK CCCCCCCCCCCCHHH	41.05	23401153
31	Acetylation	DQLGPSPKRNTEKRN CCCCCCCCCCHHHHC	63.72	25953088
76	Phosphorylation	KCAILKETVKQIRQI HHHHHHHHHHHHHHH	31.26	28348404
78	Acetylation	AILKETVKQIRQIKE HHHHHHHHHHHHHHH	47.64	23749302
99	Ubiquitination	ANIDEVQKSDVSSTG CCCHHHHHHCCCCCC	54.52	-
161	Phosphorylation	LMNKSVYSILHVGDH HHCCCHHEEEECCCH	19.27	-
195	Phosphorylation	GEPPRRNSHTFNCRM CCCCCCCCCCEEEEE	23.30	29209046
197	Phosphorylation	PPRRNSHTFNCRMLV CCCCCCCCEEEEEEE	19.16	29209046
205	Ubiquitination	FNCRMLVKPLPDSEE EEEEEEEEECCCCCC	36.55	-
210	Phosphorylation	LVKPLPDSEEEGHDN EEEECCCCCCCCCCC	44.99	29255136
239	Sumoylation	VSQPKSIKEEGEDLQ CCCCCCHHHCCCCHH	57.72	-
239	Sumoylation	VSQPKSIKEEGEDLQ CCCCCCHHHCCCCHH	57.72	28112733
267	Phosphorylation	ERPVLPSSESFTTRQ CCCCCCCCCCCCCCH	35.01	27251275
269	Phosphorylation	PVLPSSESFTTRQDL CCCCCCCCCCCCHHH	29.82	27251275
279	Ubiquitination	TRQDLQGKITSLDTS CCHHHCCCEEECCHH	29.83	-
293	Ubiquitination	STMRAAMKPGWEDLV HHHHHHHCCCHHHHH	35.33	-
306	Acetylation	LVRRCIQKFHAQHEG HHHHHHHHHHHHHCC	21.14	26051181
306	Ubiquitination	LVRRCIQKFHAQHEG HHHHHHHHHHHHHCC	21.14	-
320	Ubiquitination	GESVSYAKRHHHEVL CCCCCHHHHHHHHHH	43.99	-
338	Asymmetric dimethylarginine	LAFSQIYRFSLSDGT CHHHEEEEEECCCCC	19.12	-
338	Methylation	LAFSQIYRFSLSDGT CHHHEEEEEECCCCC	19.12	-
358	Phosphorylation	TKSKLIRSQTTNEPQ ECCHHHHCCCCCCCC	25.53	20068231
360	Phosphorylation	SKLIRSQTTNEPQLV CHHHHCCCCCCCCEE	32.60	20068231
361	Phosphorylation	KLIRSQTTNEPQLVI HHHHCCCCCCCCEEE	29.92	20068231
369	Phosphorylation	NEPQLVISLHMLHRE CCCCEEEEEEEEECC	12.54	20068231
387	Phosphorylation	CVMNPDLTGQTMGKP EEECCCCCCCCCCCC	34.32	20068231
399	Phosphorylation	GKPLNPISSNSPAHQ CCCCCCCCCCCHHHH	25.40	25159151
400	Phosphorylation	KPLNPISSNSPAHQA CCCCCCCCCCHHHHH	41.89	25159151
402	Phosphorylation	LNPISSNSPAHQALC CCCCCCCCHHHHHHH	25.97	25159151
410	Phosphorylation	PAHQALCSGNPGQDM HHHHHHHCCCCCCCC	42.32	28348404
418	Phosphorylation	GNPGQDMTLSSNINF CCCCCCCCCCCCCCC	31.60	28348404
420	Phosphorylation	PGQDMTLSSNINFPI CCCCCCCCCCCCCCC	16.51	28348404
421	Phosphorylation	GQDMTLSSNINFPIN CCCCCCCCCCCCCCC	44.86	28348404
451	Phosphorylation	SGGMNHVSGMQATTP CCCCCCCCCCCCCCC	22.46	22210691
456	Phosphorylation	HVSGMQATTPQGSNY CCCCCCCCCCCCCCE	23.32	20068231
457	Phosphorylation	VSGMQATTPQGSNYA CCCCCCCCCCCCCEE	19.34	20068231
461	Phosphorylation	QATTPQGSNYALKMN CCCCCCCCCEEEECC	22.78	20068231
463	Phosphorylation	TTPQGSNYALKMNSP CCCCCCCEEEECCCC	18.27	22210691
469	Phosphorylation	NYALKMNSPSQSSPG CEEEECCCCCCCCCC	23.56	22158970
471	Phosphorylation	ALKMNSPSQSSPGMN EEECCCCCCCCCCCC	42.38	22199227
473	Phosphorylation	KMNSPSQSSPGMNPG ECCCCCCCCCCCCCC	42.72	22199227
474	Phosphorylation	MNSPSQSSPGMNPGQ CCCCCCCCCCCCCCC	20.17	22199227
483	Phosphorylation	GMNPGQPTSMLSPRH CCCCCCCCCCCCCCC	20.91	22199227
484	Phosphorylation	MNPGQPTSMLSPRHR CCCCCCCCCCCCCCC	25.14	22199227
487	Phosphorylation	GQPTSMLSPRHRMSP CCCCCCCCCCCCCCC	15.96	22158970
489	Dimethylation	PTSMLSPRHRMSPGV CCCCCCCCCCCCCCC	27.03	-
489	Methylation	PTSMLSPRHRMSPGV CCCCCCCCCCCCCCC	27.03	97778549
493	Phosphorylation	LSPRHRMSPGVAGSP CCCCCCCCCCCCCCC	20.61	19664994
499	Phosphorylation	MSPGVAGSPRIPPSQ CCCCCCCCCCCCHHH	10.98	22158970
501	Methylation	PGVAGSPRIPPSQFS CCCCCCCCCCHHHCC	56.60	5169887
554	Phosphorylation	SLGSSLASPDLKMGN CCCCCCCCCCCCCCC	25.00	24275569
565	Phosphorylation	KMGNLQNSPVNMNPP CCCCCCCCCCCCCCC	19.77	23401153
575	Phosphorylation	NMNPPPLSKMGSLDS CCCCCCHHHCCCCCC	26.77	29396449
579	Phosphorylation	PPLSKMGSLDSKDCF CCHHHCCCCCCCCCC	26.04	28985074
636	Acetylation	QSRLHDSKGQTKLLQ CCCCCCCCCHHHHHH	62.18	19608861
640	Sumoylation	HDSKGQTKLLQLLTT CCCCCHHHHHHHHHC	39.03	-
640	Acetylation	HDSKGQTKLLQLLTT CCCCCHHHHHHHHHC	39.03	19608861
640	Sumoylation	HDSKGQTKLLQLLTT CCCCCHHHHHHHHHC	39.03	19608861
640	Ubiquitination	HDSKGQTKLLQLLTT CCCCCHHHHHHHHHC	39.03	19608861
648	Sumoylation	LLQLLTTKSDQMEPS HHHHHHCCHHHCCCC	46.96	28112733
649	Phosphorylation	LQLLTTKSDQMEPSP HHHHHCCHHHCCCCC	30.86	23312004
655	Phosphorylation	KSDQMEPSPLASSLS CHHHCCCCCCHHCCC	21.17	25159151
659	Phosphorylation	MEPSPLASSLSDTNK CCCCCCHHCCCCCCC	39.22	28450419
660	Phosphorylation	EPSPLASSLSDTNKD CCCCCHHCCCCCCCC	26.70	28450419
662	Phosphorylation	SPLASSLSDTNKDST CCCHHCCCCCCCCCC	44.32	28450419
664	Phosphorylation	LASSLSDTNKDSTGS CHHCCCCCCCCCCCC	40.57	23090842
668	Phosphorylation	LSDTNKDSTGSLPGS CCCCCCCCCCCCCCC	35.96	20068231
669	Phosphorylation	SDTNKDSTGSLPGSG CCCCCCCCCCCCCCC	40.71	20068231
671	Phosphorylation	TNKDSTGSLPGSGST CCCCCCCCCCCCCCC	31.32	20068231
675	Phosphorylation	STGSLPGSGSTHGTS CCCCCCCCCCCCCCC	27.86	25159151
677	Phosphorylation	GSLPGSGSTHGTSLK CCCCCCCCCCCCCHH	20.94	20068231
678	Phosphorylation	SLPGSGSTHGTSLKE CCCCCCCCCCCCHHH	28.05	23401153
681	Phosphorylation	GSGSTHGTSLKEKHK CCCCCCCCCHHHHHH	24.23	23401153
682	Phosphorylation	SGSTHGTSLKEKHKI CCCCCCCCHHHHHHH	41.87	20068231
697	Phosphorylation	LHRLLQDSSSPVDLA HHHHHCCCCCCCHHH	21.54	30266825
698	Phosphorylation	HRLLQDSSSPVDLAK HHHHCCCCCCCHHHH	47.12	23401153
699	Phosphorylation	RLLQDSSSPVDLAKL HHHCCCCCCCHHHHH	32.66	19664994
705	Methylation	SSPVDLAKLTAEATG CCCCHHHHHHHHHHC	54.38	-
705	Sumoylation	SSPVDLAKLTAEATG CCCCHHHHHHHHHHC	54.38	28112733
705	Ubiquitination	SSPVDLAKLTAEATG CCCCHHHHHHHHHHC	54.38	-
713	Acetylation	LTAEATGKDLSQESS HHHHHHCCCCCCCCC	51.66	23954790
716	Phosphorylation	EATGKDLSQESSSTA HHHCCCCCCCCCCCC	41.87	25159151
719	Phosphorylation	GKDLSQESSSTAPGS CCCCCCCCCCCCCCC	23.19	20068231
720	Phosphorylation	KDLSQESSSTAPGSE CCCCCCCCCCCCCCE	30.84	28450419
721	Phosphorylation	DLSQESSSTAPGSEV CCCCCCCCCCCCCEE	37.56	28450419
722	Phosphorylation	LSQESSSTAPGSEVT CCCCCCCCCCCCEEE	38.53	23927012
726	Phosphorylation	SSSTAPGSEVTIKQE CCCCCCCCEEEEEEC	28.03	23927012
729	Phosphorylation	TAPGSEVTIKQEPVS CCCCCEEEEEECCCC	20.57	23927012
731	Sumoylation	PGSEVTIKQEPVSPK CCCEEEEEECCCCCC	38.96	-
731	Sumoylation	PGSEVTIKQEPVSPK CCCEEEEEECCCCCC	38.96	28112733
736	Phosphorylation	TIKQEPVSPKKKENA EEEECCCCCCHHHHH	41.54	23927012
738	Acetylation	KQEPVSPKKKENALL EECCCCCCHHHHHHH	69.81	19814913
739	Acetylation	QEPVSPKKKENALLR ECCCCCCHHHHHHHH	69.57	19814921
747	Phosphorylation	KENALLRYLLDKDDT HHHHHHHHHHCCCCC	16.16	-
763	Phosphorylation	DIGLPEITPKLERLD CCCCCCCCCCHHHHC	16.83	21815630
765	Sumoylation	GLPEITPKLERLDSK CCCCCCCCHHHHCCC	55.09	-
765	Sumoylation	GLPEITPKLERLDSK CCCCCCCCHHHHCCC	55.09	-
771	Phosphorylation	PKLERLDSKTDPASN CCHHHHCCCCCCCCC	41.89	23401153
772	Acetylation	KLERLDSKTDPASNT CHHHHCCCCCCCCCC	57.52	25953088
773	Phosphorylation	LERLDSKTDPASNTK HHHHCCCCCCCCCCE	51.68	27794612
777	Phosphorylation	DSKTDPASNTKLIAM CCCCCCCCCCEEEEE	50.88	28450419
779	Phosphorylation	KTDPASNTKLIAMKT CCCCCCCCEEEEEEC	25.40	26699800
780	Acetylation	TDPASNTKLIAMKTE CCCCCCCEEEEEECC	41.99	19608861
785	Sumoylation	NTKLIAMKTEKEEMS CCEEEEEECCHHCCC	44.50	-
785	Acetylation	NTKLIAMKTEKEEMS CCEEEEEECCHHCCC	44.50	19608861
785	Sumoylation	NTKLIAMKTEKEEMS CCEEEEEECCHHCCC	44.50	28112733
785	Ubiquitination	NTKLIAMKTEKEEMS CCEEEEEECCHHCCC	44.50	19608861
788	Sumoylation	LIAMKTEKEEMSFEP EEEEECCHHCCCCCC	65.29	-
788	Sumoylation	LIAMKTEKEEMSFEP EEEEECCHHCCCCCC	65.29	-
847	Phosphorylation	INDLMQLTAENSPVT HHHHHHHHHCCCCCC	18.29	27732954
851	Phosphorylation	MQLTAENSPVTPVGA HHHHHCCCCCCCCCH	16.56	22199227
854	Phosphorylation	TAENSPVTPVGAQKT HHCCCCCCCCCHHHH	18.68	22199227
860	Acetylation	VTPVGAQKTALRISQ CCCCCHHHHHHEECH	34.92	25953088
864	Asymmetric dimethylarginine	GAQKTALRISQSTFN CHHHHHHEECHHCCC	24.85	-
864	Methylation	GAQKTALRISQSTFN CHHHHHHEECHHCCC	24.85	-
866	Phosphorylation	QKTALRISQSTFNNP HHHHHEECHHCCCCC	16.19	28555341
868	Phosphorylation	TALRISQSTFNNPRP HHHEECHHCCCCCCC	28.33	28555341
874	Asymmetric dimethylarginine	QSTFNNPRPGQLGRL HHCCCCCCCCCCCCC	50.53	-
874	Methylation	QSTFNNPRPGQLGRL HHCCCCCCCCCCCCC	50.53	54548471
892	Phosphorylation	QNLPLDITLQSPTGA CCCCEEEEEECCCCC	20.57	28122231
895	Phosphorylation	PLDITLQSPTGAGPF CEEEEEECCCCCCCC	27.78	30377224
897	Phosphorylation	DITLQSPTGAGPFPP EEEEECCCCCCCCCC	44.93	28122231
964	O-linked_Glycosylation	QSSAVRVTCAATTSA CCCCEEEEEEHHHCC	5.95	30059200
987	Phosphorylation	MIRNPAASIPMRPSS CCCCCCCCCCCCCCC	29.36	28348404
993	Phosphorylation	ASIPMRPSSQPGQRQ CCCCCCCCCCCCCHH	31.10	28348404
994	Phosphorylation	SIPMRPSSQPGQRQT CCCCCCCCCCCCHHH	42.97	28348404
1001	Phosphorylation	SQPGQRQTLQSQVMN CCCCCHHHHHHHHHH	29.02	25332170
1059	Phosphorylation	NRQPFGSSPDDLLCP CCCCCCCCHHHCCCC	32.50	28464451
1072	Phosphorylation	CPHPAAESPSDEGAL CCCCCCCCCCCHHHH	25.61	28348404
1074	Phosphorylation	HPAAESPSDEGALLD CCCCCCCCCHHHHHH	58.53	26657352
1129	Sumoylation	SNIMLEQKAPVFPQQ CCCCCEECCCCCHHH	45.33	-
1162	Methylation	NFHTMGQRPSYATLR CCCCCCCCCCCEEEC	19.19	115917693
1169	Methylation	RPSYATLRMQPRPGL CCCCEEECCCCCCCC	19.82	115917697
1173	Asymmetric dimethylarginine	ATLRMQPRPGLRPTG EEECCCCCCCCCCCC	22.49	-
1173	Methylation	ATLRMQPRPGLRPTG EEECCCCCCCCCCCC	22.49	24129315
1177	Asymmetric dimethylarginine	MQPRPGLRPTGLVQN CCCCCCCCCCCCCCC	32.42	-
1177	Methylation	MQPRPGLRPTGLVQN CCCCCCCCCCCCCCC	32.42	24129315
1190	Asymmetric dimethylarginine	QNQPNQLRLQLQHRL CCCCCHHHHHHHHHH	15.60	-
1190	Methylation	QNQPNQLRLQLQHRL CCCCCHHHHHHHHHH	15.60	24129315
1196	Asymmetric dimethylarginine	LRLQLQHRLQAQQNR HHHHHHHHHHHHHHC	18.61	-
1196	Methylation	LRLQLQHRLQAQQNR HHHHHHHHHHHHHHC	18.61	24129315
1203	Asymmetric dimethylarginine	RLQAQQNRQPLMNQI HHHHHHHCHHHHHHH	34.85	-
1203	Methylation	RLQAQQNRQPLMNQI HHHHHHHCHHHHHHH	34.85	24129315
1211	Phosphorylation	QPLMNQISNVSNVNL HHHHHHHHCCCCCCE	22.78	24043423
1214	Phosphorylation	MNQISNVSNVNLTLR HHHHHCCCCCCEEEC	39.03	24043423
1219	Phosphorylation	NVSNVNLTLRPGVPT CCCCCCEEECCCCCC	18.60	24719451
1221	Asymmetric dimethylarginine	SNVNLTLRPGVPTQA CCCCEEECCCCCCCC	22.23	-
1221	Methylation	SNVNLTLRPGVPTQA CCCCEEECCCCCCCC	22.23	24129315
1240	Asymmetric dimethylarginine	QMLAQRQREILNQHL HHHHHHHHHHHHHHH	34.80	-
1240	Methylation	QMLAQRQREILNQHL HHHHHHHHHHHHHHH	34.80	54548487
1248	Methylation	EILNQHLRQRQMHQQ HHHHHHHHHHHHHHH	27.75	81450733
1250	Methylation	LNQHLRQRQMHQQQQ HHHHHHHHHHHHHHH	29.38	115386619
1261	Methylation	QQQQVQQRTLMMRGQ HHHHHHHHHHHHHCC	16.85	24129315
1262	Phosphorylation	QQQVQQRTLMMRGQG HHHHHHHHHHHHCCC	18.05	24043423
1266	Asymmetric dimethylarginine	QQRTLMMRGQGLNMT HHHHHHHHCCCCCCC	21.96	-
1266	Methylation	QQRTLMMRGQGLNMT HHHHHHHHCCCCCCC	21.96	24129315
1273	Phosphorylation	RGQGLNMTPSMVAPS HCCCCCCCHHHCCCC	15.90	22210691
1275	Phosphorylation	QGLNMTPSMVAPSGM CCCCCCHHHCCCCCC	19.40	24043423
1280	Phosphorylation	TPSMVAPSGMPATMS CHHHCCCCCCCCCCC	37.68	22210691
1285	Phosphorylation	APSGMPATMSNPRIP CCCCCCCCCCCCCCC	18.43	22210691
1287	Phosphorylation	SGMPATMSNPRIPQA CCCCCCCCCCCCCCC	39.05	22210691
1454	Sumoylation	LPGMDMIKQEGDTTR CCCCCCCCCCCCCCC	35.34	28112733

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
469	S	Phosphorylation	Kinase	CDK9	P50750	PSP
469	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
487	S	Phosphorylation	Kinase	CDK9	P50750	PSP
487	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
493	S	Phosphorylation	Kinase	CDK9	P50750	PSP
493	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
499	S	Phosphorylation	Kinase	CDK9	P50750	PSP
499	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
736	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
736	S	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NCOA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NCOA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	11937504
VDR_HUMAN	VDR	physical	10748178
ERR2_HUMAN	ESRRB	physical	10598588
GCR_HUMAN	NR3C1	physical	12151000
CCNT1_HUMAN	CCNT1	physical	11704662
ESR1_HUMAN	ESR1	physical	18499756
BRCA1_HUMAN	BRCA1	physical	16860316
RARA_HUMAN	RARA	physical	12503607
MEF2C_HUMAN	MEF2C	physical	12130539
CCND3_HUMAN	CCND3	physical	12130539
CDK4_HUMAN	CDK4	physical	12130539
NCOA3_HUMAN	NCOA3	physical	18267973
NCOA1_HUMAN	NCOA1	physical	18267973
ESR1_HUMAN	ESR1	physical	14766010
CBP_HUMAN	CREBBP	physical	9192892
ESR1_HUMAN	ESR1	physical	17697320
USO1_HUMAN	USO1	physical	16051665
UBR5_HUMAN	UBR5	physical	16051665
PYR1_HUMAN	CAD	physical	16051665
WDHD1_HUMAN	WDHD1	physical	16051665
C2D1A_HUMAN	CC2D1A	physical	16051665
TBK1_HUMAN	TBK1	physical	16051665
HSP72_HUMAN	HSPA2	physical	16051665
ATR_HUMAN	ATR	physical	16051665
MAGAB_HUMAN	MAGEA11	physical	20448036
EP300_HUMAN	EP300	physical	20448036
MAGAB_HUMAN	MAGEA11	physical	19828458
GCR_HUMAN	NR3C1	physical	9920895
THB_HUMAN	THRB	physical	9920895
TAT_HV1H2	tat	physical	11704662
PIAS3_MOUSE	Pias3	physical	12208521
PIAS3_HUMAN	PIAS3	physical	12208521
H31T_HUMAN	HIST3H3	physical	14747462
ETV1_HUMAN	ETV1	physical	14747462

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NCOA2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-636; LYS-640; LYS-780 ANDLYS-785, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-699 AND SER-736, ANDMASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-565, AND MASSSPECTROMETRY.	19413330 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-699, AND MASSSPECTROMETRY.	18691976 [Abstract]
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